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  Biological simulation system and computer program productRelated Patent Categories: Data Processing: Structural Design, Modeling, Simulation, And Emulation, Simulating Nonelectrical Device Or System, Biological Or BiochemicalThe Patent Description & Claims data below is from USPTO Patent Application 20060282245. Brief Patent Description - Full Patent Description - Patent Application Claims
[0001] This application claims priority under 35 U.S.C. .sctn. 119 to Japanese Patent Application No. 2005-138868 filed May 11, 2005, the entire content of which is hereby incorporated by reference. TECHNICAL FIELD [0002] The present invention relates to a biological simulation system, particularly a system and a computer program product for simulating pathological condition of diabetes. BACKGROUND [0003] Biological bodies have been conventionally tried to describe by mathematical models. The minimal model by Bergman can be referred to for this model. Bergman's minimal model was disclosed in "American Journal of Physiology, 1979, Vol. 236-6, p.E-667-77, Bergman et al." and "Journal of Clinical Investigation, 1981, Vol. 68-6, p. 1456-67". [0004] In this minimal model, variables are blood glucose level, plasma insulin concentration, and insulin action level i.e. remote insulin of insulin action point of a peripheral tissue. The equations of the minimal model are as follows: dG(t)/dt=-p.sub.1(G(t)-G.sub.b)-X(t)G(t) dX(t)/dt=-p.sub.2X(t)+p.sub.3(I(t)-I.sub.b) dI(t)/dt=-n(I(t)-I.sub.b)+.gamma.(G(t)-h) (G(t)>h)=-n(I(t)-I.sub.b)+.gamma.(G(t)-h) (G(t)<=h) where blood glucose level for time "t" is represented by "G(t)", plasma insulin concentration is "I(t)", and remote insulin is "X(t)", and time difference is on the left sides. Parameters in the equation are: [0005] p.sub.1: insulin-independent glucose metabolism rate [0006] G.sub.b: blood-glucose level [0007] p.sub.2: insulin uptake efficiency [0008] p.sub.3: insulin consumption rate against insulin-dependent glucose metabolism [0009] I.sub.b: insulin concentration value [0010] n: insulin consumption per unit time [0011] .gamma.: insulin secretion sensitivity against glucose stimulation, [0012] h: threshold level of blood glucose starting insulin secretion. These values depend on individuals. [0013] If we try to simulate a biological body by applying such model to an individual patient and use the model for diagnosis and the like, we need to appropriately set the above-mentioned parameters constituting the biological model depending on the individual patients. [0014] That means, when we try to reproduce an actual patient body by the biological model, we need accuracy of the above-mentioned parameters and obtain accurate parameters different among individual patients as much as possible. SUMMARY [0015] An object of the present invention is to provide a technical means for obtaining parameters of biological models corresponding to individual patients. [0016] A first invention is a biological simulation system using a biological model comprising an internal parameter set generating section generating internal parameter sets constituting a biological model, and a biological model computing section computing output of a biological model which emulates a biological response of a biological organ based on the generated internal parameter set, wherein said internal parameter set generating section comprises means for automatically generating a plurality of different internal parameter sets, and a selecting means which determines an approximation between a biological model output calculated applying the automatically generated internal parameter set and an actual biological response corresponding to said output and which selects an appropriate internal parameter set from a plurality of the generated internal parameter sets. [0017] A second invention is a biological simulation system using a biological model comprising an internal parameter set generating section generating internal parameter sets constituting a biological model, and a biological model computing section simulating a biological organ based on the generated internal parameter set, wherein said internal parameter set generating section comprises means for automatically generating a plurality of different internal parameter sets, and a selecting means which determines an approximation between a biological organ condition shown by a parameter value included in the generated internal parameter set and a biological organ condition shown by a physiological index obtained from an actual body examination and which selects an appropriate internal parameter set from a plurality of generated internal parameter sets. [0018] A third invention is a biological simulation system using a biological model comprising an internal parameter set generating section generating internal parameter sets constituting a biological model, and a biological model computing section simulating a biological organ based on the generated internal parameter set, wherein said internal parameter set generating section comprises means for automatically generating a plurality of different internal parameter sets, and an obtaining means for obtaining internal parameter set showing a biological organ condition approximate to the biological organ condition shown by a biological index which is obtained from an actual body examination, based on the generated internal parameter set. [0019] A fourth invention is a biological simulation system using a biological model comprising an internal parameter set generating section generating internal parameter sets constituting a biological model, and a biological model computing section computing output of the biological model which emulates a biological response of a biological organ based on the generated internal parameter set, wherein said internal parameter set generating section comprises means for automatically generating a plurality of different internal parameter sets, and a selecting means which determines an approximation between the biological model output calculated applying the internal parameter set automatically generated and an actual biological response corresponding to said output and which selects an appropriate internal parameter set from a plurality of the generated internal parameter sets, and an obtaining means for obtaining an appropriate internal parameter set showing a biological organ condition approximate to the biological organ condition shown by the biological index which is obtained from an actual body examination, based on a plurality of the internal parameter sets selected by said selecting means. [0020] Further, with regard to an invention related to a computer program product, a computer is executed to perform the biological simulation as the biological simulation system. DESCRIPTION OF THE DRAWINGS Continue reading... Full patent description for Biological simulation system and computer program product Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Biological simulation system and computer program product patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. 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