Chemistry: analytical and immunological testing inventions 12/05

20050287673 - Reactor mixing: Immiscible substances, such as gases, solids or liquids may be included within a reaction site container as a mixer of a liquid sample. Movement of the mixer within the container may help suspend or re-suspend cells or other species. Movement of the mixer also may generate shear forces that can...

20050287674 - Labeling proteins with dyes that are insoluble or only sparingly soluble in water: The proteins in a biological sample that is sought to be analyzed for its protein composition by an electrophoretic or chromatographic procedure are coupled to a dye in an unusually efficient manner by combining the sample with a solid dry composition containing the dye a buffering agent, and in preferred...

20050287675 - Methods of measuring the extent of cure of a binder in fibrous products: A method of measuring the extent of cure of a binder in a fibrous product is provided. The method comprises (a) providing a sample of a fibrous product, the fibrous product comprising fibers and a binder, (b) subjecting the sample to infrared spectroscopy to generate a spectral analysis, and (c)...

20050287676 - Methods for synthesis and evaluation of hydrogen storage compositions: A method for identification and evaluation of the hydrogen storage capacity of materials is presented, the method comprising providing a plurality of materials, wherein the plurality of materials comprise an array of synthesized hydrides and analyzing hydrogen content in the plurality of materials....

20050287677 - Dissolvent for volumetric analysis: The subject matter of the invention is to make available novel solvents for volumetric analysis of substances or compounds, such as, e.g., proteins, cellulose, etc., which are insoluble or difficult to dissolve in conventional solvents. In this way, a direct, homogeneous titration of components of these substances is enabled. For...

20050287678 - Method and apparatus for inspecting biological samples: A method of selecting for analysis a sample of a biological material anisotropically distributed on a substrate, said method comprising the steps of directing a beam of radiation onto said substrate, said radiation being selected to interact with said anisotropically distributed biological material to an extent corresponding to said anisotropy;...

20050287679 - Calibration procedure for investigating biological systems: Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly useful for in-vivo investigation of living systems....

20050287680 - Multianalyte assay method: A plurality of groups of colorimetrically distinguishable metal nanoparticles are prepared to label specific analytes whose presence in a sample is under investigation, each group for specific analytes. After being mixed with the sample so that labeling can occur if the analyte or analytes are present, the sample is exposed...

20050287681 - Target substance detecting element, target substance detection apparatus and target substance detection method: Magnetic particles with a metal coat holding target substance captors are made to react with a target substance contained in a specimen in a solution where the magnetic particles are dispersed in a liquid medium. Subsequently, the dispersion of the magnetic particles is applied to a surface having a periodic...

20050287682 - Dissolvable films and methods including the same: A method includes providing a container, introducing a substance into the container, and introducing a readily dissolvable film into the container such that the dissolvable film overlies the substance within the container. An alternative method includes providing a container, providing a readily dissolvable film, the film comprising a substance carried...

20050282285 - Strategy for controlling nox emissions and ammonia slip in an scr system using a nonselective nox/nh3: One aspect of the invention relates to controlling the ammonia feed rate to an SCR reactor using a NOx sensor cross-sensitive to ammonia. The sensor, positioned downstream of the reactor, is interrogated by introducing a pulse in the ammonia feed rate. A positive response to a positive pulse indicates ammonia...

20050282286 - Method for determining organically bound carbon (toc): d) the gaseous carbon dioxide being transferred to the detection vessel (3, 3a) and e) the carbon dioxide content being determined by means of measurement methods known per se on the basis of the colour change of the indicator, after step a), the inorganic carbon being converted into carbon dioxide...

20050282287 - Apparatus for effecting chemical separation and plural-point sers detection using metal-doped sol-gels: Sol-gel beds and deposits are utilized for SERS analysis of liquid analytes. Measurements are made at multiple points along the length of a column or channel to increase, very significantly, the speed of analysis, and use of the same medium to both separate the chemicals and also for SERS greatly...

20050282288 - Apparatus for effecting chemical separation and sers detection using metal-doped sol-gels: Sol-gel beds and deposits are utilized for SERS analysis of liquid analytes. The use of the same medium to both separate the chemicals and also for SERS greatly reduces the complexity of such apparatus and enhances the efficiency of the method....

20050282289 - Information acquisition method, information acquisition apparatus and sampling table for time of flight secondary ion mass spectroscopy: A method for analyzing an object by means of TOF-SIMS is adapted to apply an ionization promoter (metal such as silver or gold) to the object and generate secondary ions that correspond to parent molecules and can be used to determine the type of the object. A segregation/refinement technique such...

