| Acidic composition for external use, and agent for accelerating penetration into skin or the like of cosmetic preparation, hair-growing agent and preparation for external use each containing the composition -> Monitor Keywords |
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Acidic composition for external use, and agent for accelerating penetration into skin or the like of cosmetic preparation, hair-growing agent and preparation for external use each containing the compositionRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Bleach For Live Hair Or Skin (e.g., Peroxides, Etc.)Acidic composition for external use, and agent for accelerating penetration into skin or the like of cosmetic preparation, hair-growing agent and preparation for external use each containing the composition description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20080069787, Acidic composition for external use, and agent for accelerating penetration into skin or the like of cosmetic preparation, hair-growing agent and preparation for external use each containing the composition. Brief Patent Description - Full Patent Description - Patent Application Claims
TECHNICAL FIELD [0001] The present invention relates to an acidic composition for external use which has cosmetic effects, a hair-growing effect, and an effect in accelerating penetration into skin or the like of preparations for external use such as drugs, cosmetic preparations, and relates to an agent for accelerating, penetration into skin or the like of a cosmetic preparation, a hair-growing agent and a preparation for external use each containing the composition. BACKGROUND ART [0002] Acidic polysaccharides are known to show diverse forms of physiological activity such as an effect in impeding coagulation of the blood, an effect in controlling the activity of cell proliferation factors, an effect in hindering the adhesion of viruses to cells, an anti-inflammatory effect, an immunological activating effect, an anti-cancer effect, a hemostatic effect and the like, and these compounds may be expected to have various effects as active ingredients in drugs and cosmetics. However, the use of such compounds in preparations for external use is rare, and the effects of these compounds in the case of such use are insufficient. As examples of cosmetic preparations, a pore shrinking agent containing a sulfated polysaccharide as an active ingredient, and a cosmetic preparation for suppressing the prominence of pores that contains this pore shrinking agent, have been proposed in Japanese Patent Application Laid-Open No. 2000-169322; however, the effects of these preparations are insufficient. [0003] In regard to hair-growing agents, for example, a hair-nurturing agent containing a de-cationized acidic polysaccharide obtained from an acidic polysaccharide as an active ingredient is disclosed in Japanese Patent No. 2583812. However, the effect of this agent is insufficient, and since the metal cations of the acidic polysaccharide are converted into hydrogen ions using a cationic ion exchange resin in the manufacturing process, the amount of the agent that can be manufactured is limited, and considerable time and expense are required in order to manufacture this agent. [0004] In light of such conditions, it is an object of the present invention to provide an acidic polysaccharide composition for external use which is easy to manufacture, and which has stronger cosmetic effects, hair-growing effect or therapeutic effect than other novel or universally known compositions. DISCLOSURE OF THE INVENTION [0005] The present inventor discovered that an acidic composition for external use containing acidic polysaccharides and water as essential ingredients has (1) cosmetic effects in making hair smooth and supple, adjusting the texture of skin, increasing the tension of skin, stretching out wrinkles, whitening skin, imparting an impression of transparency and moistened feeling to skin, lightening spots and making pores less noticeable, (2) a hair-growing effect in suppressing hair-loss and promoting growth of hair, and (3) a penetration accelerating effect in accelerating penetration of preparations for external use, such as drugs, cosmetics or the like, into skin or the like. This discovery led to the perfection of the present invention. Furthermore, the term "skin or the like" as used in the present invention refers to tissues of epithelial cell origin such as skin, mucous membranes, hair, nails and the like. [0006] The acidic polysaccharides used in the acidic composition for external use provided by the present invention may appropriately comprise one or more polysaccharides selected from a group comprising sulfated polysaccharides that have sulfuric acid groups in the molecule, and acidic polysaccharides that have carboxyl groups in the molecule (hereafter referred to as "carboxyl polysaccharides"). Furthermore, because of problems in terms of solubility and the like, acidic polysaccharides are ordinarily used as salts of alkali metals such as sodium, potassium or the like, or salts of alkaline earth metals such as calcium or the like; in the present invention, acidic polysaccharides include such salts unless otherwise specifically noted. [0007] One or more sulfated polysaccharides selected from a group comprising natural sulfated polysaccharides and semi-synthetic sulfated polysaccharides obtained by converting neutral polysaccharides or natural sulfated polysaccharides using a sulfating reagent or the like may be used as sulfated polysaccharides; however, the present invention is not particularly limited to such polysaccharides. Concrete examples of such sulfated polysaccharides include carrageenan, keratan