Chemistry: analytical and immunological testing inventions 05/06

20060110831 - Automated clinical analyzer reagent formulation: This invention significantly reduces the frequency of hydraulic failure in the analytical line of a capsule chemistry sample liquid analysis system which can occur when the reagents required for the specific analytical test have an imperfect merger with the sample aliquot reagent in the vanish zone of the analytical line....

20060110833 - Method and apparatus for coupling an analyte supply to an electrodynamic droplet processor: This application relates to a method and apparatus for coupling an analyte supply, such as a biomolecule separator, to an electrodynamic droplet processor. In one embodiment the biomolecule separator is a capillary liquid chromatography column and the droplet processor includes an droplet generator and an electrodynamic balance. The biomolecule separator...

20060110832 - Methods and systems for discovering protein modifications and mutations: Accordingly, systems and methods for protein identification are provided. The present teaching provide for a system with one protein identification methodology based on one method and a second protein identification methodology based on a second protein identification methodology to interact and increase confidence in protein identification. Various embodiments employ protein...

20060110834 - Real-time monitoring the variation of dye solution in the process of a polarizer: A method of real-time monitoring the variation of dye solution in the process of a polarizer is provided that an ion chromatography is utilized to measure the variation of a reduction in the dye solution and analyze the components therein; moreover, an ion meter is utilized to measure the concentration...

20060110835 - Apparatus for indicating the passage of time and method therefor and articles therewith: A time-indicating apparatus based on the color change property of a reduced redox dye in the presence of oxygen is characterized by the initial introduction into a receptacle of a predetermined metered amount of a redox dye in its oxidized form together with a predetermined effective amount of a reducing...

20060105460 - Thermal cycler including a temperature gradient block: A method in which a temperature gradient is generated across a “gradient” block, and an apparatus comprising a block across which a temperature gradient can be generated. By setting up such a gradient, multiple reaction mixtures held in wells on the gradient block can be simultaneously run at temperatures which...

20060105461 - Nanopore analysis system: Nanopore analysis systems, methods of preparing nanopore analysis systems, and methods of automating the analysis of samples using nanopore analysis systems, are provided....

20060105462 - Apparatus and method for processing biological liquids: A method and apparatus for controlling the processing of a liquid sample, e.g., a blood sample, based on a measurement related to the sample's ability to coat a surface against which the sample is brought into contact while being routinely transported. Preferably, the sample is advanced through a tube, and...

20060105463 - Distinction method for the catch capacity of proteins: A distinction method is provided to distinguish catch capacity where myosin, a protein that constitutes muscles, or filaments containing myosin bind to actin due to the contribution of twitchin that constitutes thick filaments along with myosin, while certain tension is sustained. The catch capacity is distinguished by using synthetic thick...

20060105464 - Quantitative determination of analyte: The invention relates to an analytical technique for the quantitative determination of an analyte and a reagent solution useful in said quantitative determination. The analytical technique is conveniently adapted for quantitative determination of carbonyl and even more particularly adapted for finishing an alcohol produced in the Oxo Process....

20060105465 - Quantitative determination of analyte: The invention relates to an analytical technique for the quantitative determination of an analyte and a reagent solution useful in said quantitative determination. The analytical technique is conveniently adapted for quantitative determination of carbonyl and even more particularly adapted for finishing an alcohol produced in the Oxo Process....

20060105466 - Sensor for determining concentration of ozone: The present invention discloses a sensor for detecting ozone, the sensor comprises an element exhibiting piezoelectric properties having a coating that is removed from the quartz crystal upon exposure to ozone....

20060105467 - Mems-based sensor for lubricant analysis: A fluid contamination analyzer employs one or more MEMS-based sensors. The sensors are incorporated into probes or alternatively may be employed in an in-line analyzer residing in the fluid. The sensors, which can be selective to detect a distinct contaminant within the fluid, sense an impedance of the fluid, which...

