Chemistry: analytical and immunological testing inventions 02/06

20060040394 - Method of searching for and generating polymrophs of a substance: The present invention provides a method and apparatus for producing polymorphs of a desired substance providing a plurality of enclosed spaces. The temperature and pressure of the enclosed spaces can be controlled. Various crystal identification means can be used to identify the polymorphic form of the solidified substance....

20060040395 - Anti-clogging device and method for in-gel digestion applications: An integrated proteomics sample preparation device and method for in-gel digestion of proteins and for desalting and concentrating samples prior to further analysis such as by MALDI TOF and/or electro-spray ionization (ESI) mass spectrometry. The device and method of the present invention allow for digestion, desalting and concentration of sample...

20060040396 - Electrophoretic buffer: By using an electrophoretic buffer comprising a polymerized polymer micelle formed by the steps comprising dispersing into an aqueous medium a block copolymer represented by HPLS-HPBS-PLZA, wherein HPLS is a hydrophilic polymer segment, HPBS is a hydrophobic polymer segment, and PLZA is a polymerizable group having an ethylenically unsaturated double...

20060040397 - Denitration catalyst management method and denitration catalyst management device: Secular change data on each unit of denitration catalysts (101) is managed based on data obtained by a periodic maintenance management (step S110) and a daily management (step S120), and management of a secular change and a performance variation prediction until a next periodic check is performed (step S130). It...

20060040398 - Method and apparatus for forming a dilution by fluid dispersion: According to one aspect of the invention, a method of creating a dilution series is provided. The method may include providing a first vessel including a sample, and aspirating at least a portion of the sample from the first vessel into a first conduit primed with solvent such that the...

20060040399 - Process for controlling hydrogen partial pressure in single and multiple hydroprocessors: A control scheme for controlling hydrogen partial pressure is provided that generally comprises a hydrogen purity analyzer that measures hydrogen purity on one or more hydroprocessing units. The hydrogen analyzer measures the purity of the treat gas, which is converted into a control signal and is transmitted to the appropriate...

20060040400 - Method of detecting viable cells: A method of detecting and quantifying viable cells in a sample. The method includes fluorescently staining the cells by adding a fluorescent dye into the sample or putting the sample in contact with the fluorescent dye. A quenching dye is then added to the stained sample, or the sample is...

20060040401 - Method and equipment for measuring the concentration of antiseptic solution: [Means for Solving Problem] The temperature of the antiseptic solution S, such as the glutaral or phtharal solution, is measured by a thermometer, and at the same time the ultraviolet absorbance of the antiseptic solution is electrically detected by a light-receiving part 9, then a function of proportionality between the...

20060040402 - System and methods for processing analyte sensor data: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The...

20060040404 - Inkjet spotting apparatus for manufacturing microarrays and method of spotting using the same: Provided are an inkjet-type spotting apparatus for manufacturing microarrays and a method of spotting using the same. The spotting apparatus includes a plurality of reservoirs which are arranged in rows and filled with a predetermined biomolecule solution; and a plurality of nozzles, each corresponding to one of the reservoirs and...

20060040403 - System and method for providing a reaction using a limited reaction surface area: A method and apparatus for chemical analysis is disclosed that uses a sample cup insert. The insert is pre-coated with a reaction agent, enzyme, or chemical to facilitate testing of the sample. A sample fluid in the sample cup is agitated by fluid pulsing to speed the reaction or to...

20060040405 - Test device and method for colored particle immunoassay: Disclosed is a test cell and a method for detection of a preselected ligand in a liquid sample such as a body fluid. The test cell includes an elongate outer casing which houses an interior permeable material capable of transporting an aqueous solution and defining a sample inlet, a test...

20060040406 - Narcotic analgesic tracking system: A device and method for testing the contents of a sample of a controlled substance to confirm the presence or absence of the controlled substance within that sample. In one implementation, the device and method utilize antibodies designed to interact with one or more anesthetics, e.g., opioid analgesics. The antibodies...