sulfate, chondroitin sulfate, dextran sulfate, dermatan sulfate, fucoidan, funoran, heparin, porphyran and the like. One or more of these polysaccharides may be used. Of course, one or more compounds selected from the above-mentioned group comprising alkali metal salts of sulfated polysaccharides such as sodium salts, potassium salts and the like, and alkaline earth metals salts of sulfated polysaccharides such as calcium salts and the like, may also be used. Among these substances, carrageenan has protein reactivity and a high affinity for tissues such as skin or the like, and is therefore especially desirable. [0008] One or more carboxyl polysaccharides selected from a group comprising natural carboxyl polysaccharides and semi-synthetic carboxyl polysaccharides obtained by carboxylating neutral polysaccharides or natural polysaccharides using a carboxylating reagent or the like may be used as carboxyl polysaccharides; however the present invention is not particularly limited to such polysaccharides. Concrete examples of such compounds include alginic acid, karaya gum, carboxymethylcellulose, carboxyethylcellulose, carboxymethylethylcellulose, carboxymethyldextran, carboxymethyl starch, gellan gum, hyaluronic acid, pectin and the like. One or more of these compounds may be used. Of course, one or more compounds selected from the above-mentioned group comprising alkali-metal salts of carboxyl polysaccharides such as sodium salts, potassium salts and the like, and alkaline earth metals salts of carboxyl polysaccharides such as calcium salts and the like, may also be used. Among these compounds, alginic acid, hyaluronic acid and pectin also have moisture retaining properties and the like, and are therefore desirable, and alginic acid is superior in terms of use characteristics and the like, and is therefore especially desirable. [0009] The amount of acidic polysaccharides mixed with the acidic composition for external use provided by the present invention is preferably 0.001 to 5 wt %, and even more-preferably 0.01 to 3 wt %, relative to the total amount of the composition. If the amount that is mixed is less than 0.001 wt %, no cosmetic effect, hair-growing effect of effect in accelerating the penetration of preparations for external use into skin or the like can be expected. On the other hand, even if the amount mixed exceeds 5 wt %, no additional effect can be expected. It is known that acidic polysaccharides show an effect in impeding coagulation of the blood, an effect in controlling the activity of cell proliferation factors, an effect in hindering the adhesion of viruses to cells, an anti-inflammatory effect, an immunological activating effect, an anti-cancer effect, a hemostatic effect and the like; in all cases, such activity is shown in the vicinity of a pH of 7, which is more or less the same as the pH of body fluids. However, the fact that acidic polysaccharides show (1) cosmetic effects in making hair smooth and supple, adjusting the texture of skin, increasing the tension of skin, stretching out wrinkles, whitening skin, imparting an impression of transparency and moistened feeling to skin, lightening spots and making pores less noticeable, (2) a hair-growing effect in suppressing hair-loss and promoting growth of hair, and (3) an penetration accelerating effect in accelerating penetration of preparations for external use such as drugs, cosmetics or the like into skin or the like, when such acidic polysaccharides are applied to skin or the like as an acidic composition for external use has been completely unknown in the past. Furthermore, if the acidic composition for external use provided by the present invention is administered by a method other than external application, such as oral administration, injection or the like, the acidic polysaccharides cannot act under acidic conditions in desired organs, tissues or the like because of the buffering action of body fluids and the like, so that the effect of the present invention is not obtained. [0010] Since acidic polysaccharides hardly dissolve when used "as", these polysaccharides are ordinarily used in the form of salts; when dissolved in water, the resulted solutions are roughly neutral to weakly alkaline. The acidic composition for external use provided by the present invention can be made into an acidic solution using an acid or acidic electrolyzed water. For example, in cases where an acid is used, manufacture can easily be accomplished by mixing the acid(s) and water with the acidic polysaccharide(s) avoiding decomposition or the like of the acidic polysaccharide(s) by the acid(s). Natural water, tap water, or purified water such as ion exchanged water, membrane-filtered water, distilled water or the like can be used without any particular restrictions as the above-mentioned water. However, if water in which clusters (aggregations of water molecules) are decreased in size by using irradiation with electromagnetic waves such as high-frequency waves, far infrared radiation or the like, exposure to ultrasound, application of a voltage, electrolysis, high-speed rotation of the water or the like is used, not only can the dissolution of the acidic polysaccharides be promoted, but the penetration and absorption of the prepared acidic composition for external use into skin or the like can be accelerated; accordingly, such water is more desirable. [0011] One or more acids selected from a group comprising inorganic acids and organic acids may be used as the above-mentioned acid; there are no particular restrictions on the acid used. Examples of inorganic acids that can be used include sulfuric acid, hydrochloric acid, nitric acid, sulfamic acid, phosphoric acid, potassium