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Biologically active peptidesBiologically active peptides description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20080293641, Biologically active peptides. Brief Patent Description - Full Patent Description - Patent Application Claims
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This application is a divisional of U.S. patent application Ser. No. 11/455,289, filed on Jun. 16, 2006, which is a divisional of U.S. patent application Ser. No. 10/237,405, filed on Sep. 5, 2002, which is a continuation-in-part of U.S. patent application Ser. No. 10/178,684, filed on Jun. 20, 2002, which is a continuation-in-part of U.S. patent application Ser. No. 09/904,492, filed on Jul. 13, 2001, the disclosures of which are all incorporated herein by reference in their entireties. FIELD OF INVENTIONThe present invention is related to the field of immunology. In particular, the present invention is directed to peptides and their pharmaceutical compositions which are capable of modulating immune responses. BACKGROUND OF INVENTIONSpleen extracts from mammals have been used successfully for years as medical immune modulators. However, the molecular composition of such extracts is unknown and therefore the exact pharmacological actions of these extracts cannot be identified. The dosage response function also cannot be accurately titrated because of the intrinsic heterogeneous nature of these extracts. Because of such heterogeneity, active ingredients in spleen extracts cannot be singled out and their pharmacological actions cannot be fully utilized. And, no matter how careful the extraction process can be, there is always the possibility of transmission of diseases of animal origin to human if animal tissue is used as the raw material for extraction. U.S. Pat. No. 3,992,364 to Kuhlmey describes a physiologically active polypeptide produced from an animal spleen extract. The exact sequence of the peptide was not disclosed and the preparation was described as being useful for decreasing cholesterol levels and increasing the 17 keto-steroid elimination of human patients. SUMMARY OF INVENTIONIt is an object of the present invention to identify biologically active polypeptides. A study was conducted in which a number of peptides have been identified from a porcine spleen extract according to the method described in U.S. Pat. No. 3,992,364. The active fraction is also sold under the trade name “Polyerga”. The peptides in the 10 arative HPLC followed by analysis using electrospray ionisation mass spectroscopy (ESMS) and matrix assisted laser desorption ionisation mass spectroscopy (MALDI-MS) at the W. M. Keck Foundation Biotechnology Resource Laboratory at Yale University. Once the identity of the peptides was found, they were individually synthesized by standard chemical methods. Using known animal and in vitro methods, the immunological function of these peptides was analyzed. The in vivo study of the effect of the peptides on immunity was performed using methods described in the following references. The peptides are given codes having the letters CMS followed by a number. The peptide sequence and the corresponding ID numbers are shown in Table A. A total of 30 peptides have been identified as having in vivo biological activities. The effect of the peptides on kidney function, liver function, cancer and body weight was also analyzed.
TABLE A
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