20060105468 - Compositions and methods for preserving rna in biological samples: The present invention concerns methods and compositions to prepare biological samples to preserve the macromolecules in the samples. Embodiments of the invention concern the use of a soak solution that contains one or more water-miscible solvents. A sample is incubated with the soak solution to the point of saturation at...

20060105469 - Assay devices: Assay devices are disclosed comprising a base defining a cavity and an insert received in the cavity. The cavity has major surface and at least one sidewall, preferably surrounding the major surface. The insert comprises a first surface with a portion opposing the major surface of the cavity. A space...

20060105470 - Method and apparatus for detecting conception in animals: The present invention provides antibodies which specifically bind early conception factor, which can be found in body fluids of animals including but not limited to the cow, cat, dog, horse, human, sheep, and pig. The invention provides methods for detecting conception or the absence of conception in an animal, the...

20060105471 - Coated metal surface on solid support useful in analyte detection by displacement: A coated metal surface on a solid support, wherein the coating consists of a protein layer firmly attached to the metal surface, and said protein layer is coupled to linker molecules that are bound to low molecular weight antigens, wherein the linker molecules are coupled to the protein layer and...

20060105472 - Reduction of non-specific binding in assays: Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the...

20060099711 - Cell lysis method by immobilized metal-ligand complex: Provided is a lysis method for cells or viruses, including: immobilizing a metal-ligand complex on a solid support; and mixing the complex immobilized on the support with a cell or virus solution. According to the lysis method, by immobilizing a chemical on a solid support to perform cell lysis, the...

20060099712 - Correlation of anti-cancer activity of dyes with redox potentials: The present invention relates to a method for selecting pharmacological compounds for selective inhibition of cancer cells comprising identifying a compound, determining the reduction potential (ER) of the compound, and selecting the compound which has a reduction potential from −1.1 to −0.8 volts. The invention also relates to a pharmacological...

20060099713 - Targeted-assisted iterative screening (tais):a novel screening format for large molecular repertoires: This invention provides a new in vitro screening method for the detection of protein-protein and other interactions. The method has been developed and applied to a commercial cDNA library to search for novel protein-protein interactions. PDZ, WW and SH3 domains from PSD95, Nedd4, Src, Abl and Crk proteins were used...

20060099714 - Detection and analysis of ophthalmically-relevant fluorescent molecules: Disclosed herein are methods and devices for detecting fluorescent molecules that are relevant to the health of the eye and related tissues. The presence of such molecules in the eye and related tissues can be used to diagnose whether the patient has certain diseases, including the macular degenerations and macular...

20060099715 - Sensors with improved properties: A sensor or a sensor array connected to an electrical measuring apparatus is disclosed. In one embodiment, at least one sensor contains a layer of conductive modified particles which forms an electrical pathway or electrical circuit between two electrodes which are connected to an electrical measuring apparatus. In another embodiment,...

20060099716 - Interface assembly for pre-concentrating analytes in chromatography: A system for interfacing a sampling device and a chromatograph and for pre-concentrating analytes in a sample prior to introducing the sample into the chromatographic column is generally disclosed comprising an interface housing with a first channel and an adsorbent housing with a second channel, which contains at least one...

20060099717 - Method of nmr measurement and nmr pulse sequence: There is disclosed an NMR measurement method of observing plural magnetization transfer patterns in one experiment and observing their respective time-modulated, evolved chemical shifts. In an earlier portion of a pulse sequence, a transition is made from in-phase magnetizations to antiphase magnetizations using RF pulses. In an intermediate portion of...

20060099718 - System and method for extracting headspace vapor: A system and method for extracting headspace vapor is generally disclosed comprising pressurizing a vessel containing headspace vapor with a carrier gas and subsequently venting the sample mixture through an adsorbent trap and out a vent. A flow controller is employed to gradually increase the flow therethrough as the pressure...

20060099719 - Biochemical assay: A biochemical assay is provided comprising a substrate being capable of binding at least a target analyte and eventually other constituents contained in a biological sample, a test zone on the substrate for sample application, a non-immobilized conjugate reagent provided in the test zone for labelling the analyte, the conjugate...