dihydrogenphosphate, sodium dihydrogenphosphate, sodium pyrosulfite, potassium pyrosulfite, sodium sulfite, potassium sulfite, acidic sodium hexametaphosphate, acidic potassium hexametaphosphate, acidic sodium pyrophosphate, acidic potassium pyrophosphate and the like. One or more of these acids may be used. [0012] Examples of organic acids that can be used include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid, valeric acid and the like, dicarboxylic acids such as oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, fumaric acid, maleic acid, phthalic acid, isophthalic acid, terephthalic acid and the like, acidic amino acids such as glutamic acid, aspartic acid and the like, and oxy acids such as glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, alpha-oxybutyric acid, glyceric acid, tartronic acid, salicylic acid, gallic acid, tropic acid, ascorbic acid, gluconic acid and the like. One or more of these acids may be used. [0013] Acidic electrolyzed water manufactured by a universally known method can be used as the above-mentioned acidic electrolyzed water. For example, in the case of a batch type electrolyzed water manufacturing apparatus, acidic water rich in hydrogen ions that are produced on the anode side can be used. In regard to the water used in the manufacture of such acidic electrolyzed water, purified water or tap water may be appropriately used in accordance with the application. However, in order to increase the electrolysis efficiency of the water it is desirable to perform electrolysis with an electrolyte such as sodium chloride or the like added to the water. Since clusters (comprising aggregations of water molecules) are small in acidic electrolyzed water, dissolution of acidic polysaccharides is easy, and the power of penetration into skin or the like is increased compared to cases in which the prepared composition for external use is manufactured using an acid and ordinary water, so that the cosmetic effects, hair-growing effect and effect in accelerating the penetration into skin or the like of preparations for external use such as drugs for external use, cosmetic preparations or the like, are strengthened. Furthermore, since acidic electrolyzed water is superior, in terms of microbicidal and virucidal effects, a microbicidal action can be performed at the same time that the acidic composition for external use is prepared. Accordingly, not only is this convenient, but there is no need to mix preservatives, microbicidal agents or the like, that might possibly damage skin or mucous membranes, with the composition. An acid or alkali may be used together with acidic electrolyzed water for purposes of pH adjustment or the like; there are no particular restrictions on an acid or an alkali used in this case. [0014] It is sufficient if the pH of the acidic composition for external use provided by the present invention is acidic within a range that is such that the composition does not damage skin; a pH of 2.0 to 6.0 is desirable, and a pH of 2.5 to 5.0 is even more desirable. If the pH is lower than 2.0, the acidity is too strong, so that there is a danger of damage to skin or the like, on the other hand, if the pH exceeds 6.0, the effect of the present invention cannot be obtained. As long as the acidity of the composition for external use provided by the present invention is within the pH range of 2.0 to 6.0, the acidity of the composition can be adjusted to any desired acidity using an alkali such as sodium hydroxide or the like. [0015] In addition to the above-mentioned essential components, raw materials ordinarily used in preparations for external use, e.g., alcohols, moisturizing agents, surfactants, thickeners, preservatives, oils fragrances, coloring agents ultraviolet absorbing/scattering agents, physiologically active substances and the like, may also be used in the acidic composition for external use provided by the present invention as long as they do not impair the effects of the present invention. Furthermore, the term "physiologically active substances and the like" as used in the present invention includes both substances used as drugs to treat or prevent diseases, and substances that have cosmetic effects such as whitening, amelioration of spots, amelioration of pigment deposition, stretching out of wrinkles and the like. [0016] The acidic composition for external use provided by the present invention may be applied "as is" to skin or the like. However, as long as the composition is a preparation for external use, there are no particular restrictions on the agent type such as lotion, emulsion, gel, cream, plaster, spray, adhesive patch agent or the like. The composition itself shows a strong penetration into skin or the like. However, if the composition is mixed with another preparation for external use, the penetration into skin or the like of the preparation for external use that is thus nixed is reinforced; accordingly, especially in the case of preparations for external use that have a sticky feeling, this sticky feeling disappears in a short time when the agent is ribbed into skin or the like, so that a clean feeling is obtained, thus producing a desirable feeling of use. Furthermore, since there is no adhesion of the composition to clothing or the like following application, there is no soiling of clothing or the like, and in the case of drugs or the like for external use, the active ingredients or the like can be administered without waste. Accordingly, if the acidic composition for external use provided by the present invention is mixed with a preparation for external use such as a drug for external use, cosmetic preparation or the like and used as an agent for accelerating