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Chemistry: molecular biology and microbiology

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
09/04/2014 > 104 patent applications in 53 patent subcategories.

20140248600 - Blood treatment apparatus adapted to preserve parts thereof: A blood treatment apparatus adapted to preserve a blood treatment unit between blood treatment sessions. The blood treatment apparatus is configured to i) perform a blood treatment session and thereby use the blood treatment unit, ii) fill the blood treatment unit with a preservation fluid comprising at least one treatment... Agent: Gambro Lundia Ab

20140248601 - Method and system for growing microalgae in an expanding plug flow reactor: A method and system are provided for supporting the growth of algae cells. Initially, an inoculum of algae cells are grown in a closed bioreactor. Thereafter, the inoculum is passed into an open Expanding Plug Flow Reactor (EPFR). Growth medium is added at a plurality of locations along the EPFR.... Agent: General Atomics

20140248605 - Bacterial challenge model in cattle using a trans- and intra-dermal route to infect peripheral lymph nodes: The present invention includes a method of observing and evaluating bacterial infections within the lymph nodes of animals presented for harvest comprising: inoculating at one or more sites of an animal a known amount of a pathogen, wherein the one or more inoculation sites comprise lymph node drainage areas, and... Agent: Texas Tech University System

20140248607 - Brucella phage polynucleotides and uses thereof: An isolated polynucleotide is disclosed which comprises a nucleic acid sequence of a Brucella phage, the nucleic acid sequence being specific to the Brucella phage and comprising a sequence selected from the group consisting of SEQ ID NOs: 387-393. An exemplary polynucleotide sequence is one which comprises at least 100... Agent: The State Of Israel, Ministry Of Agriculture & Rural Development, Kimron Veterinary Institute

20140248606 - Cell- or virus simulating means comprising encapsulated marker molecules: The present invention refers to a method, a composition and a kit for isolating biomolecules from any biological sample material containing cells, virus(es), microorganism(s) or a combination thereof comprising a cell- or virus-simulating means, wherein said cell- or virus-simulating means comprises at least one type of marker molecule(s), incorporated in... Agent: Qiagen Gmbh

20140248604 - Method for detecting hiv-1 co-receptor tropism: A method for determining HIV-1 co-receptor tropism in an HIV-infected patient includes preparing an HIV-1 envelope protein coding sequence from a sample, introducing the HIV-1 envelope protein coding sequence into a first expression construct using yeast homologous recombination, and using the first expression construct in a cell to cell fusion... Agent:

20140248603 - Quantification of vaccine compositions: The invention provides methods and mass-labeled peptides for use in said methods for quantifying the presence of a one or more viral proteins in a sample of a preparation containing agents which bind to said viral protein, using mass-spectroscopic analyses of the sample and standards containing known amounts of labeled... Agent: Boehringer Ingelheim Vetmedica, Inc.

20140248602 - Torque teno virus diagnostics: The present invention relates to methods for the detection of the presence of swine Torque Teno virus in a sample, for the detection of replication of swine Torque Teno virus in a sample, to Torque Teno virus (RT)-PCR primers and probes, and to diagnostic test kits for the detection of... Agent:

20140248608 - Methods for characterizing a device component based on a contrast signal to noise ratio: The general concept of using a nanopore for DNA sequencing is to electrophoretically drive a polymer (e.g. single stranded DNA) through a nanopore under aqueous conditions, and identify each individual monomer (e.g. nucleotide) of the strand as it passes through the sensitive region of the nanopore based on its characteristic... Agent: Electronic Biosciences, Inc.

20140248613 - Automatic detection kit for detecting hla alleles using real-time polymerase chain reaction: Provided is an automatic detection kit for automatically detecting HLA alleles using a real-time polymerase chain reaction (PCR). The real-time PCR is performed on DNA isolated from a sample using a primer which is able to specifically bind to HLA alleles and a fluorescent probe which is able to detect... Agent: Catholic University Industry Academic Cooperation Foundation

20140248612 - Compositions and methods for detecting allelic variants: The present invention provides compositions, methods, and kits for discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides compositions, methods, and kits for determining the presence and/or level (e.g., quantitating) of rare (e.g., mutant) allelic variants, such as single nucleotide polymorphisms (SNPs) or nucleotide... Agent: Nestec S.a.

