Chemistry: analytical and immunological testing inventions 06/07

20070148777 - Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system: A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first... Agent: Lahive & Cockfield, LLP

20070148778 - Method and device for monitoring analyte concentration by determining its progression in the living body of a human or animal: The present invention generally relates to a method and a device for monitoring an analyte concentration in the living body of a human or animal. In particular to a method and device for determining analyte values y(tn) correlating with the concentration to be determined are determined for consecutive points in... Agent: Barnes & Thornburg LLP

20070148779 - Multidimensional mass spectrometry or serum and celluar lipids directly from biologic extracts: A method for determination of at least one of the lipid species in a biological sample comprising subjecting the sample to lipid extraction to obtain a lipid extract and subjecting the resulting lipid extract to multidimensional electrospray ionization mass spectrometry using either precursor ion or neutral loss scanning (or both)... Agent: Patrick W. Rasche (15060) Armstrong Teasdale, LLP

20070148780 - Method of raising temperature of received object, and analyzing device: The present invention relates to an analyzing apparatus (1) for analyzing a sample using a container (2) accommodating reagents sealed therein, while raising the temperature of the reagents up to a predetermined temperature. The analyzing apparatus (1) comprises a first temperature measuring means (31) for measuring temperature of the container... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20070148782 - Calibration procedure for investigating biological systems: Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly useful for in-vivo investigation of living systems.... Agent: Mr. Janusz Pawliszyn

20070148781 - Dual path immunoassay device: The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test line or test site with immobilized antigens or... Agent: Gordon & Jacobson, P.C.

20070148783 - Composite microarray slides: Improved composite microarray slides for use in micro-analytical diagnostic applications are disclosed. Specifically, composite microarray slides useful for carrying a microarray of biological polymers on the surface thereof including composite microarray slides having a porous membrane formed by a phase inversion process effectively attached by covalent bonding through chemical agents... Agent: 3m Innovative Properties Company

20070148784 - Novel methods for determining the negative control value for multi-analyte assays: The present invention provides unique and advantageous methods for selecting the negative control value to be used as a correction to the results obtained when measuring the reaction of a complex biological mixture in a multi-analyte assay. The methods of the subject invention are particularly advantageous because the negative control... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070148785 - Separation and cleaning of a suspension comprising magnetic microparticles: A device (10) for automatically separating the solid and liquid phase of a suspension (78) and for purifying magnetic microparticles (76) loaded with organic, in particular molecular biological or biochemical substances, comprises a process area (12) with devices, which move in a cyclic manner for transporting the magnetic microparticles (76)... Agent: Thaddius J. Carvis

20070141709 - Calibrating dispensing device performance for complex and/or non-aqueous liquids: A method for precisely and accurately determining the volume of a test liquid aliquot which can be used to calibrate a liquid delivery device. The method is particularly useful for determining the volume of an aliquot of a test liquid which is complex or non-aqueous, or is both complex and... Agent: Chris A. Caseiro

20070141710 - Stable calibrators for immunoassays: Compositions, methods, and kits comprising calibrators with enhanced stability for immunoassays are provided. The compositions and kits of the invention comprise calibrators that have been linearized. They include calibrators that have been exposed, in a denatured state, to at least one ionic surface charge modifier, and they include calibrators that... Agent: Beckman Coulter, Inc.

20070141711 - Automated lean methods in anatomical pathology: An embodiment of the method of the invention is a method of automating information flow in a laboratory performing tissue staining comprising positioning a networked label printer adjacent to a cutting station, the printer configured to access patient data directly or indirectly from the hospital LIS, the printer being configured... Agent: Muirhead And Saturnelli, LLC

20070141712 - Method for analysing metabolites: Described is a method for analysing the metabolites of a biological sample which comprises quantitatively determining one or more metabolites in said sample in a way that said quantitative determination resolves isotopic mass differences within one metabolite, said method being characterized in that the sample comprises or is derived from... Agent: Foley And Lardner LLP Suite 500

20070141713 - Method of diagnosing chronic diarrhea: A method for obtaining information about a chronic diarrhea condition in a patient, including possible diagnosis of chronic diarrhea, is disclosed. In the method, a sample of a gastrointestinal secretion that contains mitochondria is obtaining from the patient. The sample is analyzed using an analytical technique, such as mass spectroscopy,... Agent: Kirton And Mcconkie

20070141714 - Method to detect small molecules binding to proteins using surface enhanced raman scattering (sers): Embodiments of the invention relate to detecting binding of a first analyte to a second analyte by Raman spectroscopy. An embodiment includes attaching one analyte to a substrate and then detecting the binding of another analyte to the analyte on the substrate by Raman spectroscopy. Another embodiment includes contacting analytes... Agent: Morrison & Foerster LLP