20060040407 - Alleviation of non-specific binding in microarray assays: A post-incubation treatment is employed to effectively remove targets, such as proteins/protein complexes, or other label-bearing moieties that may non-specifically bind to a microarray substrate during a binding assay. Following incubation, a one-step wash is carried out with a liquid containing digester, e.g., a digestive enzyme (protease) or lysosome, which...

20060040408 - Lateral flow format, materials and methods: The present invention provides a lateral flow format and materials and methods for using the format in a variety of applications. More particularly, the present invention provides single-layer lateral flow formats, materials and methods for detecting the presence of an analyte using a test strip comprising a dry porous medium...

20060040409 - Method for measuring dissociation rate coefficient by surface plasmon resonance analysis: An object of the present invention is to provide a method for measuring the dissociation rate coefficient (Kd) by surface plasmon resonance analysis without measuring the theoretical maximum amount of binding (Rmax). The present invention provides a method for measuring the dissociation rate coefficient (Kd) of the reaction between an...

20060040410 - Biosensor: It is an object of the present invention to provide a technique of converting carboxylic acid into an active ester with no generation of air bubbles and a technique of stabilizing the obtained active ester. The present invention provides a biosensor wherein a carboxyl group existing on the surface of...

20060040412 - Indirect detection of cardiac markers for assessing acute myocardial infarction: Assay systems and methods are provided for detecting a target antigen in a physiological fluid (e.g., blood, serum, or urine). The method includes linking via a first antibody a magnetic microparticle to the target antigen in the physiological fluid; linking via a second antibody a glucose molecule to the target...

20060040411 - Light-controlled electrokinetic assembly of particles near surfaces: A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolytc solution. Light-controlled electrokinetic assembly of particles near surfaces relics on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates;...

20060035380 - Fake-proof marking of a composition: The invention relates to a process for the fake-proof marking of a product, by introducing at least one non-radioactive stable isotope of at least one atomic element, such that the content of the isotope in the product is higher than its natural content, the isotope being chosen from natural isotopes...

20060035381 - Blending processes and systems: Processes and systems are provided for monitoring and blending a first stream and a second stream to produce a third stream of desired compositional characteristics. The processes and systems are found to be particularly useful for the blending of two or more hydrocarbon streams to economically produce a targeted hydrocarbon...

20060035382 - Method of analyzing metabolism for animal, method of producing labeled animals, labeled animals and method of measuring nmr for animals: The present invention provides a novel NMR metabolomics method for observing an animal by labeling the animal itself. A labeled animal labeled with a stable isotope is produced by feeding an animal a labeled food labeled with the stable isotope. Metabolism of a biological substance in the animal is analyzed...

20060035383 - Dry platelet preparations for use in diagnostics: The present invention provides compositions comprising freeze-dried platelets, microparticles, or both for use as a diagnostic for blood coagulation function. The invention also provides methods of diagnosing or monitoring blood coagulation function, including diagnosing or monitoring blood coagulation diseases and disorders. Kits for performing the methods of the invention are...

20060035384 - Instrument: A method and apparatus for performing a first measurement on a biological fluid or control, which first measurement varies with both the concentration of a first component and at least one of the presence and concentration of a second component. The method and apparatus perform a second measurement on the...

20060035385 - Methods of detecting nitrotyrosine and aminotyrosine residues of peptides and proteins: Methods and compositions are disclosed for quantifying and/or identifying a nitroderivative compound, or a residue thereof, and are applicable for assessing in vivo nitrative stress and for aiding in diagnosis of mammalian pathologies such as asthma, atherosclerosis, Alzheimer's disease, inflammation, ischemia, Parkinson's disease, and cancer. A preferred method comprises a)...

20060035386 - Fine particle handling unit, chip and sensor mounted with same, and methods for separating, capturing and sensing protein: A channel (1) formed in a substrate (41) branches into channels (2, 3) at a branch point (43). On this branch point, obstacles (8) having a columnar structure are aligned at certain intervals....

20060035387 - Non-specific binding resistant protein arrays and methods for making the same: Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the...