20050282290 - Analysis instrument, sample analysis method and analysis device using the instrument, and method of forming opening in the instrument: The present invention relates to a technique for moving a mobile component such as a sample and a reagent, in an analyzing article. A method of analyzing a sample according to the present invention includes a first movement step of moving a mobile component from a fluid entrance port (61)...

20050282292 - Automated slide staining apparatus: Disclosed is an automated staining apparatus (autostainer) capable of staining sample on a microscope slide. The autostainer is capable of limiting the amount of reagent used through a process including image acquisition and processing techniques, wherein an image of the slide is acquired and used to determine a region on...

20050282291 - Method for aspiration of a liquid sample: A liquid aspiration method which includes aspirating partial aliquots of liquid at a number of different depths of penetration of a pipette tip into a liquid. The different depths are selected so that partial aliquot segments are obtained throughout the entire depth of sample, optionally excluding the extreme top and...

20050282293 - System for delivering a diluted solution: The invention features methods and devices for the delivery of a fluid medium containing analytes, e.g., particles, solutes, or solvents, to an analytical device. The systems are designed to minimize contact with potentially hazardous, fragile, or valuable samples. The systems allow for the dilution, mixing, and introduction of the fluid...

20050282294 - Affinity supports with immobilised protein a: The present invention relates to affinity supports with immobilised, covalently bonded protein A, which have a particularly high functional efficiency, wherein protein A is bonded to the support via an aminocarboxylic acid as spacer, to the preparation thereof, and to the use thereof in the purification and analysis of antibodies...

20050277195 - Integrated microfluidic device (ea): A method for characterizing n components An of n catalytic systems. The method is characterized in comprising the steps of: I) providing a microfluidic device which comprises a plurality of identical microchannel structures, each microchannel structures comprising in the downstream direction (a) an inlet arrangement IA with at least one...

20050277196 - Detection of gels in a solution polymerization: In a solution polymerization process the increase in gel content in the solution at one or more locations may be detected by monitoring the structure of a spectrum obtained by analyzing the reaction at said one or more locations using a spectrometer selected from the group consisting of infrared spectrometers,...

20050277197 - Microparticles with multiple fluorescent signals and methods of using same: This invention provides a novel fluorescent particle including a core or carrier particle having on its surface a plurality of smaller polymeric particles or nanoparticles, which are stained with different fluorescent dyes. When excited by a light source they are capable of giving off multiple fluorescent emissions simultaneously, which is...

20050277198 - System and method of material testing using permittivity measurements: A system for material testing includes an impedance measuring circuit and an sensing element connected to the impedance measuring circuit. An analyte is proximate to the sensing element. The impedance measuring circuit measures a first impedance of the sensing element. When the analyte is exposed to an associated material, the...

20050277200 - Method of modulating a second carrier for partial modulation via pulsed flow modulator for comprehensive two-dimensional liquid or gas chromatography: This invention is a method and device for use with multi-dimensional chromatography that utilizes partial modulation. An analyte-bearing sample is subjected to a first dimension of chromatography. Thereafter the separated analyte-bearing sample is diluted with a modulated second carrier such at the analyte-bearing sample is not stopped or its temperature...

20050277199 - Single-pass compound purification and analysis: The present invention relates to high-throughput compound purification and analysis systems that include representative sample fraction storage components that are structured to at least transiently store representative sample fraction aliquots prior to analysis. In addition, related computer program products and methods are also provided....

20050277201 - Carbon nanotubes and their derivatives as matrix elements for the matrix-assisted laser desorption mass spectrometry of biomolecules and sequencing using associated fragmentation: The present invention is directed toward novel matrix elements, generally comprising functionalized carbon nanotubes, for matrix-assisted laser desorption ionization (MALDI)-mass spectroscopy (MS), methods of making such matrix elements, and to methods of using such matrix elements in MALDI-MS applications, particularly for the analysis of biological molecules. In some embodiments, by...

20050277202 - Collection device for lateral flow chromatography: A device for collecting oral liquids includes a lateral flow chromatography strip having a collection member. The collection member is separated from the remainder of the chromatography strip by a liquid impermeable removable barrier which prevents liquid in the collection member from entering the chromatography strip. Once adequate oral liquid...

