| Chemical derivatives and their application as antitelomerase agent -> Monitor Keywords |
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Chemical derivatives and their application as antitelomerase agentRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai, Hetero Ring Is Six-membered Consisting Of One Nitrogen And Five Carbon Atoms, Polycyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos, Bicyclo Ring System Having The Six-membered Hetero Ring As One Of The Cyclos, Quinolines (including Hydrogenated)Chemical derivatives and their application as antitelomerase agent description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060199840, Chemical derivatives and their application as antitelomerase agent. Brief Patent Description - Full Patent Description - Patent Application Claims
[0001] This application is a division of U.S. application Ser. No. 10/721,210, filed Nov. 25, 2003, now allowed, which is a continuation of International application No. PCT/FR02/01,767, filed May 27, 2002; which claims the benefit of priority of French Patent Application No. 01/06,909, filed May 28, 2001 and French Patent Application No. 02/01,256, filed Feb. 4, 2002. [0002] The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their therapeutic application in humans. [0003] The present invention relates to the use of novel non-nucleotide chemical compounds which interact with specific structures of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). These novel compounds consist of a distribution agent linked to two aminoaromatic groups. These novel compounds are useful in the treatment of cancers and act in particular as telomerase-inhibiting agents. They are particularly useful for stabilizing DNA in G-quadruplex structure (guanine tetrads). The therapeutic application of the inhibition of telomerase via the stabilization of these G-quadruplexes is the termination of cellular mitosis and the death of rapidly-dividing cells such as cancer cells and possibly the induction of the senescence of cancer cells. [0004] The compounds of the present invention have the advantage, from the therapeutic point of view, of blocking telomerase. From a biological point of view, telomerase allows the addition of repetitive DNA sequences of the T T A G G G type, termed telomeric sequences, at the end of the telomere, during cell division. Through this action, telomerase renders the cell immortal. Indeed, in the absence of this enzymatic activity, the cell loses, at each division, 100 to 150 bases, which rapidly renders it senescent. During the appearance of rapidly-dividing cancer cells, it appeared that these cells possessed telomeres which were maintained at a stable length during cell division. In these cancer cells, it appeared that telomerase was highly activated and that it allowed the addition of repetitive motifs of telomeric sequences at the end of the telomere and therefore allowed conservation of the length of the telomere in the cancer cells. It appeared during the past few years that more than 85% of cancer cells showed positive tests for the presence of telomerase whereas somatic cells do not show this characteristic. [0005] Thus, telomerase is a highly coveted target for treating cancer cells. The first obvious approach for blocking telomerase was the use of nucleotide structures (Chen and al., Proc. Natl. Acad. Sci. USA 93(7), 2635-2639). Among the non-nucleotide compounds which have been used in the prior art, there may be mentioned the diaminoanthraquinones (Sun and al., J. Med. Chem. 40(14), 2113-6) or the diethyloxadicarbocyanins (Wheelhouse R. T. et al., J. Am. Chem. Soc. 1998(120) 3261-2). [0006] WO 99/40087 describes the use of compounds which interact with the G-quadruplex structures which are perylene compounds and carbocyanins containing at least seven rings including two heterocycles. [0007] It appeared, quite surprisingly, that simple structures made it possible to obtain a result which is at least equivalent with structures which are a lot less complicated from a chemical point of view. The compounds of the present invention which meet the intended objective, that is to say which bind the G-quadruplex structure of DNA or of RNA and in particular the G-quadruplex structure of telomeres and thereby exhibit a telomerase-inhibiting activity, correspond to the following