Chemistry: analytical and immunological testing inventions 10/06

20060240557 - Automated mechanical stress assay for screening cleaning ingredients: A method for testing cleaning effect of a compound or compositions is disclosed. The method comprises: (a) Preparing a liquid sample of less than 10 ml comprising the test compound, (b) applying liquid sample to a stained surface, (c) applying mechanical stress to the stained surface by contacting it with...

20060240558 - Photoelectrochemical determination of chemical oxygen demand: A photoelectrochemical assay apparatus for determining chemical oxygen demand (COD) of a water sample which consists of a) a measuring cell for holding a sample to be analysed b) a titanium dioxide nanoparticle photoelectric working electrode and a counter electrode disposed in said cell, c) a UV light source adapted...

20060240559 - 5-hydroxytryptamine transporter gene polymorphisms: A method of determining the susceptibility of a human patient to gastrointestinal diseases such as IBS is disclosed. The method comprises detecting polymorphisms in genes encoding the 5-hydroxytryptamine transporter. Kits for carrying out such methods and methods of medical treatment of human patients are also disclosed...

20060240560 - Microsphere optical ion sensors based on doped silica gel templates: A sensor for determining the concentration of a target ion in a liquid sample having a particulate silica doped with: an ionophore capable of binding the target ion; and an indicator capable of producing a detectable signal in response to binding by the ionophore of the target ion. The detectable...

20060240561 - Biomarkers for diagnosing alzheimer's disease: A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies detection of specific peptide markers, e.g., using mass spectrometric analysis....

20060240562 - Cleavable surfactants and methods of use thereof: Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins....

20060240563 - Electronic system for tracking and monitoring articles to be sterilized and associated method: An electronic system for tracking and monitoring articles to be subjected to a sterilization cycle is disclosed. The method uses a sterilization indicator and electronically links sterilization information with the articles subjected to the sterilization process. The indicator allows a sterilization cycle to be monitored without the need for a...

20060240564 - Ph gradient ion exchange lc-ms and mass compatible buffers: A system for pH gradient ion exchange LC-MS and methods of using such system are described. A buffer system for pH gradient LC-MS that are compatible with a mass spectrometer and methods of using such buffer system are also disclosed....

20060240565 - Environment sensor and conjugated polyene for manufacturing environment sensors: The present invention relates to devices for detecting the presence or absence of a target molecule or substance, compounds which may be employed in such devices and methods of using such compounds. In some embodiments, the compounds are conjugated polyenes....

20060240566 - Delivery of metered amounts of liquid materials: Techniques for the delivery of metered amounts of liquid material include the use of a pin, such as an optical fiber. A sample of the liquid material may be placed on the tip of the pin for delivery to a target area, such as a specific location on a microarray,...

20060240568 - Assay test strips and reading same: An assay test strip includes a flow path, a sample receiving zone, a label, a detection zone that includes a region of interest, and at least one position marker. The at least one position marker is aligned with respect to the region of interest such that location of the at...

20060240567 - Method of immobilizing a protein to a zeolite: The present invention relates to a polypeptide tag and a method using said polypeptide tag sequence for immobilizing a protein on a microporous material, said microporous material is selected from the group consisting of zeolite or similar solid surfaces whereby loss of activity of said protein is less than 10%...

20060240569 - Semi-quantitative immunochromatographic device: The invention provides a device comprising one or more support materials capable of providing lateral flow. The one or more support materials contain an area for a receiving a biological sample containing a target analyte, an area having a movably contained detector ligand capable of forming a complex with the...

20060240571 - Biosensors and methods for detecting agents based upon time resolved luminescent resonance energy transfer: Disclosed are biosensors useful in the detection of potentially harmful or undesirable agents, particularly chemicals and microorganisms in food and water. The biosensors operate under the principle of time-resolved luminescence resonance energy transfer. In a preferred embodiment, the biosensor comprises at antibodies that recognized different but proximal epitopes on a...

