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  Anti-diabetic composition with high-potency sweetenerUSPTO Application #: 20080107787Title: Anti-diabetic composition with high-potency sweetener Abstract: The present invention relates generally to anti-diabetic compositions comprising non-caloric or low-caloric high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different anti-diabetic compositions comprising at least one non-caloric or low-caloric natural and/or synthetic high-potency sweetener, at least one sweet taste improving composition, and an anti-diabetic substance. The present invention also relates to anti-diabetic compositions and methods that can improve the tastes of non-caloric or low-caloric natural and/or synthetic, high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the anti-diabetic compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and/or a more sugar-like flavor profile. (end of abstract) Agent: Sutherland Asbill & Brennan LLP - Atlanta, GA, US Inventors: Indra Prakash, Grant E. DuBois USPTO Applicaton #: 20080107787 - Class: 426548 (USPTO) The Patent Description & Claims data below is from USPTO Patent Application 20080107787. Brief Patent Description - Full Patent Description - Patent Application Claims
RELATED APPLICATION DATA [0001]The present application is related to U.S. Provisional Application No. 60/739,302, entitled "Natural High-Potency Sweetener Compositions With Improved Temporal Profile And/Or Flavor Profile, Methods For Their Formulations, and Uses," filed on Nov. 23, 2005; U.S. Provisional Application No. 60/739,124, entitled "Synthetic Sweetener Compositions with Improved Temporal Profile and/or Flavor Profile, Methods for Their Formulation, and Uses," filed on Nov. 23, 2005; U.S. Provisional Application No. 60/805,209, entitled "Natural High-Potency Tabletop Sweetener Compositions with Improved Temporal and/or Flavor Profiles, Methods for Their Formulation, and Uses," filed on Jun. 19, 2006; and U.S. Provisional Application No. 60/805,216, entitled "Rebaudioside A Composition and Method for Purifying Rebaudioside A," filed on Jun. 19, 2006. These applications are hereby incorporated by reference in their entirety. FIELD OF THE INVENTION [0002]The present invention relates generally to an anti-diabetic composition comprising a high-potency sweetener composition with improved temporal profile and/or flavor profile. BACKGROUND OF THE INVENTION [0003]Natural caloric sugars, such as sucrose, fructose, and glucose are utilized heavily in beverage, food, pharmaceutical, and oral hygienic/cosmetic industries due to their pleasant taste. In particular, sucrose imparts a desirable taste for consumers. Although sucrose provides superior sweetness characteristics, it is caloric. While calories are necessary for proper bodily functions, there is a need in the market to provide alternative non-caloric or low-caloric sweeteners with sugar-like taste for consumers with sedentary lifestyles or those who are calorie conscious. However, in general, non-caloric or low caloric sweeteners have associated undesirable tastes to consumers such as delayed sweetness onset; lingering sweet aftertaste; bitter taste; metallic taste; astringent taste; cooling taste; licorice-like taste; and/or the like. [0004]For example, the sweet tastes of natural and/or synthetic high-potency sweeteners are slower in onset and longer in duration than the sweet taste produced by sugar and thus change the taste balance of a food composition. Because of these differences, use of a natural high-potency sweetener to replace a bulk sweetener, such as sugar, in a food or beverage, causes an unbalanced temporal profile and/or flavor profile. In addition to the difference in temporal profile, high-potency sweeteners generally exhibit (i) lower maximal response than sugar, (ii) off tastes including bitter, metallic, cooling, astringent, licorice-like taste, etc., and/or (iii) sweetness which diminishes on iterative tasting. It is well known to those skilled in the art of food/beverage formulation that changing the sweetener in a composition requires re-balancing of the flavor and other taste components (e.g., acidulants). If the taste profile of natural and synthetic high-potency sweeteners could be modified to impart specific desired taste characteristics to be more sugar-like, the type and variety of compositions that may be prepared with that sweetener would be significantly expanded. Accordingly, it would be desirable to selectively modify the taste characteristics of natural and synthetic high-potency sweeteners. SUMMARY OF THE INVENTION [0005]Generally, this invention addresses the above described need by providing an anti-diabetic composition having improved temporal profile and/or flavor profile and a method for improving the temporal profile and/or flavor profile for anti-diabetic compositions. In particular, this invention improves the temporal profile and/or flavor profile by imparting a more sugar-like temporal profile and/or flavor profile. More particularly, this invention comprises an anti-diabetic composition comprising an anti-diabetic substance; at least one high-potency sweetener; and at least one sweet taste improving composition. [0006]Objects and advantages of the invention will be set forth in part in the following description, or may be obvious from the description, or may be learned through practice of the invention. Unless otherwise defined, all technical and scientific terms and abbreviations used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Although methods and compositions similar or equivalent to those described herein can be used in practice of the present invention, suitable methods