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09/13/07 - Class 435 site info Info monitor Monitor Keywords monitor archive Archive organizer Organizer account info Account |  Prev - Next

Assays for determining anticoagulant cofactor activity pdficon_sm

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Abstract: Methods are disclosed for determining, in a sample derived from a human, the functional activity of a component of the human blood coagulation system, which activity can be correlated to conversion of a substrate specific for activated Protein C (APC), by measuring in an assay medium containing the sample and a substrate for APC, the conversion of the substrate by APC and correlating the conversion to the functional activity of the component. When the component is anticoagulant Factor V, at least one of exogenous APC, Protein S or an inhibitor of Protein S activity is added to the medium. When the component is Protein C, APC, or Protein S, exogenous anticoagulant Factor V or an inhibitor of anticoagulant activity of Factor V is added to the medium. Methods are also disclosed for diagnosing a blood coagulation/anticoagulation disorder or for determining a predisposition thereto in a human by determining anticoagulant Factor V activity in an assay medium containing a sample derived from the human. ...

Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP (formerly Kirkpatrick & Lockhart Nicholson Graham) - Boston, MA, US
Inventor: Björn Dahlbäck
USPTO Applicaton #: #20070212743 - Class: 435013000 (USPTO)

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Related Terms: Anticoagulant   Cofactor   Exogenous   F Factor   Factor V   Sample Derived    Related Patent Categories: Chemistry: Molecular Biology And Microbiology, Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip, Involving Blood Clotting Factor (e.g., Involving Thrombin, Thromboplastin, Fibrinogen, Etc.)
The Patent Description & Claims data below is from USPTO Patent Application 20070212743, Assays for determining anticoagulant cofactor activity.

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Anticoagulant   APC   Apc   Cofactor   Exogenous   F Factor   Factor V   Ofa   Sample Derived   


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