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Accelerator for mineral absorption and use thereofRelated Patent Categories: Drug, Bio-affecting And Body Treating Compositions, Inorganic Active Ingredient Containing, Heavy Metal Or Compound ThereofAccelerator for mineral absorption and use thereof description/claimsThe Patent Description & Claims data below is from USPTO Patent Application 20060210646, Accelerator for mineral absorption and use thereof. Brief Patent Description - Full Patent Description - Patent Application Claims
TECHNICAL FIELD [0001] The present invention relates to a novel accelerator for mineral absorption and use thereof, more particularly, to a novel accelerator for mineral absorption, which contains as an effective ingredient a non-reducing saccharide composed of four glucose residues which cyclically bind each other via the .alpha.-1,3 and the .alpha.-1,6 linkages, namely, cyclo{.fwdarw.6)-.alpha.-D-glucopyranosyl-(1.fwdarw.3)-.alpha.-D-glucopyr- anosyl-(1.fwdarw.6)-.alpha.-D-glucopyranosyl-(1.fwdarw.3)-.alpha.-D-glucop- yranosyl-(1.fwdarw.} (hereinafter, it is called as "cyclic tetrasaccharide"), and/or a saccharide derivative thereof, and a composition containing the accelerator for mineral absorption. BACKGROUND ART [0002] Minerals, for example, calcium, magnesium, phosphorus and iron, have been being analyzed to be a physiologically important nutrition for living bodies. Modern people would have to make considerable effort for continually attaining the intake of the necessary amounts of minerals everyday in their food lives. Excessive diet or aging causes breaking down hormone balances, and excessive intake of instant foods or increased frequent eating out in food life may cause a chronic mineral deficiency. Subsequently, the balance between bone-formation and bone-absorption may be broken down. Then, calcium as a main ingredient may be reduced in calcium-containing tissues such as bones and teeth. Further, bone disorders such as osteoporosis, bone fracture and backache; tooth-disorders such as dental caries and periodontosis; urinary organ disorders such as nephrolithiasis; circulatory diseases such as hypertension and ischemic heart diseases; anemia; diabetes; or reduction of homeostatic function is easily developed. [0003] In order to solve such mineral deficiency, oily vitamins or hormone preparations such as vitamin D, calcitonin preparations, estrogen preparations, protein anabolic hormone preparations and bisphosphonate have been administered in addition to various mineral preparations. Although this method is more effective than a single administration of minerals, it is not necessarily satisfactory because of its complicated administration schedule and fear of side effect due to excessive administration of oily vitamins or hormone preparations. In addition, such mineral preparations also have a problem that they may cause the rise of blood mineral level when excessively administered. [0004] In consideration with such situation, food business has been developing exploitation of a raw material which is tasty, safe even if administered every day, effective on promoting mineral absorption, and capable of effectively supplementing minerals in a sufficient daily amount in daily food life in a single use or in combination with meals, foods between meals, or health foods. For example, accelerators for mineral absorption, containing either xylooligosaccharide, mannooligosaccharide or lactuloseoligosaccharide as an effective ingredient, are disclosed in Japanese Patent Publication Kokai Nos. 67575/95, 306093/2002 and 205653/94, respectively. A magnesium supplement, containing magnesium and at least one member selected from the group consisting of nondigestible oligosaccharide, nondigestible sugar alcohol and dietary fiber, is disclosed in Japanese Patent Kokai No. 69902/95. An agent for strengthening bone, containing lactosucrose and calcium chondroitin sulfate, is disclosed in Japanese Patent Kokai No. 33668/95. However, some kinds of such raw materials have the following problems when added to foods and beverages; they may lower foods and beverages in flavor such as taste, smell and mouth feeling, and need a large amount to exert a satisfactory effect. While, some kinds of minerals may lower foods and beverages in preference due to its characteristic bitter taste and metal taste. To meet a variety of food life, the development of food materials having satisfactory effect on promoting mineral absorption without lowering their flavor such as taste, smell and mouth feeling, and being safe even when continually taken, has been further desired. [0005] The present applicant disclosed a novel process for producing cyclic tetrasaccharide or a saccharide mixture containing it and its saccharide derivatives, and a composition containing them. The present applicant disclosed that these saccharides are hardly utilized by intestinal bacteria and