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Anti-aging composition containing phloretinAnti-aging composition containing phloretin description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20070225360, Anti-aging composition containing phloretin. Brief Patent Description - Full Patent Description - Patent Application Claims
[0001]This application is a non-provisional application of, and claims benefit to, U.S. Provisional Application No. 60/784,571, filed Mar. 22, 2006, which is incorporated by reference in its entirety for all purposes. BACKGROUND OF THE INVENTION [0002]Aging skin is the result of more than just chronological age. Skin is exposed to environmental elements that cause radicals to form in the skin. These radicals attack the collagen layer of the skin and break it down, causing lines and wrinkles to appear. This process is commonly called photo-aging. Diseases and disorders of skin that also may result from radical damage include skin cancer, skin irritation or inflammation, dermatitis, allergy, psoriasis, acne, eczema, rosacea. [0003]Application of antioxidants can help prevent radical-induced damage in skin. Applying Vitamin C, for example, to the skin can provide antioxidant protection, prevent photo-aging, and stimulate collagen production. However, not all Vitamin C formulations produce these benefits due to lack of stability. [0004]The present invention is thus directed to a composition and process for inhibiting radical-induced damage to skin which does not suffer from conventional stability issues. BRIEF SUMMARY OF THE INVENTION [0005]The present invention is directed to an anti-aging composition containing: [0006](a) at least one first active ingredient chosen from phloretin and its derivatives; [0007](b) at least one second active ingredient chosen from cinnamic acid, resveratrol, retinol, ascorbic acid, tocopherol, and their derivatives; and [0008](c) at least one non-aqueous organic solvent, and with the proviso that, if the composition contains ascorbic acid, water is present as a co-solvent. [0009]The present invention is also directed to a process for treating radical-induced damage to skin by contacting the skin with the above-disclosed composition. DETAILED DESCRIPTION OF THE INVENTION [0010]Other than in the operating examples, or where otherwise indicated, all numbers expressing quantities of ingredients and/or reaction conditions are to be understood as being modified in all instances by the term "about". [0011]The present invention is directed to the surprising discovery that by combining at least one first active ingredient chosen from phloretin, and its derivatives, with at least one second active ingredient chosen from cinnamic acid, resveratrol, retinol, ascorbic acid, tocopherol and their derivatives, an effective treatment for radical-induced damage to skin is realized. [0012]First Active Ingredient [0013]Phloretin is the aglucone portion of phlorizin and is a polyphenolic compound. It is split from phlorizin by acid hydrolysis. Alternatively, phloretin can be completely synthesized directly by known processes. [0014]Suitable phloretin derivatives include, but are not limited to, dihydrochalcone derivatives, such as those disclosed in U.S. Pat. No. 6,448,232, the entire contents of which is hereby incorporated by reference. [0015]The composition of the present invention contains the at least one first active ingredient in an amount of from about 0.1 to about 10% by weight, such as from about 0.5 to about 7% by weight, such as from about 1 to about 5% by weight, such as from about 0.5 to about 3% by weight, such as from about 1 to about 2% by weight, all weights based on the total weight of the composition. [0016]Second Active Ingredient [0017]The at least one second active ingredient is chosen from cinnamic acid, resveratrol, retinol, ascorbic acid, tocopherol, and their derivatives. [0018]In one embodiment, the at least one second active is a cinnamic acid derivative, examples of which include, but are not limited to, caffeic acid, p-coumaric acid, ferulic acid, sinapinic acid, mixtures thereof, cis and trans isomers thereof, salts thereof, and equivalent derivatives thereof. [0019]In a particularly preferred embodiment, the at least one second ingredient is a combination of ferulic acid and ascorbic acid. [0020]The at least one second active ingredient is present in the composition in an amount of from about 0.1 to about 25% by weight, such as from about 0.2 to about 15% by weight, such as from about 0.2 to about 10% by weight, all weights based on the total weight of the composition. [0021]The ratio by weight of first active ingredient to second active ingredient will typically be from about 0.1:10 to about 10:0.1, such as about 0.3:5, such as about 0.5:2. [0022]Non-Aqueous Organic Solvent [0023]Any non-aqueous organic solvent capable of solubilizing the first and second active ingredients may be employed. Examples of suitable solvents include, but are not limited to, non-aqueous polar organic solvents, and non-aqueous non-polar organic solvents. [0024]Non-Aqueous Polar Organic Solvent Continue reading about Anti-aging composition containing phloretin... Full patent description for Anti-aging composition containing phloretin Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Anti-aging composition containing phloretin patent application. 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