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12/27/07 - USPTO Class 514 |  130 views | #20070299028 | Prev - Next | About this Page  514 rss/xml feed  monitor keywords

Backbone modifications to modulate oligonucleotide targeting in vivo

USPTO Application #: 20070299028
Title: Backbone modifications to modulate oligonucleotide targeting in vivo
Abstract: The present invention provides antisense compounds and methods for modulating the expression of target genes expressed in the kidney. In particular, this invention provides antisense oligonucleotide compounds optimized for targeting nucleic acid molecules expressed in the kidney. Such compounds are shown herein to efficiently modulate the expression of target genes PTEN, SGLT2 and connective tissue growth factor (CTGF) in the kidney. (end of abstract)



Agent: Mcdermott Will & Emery - San Diego, CA, US
Inventors: Andrew M. Siwkowski, Edward Wancewicz, Thomas A. Leedom, Lynnetta Watts, Mausumee Guha, Brett P. Monia, Richard H. Griffey, Richard S. Geary, Scott Henry, Arthur Levin
USPTO Applicaton #: 20070299028 - Class: 514044000 (USPTO)

Related Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Designated Organic Active Ingredient Containing (doai), O-glycoside, , Nitrogen Containing Hetero Ring, Polynucleotide (e.g., Rna, Dna, Etc.)

Backbone modifications to modulate oligonucleotide targeting in vivo description/claims


The Patent Description & Claims data below is from USPTO Patent Application 20070299028, Backbone modifications to modulate oligonucleotide targeting in vivo.

Brief Patent Description - Full Patent Description - Patent Application Claims
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