general formula (1A):nitrogen-containing aromatic ring--(NR.sub.3)p--(CO)n-distribution agent--(CO)m--(NR'.sub.3)q--aromatic or non-aromatic ring with n, m, p and q, which are identical or different, representing the integer 0 or 1, [0008] in which [0009] the nitrogen-containing aromatic ring represents: [0010] a quinoline optionally substituted with at least [0011] one group N(Ra)(Rb) in which Ra and Rb, which are identical or different, represent hydrogen or a C1-C4 alkyl radical or [0012] one short-chain C1-C4 alkyl or alkoxy group or [0013] a quinoline possessing a nitrogen atom in quaternary form or [0014] a benzamidine or [0015] a pyridine [0016] the aromatic or non-aromatic ring represents [0017] a quinoline optionally substituted with at least [0018] one group N(Ra)(Rb) in which Ra and Rb, which are identical or different, represent hydrogen or a C1-C4 alkyl radical or [0019] one short-chain C1-C4 alkyl or alkoxy group or [0020] a quinoline possessing a nitrogen atom in quaternary form or [0021] a benzamidine or [0022] a pyridine or [0023] a phenyl nucleus optionally substituted with a halogen atom, a C1-C4 alkoxy group, a cyano group, a carbonylamino group optionally substituted with one or more C1-C4 alkyl groups, a guanyl group, a C1-C4 alkylthio group, an amino group, a C1-C4 alkylamino group, a C1-C4 dialkylamino group for each alkyl group, a nitro group, a C1-C4 alkyleneamino group or a C2-C4 alkenyleneamino group or [0024] a mono- or bi- or tricyclic aromatic or non-aromatic heterocyclic nucleus containing 0 to 2 heteroatoms per ring provided that at least one heteroatom is present in at least one ring optionally substituted with one or more C1-C4 alkyl groups or with C1-C4 alkylene or C2-C4 alkenylene groups [0025] R.sub.3 and R'.sub.3, which are identical or different, represent independently of each other hydrogen or a C1-C4 alkyl radical [0026] the distribution agent represents: [0027] a triazine group optionally substituted with one or more radicals chosen from halogen atoms, alkyl radicals having 1 to 4 carbon atoms and thio, oxy or amino radicals which are themselves optionally substituted with one or more short-chain alkyl chains containing 1 to 4 carbon atoms or [0028] a 5- or 6-membered heterocyclic radical containing a sulfur, oxygen or nitrogen atom [0029] a phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH--CH2-phenyl-CH2-NH--, --NH--CH2-phenyl-NH--, --CH2-phenyl-CH2-, --CH2-phenyl, -phenyl-CH2-, --CH2-thienyl-, -thienyl-CH2-, or --CH.dbd.CH-- radical, or [0030] a diazine group, and wherein the heterocyclic, phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH-CH2-phenyl-CH2-NH--, --NH--CH2-phenyl-NH--, --CH2-phenyl-CH2-, --CH2-phenyl, -phenyl-CH2-, --CH2-thienyl-, -thienyl-CH2-, or --CH.dbd.CH-- radical, and diazine radicals being optionally substituted with the same groups as the triazine it being understood that when the distribution agent represents phenyl optionally substituted with NH.sub.2, and when n, m, p and q represent 1 and R.sub.3 and R'.sub.3 represent hydrogen, then the nitrogen-containing aromatic ring and the aromatic ring do not both represent a quinoline which is unsubstituted or substituted on its nitrogen atom with an alkyl radical containing 1 to 6 carbon atoms, or one of its salts and when the distribution agent represents a triazine and p and q both represent the integer 1, then n and m do not both represent the integer 0. [0031] The subject of the present invention is thus in particular the products which correspond to the following general formula:nitrogen-containing aromatic ring --NR.sub.3--(CO)n-distribution agent --(CO)m-NR'.sub.3--aromatic or non-aromatic ring with n and m which are identical or different, representing the integer 0 or 1, [0032] in which [0033] the nitrogen-containing aromatic ring represents: [0034] a quinoline optionally substituted with at least [0035] one group N(Ra)(Rb) in which Ra and Rb, which are identical or different, represent hydrogen or a C1-C4 alkyl radical or [0036] one short-chain C1-C4 alkyl or alkoxy group or [0037] a quinoline possessing a nitrogen atom in quaternary form or [0038] a benzamidine or [0039] a pyridine [0040] the aromatic or non-aromatic ring represents [0041] a quinoline optionally substituted with at least [0042] one group N(Ra)(Rb) in which Ra and Rb, which