capable of acting as a dietary fiber, in the specification of the International Publication Nos. WO 01/090338, WO 02/010361 and WO 02/072594. However, the above described patent publications, i.e. Japanese Patent Kokai No.67575/95 through International Publication No. WO 02/072594, never disclose the fact that cyclic tetrasaccharide and/or saccharide derivatives thereof, or composition containing such saccharides have a mineral absorption-promoting action. DISCLOSURE OF THE INVENTION [0006] The present invention has the first object to provide an accelerator for mineral absorption, which is safely administered and is satisfactorily effective on promoting mineral absorption. The present invention has the second object to provide a composition for promoting mineral absorption, which contains the accelerator. [0007] The present inventors have studied an accelerator for mineral absorption, which contains saccharides as effective ingredients, to attain the above objects. As a result, they revealed that cyclic tetrasaccharide and/or saccharide derivatives thereof strongly act to promote mineral absorption and to strengthen bone as a representative of strengthening calcium-containing tissues. They established a novel accelerator for mineral absorption and a composition for promoting mineral absorption, which contains the accelerator, and thus they accomplished the present invention. BEST MODE FOR CARRYING OUT THE INVENTION [0008] The term "composition" as referred to as in the present invention means foods, beverages, cosmetics, quasi-drugs, pharmaceuticals, feeds or pet foods. It further includes raw or intermediate materials and products produced by either processing or using them. [0009] The term "cyclic tetrasaccharide" as referred to as in the present invention means a non-reducing saccharide composed of four glucose residues which cyclically bind each other via the .alpha.-1,3 and the .alpha.-1,6 linkages, represented by cyclo{.fwdarw.6)-.alpha.-D-glucopyranosyl-(1.fwdarw.3)-.alpha.-D-glucopyr- anosyl-(1.fwdarw.6)-.alpha.-D-glucopyranosyl-(1.fwdarw.3)-.alpha.-D-glucop- yranosyl-(1.fwdarw.}, which is disclosed in the specification of the International Publication Nos. WO 01/090338 and WO 02/010361. [0010] The term "saccharide derivative of cyclic tetrasaccharide" as referred to as in the present invention means a saccharide where one or more of the same or different glycosyl residues are bound to cyclic tetrasaccharide; for example, a saccharide mixture having cyclic tetrasaccharide and a saccharide where one or more glucose molecules are bound to one or more hydroxyl groups of cyclic tetrasaccharide, which is obtained by allowing .alpha.-isomaltosylglucosaccharide-forming enzyme and .alpha.-isomaltosyl-transferring enzyme to act on starch. Such saccharides can be further reacted by the same or different saccharide-transferring enzymes selected from the group consisting of cyclomaltodextrin glucanotransferase, .beta.-galactosidase, .alpha.-galactosidase, lysozyme, etc., in the presence of their substrates such as monosaccharides, oligosaccharides and/or polysaccharides according to the method disclosed by the inventors of the present invention in the specification of the International Publication No. WO 02/010361 in order to produce a saccharide having one or more of the same or different glycosyl residues selected from the group consisting of .alpha.-D-glucopyranosyl residue, .beta.-D-galactopyranosyl residue and .beta.-D-chitosaminyl residue at one or more hydroxyl groups of such saccharide. Furthermore, such saccharide can be transferred with one or more of the same or different glycosyl residues selected from the group consisting of .alpha.-D-glucopyranosyl residue, .beta.-D-galactopyranosyl residue, .beta.-D-chitosaminyl residue, etc, at the previously transferred .alpha.-D-glucopyranosyl residue, .beta.-D-galactopyranosyl residue, or .beta.-D-chitosaminyl residue to saccharide derivatives of cyclic tetrasaccharide. [0011] The cyclic tetrasaccharide and saccharide derivatives thereof usable in the present invention are not specifically restricted by their origins and processes. They can be produced by fermentation method, enzymatic method, and organic synthesis. Optionally, they can contain other saccharides co-existing through the process of cyclic tetrasaccharide, such as glucose, isomaltose, maltose, oligosaccharides and dextrin. Such reaction mixtures obtainable by the above methods can be used as the cyclic tetrasaccharide and saccharide derivatives thereof in the present invention. If necessary, they are partially or highly purified by using ion-exchange resins to remove impurities. Also, a saccharide mixture, containing one or more members selected from the group consisting of a highly purified cyclic tetrasaccharide and saccharide derivatives thereof, can be used in the present invention. These cyclic tetrasaccharide and saccharide derivatives thereof can be produced from amylaceous substances or saccharides deriving therefrom by the enzymatic methods; for example, converting panose into cyclic tetrasaccharide by .alpha.