20060099720 - Methods for performing differential capture proteomics: Disclosed herein are improved methods for identifying, isolating, and comparing proteins and other biomolecules differing between two biological samples using affinity chromatography and phage display techniques....

20060099721 - Radioimmunoassay using nanoparticle-antibody conjugates: A radioimmunoassay method for determining the quantity of an analyte of interest in a sample is disclosed. The analyte of interest may be an antigen or other chemical entity. A known antibody to the antigen or other entity is employed and is conjugated to a functionalized nanoparticle. Because of the...

20060094118 - Method for verifying the integrity of thermal desorption sampling tubes: An analyte of a sample is transferred to an analytical instrument by introducing a quantity of a compound of a standard material into a vessel containing an adsorbent material; introducing a quantity of the analyte of the sample into the vessel; and transferring the analyte of the sample and the...

20060094119 - Microfluidic system: The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale....

20060094120 - Solution for calibrating a chemical analyzer for alcohol, carbonate and ammonia assays: A multi-analyte calibration solution having known amounts of sodium carbonate, ammonium bicarbonate, and ethyl alcohol, with pH adjusted within a range between about 7.8 and 8.4....

20060094121 - Method for analysing amino acids, peptides and proteins: The invention provides methods, reagents and kits for amino acid, peptide and protein identification, differential quantitation and for the analysis of post translational modification and cross-linking status, comprising: derivatizing a mixture of amino acids peptides or proteins, to form at least one amino acid peptide or protein containing a fixed-charge...

20060094122 - Method for determination of arginine, methylated arginines and derivatives thereof: A method for detecting in biological samples one or more analytes of the group formed by arginine, monomethylated argenine, dimethylated argenine and related argenine compounds includes the steps of derivatizatio and detection of analytes derivatives. The method ARG and its derivatives (i.e., MMA, ADMA and SDMA) with greater sensitivity, specificity...

20060094123 - Oral detection test for cannabinoid use: A method for confirming the active intake of marijuana and its active component Δ9-tetrahydrocannabinol (“Δ9-THC”) by detecting the amount of 11-nor-Δ9-THC carboxylic acid (“THCA”) in oral fluid at the picogram per milliliter (pg/ml) level using chromatography/mass spectrometry/mass spectrometry (“GC/MS/MS”)....

20060094124 - Urine sugar meter: A urine sugar meter measures an immediately-before-meal urine sugar value by immediately-before-meal urine sugar measuring means, notifies a subject that an after-meal urine sugar value should be measured after passage of a predetermined time from this measurement by after-meal urine sugar time signal means, measures an after-meal urine sugar value...

20060094125 - Vitamin d deficiencies: Methods for determining the amount of vitamin D compounds in a sample are provided. The methods can employ LC-MS/MS techniques and optionally the use of deuterated internal standards. Methods for diagnosing vitamin D deficiencies are also provided....

20060094126 - Ph indicator for solid food called phind: The pH indicator for solid food called PHIND is a detector that reveals the acidity of solid food. Because the acidity of human stomach is about pH 3 and because the possibilities of the body to neutralize excesses of acidity are limited, the sole fact of eating acidic food can...

20060094127 - Method of automatically detecting a test result of a probe zone of a test strip: A method of automatically detecting a test result of a probe zone of a test strip is provided. The present method scans a scanning object including a bar code and a plurality of test strips to read the bar code pattern and the images of the test strips. Decoding the...

20060094128 - Process for (a) separating biological/ligands from dilute solutions and (b) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughout: Superparamagnetic (“SPM”) subunits of 1-30 nm average mean diameter (e.g. ferro fluid) subparticles are treated with a magnetically noninterfering substance capable of coating and covering them (e.g, BSA) and they spontaneously form agglomerates of about 100 nm to about 450 nm or higher average mean diameter and are then used...