are identical or different, represent hydrogen or a C1-C4 alkyl radical or [0043] one short-chain C1-C4 alkyl or alkoxy group or [0044] a quinoline possessing a nitrogen atom in quaternary form or [0045] a benzamidine or [0046] a pyridine or [0047] a phenyl nucleus optionally substituted with a halogen atom, a C1-C4 alkoxy- group, a cyano group, a carbonylamino group optionally substituted with one or more C1-C4 alkyl groups, a guanyl group, a C1-C4 alkylthio group, an amino group, a C1-C4 alkylamino group, a C1-C4 dialkylamino group for each alkyl group, a nitro group, a C1-C4 alkyleneamino group or a C2-C4 alkenyleneamino group or [0048] a mono- or bi- or tricyclic aromatic or non-aromatic heterocyclic nucleus containing 0 to 2 heteroatoms per ring provided that at least one heteroatom is present in at least one ring optionally substituted with one or more C1-C4 alkyl groups or with C1-C4 alkylene or C2-C4 alkenylene groups [0049] R.sub.3 and R'.sub.3, which are identical or different, represent independently of each other hydrogen or a C1-C4 alkyl radical [0050] the distribution agent represents: [0051] a triazine group optionally substituted with one or more radicals chosen from halogen atoms, alkyl radicals having 1 to 4 carbon atoms and thio, oxy or amino radicals which are themselves optionally substituted with one or more short-chain alkyl chains containing 1 to 4 carbon atoms or [0052] a 5- or 6-membered heterocyclic radical containing a sulfur, oxygen or nitrogen atom [0053] a phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH-- or --NH--CH2-phenyl-CH2-NH-- radical or [0054] a diazine group, and wherein the heterocyclic, phenyl, --NH-phenyl-NH, --NH-phenyl-CH2-NH-- or --NH--CH2-phenyl-CH2-NH-- radicals, and diazine radicals being optionally substituted with the same groups as the triazine it being understood that when the distribution agent represents phenyl optionally substituted with NH.sub.2, that n and m represent 1 and R.sub.3 and R'.sub.3 represent hydrogen, then the nitrogen-containing aromatic ring and the aromatic ring do not both represent a quinoline which is unsubstituted or substituted on its nitrogen atom with an alkyl radical containing 1 to 6 carbon atoms, or one of its salts. [0055] Within the meaning of the above formula, the expression nitrogen-containing aromatic ring is understood to mean a heterocycle containing at least one nitrogen atom or an aromatic group not containing a heteroatom in the ring but containing at least one nitrogen atom in a hydrocarbon chain linked to the ring such as, for example, a guanidino or guanyl chain. [0056] The present invention relates in particular to the above compounds, characterized in that the distribution agent is chosen from the heterocyclic groups, the phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH--CH2-phenyl-CH2-NH--, --NH--CH2-phenyl-NH--, --CH2-phenyl-CH2-, --CH2-phenyl, -phenyl-CH2-, --CH2-thienyl-, -thienyl-CH2-, --CH.dbd.CH-- and diazine radicals, more particularly from the heterocyclic groups, the phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH--CH2-phenyl-CH2-NH--, --CH2-phenyl-CH2-, --CH2- phenyl, --CH2-thienyl-, --CH.dbd.CH-- and diazine radicals, and still more particularly from the heterocyclic groups, the phenyl, --NH-phenyl-NH--, --NH-- phenyl-CH2-NH--, --NH--CH2-phenyl-CH2-NH--, --CH2-phenyl-CH2-, --CH.dbd.CH--, and diazine radicals as defined above. [0057] Among all the compounds above, those preferred contain a distribution agent chosen from the heterocyclic groups such as for example thienyl and pyridyl, a phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH--CH2-phenyl-CH2-NH-- and diazine radical as defined above and which are optionally substituted as indicated above. Among the diazine groups, the use of pyrimidines is preferred. [0058] Among the compounds of the present invention, the compounds defined above, characterized in that p and q represent the integer 1, are especially preferred. [0059] The present invention relates particularly to the compounds defined above, characterized in that they correspond to formula (IA) below: with n, m, p and q, which are identical or different, representing the integer 0 or 1 and in which: [0060] A represents: [0061] a 5- to 6-membered heterocyclic radical containing a sulfur, oxygen or nitrogen atom, [0062] a phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH--CH2-phenyl-CH2-NH--, --NH--CH2-phenyl-NH--, --CH2-phenyl-CH2-, --CH2-phenyl, -phenyl-CH2-, --CH2-thienyl-, -thienyl-CH2- or --CH.dbd.CH-radical, or [0063] a diazine group, and wherein the heterocyclic, phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH--CH2-phenyl-CH2-NH--, --NH--CH2-phenyl-NH--, --CH2-phenyl-CH2-, --CH2-phenyl, -phenyl-CH2-, --CH2-thienyl-, -thienyl-CH2- or --CH.dbd.CH-- radical, and diazine radicals which A may represent, are optionally substituted with one or more radicals chosen from halogen atoms, alkyl radicals having 1 to 4 carbon atoms and thio, oxy or amino radicals which are themselves optionally substituted with one or more short-chain alkyl chains containing 1 to 4 carbon atoms, [0064] R.sub.3 and R'.sub.3, which are identical or different, represent independently of each other hydrogen or a C1-C4 alkyl group [0065] Ar.sub.1 and Ar.sub.2, which are identical or different, represent [0066] when Ar.sub.1 and Ar.sub.2 are identical: [0067] quinoline unit optionally substituted with at least [0068] a group N(Ra)(Rb) in which Ra and Rb, which are identical or different, represent hydrogen or a C1-C4 alkyl radical or [0069] a short-chain alkyl or alkoxy group containing 1 to 4 carbon atoms or [0070] a quinoline possessing a nitrogen atom in quaternary form or [0071] a benzamidine or [0072] a pyridine attached at the 4-position or fused with an aryl or heteroaryl group, optionally substituted with a C1-C4 alkyl group [0073] when Ar.sub.1 and Ar.sub.2 are different [0074] Ar.sub.1 and Ar.sub.2 both represent one of the possibilities mentioned above for Ar.sub.1 and Ar.sub.2 or [0075] Ar.sub.1 represents one of the above possibilities and Ar.sub.2 represents [0076] a phenyl nucleus optionally substituted with a halogen atom, a C1-C4 alkoxy group, a cyano group, a carbonylamino group optionally substituted with one or more C1-C4 alkyl groups, a guanyl group, a C1-C4 alkylthio group, an amino group, a C1-C4 alkylamino group, a C1-C4 dialkylamino group for each alkyl group, a nitro group, a C1-C4 alkyleneamino group or [0077] a C2-C4 alkenyleneamino group [0078] a pyridyl nucleus [0079] a mono- or bi- or tricyclic aromatic or non-aromatic heterocyclic nucleus containing 0 to 2 heteroatoms per ring provided that at least one heteroatom is present in at least one ring optionally substituted with one or more C1-C4 alkyl groups or with C1-C4 alkylene or C2-C4 alkenylene groups, it being understood that when A represents a phenyl optionally substituted with NH2 and when n, m, p and q represent 1 and R.sub.3 and R.sub.3' represent hydrogen, then the nitrogen-containing aromatic ring and the aromatic ring do not both represent a quinoline which is unsubstituted or substituted on its nitrogen atom with an alkyl radical containing 1 to 6 carbon atoms or one of its salts and when A represents a triazine and p and q both represent the integer 1, then n and m do not both represent the integer 0. [0080] The present invention relates in particular to the above compounds, characterized in that A is chosen from the heterocyclic groups, the phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH--CH2-phenyl-CH2-NH--, --NH--CH2-phenyl-NH--, --CH2-phenyl-CH2-, --CH2-phenyl, -phenyl-CH2-, --CH2-thienyl-, -thienyl-CH2-, --CH.dbd.CH-- and diazine radicals, more particularly from the heterocyclic groups, the phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH--CH2-phenyl-CH2-NH--, --CH2-phenyl-CH2-, --CH2-phenyl, --CH2-thienyl-, --CH.dbd.CH-- and diazine radicals, and still more particularly from the heterocyclic groups, the phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH--CH2-phenyl-CH2-NH--, --CH2-phenyl-CH2-, --CH.dbd.CH--, and diazine radicals as defined above. [0081] Among the compounds of the present invention, those preferred are in particular the compounds corresponding to formula (I) below: with n and m, which are identical or different, representing the integer 0 or 1 and in which: [0082] A represents: [0083] a 5- to 6-membered heterocyclic radical containing a sulfur, oxygen or nitrogen atom, [0084] a phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH-- or --NH--CH2-phenyl-CH2-NH-- radical, or [0085] a diazine group, and wherein the heterocyclic, phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH--CH2-phenyl-CH2-NH-- and