20060240570 - Cobalamin assay: The present invention provides a specific binding partner for holoTC having a specificity for holoTC over apoTC of at least 40-fold and an assay method for assaying for holoTC in a sample, the method comprising contacting the sample with a specific binding partner for holoTC and detecting the resultant conjugates....

20060240573 - Optical system including nanostructures for biological or chemical sensing: An analytical device is disclosed. In one embodiment, the analytical device includes a three-dimensional substrate structure comprising a three-dimensional surface. A plurality of noble metal nanoparticles are on the three-dimensional substrate structure. A plurality of capture agents are on the noble metal nanoparticles....

20060240572 - System and method for raman spectroscopy assay using paramagnetic particles: A Raman spectroscopy technique allows an analyte, a paramagnetic particle, and a spectral enhancement particle to combine in solution and for the combination product to be localized by a magnetic field for analysis. The spectral enhancement particle may be comprised of an active SERS metal particle with or without a...

20060234380 - Stable water standard: The invention relates to water standards that are producible by grounding and mixing at least one component abounding in water and one water-free or low water component each. The inventive water standards are characterized by a good storage stability. They are suitable for the calibration or the inspection of devices...

20060234381 - System and method for determining optimal reaction parameters using continuously running process: A reaction system enables a plurality of optimization experiments for a reaction to be performed continuously, to enable optimal reaction parameters to be determined. Dilution pumps are included to automatically vary the solvent mixed with reactants so a concentration of each reactant can be selectively varied. The reactants are introduced...

20060234382 - System and method for predicting mold growth in an environment: Mold growth monitoring and prediction systems and methods for an environment are disclosed. The system includes a processing unit, a temperature sensor, and a humidity sensor. The processing unit obtains a temperature reading and a humidity reading of the environment from the sensors. The processing unit uses an algorithm to...

20060234383 - Tissue assessment: The tissue assessment device consists of a fluid pressure system (1, 2, 11); an optical system (3, 5, 6); and a micro-controller (13). Compression of bladder (11) by actuator (12) displaces the fluid within the bladder 11 into chamber (2) causing diaphragm (1) to inflate and apply pressure onto the...

20060234384 - Use of phosphonazo iii for the measurement of calcium, magnesium and sodium in analytical samples: Novel reagent formulations and methods are described for the use of phosphonazo III to measure calcium, magnesium and sodium in biological fluids....

20060234385 - Polyglutamine repeat sequences: Several neurodegenerative diseases result from the aggregation of polyglutamine repeat proteins into insoluble neuronal intranuclear inclusions. The invention provides methods with which to study the processes of these diseases, including methods for solubilizing polypeptides containing a polyglutamine repeat sequence, for storing these polyglutamine polypeptides and inhibit their spontaneous aggregation, for...

20060234386 - Method and system for measuring lactate levels in vivo: There is described a system and method for the in vivo determination of lactate levels in blood using Near-Infrared Spectroscopy (NIRS) and/or Near-infrared Raman Spectroscopy (NIR-RAMAN). The method teaches measuring lactate in vivo comprising: optically coupling a body part with a light source and a light detector the body part...

20060234387 - Gas analyzer for measuring the flammability of mixtures of combustible gases and oxygen: A novel Flame Temperature Analyzer (FTA) method and apparatus for measuring combustible gas concentration and oxygen content in a sample gas includes supplying a mixture of oxidant and fuel to a sensing flame and measuring the temperature of the flame as the sample is added to the combustion chamber....

20060234388 - Spectrophotometric measurements of ph in-situ: Automated in-situ instrumentation has been developed for sensitive, precise and accurate measurements of a variety of analytes in natural waters. In this work we describe the use of ‘SEAS’ (Spectrophotometric Elemental Analysis System) instrumentation for measurements of solution pH. SEAS-pH incorporates a CCD-based spectrophotometer, an incandescent light source, and dual...