20060035388 - High-sensitivity magnetic marker used for immune response measurement: Disclosed are a highly-sensitive magnetic marker for use in measuring an immunoreaction with a SQUID magnetic sensor and the preparation thereof. The magnetic marker is composed of a magnetic fine particle and a polymer encapsulating the particle, wherein the particle diameter of the magnetic fine particle (preferably ferrite Fe3O4) is...

20060035389 - Immobilization of glycorproteins: Methods and compositions for the immobilization of glycoproteins are presented herein. In addition, the present invention provides arrays of immobilized glycoproteins. The methods of immobilizing glycoproteins include oxidation of the glycosyl moiety....

20060030049 - Apparatus for diagnostic testing and method: Controlled dispense of a flowable reagent in a diagnostic system is characterized by placing in the diagnostic system at least one cartridge containing a reservoir of reagent and carrying an identifier device that has information pertinent to the reagent in the reservoir. The diagnostic system automatically reads the information contained...

20060030050 - Assay: Compositions and assay methods for and relating to the detection of glycated hemoglobin are provided. In particular, the presence and level of glycated hemoglobin can be detected in a blood sample. The compositions comprise microparticles which have zinc coating for use in the improved binding of proteins exhibiting a zinc...

20060030051 - Erythrocyte sedimentation rate (esr) test measurement instrument of unitary design and method of using the same: An erythrocyte sedimentation rate (ESR) measurement instrument having a Blood Collection Configuration and an ESR Measurement Configuration. The ESR measurement instrument comprises a sedimentation measurement tube having an hollow interior volume containing a predetermined quantity of blood sample diluting agent therewithin and being air/fluid sealed with respect to the ambient...

20060030052 - Method of analyzing c-terminal amino acid sequence of peptide: The present invention provides, as a method of analyzing the C-terminal amino acid sequence of a peptide with use of reaction technique for successively releasing the C-terminal amino acids, in which undesirable side reactions, such as cleavage of a peptide bond at the middle of the peptide, can be prevented...

20060030053 - Methods and systems for protein and peptide evidence assembly: The present teachings provide methods and systems for the identification of proteins via peptide analysis. Some embodiments analyze proteins identified by analysis techniques such as mass spectrometry and build protein groups out of results. Groups can be formed by collecting like proteins and examining the group so as to identify...

20060030054 - Fluorescent probe: (wherein, R1 and R2 represent hydrogen atom, or a substituent for trapping proton, a metal ion, or an active oxygen species, or the like; R3 represents a monovalent substituent; R4 and R5 represent hydrogen atom or a halogen atom; R6 represents hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group,...

20060030055 - Methods and kits for separation and detection of proteins in biological samples: Methods and kits are provided for separating a mixture of proteins in a biological sample. Methods for detecting and profiling proteins in biological samples by the separation method and kits are also provided. These methods are particularly useful in assessing damage to cells such as cardiac and skeletal muscle cells...

20060030056 - Use of magnetic material to fractionate samples: A method useful for the reversible binding of a protein molecule in a biological sample. The method uses paramagnetic particles having an associated electronic charge to bind proteins with the opposite charge to form a particle/protein complex. The complex can be immobilized to a container wall by applying a magnetic...

20060024831 - Normalization of data using controls: An apparatus for normalizing a PCR instrument, can comprise a microplate comprising at least 6,000 wells and a system of dyes at known concentrations in a plurality of the at least 6,000 wells. A method for normalizing a system can comprise (a) providing a microplate comprising at least 6,000 wells...

20060024832 - Water-soluble derivatives of lipophilic drugs: where G is a lipophilic drug, L is a linker which is an alkyl group or heteroalkyl group containing from 1 to 20 carbon atoms, n is 0 or 1, and Y is a water-solubilizing group such as —SO3−, —NR—SO3−, —P(═O)(OH)(O−), or —O—P(═O)(OH)(O−), where R is H or an alkyl...

20060024833 - Fluorescent metal ion indicators with large stokes shift: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the...