diazine radicals which A may represent, are optionally substituted with one or more radicals chosen from halogen atoms, alkyl radicals having 1 to 4 carbon atoms and thio, oxy or amino radicals which are themselves optionally substituted with one or more short-chain alkyl chains containing 1 to 4 carbon atoms, [0086] R.sub.3 and R'.sub.3, which are identical or different, represent independently of each other hydrogen or a C1-C4 alkyl group, [0087] Ar.sub.1 and Ar.sub.2, which are identical or different, represent [0088] 1. when Ar.sub.1 and Ar.sub.2 are identical: [0089] a quinoline unit optionally substituted with at least [0090] a group N(Ra)(Rb) in which Ra and Rb, which are identical or different, represent hydrogen or a C1-C4 alkyl radical or [0091] a short-chain alkyl or alkoxy group containing 1 to 4 carbon atoms or [0092] a quinoline possessing a nitrogen atom in quaternary form or [0093] a benzamidine or [0094] a pyridine attached at the 4-position or fused with an aryl or heteroaryl group, optionally substituted with a C1-C4 alkyl group [0095] 2. when Ar.sub.1 and Ar.sub.2 are different [0096] Ar.sub.1 and Ar.sub.2 both represent one of the possibilities mentioned above for Ar.sub.1 and Ar.sub.2 or [0097] A.sub.1 represents one of the above possibilities and Ar.sub.2 represents [0098] a phenyl nucleus optionally substituted with a halogen atom, a C1-C4 alkoxy group, a cyano group, a carbonylamino group optionally substituted with one or more C1-C4 alkyl groups, a guanyl group, a C1-C4 alkylthio group, an amino group, a C1-C4 alkylamino group, a C1-C4 dialkylamino group for each alkyl group, a nitro group, a C1-C4 alkyleneamino group or a C2-C4 alkenyleneamino group [0099] a pyridyl nucleus [0100] a mono- or bi- or tricyclic aromatic or non-aromatic heterocyclic nucleus containing 0 to 2 heteroatoms per ring provided that at least one heteroatom is present in at least one ring optionally substituted with one or more C1-C4 alkyl groups or with C1-C4 alkylene or C2-C4 alkenylene groups, it being understood that when A represents a phenyl optionally substituted with NH2 and when n and m represent 1 and R.sub.3 and R.sub.3' represent hydrogen, then the nitrogen-containing aromatic ring and the aromatic ring do not both represent a quinoline which is unsubstituted or substituted on its nitrogen atom with an alkyl radical containing 1 to 6 carbon atoms or one of its salts. [0101] It is evident that quinoline units may be substituted with any other group not involved in the desired application; thus, acridine or isoquinoline or quinazoline or quinoxaline or phthalazine or benzothiazine or benzoxazine or phenoxazine or phenothiazine groups are included in the definition of quinoline groups. [0102] In the above compounds, the diazine groups which A may represent are preferably pyrimidines. [0103] Among the compounds of formula (I) above, those preferred are the ones for which A is chosen from heterocyclic groups such as in particular thienyl and pyridyl, phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH--CH2- phenyl-CH2-NH-- and pyrimidine radicals as defined above. [0104] Among the compounds of formula (I) above, there may be particularly mentioned the compounds characterized in that Ar.sub.1 and Ar.sub.2 represent: [0105] a quinoline unit optionally substituted with at least [0106] a group N(Ra)(Rb) in which Ra and Rb, which are identical or different, represent hydrogen or a C1-C4 alkyl radical or [0107] a short-chain alkyl or alkoxy group containing 1 to 4 carbon atoms or [0108] a quinoline possessing a nitrogen atom in quaternary form or [0109] a pyridine. [0110] Among the compounds of formula (I) above, there may be mentioned more particularly the compounds characterized in that Ar.sub.1 and Ar.sub.2 represent a group chosen from the following groups: 4-amino- or 4-methylamino-, 4-dimethylamino- or 4-alkoxy-quinolyl or -quinolinium in which the quinolinium nucleus is optionally substituted with a methyl group. [0111] Among the compounds of formula (I) above, there may also be mentioned the compounds characterized in that A is optionally substituted with one or more radicals chosen from halogen atoms and thioalkyl, amino, alkylamino or dialkylamino radicals, radicals in which the alkyl groups possess 1 to 4 carbon atoms and most particularly