20060234389 - System and method for spectrophotometric measurement of total alkalinity using a liquid core waveguide: A system and method for spectrophotometrically measuring the total alkalinity of a liquid sample. In a particular aspect, the method involves equilibration of a CO2 gas with a sample solution across the permeable walls of a Teflon AF 2400 liquid core waveguide. The waveguide acts as both an equilibration membrane...

20060234391 - Optical sensor based on resonant porous silicon structures: A sensor includes at least one high refractive index layer; and at least one low refractive index layer coupled to the high refractive index layer....

20060234390 - Process for determining target function and identifying drug leads: The present invention relates to methods for using chemical ligands to determine target function and identify drug leads....

20060234392 - Solid phase immobilization of phospholipids and cofactor proteins via covalent attachment: The present invention provides methods and reagents for detecting anti-phospholipid-cofactor protein-antibodies....

20060228801 - Integator system and method for rapidly determining effectiveness of a germicidal treatment: The effectiveness of an oxidative sterilization process is determined by exposing a substrate having a known amount of a primary amine or aldehyde indicator chemical to an oxidative germicide. The oxidative germicide reacts with the indicator chemical. The amount of indicator chemical remaining after exposure to the germicide is determined...

20060228802 - Method of marking a product, marked product resulting thereof, and method of identifying same: A method and means for identifying the authenticity and the genuine nature of a solid or liquid bulk material, by incorporating a marking composition containing at least one trace ion into the said bulk material, whereby the total concentration of the incorporated trace ions in the market bulk material is...

20060228803 - Cellular controls for glycated hemoglobin hb a1c: Disclosed are cellular hemoglobin Alc (Hb Alc ) normal and abnormal (high) controls for use in detecting Hb Alc levels. The present invention also relates to methods for generating cellular Hb Alc controls using red blood cells and methods for using the cellular controls. The present invention encompasses several methods...

20060228804 - Modified ruthenium complex luminescence dye for oxygen sensing: Modification of ruthenium complex luminescence dye for oxygen sensing is provided. Generally, modification includes bonding long chain hydrophobic organic groups to the ligands of the ruthenium complex in order to increase solubility of the ruthenium complex in non-polar organic solvents. A sensor manufacture using the modified ruthenium complex luminescence dye...

20060228805 - Method of measuring protein solubility, process for producing crystal and apparatus therefor: Efficient measuring of protein solubility with the use of a precipitating agent as crystallization parameter; and production of a high-quality protein crystal with the use of a solubility curve obtained by the measuring. Protein crystal is disposed, and the surrounding thereof is filled with a protein solution. Not only is...

20060228806 - Method for detecting the modification of a characteristic of a sample caused by an enviromental influence: A method detecting change of a physically measurable property of a sample due to an environmental effect, including (i) subjecting the sample to the environmental effect for an action time, the environmental effect acting on the sample with a known position-dependent intensity distribution based on a pattern function, (ii) subsequently...

20060228807 - Method for measuring blood sample and apparatus thereof: The present invention relates to a method for measuring a blood sample comprising the steps of: communicating the inside of a sealed container with atmosphere by piercing a cap for sealing the sealed container; supplying a diluted solution from the base end side of the aspiration pipe to fill the...

20060228808 - Methods for detecting vitamin d metabolites: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite...

20060228809 - Methods for detecting vitamin d metabolites by mass spectrometry: Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite...

20060228810 - Method for histoprocessing: The invention relates to the processing of a biological sample for histological analysis. In particular, it relates to a rapid automated processing system that can be operated with continuous throughput and that eliminates the use of toxic solvents such as xylene. Provided is a method for processing a biological sample...

20060228811 - Sample processing devices: Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group pf process chambers located in fluid communication with the main conduits. The sample processing devices may include...

20060228812 - Micro analysis system: A micro integrated analysis system includes a testing chip, system main body and heat insulating section. The chip has a pump connecting section to communicate with micro pumps; a mixing flow path for mixing a specimen and reagent and for reaction processing by heating; and a testing flow path for...

20060228814 - Electrochemical immunoassays using colloidal metal markers: The invention concerns a method for detecting or quantifying a biological substance coupled with a colloidal metal particle by electrochemical detection, characterized in that it comprises a step which consists in dissolving by chemical treatment of said colloidal metal particle, prior to detection....