20070141715 - Quantitative method of determining beryllium or a compound thereof in a sample: A method of determining beryllium or a beryllium compound thereof in a sample, includes providing a sample suspected of comprising beryllium or a compound thereof, extracting beryllium or a compound thereof from the sample by dissolving in a solution, adding a fluorescent indicator to the solution to thereby bind any... Agent: Los Alamos National Security, LLC

20070141716 - Pem-3-like compositions and related methods thereof: The application discloses methods and compositions relating to PEM-3-like polypeptides and nucleic acids involved in a variety of biological processes, including viral reproduction.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070141717 - Dual standard curve immunoassay: A method and a kit for determining the presence or amount of analytes in samples over a broad potential concentration range for the analyte. The method and kit incorporate chemiluminescent and fluorescent labels conjugated to a specific binding partner for the analyte for sandwich assays, or to the analyte or... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070141718 - Reduction of scan time in imaging mass spectrometry: Techniques are disclosed for reducing scan times in mass spectral tissue imaging studies. According to a first technique, a tissue imaging boundary is defined that closely approximates the edges of a tissue sample. According to a second technique, a low-resolution scan is performed to identify one or more areas of... Agent: Thermo Finnigan LLC

20070141719 - Reduction of scan time in imaging mass spectrometry: Techniques are disclosed for reducing scan times in mass spectral tissue imaging studies. According to a first technique, a tissue imaging boundary is defined that closely approximates the edges of a tissue sample. According to a second technique, a low-resolution scan is performed to identify one or more areas of... Agent: Thermo Finnigan LLC

20070141720 - Automated analysis of cations in acidic solutions: In one embodiment, a matrix elimination apparatus for eliminating an acidic matrix includes: at least one column packed with a weak anion exchange resin; a source of samples, each sample having an acidic matrix; a basic solution source; a weakly acidic metal complexing reagent source, and an at least one... Agent: Macpherson Kwok Chen & Heid LLP

20070141722 - Device, system and method of detecting targets in a fluid sample: The present invention provides a biochemical detection system that comprises an exchangeable cartridge unit with light guiding tubes pre-coated with capture agent(s) and an optical detection unit Upon flowing the liquid or gaseous sample containing the target(s) through the cartridge until the target(s) bind(s) to the capture agent(s) and is... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070141723 - Immunohistochemistry staining controls: A method and device is described for a quality control device for immunohistochemical testing of surgical biopsies. Immunohistochemistry testing involves the use of antibodies to detect the presence of proteins that have diagnostic or prognostic importance. A cell-free moiety is covalently attached to glass microscope slides. The cell-free moiety can... Agent: Steptoe & Johnson LLP

20070141725 - Immunological assay system and method: An immunological or immunohematological assay system is disclosed that includes a filter vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition system, and a robotic pipettor. The immunological assay system may also include a washer. Also disclosed is an immunological assay method that... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070141721 - Microcantilevers for biological and chemical assays and methods of making and using thereof: Disclosed herein are microcantilevers having structural shapes that are less sensitive to turbulence and drift effects yet provide greater deflections due to analyte concentration. The structural shapes include a C-shaped microcantilever, an E-shaped microcantilever, an L-shaped microcantilever, a double microcantilever, a slit microcantilever, a tapered microcantilever, and a triangular microcantilever.... Agent: Smith, Gambrell & Russell, LLP (uc) Suzannah K. Sundby

20070141724 - Solid phase immobilized trifunctional linker: The present invention is directed to a method of forming an immobilized chemical moiety, such as a trifunctional chemical moiety that includes membrane-anchoring functionalities, on a solid support for use in automated chemical synthesis of a recognition molecule. The invention is further directed to a method of easily and efficiently... Agent: Los Alamos National Security, LLC

20070141726 - Detection via switchable emission of nanocrystals: The present invention relates to methods for determination of an analyte. The invention provides various methods involving exposure of a luminescent material to an analyte wherein, upon interaction with the analyte, a change in luminescence may be observed as a function of the duration of exposure to electromagnetic radiation, thereby... Agent: Wolf Greenfield & Sacks, P.C.

20070141727 - Luminescent metallic cluster particles and uses thereof: A luminescent particle having a luminescent core structure formed from at least one type of luminescent metallic cluster complex and a shell that covers said core structure is described. The luminescent core structure includes one or more aggregates of metal cluster complexes. The shell has one or more layers of... Agent: Kimberly-clark Worldwide, Inc.