the compounds characterized in that A is optionally substituted with a methylthio group and optionally with a halogen atom. [0112] The present invention relates in particular to the compounds of formula (IA) as defined above in which: n, m, p and q, which are identical or different, represent the integer 0 or 1 [0113] A represents: [0114] a thienyl or pyridyl radical, [0115] a phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH--, --NH--CH2-phenyl-CH2-NH--, --CH2-phenyl-CH2-or --CH.dbd.CH-- radical, or [0116] a pyrimidyl radical optionally substituted with one or more radicals chosen from halogen atoms and alkylthio radicals having 1 to 4 carbon atoms, [0117] R.sub.3 and R'.sub.3, which are identical or different, represent independently of each other hydrogen or a C1-C4 alkyl group [0118] Ar.sub.1 and Ar.sub.2, which are identical or different, represent [0119] when Ar.sub.1 and Ar.sub.2 are identical: [0120] a quinoline unit optionally substituted with at least [0121] a group N(Ra)(Rb) in which Ra and Rb, which are identical or different, represent hydrogen or a C1-C4 alkyl radical or [0122] a short-chain alkyl or alkoxy group containing 1 to 4 carbon atoms or [0123] a quinoline possessing a nitrogen atom in quaternary form or [0124] when Ar.sub.1 and Ar.sub.2 are different [0125] Ar.sub.1 and Ar.sub.2 both represent one of the possibilities mentioned above for Ar.sub.1 and Ar.sub.2 or [0126] Ar.sub.1 represents one of the above possibilities and Ar.sub.2 represents [0127] a pyridyl nucleus [0128] a mono- or bi- or tricyclic aromatic or non-aromatic heterocyclic nucleus containing 0 to 2 heteroatoms per ring provided that at least one heteroatom is present in at least one ring optionally substituted with one or more C1-C4 alkyl groups or with C1-C4 alkylene or C2-C4 alkenylene groups, or one of its salts. [0129] The present invention relates in particular to the compounds of formula (IA) as defined above in which: n and m, which are identical or different, represent the integer 0 or 1, and p and q represent the integer 1 [0130] A represents: [0131] a thienyl or pyridyl radical, [0132] a phenyl, --NH-phenyl-NH--, --NH-phenyl-CH2-NH-- or --NH--CH2-phenyl-CH2-NH--, radical, or [0133] a pyrimidyl radical optionally substituted with one or more radicals chosen from halogen atoms and alkylthio radicals having 1 to 4 carbon atoms, [0134] R.sub.3 and R'.sub.3, which are identical or different, represent independently of each other hydrogen or a C1-C4 alkyl group [0135] Ar.sub.1 and Ar.sub.2, which are identical or different, represent [0136] 1. when Ar.sub.1 and Ar.sub.2 are identical: [0137] a quinoline unit optionally substituted with at least [0138] a group N(Ra)(Rb) in which Ra and Rb, which are identical or different, represent hydrogen or a C1-C4 alkyl radical or [0139] a short-chain alkyl or alkoxy group containing 1 to 4 carbon atoms or [0140] a quinoline possessing a nitrogen atom in quaternary form or [0141] 2. when Ar.sub.1 and Ar.sub.2 are different [0142] Ar.sub.1 and Ar.sub.2 both represent one of the possibilities mentioned above for Ar.sub.1 and Ar.sub.2 or [0143] Ar.sub.1 represents one of the above possibilities and Ar.sub.2 represents [0144] a pyridyl nucleus [0145] a mono- or bi- or tricyclic aromatic or non-aromatic heterocyclic nucleus containing 0 to 2 heteroatoms per ring provided that at least one heteroatom is present in at least one ring optionally substituted with one or more C1-C4 alkyl groups or with C1-C4 alkylene or C2-C4 alkenylene groups, or one of its salts. [0146] The present invention thus relates particularly to the compounds defined above, characterized in that Ar.sub.1 and Ar.sub.2, which are identical or different, represent a group chosen from the 4-amino- or 4-methylamino- or 4-dimethylamino-, or 4-alkoxy-quinolyl or -quinolinium groups in which the quinolinium nucleus is optionally substituted with one or two methyl groups. Continue reading about Chemical derivatives and their application as antitelomerase agent... Full patent description for Chemical derivatives and their application as antitelomerase agent Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Chemical derivatives and their application as antitelomerase agent patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. 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