20050277203 - Immunochemical filter device and methods for use thereof: The invention provides an immunochemical filter device and use thereof, said filter device comprising a filter material attached to a support member. The filter material comprises a labeled binding reagent, wherein said labeled binding reagent is released from the filter material into solution by migration of a liquid sample solution...

20050277204 - Sample preparation methods and devices: The present invention provides improved devices for separating and/or detecting targets from biological, environmental, or chemical samples....

20050277205 - Multicomponent magnetic nanorods for biomolecular separations: The present invention relates to methods and compositions for separation of proteins. In particular, the present invention provides multicomponent nanorods for biomolecular separations of proteins....

20050272157 - Method of evaluating freshness of a fish product: A method of evaluating freshness of a fish product by cutting a small quantity of sample from the fish product, adding an effective amount of a staining reagent containing at least one of a cell-permeant dye and a cell-impermeant fluorescent dye onto the sample, incubating the sample for a predetermined...

20050272158 - Method and apparatus for detecting hydrocarbons with nmr logs in wells drilled with oil-based muds: A method and system for estimating native hydrocarbons from oil-based drilling muds with the aid of NMR data. Adaptive echo stacking may be used to balance between precision and sensitivity to changes in the fluid composition. Apparent T2 decay time and effective diffusion constants derived from the NMR data may...

20050272159 - Device and method for pressure-driven plug transport and reaction: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid....

20050272160 - Surface enhanced spectroscopy-active composite nanoparticles: Metal nanoparticles associated with a spectroscopy-active (e.g., Raman-active) analyte and surrounded by an encapsulant are useful as sensitive optical tags detectable by surface-enhanced spectroscopy (e.g., surface-enhanced Raman spectroscopy)....

20050272161 - Delivery of compounds with rehydrated blood cells: Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the same. The blood cells may be red blood cells or blood platelets....

20050272162 - Functional assay of high-density lipoprotein: This invention provides novel assays that are prognostic and/or diagnostic for atherosclerosis or risk of atherosclerosis. It was discovered that high density lipoprotein (HDL) or components thereof can prevent the oxidation of lipids (e.g., lipids present in LDLs) and can also repair (reduce) already oxidized lipids and thereby reduce the...

20050272163 - Method for producing purified hematinic iron-saccharidic complex and product produced: A method for separating and purifying the active hematinic species (AHS) present in iron-saccharidic compositions, including AHS such as sodium ferric gluconate complex, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function. The method separates the AHS from one or more excipients and, preferably, lyophilizes...

20050272164 - Identification of modified peptides by mass spectrometry: In various aspects, provided are methods for identification of the presence of modified peptides using at least in part mass spectrometric signals from metastable ions that are formed in the field free region of the analyzer. For example, in various embodiments where the modified peptides are phosphopeptides, such metastable ions...

20050272165 - Method for detecting protein as fluorescence image: It is an object of the present invention to provide a method for enabling the detection of a trace amount of protein contained in an electrophoresis gel, which cannot visually be observed even in CBB staining capable of confirming a protein by visual observation, so as to enable the combined...

20050272166 - Methods and systems for detection, identification and quantitation of macrolides and their impurities: The present invention relates to reverse-phase high performance liquid chromatography (RP-HPLC) methods and systems for detecting macrolides as well as detecting, identifying and quantifying impurities in samples containing a macrolide....

20050272167 - Methods and systems for detecting hydrogen: Methods and systems are provided for the detection and quantification of hydrogen. Preferred methods and systems enable rapid, accurate hydrogen detection that include exposing a gaseous material to activating radiation, and measuring a change in humidity of the gaseous material following the radiation exposure to an amount of hydrogen in...

20050272168 - Mass defect filter: A method for detecting and identifying metabolites in biological samples includes subjecting the samples to high resolution mass spectrometry (MS) analysis to detect ions of the molecular species. Mass defect values for the detected ions are determined. The method also includes specifying a predetermined range for mass defect values. Detected...

20050272169 - Device for chemical or biochemical analysis: A device for analysis of a sample, the device comprising: a first layer having a network of passages and chambers through which fluid is caused to flow during analysis; a second layer in which a plurality of chambers are formed, the chambers containing fluids for use in the analysis; an...

20050266570 - Cuvette for an automated analyzer: An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection system for reagent containers, sample and reagent aspirating and dispensing probes, a separation...

20050266571 - Method for feedback control of a microfluidic system: A method for the feedback control of a microfluidic system includes measuring an electrical characteristic (such as impedance or resistance) of a position electrode(s) of the microfluidic system with a meter of the microfluidic system. A feedback controller is then employed to control the flow of bodily fluid sample through...