20060024834 - Synthetic receptors for the detection of analytes: wherein R comprises at least one moiety chosen from a hydroxyl group, an amine group, and derivatives thereof. Synthetic receptors are provided that comprise a synthetic receptor core; and an analyte binding moiety, wherein the analyte binding moiety is capable of complexion with an analyte. Systems, methods, and kits are...

20060024835 - Analytical test strip with control zone: An analytical test strip for the determination of an analyte (e.g., glucose) in a liquid sample (such as whole blood) includes a matrix, with the matrix having a sample detection zone and a control zone(s). The sample detection zone includes a first reagent composition that reacts with analyte in the...

20060024836 - Quantitative analysis of nitrogen oxides occluded in heterogeneous catalysis: A method of performing quantitative analysis of nitrogen oxides occluded in heterogeneous catalysts, comprising the following steps, each performed in parallel for multiple samples: adsorption of nitrogen oxides by multiple samples using a batch adsorption apparatus, extraction of nitrogen oxides from the occluded samples using a solvent, reduction of nitrogen...

20060024837 - Method and apparatus for mass analysis of samples: The present invention comprises an apparatus and a method for mass analyses of an array of samples contained in distinct sample holders. The sample holders are placed on a plurality of sensors which preferably comprise an array of microbalances providing output signals comprising mass data on the array of samples....

20060024838 - Method and apparatus for preserving urine specimens at room temperature: A method and apparatus for preserving urine specimens at room temperature for testing includes a container which is made of a plastic and an antimicrobial where the plastic and antimicrobial form a uniform composition throughout the entire mass of the container by simultaneously injection molding the plastic and antimicrobial to...

20060024839 - Inorganic carbon removal: Methods and related apparatus are disclosed for selective removal of inorganic carbon from a fluid sample using selective membranes to minimize the loss of volatile organic compounds from the fluid sample prior to analysis for determination of the total organic carbon contents of the sample....

20060024840 - Method and apparatus for testing heavy oil production processes: A method of testing oil extraction processes is shown. The method includes the steps of placing a sample to be tested in a sample holder which has a configurable temperature profile. The sample holder is then placed in a pressure vessel and the pressure in the pressure vessel is increased...

20060024841 - Method and apparatus for delivery of submicroliter volumes onto a substrate: A slotted pin tool, a delivery system containing the pin tool, a substrate for use in the system and methods using the pin tool and system are provided. The slotted pin tool contains a plurality of pins having slotted ends designed to fit around each loci of material deposited on...

20060024843 - Assay device: A device for carrying out a lateral flow assay on a sample comprising: (a) a sample containing unit comprising a sample container, said sample container being closed off at one end by a bottom wall, said bottom wall having a hole sealed by a plug; and (b) a housing located...

20060024842 - Portable diagnostic device and method for determining temporal variations in concentrations: A rapid assay concentration device. In one form, the device includes a substrate and a plurality of elongated membranes on the substrate. At least one capture zone is formed in each membrane. Each capture zone is responsive to the presence of a target chemical in the fluid. Capture zones on...

20060024844 - Method for the idenification of ligands: The present invention relates generally to a method of identifying ligands that modulate protein-protein interactions. More particularly, the present invention relates to methods of determining agonists or antagonists of a co-regulator dependent target molecule based on the ability to modify the stability of the target molecule....

20060024845 - Method of immobilizing compound on solid phase support: The present invention provides a method of analyzing the specific interaction between a molecule to be analyzed and a molecule that specifically interacts with the former molecule on a solid phase using a molecule-immobilized solid phase support mixture prepared by binding the subject molecule to the solid phase support without...

20060024846 - Multiplex analysis using membrane-bound sensitizers: The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tags specifically bind to selected membrane-associated analytes, after which the molecular tags are released...

20060024847 - Controlled optoelectronic coupling in nanoparticle arrays: In some embodiments, the present invention is directed to methods by which nanoparticle interactions can be controlled, compositions with which such interactions can be controlled, and devices which utilize the control of such interactions. Generally, such methods involve grafting polymer to electromagnetically-functional cores to form a core/shell nanoparticle, assembling a...