20060228813 - Method for immobilizing biomolecules on metal oxide substrates: The present invention relates to an improved method for providing biomolecules on a metal oxide substrate. In another aspect, the invention relates to a metal oxide substrate, having a surface that is coated with a polymer, said substrate having biomolecules immobilised thereon, wherein said biomolecules are immobilized on said coated...

20060223187 - Preparation of platelet analogs: Erythrocytes from a vertebrate animal other than a human that have been size reduced and treated with a fixing agent by conventional methods to resemble human platelets are further treated to achieve a size distribution that is detected in a consistent manner by different methodologies of blood cell counting. The...

20060223188 - Free thyroxine and free triiodothyronine analysis by mass spectrometry: Methods, systems and kits for the simultaneous or sequential analysis of one or more hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal preparation time. The methods comprise ionizing the hormones and analyzing the hormones by mass spectrometry. In addition, methods, systems and kits for...

20060223189 - Solid-phase saccharide sensing compounds: The present invention provides solid-phase saccharide dyes. The dyes are bisboronic acids covalently bonded to a solid substrate. The dyes selectively conjugate with saccharides, particularly glucose, and register a signal. The signal is proportional to the quantity of saccharide. Thus, the dyes of the present invention are useful for measuring...

20060223190 - Nitrogen oxide analyzer and method for setting parameter applied to nitrogen oxide analyzer: The nitrogen oxide analyzer obtains the ozone concentration-luminescence response characteristics that show the relationship between the ozone concentration and the light intensity by chemiluminescent response obtained by varying the ozone concentration alone in a steady state, and sets the relationship of the parameter that determines an average period of the...

20060223191 - Methods for measuring carbon single-walled nanotube content of carbon soot: Methods and processes for quantitating the carbon single-walled nanotubes (SWNTs) content in a sample are disclosed. The SWNTs soot can be produced by any of the known methods. The magic angle spinning (MAS) 13C NMR of a sample suspected of containing SWNTs and a standard at a known concentration are...

20060223193 - Diagnostic test kits employing an internal calibration system: A diagnostic test kit that employs a lateral flow assay device and a plurality of assay reagents for detecting a test analyte within a test sample is disclosed. The assay reagents include detection probes that are capable of producing a detection signal representing the presence or quantity of the test...

20060223194 - Methods of screening for post-translationally modified proteins: The invention provides methods of analyzing a sample. In general, the methods involve: a) depositing sub-fractions of a multi-dimensionally fractionated sample into wells of a multi-well substrate; b) contacting each of the deposited sub-fractions with an array to produce a set of sub-fraction-contacted arrays; and c) interrogating the sub-fraction-contacted arrays...

20060223192 - Rapid test for glycated albumin: A rapid immunochromatographic assay system is provided for measuring the amount of glycated albumin in a blood sample relative to the total level of albumin in the sample. The assay system is comprised of a disposable cassette that contains the test strips and testing reagents, and a measurement device that...

20060223196 - Method and system for controllably releasing solutions: A method and system for releasing active ingredients into the surrounding atmosphere is disclosed. In one embodiment, the dispersion rate of the active ingredient through the membrane is passively regulated by adjusting the porosity of the membrane. In another embodiment, materials with microfluidic channels of various diameters are interposed together...

20060223195 - Stress based removal of nonspecific binding from surfaces: A biological material sensing surface is exposed to a biological material that is selectively bound to a selected sensing portion of the sensing surface. The sensing surface is then subjected to shear stress oscillations to selectively remove nonspecifically bound material. The shear stress may be provided by an ultrasound resonator...

20060223197 - Method and apparatus for the detection of biological molecules: A detection system and a method for the detection of a plurality of substances is disclosed. The detection system has a plurality of detection probes, each of the detection probes having an up-conversion fluorescing core of dimensions less than 200 nm and is linked to an affinity moiety. The affinity...