20050266572 - Method for marking hydrocarbons with substituted anthraquinones: wherein R1 and R2 independently are hydrogen, hydroxy, OR11, amino or NR11R12; R3 and R5 independently are alkyl, aryl, aralkyl, heteroalkyl or heterocyclic; R4 and R6 independently are hydrogen or alkyl; R7, R8, R9 and R10 independently are cyano, nitro or hydrogen, provided that at least two of R7, R8,...

20050266573 - Reference control for optical measurement of nucleated red blood cells of a blood sample: Reference control compositions and the method of use are disclosed for measurement of nucleated red blood cells, which includes one set of synthetic spherical particles having a mean particle diameter ranging from 6.2 μm to 6.8 μm and a refractive index from 1.58 to 1.62 monodispersed in an aqueous suspension...

20050266576 - Identifying patients at risk for life threatening arrhythmias: The invention is a method for identifying proteins associated with sudden cardiac death (SCD) and for assessing a patient's risk of SCD by determining the amount of one or more SCD-associated proteins in the patient. Typically, the patient submits a sample, such as a blood sample, which is tested for...

20050266575 - Pharmacophores for nociceptin, methods of obtaining and using in screening for nociceptin mimics: Nociepeptin pharmacophores, methods of determining a nociceptin pharmocophore, nociceptin solution structures, and methods of identifying compounds as potential nociceptin mimics are provided....

20050266574 - Test strip for creatinine determination: The present invention provides a novel test piece for creatinine measurement. The test piece includes a compound expressed by the following formula (1), a metal that forms a colored complex with the compound, and a buffer agent in a porous material. The amount of creatinine is determined by optically measuring...

20050266577 - Ultrafiltration device for drug binding studies: The combination of a supported UF membrane having low non-specific binding (NSB) and high protein retention of the tested chemical entity (CE) in a device that is SBS complaint. The membrane is heat sealed to form one or more integral wells that are used to reduce NSB and improve protein...

20050266578 - Methods and systems for detection of macrolides: The present invention relates to reverse-phase high performance liquid chromatography (RP-HPLC) methods and systems for detecting macrolides such as erythromycylamine and related compounds....

20050266579 - Assay system with in situ formation of diazo reagent: A total bilirubin diazo assay is disclosed in which an acidic solution containing a primary aryl amine is combined directly with a nitrite-containing sample solution at approximately neutral pH, resulting in the in situ generation of a diazo compound in the sample solution. The diazo compound reacts with bilirubin in...

20050266580 - Automated analyser for determining nitrogen derived from organic compounds: An automated analyser is described for determining, by way of combustion, nitrogen contained in organic compounds, in particular proteins present in foods, animal feeds, polymers, fuels etc., characterised in that the carbon dioxide absorption device upstream of the nitrogen detector is self-regenerating and comprises: a distributor valve able to switch...

20050266581 - Methods and apparatus for analyzing materials: A method and apparatus for testing materials according to various aspects of the present invention comprises an oven and a control system. The oven is configured to receive a test material for testing and expose the test material to heat to promote drying and/or ashing. The control system receives data,...

20050266582 - Microfluidic system with integrated permeable membrane: A microfluidic system for performing chemical reactions or biochemical, biological, or chemical assays utilizing a microfabricated device or “chip.” The system may include, among others, an integrated membrane fabricated from a chemically inert material whose permeability for gases, liquids, cells, and specific molecules, etc. can be selected for optimum results...

20050266584 - Method and apparatus for performing sers analysis using a chemical reference: Apparatus for use in effecting surface-enhanced Raman spectroscopy comprises first and second containment means, the first containment means containing a known quantity of a reference chemical having an effective surface-enhanced Raman factor, and the second containment means containing a surface-enhanced Raman-active medium and being sufficiently transparent, at least at one...

20050266583 - Method for quantitative surface-enhanced raman spectroscopy using a chemical reference: A method for obtaining quantitative surface-enhanced Raman (SER) spectra that corrects for deficiencies of, and variations in, the materials and devices employed, especially the SER-active media utilized, employs a reference chemical, having an effective surface-enhanced Raman factor, of known concentration within the same SER experimental field of view as the...

20050266585 - Filtration unit: Two interconnected systems for retaining and filtering a fluid are provided. The systems may be used individually or together. The first system comprises a vessel having a lower section with an opening in its underside; filtration means provided in the lower section of the vessel; and means for providing a...