penetration into skin or the like, an effect comparable to that of the original preparation for external use can be obtained even if the dosage, number of times of administration, administration time or the like of preparation for external use is reduced. [0017] The acidic composition for external use provided by the present invention can be more appropriately used as a hair-growing agent or cosmetic preparation by adding other raw materials. The hair-growing agent of the present invention can be manufactured by mixing the acidic composition for external use provided by the present invention as the active ingredient of a conventional hair-growing agent preparation. The amount that is mixed is preferably 0.001 to 5 wt %, and even more preferably 0.01 to 3 wt % (in terms of acidic polysaccharides), relative to the total amount of the hair-growing agent. The acidity is preferably pH 2.0 to 6.0, and is even more preferably pH 2.5 to 5.0. In cases where it is necessary to adjust the pH, the pH can be adjusted to the desired ph by adding an arbitrary acid or alkali. Other hair-Clean growing substances and other physiologically active substances or the like may be mixed with the hair-growing agent of the present invention within limits as long as they do not impair the effects of the present invention. The hair-growing agent of the present invention can be used in the same manner as conventional hair-growing agents, it is sufficient if the hair-growing agent is rubbed into scalp once or more per day so that the hair-growing agent is uniformly spread over the entire scalp. [0018] The cosmetic preparation of the present invention can be manufactured by mixing the acidic composition for external use provided by the present invention with a conventional cosmetic preparation composition; the amount that is mixed is preferably 0.001 to 5 wt %, and even more preferably 0.01 to 3 wt % (in terms of acidic polysaccharides), relative to the total amount of the cosmetic preparation. The acidity of the cosmetic preparation of the present invention is preferably pH 2.0 to 6.0, and is even more preferably pH 2.5 to 5.0. In cases where it is necessary to adjust the pH, the pH can be adjusted to the desired pH value by mixing an arbitrary acid or alkali with the composition. The cosmetic preparation of the present invention can be used in the same manner as a conventional cosmetic preparation; it is sufficient if an appropriate amount of this preparation is applied to desired area. The cosmetic preparation may be used once in order to obtain effects in making hair smooth and supple, adjusting the texture of skin, increasing the tension of skin, whitening skin, increasing a transparent impression of skin, or giving a moistened feeling to skin; however, the effects are greatly increased by using the preparation every day. In order to obtain effects in stretching out wrinkles, lightening spots, ameliorating pigment deposition or making pores less prominent, it is desirable to use the preparation once or more per day for four days or longer. [0019] The acidic composition for external use provided by the present invention can be mixed with a conventional preparation for external use as an agent that accelerates the penetration into skin or the like of drugs for external use, cosmetic preparations or the like. The amount of the composition that is mixed is preferably 0.001 to 5 wt %, and even more preferably 0.01 to 3 wt % (in terms of acidic polysaccharides), relative to the total amount of the preparation for external use. The acidity of the preparation for external use with which the composition is mixed is preferably pH 2.0 to 6.0, and is even more preferably pH 2.5 to 5.0. In cases where it is necessary to adjust the pH, the pH can be adjusted to the desired pH value by mixing an arbitrary acid or alkali with the composition. The preparation for external use with which the agent for accelerating penetration into skin or the like provided by the present invention is mixed can be used in the same manner as an conventional preparation for external use, since penetration into skin or the like is accelerated, an effect comparable to that of the original preparation for external use can be obtained even if the dosage, number of times of administration, administration time or the like of preparation for external use is reduced. Furthermore, in the case of a preparation for external use such as a physiologically active substance or the like, the amount that is mixed can be reduced as long as this substance is a physiologically active substance which does not suffer from problems such as modification, degeneration, loss of activity, a conspicuous drop in activity or the like as a result of acidity. Furthermore, if physiological substances or the like which do not suffer from problems such as modification, degeneration, loss of activity, a conspicuous drop in activity or the like as a result of acidity but which could not be utilized in the past in preparations for external use because of a low transdermal absorption rate, are used as the above-mentioned preparations for external use with which the above-mentioned composition is mixed, the transdermal absorption rate of such agents is increased. BEST MODE FOR CARRYING OUT THE INVENTION [0020] Next, the present invention will be concretely described in terms of examples; however, the present invention is not limited to these examples. Continue reading about Acidic composition for external use, and agent for accelerating penetration into skin or the like of cosmetic preparation, hair-growing agent and preparation for external use each containing the composition... 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