and compositions are described without intending that any such methods and compositions limit the invention herein. BRIEF DESCRIPTION OF THE DRAWINGS [0007]FIG. 1 is a powder x-ray diffraction scan of rebaudioside A polymorph Form 1 on a plot of the scattering intensity versus the scattering angle 2.theta. in accordance with an embodiment of this invention. [0008]FIG. 2 is a powder x-ray diffraction scan of rebaudioside A polymorph Form 2 on a plot of the scattering intensity versus the scattering angle 2.theta. in accordance with an embodiment of this invention. [0009]FIG. 3 is a powder x-ray diffraction scan of rebaudioside A polymorph Form 3A on a plot of the scattering intensity versus the scattering angle 2.theta. in accordance with an embodiment of this invention. [0010]FIG. 4 is a powder x-ray diffraction scan of rebaudioside A polymorph Form 3B on a plot of the scattering intensity versus the scattering angle 2.theta. in accordance with an embodiment of this invention. [0011]FIG. 5 is a powder-x-ray diffraction scan of rebaudioside A polymorph Form 4 on a plot of the scattering intensity versus the scattering angle 2.theta. in accordance with an embodiment of this invention. DETAILED DESCRIPTION OF THE INVENTION [0012]Reference now will be made in detail to the presently proffered embodiments of the invention. Each example is provided by way of explanation of embodiments of the invention, not limitation of the invention. In fact, it will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the invention. For instance, features illustrated or described as part of one embodiment, can be used on another embodiment to yield a still further embodiment. Thus, it is intended that the present invention cover such modifications and variations within the scope of the appended claims and their equivalents. [0013]Generally described, embodiments of the present invention provide anti-diabetic compositions comprising at least one natural and/or synthetic high-potency sweetener, at least one sweet taste improving composition, and an anti-diabetic substance. I. ANTI-DIABETIC COMPOSITIONS [0014]Anti-diabetic compositions generally comprise an anti-diabetic substance and an excipient material. The excipient material typically includes the at least one natural and/or synthetic high-potency sweetener and the at least one sweet taste improving composition. In accordance with particular embodiments, the anti-diabetic composition may be in the form of a tablet, a capsule, a liquid, an aerosol, a powder, an effervescent tablet or powder, a syrup, an emulsion, a suspension, a solution, or any other form for providing the anti-diabetic composition to an individual. In particular embodiments, the anti-diabetic composition may be in a form for oral administration, sublingual administration, or any other route of administration as known in the art. In oral or sublingual administration embodiments of anti-diabetic compositions, the anti-diabetic compositions comprising at least one natural and/or synthetic high-potency sweetener and at least one sweet taste improving composition can mask a bitter or otherwise undesirable taste of an anti-diabetic substance or an excipient material. [0015]As referred to herein, "anti-diabetic substance" means any drug, drug formulation, medication, prophylactic agent, therapeutic agent, or other substance which lowers glucose levels in a individual's blood by any mechanism, including triggering insulin release, reducing hepatic glucose output, increasing glucose uptake by periphery tissues away from the blood, or supplementing insulin into the blood. As referred to herein, "excipient material" refers to any inactive substance used as a vehicle for an active ingredient, such as any material to facilitate handling, stability, dispersibility, wettability, and/or release kinetics of an anti-diabetic substance. [0016]Suitable anti-diabetic substances for embodiments of this invention include, but are not limited to, sulfonylureas, meglitinides, biguanides, thiazolideinediones, alpha glucosidase inhibitors, insulin, Gymnema sylvestre and extracts thereof, or similar type substances, or combinations thereof. For example, the anti-diabetic substance may comprise tolbutamide, acetohexamide, tolazamide, chloropropamide, glipizide, glyburide, glimepiride, gliclazide, repaglinide, nateglinide, metformin, rosiglitazone, pioglitiazone, miglitol, acarbose, exenatide (i.e., exendin-4), or similar type substances, or combinations thereof. Such components generally show indications of being effective by clinical trials, are recognized as safe (GRAS) and/or are U.S. Food and Drug Administration (FDA)-approved. [0017]According to particular embodiments of the invention, the anti-diabetic substance is present in the anti-diabetic composition in widely ranging amounts depending on the particular anti-diabetic agent being used and its intended applications. Suitable amounts can be readily discerned by those skilled in the art. Continue reading... Full patent description for Anti-diabetic composition with high-potency sweetener Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Anti-diabetic composition with high-potency sweetener patent application. Patent Applications in related categories: 20080171124 - All natural sweetener composition - An all natural zero and low calorie sweetener composition is disclosed, which can be supplemented with calcium. The disclosed sweetener can be used in foodstuffs including food, beverages, and beverage products as a substitute for high calorie sweeteners along with calcium supplementation. ... ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. 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