20070141728 - Microfluidic platform of arrayed switchable spin-valve elements for high-throughput sorting and manipulation of magnetic particles and biomolecules: Arrays of spin-valve elements that can be selectively activated to trap, hold, manipulate and release magnetically tagged biological and chemical particles, including molecules and polymers. The spin-valve elements that can be selectively activated and deactivated by applying a momentary applied magnetic field thereto. The spin valve element array can be... Agent: Butzel Long

20070134797 - Hydrogen peroxide and peracetic acid indicators and methods: The present invention provides a hydrogen peroxide indicator and a peracetic acid indicator that include a substrate on which is disposed an indicator composition that includes at least one of a select group of colorants and a transition metal salt. As a result of exposure to hydrogen peroxide and/or peracetic... Agent: 3m Innovative Properties Company

20070134798 - Light curing fixative: The invention relates to a cell fixative that can be used in the preparation of slides for investigation by microscopy techniques. In particular the present invention provides a cell fixative that contains a light curable mounting medium.... Agent: Theodore Allen, Esq. Cytyc Corporation

20070134799 - Method and apparatus for controlling reactions: The invention relates to a method and an apparatus for performing an assay on chemical, biochemical, or biological fluids. The apparatus includes an assay chamber for fluid reactions and a centrifugal force activated-valve for controlling fluid movement through the assay chamber. An active surface can be positioned in the assay... Agent: Agilent Technologies Inc.

20070134800 - Method of monitoring a predetermined type of molecule conveyed through a gaseous medium: The present invention provides a method of monitoring a predetermined type of molecule conveyed through a gaseous medium. The method comprises that step of positioning at least one electronic detector for detecting the predetermined type of molecule. The method also comprises the steps of measuring molecules of the predetermined type... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20070134801 - Method and apparatus for analysing a liquid: An apparatus and method for determining the coagulation status of a liquid, especially blood. The apparatus includes a chamber (1) for holding a quantity of said liquid, a body (2) disposed in the chamber and a magnetic device (4,5), the magnetic device co-operating with said chamber and being arranged in... Agent: Kaplan Gilman Gibson & Dernier L.L.P.

20070134802 - Ionization modifier for mass spectrometry: wherein R, R′, R″, R′″, R″″, X and n are as defined in the description and the use of said compound as ionization modifier. The invention further relates to a method for the quantification of a polypeptide or fragments thereof from a source containing said polypeptide in labeled and unlabeled... Agent: Hoffmann-la Roche Inc. Patent Law Department

20070134803 - Process for the parallel detection of crystalline forms of molecular solids: A process for the detection of polymorphic or pseudopolymorphic forms of solid, molecular and crystallizing compounds, or of molecular, cocrystalline compounds or of solid solutions which consist of at least two solid, molecular and crystallizing compounds, in a series investigation using an apparatus for parallel investigations in vessels of an... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070134804 - Method of characterizing a dispersion using transformation techniques: A method for analyzing a dispersion such as an oil/solid suspension or an oil/water emulsion. A set of original domain data is collected relating to an attribute of the dispersion, such as light transmittance therethrough. The set of original domain data is then transformed into a transformed set of original... Agent: Rodman Rodman

20070134805 - Molecular detector arrangement: A method of detecting the presence or absence of an analyte in a sample uses an analyte carrier with a calibration dye held in a region near a metal surface. A reporter dye is held away from a region near the metal surface and is displaceably attached to a selective... Agent: Venable LLP

20070134806 - Quantitation method using isotope labeled internal standard substance, analysis system for executing the quantitation method, and program for the analysis: Problem: An object of the present invention is to quantitate with good accuracy, furthermore, quantitate absolutely, one or a plurality of biological molecules in a sample such as a tissue, a biological fluid, a cell, a cell organ or protein complex. Solution: By adding a metabolically isotope labeled biological molecule... Agent: Morgan Lewis & Bockius LLP

20070134807 - Method and device for regulating fluid flow in microfluidic devices: A method and a microfluidic device are provided to regulate fluid flow by equalization of channel pressures. The fluid flow is regulated by way of valve-actuated channel pressures.... Agent: Ladas & Parry Suite 2100

20070134809 - Microfluidic device and method for concentration and lysis of cells or viruses: A microfluidic device for the concentration and lysis of cells or viruses and a method of concentrating and lysing cells or viruses using the microfluidic device include: magnetic beads, a reaction chamber in which the magnetic beads are accommodated and a laser source. The reaction chamber includes a plurality of... Agent: Cantor Colburn, LLP

20070134808 - Simultaneous multi-column liquid chromatograph for direct sampling of an array of liquid samples: An apparatus and method for transferring one or more liquid samples in one or more sample containers to one or more measurement devices. The invention provides a sample transfer device that is small enough to be mounted over a microtiter plate in an array for simultaneous sampling. In a preferred... Agent: Pacific Ring Services, Inc.