-isomaltosyl-transferring enzyme, disclosed by the same applicant as the present invention in the specification of the International Publication No. WO 01/090338; or producing cyclic tetrasaccharide from starch by using .alpha.-isomaltosylglucosaccharide-forming enzyme and .alpha.-isomaltosyl-transferring enzyme in combination, disclosed in the specification of the International Publication No. WO 02/010361. Such cyclic tetrasaccharide and saccharide derivatives thereof can be also produced by the method disclosed by the same applicant as in the present invention in International Publication No. WO 02/072594. These methods can be used for producing cyclic tetrasaccharide and saccharide derivatives thereof in a high efficiency and a lower cost using starch as an abundant and low cost material. Therefore, the cyclic tetrasaccharide and saccharide derivatives thereof can be advantageously produced on an industrial scale. Such cyclic tetrasaccharide may be in the form of an anhydrous amorphous, anhydrous crystalline, crystalline monohydrate, or crystalline pentahydrate. Any form of cyclic tetrasaccharide can be used in the present invention. Among these, cyclic tetrasaccharide in an anhydrous crystalline, crystalline monohydrate, and anhydrous amorphous form have a satisfactory dehydrating activity. They can be used as a dehydrating agent to powderize or solidify hydrous substances by admixing with a hydrous substance such as unsaturated compounds. Therefore, cyclic tetrasaccharide in such a form can be advantageously used for producing a powdery or solid product with a high quality, which comprises cyclic tetrasaccharide as an effective ingredient. [0012] The term "mineral" as referred to as in the present invention means a mineral required in living bodies, for example, calcium, magnesium, phosphorus, iron, manganese, sodium, potassium, copper, molybdenum, zinc, manganese, cobalt, selenium, iodine, fluorine, etc. [0013] Mineral compounds can be contained in the accelerator of the present invention in addition to cyclic tetrasaccharide and/or saccharide derivatives thereof, and are illustrated with the above mineral compounds absorbable into living bodies, natural materials abundantly containing thereof or processed products containing thereof. Examples of calcium compounds are calcium carbonate, calcium chloride, calcium citrate, calcium gluconate, calcium glycerophosphate, calcium lactate, calcium orthophosphate, calcium hydroxide, and calcium oxide. Further, wheyey calcium, bittern, eggshell calcium, cow bone calcium, fish bone powder, coral powder, shell, or processed product thereof can also be usable. [0014] Examples of magnesium compounds are magnesium carbonate, magnesium chloride, magnesium sulfate, magnesium acetate, magnesium gluconate, magnesium glycerophosphate, magnesium lactate, magnesium orthophosphate, magnesium hydroxide, and magnesium oxide. Further, cacao bean, almond, soy bean, peanut, bittern, rice bran, seaweed including "hijiki" (Hiziki fusiforme) and oarweed, and processed products thereof can also be usable because they highly contain magnesium. [0015] Examples of potassium compounds are potassium orthophosphate, potassium citrate, potassium chloride, potassium carbonate, potassium gluconate, potassium glycerophosphate, potassium lactate, and potassium hydroxide. [0016] Examples of sodium compounds are sodium orthophosphate, sodium citrate, sodium chloride, sodium carbonate, sodium gluconate, sodium glycerophosphate, sodium lactate, and sodium hydroxide. [0017] Examples of iron compounds are ferrous citrate, ferrous carbonate, ammonium ferric citrate, potassium bicarbonate ferrous gluconate, ferrous lactate, ferrous sulfate, ferrous fumarate, sodium ferric phosphate (ferric biphosphate), ferric monophosphate (ferric pyrophosphate), saccharated iron oxide and elementary iron. [0018] Examples of manganese compounds are manganese carbonate and manganese sulfate. [0019] Examples of cobalt compounds are cobalt chloride, cobalt carbonate and cobalt sulfate. [0020] Examples of copper compounds are cupric carbonate, cupric citrate, cupric gluconate, cupric sulfate and lysine-copper complex. Continue reading about Accelerator for mineral absorption and use thereof... Full patent description for Accelerator for mineral absorption and use thereof Brief Patent Description - Full Patent Description - Patent Application Claims Click on the above for other options relating to this Accelerator for mineral absorption and use thereof patent application. ###  How KEYWORD MONITOR works... a FREE service from FreshPatents1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored. 3. Each week you receive an email with patent applications related to your keywords. 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