20070134810 - Metering strip and method for lateral flow assay devices: A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. The kit includes a housing, and a membrane disposed within the housing having a detection region and a collection region. A blood sample meter is provided having a first end for absorption... Agent: Dority & Manning, P.A.

20070134811 - Metering technique for lateral flow assay devices: A diagnostic method and associated test kit for detecting an analyte residing in a test sample is provided. A sample membrane is utilized having a collection region and a detection region, the collection region having a known saturation volume for the intended test sample. A barrier is defined between the... Agent: Dority & Manning, P.A.

20070134812 - Controlled electrophoresis method: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having... Agent: Jeffer, Mangels, Butler & Marmaro, LLP

20070134813 - Identification of compounds for inhibiting complexation of c-reactive protein with fibronectin: Disclosed are screening processes for identification of compounds that may inhibit complex formation between C-reactive protein and fibronectin. Compounds identified by the disclosed methods may be utilized to inhibit the target analytes that are known to occur during skin aging as well as during the course of several diseases. Accordingly,... Agent: Dority & Manning, P.A.

20070134814 - Methods and compositions for the detection of calcifying nano-particles, identification and quantification of associated proteins thereon, and correlation to disease: Disclosed are methods and compositions for detecting, analyzing and assessing the significance of calcifying nano-particles. The disclosed methods and compositions generally involve detecting one or more proteins present on a calcifying nano-particle. It has been discovered that particular proteins become associated with calcifying nano-particles. This association provides a means for... Agent: Needle & Rosenberg, P.C.

20070134815 - Sensitivity enhancement of poct devices using gold and silver nanoparticles on substrates containing nanostructures or nanoparticles that interact with labeling particles: The present invention is directed to a substrate for use in detection of an analyte where the substrate includes an engineered surface having nanostructures and the analyte is labeled with nanoparticles. The substrate also includes at least one molecule having binding affinity for the nano-particle labeled analyte; wherein association of... Agent: Agilent Technologies Inc.

20070128729 - Method for the identification and relative quantification of proteins based on the selective isolation of rrnk peptides for the simplification of complex mixtures of proteins: A method based on the selective isolation of peptides originated by the cleavage at the C-terminal end of the arginine residues and do not possess lysine inside their sequences (péptidos RRnK), is described. The method is based on the blocking of amino groups of the LEP peptides and the separation... Agent: Hoffmann & Baron, LLP

20070128730 - Method and device for direct quantitative determination of pesticide seed loading on individual seeds: The present invention provides methods and devices for the direct quantitative analysis of multiple pesticides on individual seeds with or without fluorescent pigments. The seed varieties include corn, cotton, wheat, soybean and canola.... Agent: Syngenta Crop Protection , Inc. Patent And Trademark Department

20070128731 - Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry: Methods for purifying rapamycin are described. Methods for measuring particle quality, median particle size, and crystallinity of samples containing rapamycin or a derivative thereof are also provided.... Agent: Howson And Howson Cathy A. Kodroff

20070128732 - Scintillator composition for a radioassay, and method for its use: A medium for a scintillation assay includes a fluorescent Coumarin dye, typically having a Stokes shift of at least 50 nm and a fluorescence in the range of 460-500 nm. The composition may further include secondary scintillator materials which as PPO, DPA, bis-MSB, BiBuQ, and the like. The scintillator medium... Agent: Lauren Harmon

20070128733 - Two-color (two-photon) excitation with focused excitation beams and a raman shifter: Two-color (two-photon) excitation with two confocal excitation beams is demonstrated with a Raman shifter as excitation light source. Two-color excitation fluorescence is obtained from Coumarin 6H dye sample (peak absorption=394 nm, peak fluorescence=490 nm) that is excited using the first two Stokes outputs (683 nm, 954 nm, two-color excitation=398 nm)... Agent: Ohlandt, Greeley, Ruggiero & Perle, LLP

20070128734 - Method and apparatus for mass spectrometric immunoassay analysis of specific biological fluid proteins: Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins and their variants that are present in complex biological fluids or extracts. Protein and variant levels can be determined using quantitative methods in which the protein/variant signals are normalized to signals of internal reference standard... Agent: Snell & Wilmer L.L.P. (main)