20140248609 - Gene detection assay for improving the likelihood of an effective response to an egfr antagonist cancer therapy: The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing EGFR, as determined by a gene amplification assay, with an EGFR antagonist. Such method comprises administering a cancer-treating dose of the EGFR antagonist, preferably in addition to chemotherapeutic agents, to a subject... Agent: Genentech, Inc.

20140248615 - Genetic variants on chr 11q and 6q as markers for prostate and colorectal cancer predisposition: It has been discovered that certain polymorphic markers on chromosome 6 and chromosome 11 are indicative of a susceptibility to prostate cancer and colon cancer. The invention describes diagnostic applications for determining a susceptibility to cancer using such markers, as well as kits for use in such applications.... Agent: Decode Genetics Ehf.

20140248619 - Method for detecting the presence of a nucleic acid in a sample: An automated method for detecting the presence of a nucleic acid in a sample, where the method is performed within a housing of a self-contained, stand-alone analyzer. The method includes purifying the nucleic acid after it has been immobilized on a magnetically-responsive solid support. A pipette of the analyzer is... Agent: Gen-probe Incorporated

20140248616 - Methods of monitoring fluid samples using multi-dimensional fluid sensors: The present invention provides multi-dimensional sensors with fluidic flow channels for processing fluid samples.... Agent:

20140248614 - Methods, primers, probes and kits useful for the detection of braf mutations: The present invention relates to methods, primers and probes useful for detecting the presence of mutant BRAF sequences in a sample, specifically for detecting the presence of the BRAF V600E, V600D, V600K, and V600M mutations.... Agent: Response Genetics

20140248618 - Microfluidic flow cell assemblies and method of use: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors... Agent: General Electric Company

20140248617 - Microfluidic flow cell assemblies for imaging and method of use: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. As configured, the... Agent: General Electric Company

20140248611 - Nucleic acid probe for assaying nucleic acids: Provided is a nucleic acid probe having a base sequence hybridizable with a target nucleic acid sequence in a target nucleic acid. At least one terminal base is labeled with a fluorescence quenching dye, the base labeled with the fluorescence quenching dye is cytosine, the base sequence is designed such... Agent: Nippon Steel & Sumikin Eco-tech Corporation

20140248610 - Reagents, methods, and libraries for bead-based sequencing: The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate... Agent: Life Technologies Corporation

20140248624 - Dna recombination junction detection: The present invention provides methods, compositions and kits for detecting the presence or absence of an integrated insertion polynucleotide.... Agent:

20140248628 - Isoforms of the human sst5 receptor originated by alternative splicing and oligonucleotide pairs to detect them by pcr: The present invention is referred to two human nucleic 5 acids that comprise sequences encoding two new isoforms of the human somatostatin receptor type 5 originated by alternative splicing, named sst5B and sst5C, with possible involvement in tumor processes. In addition, the invention is referred to oligonucleotide pairs allowing 10... Agent: Universidad De Cordoba

20140248620 - Methods and compositions for prostate cancer metastasis: Provided are methods and compositions for determining an increased likelihood of prostate cancer cells in a subject to metastasize.... Agent: Florida Agricultural And Mechanical University (famu)

20140248626 - Methods for removing nucleic acid contamination from reagents: In general, the disclosed method can be used to remove contaminating microbes and nucleic acids from microorganisms-derived reagents, apparatus and processes (materials and apparatus) related to PCR (and RT-PCR), including sample prep reagents and materials that are used to isolate, purify and detect nucleic acids.... Agent: Life Technologies Corporation

20140248621 - Microfluidic devices and methods for cell sorting, cell culture and cells based diagnostics and therapeutics: Microfluidic devices and methods that use cells such as cancer cells, stem cells, blood cells for preprocessing, sorting for various biodiagnostics or therapeutical applications are described. Microfluidics electrical sensing such as measurement of field potential or current and phenomena such as immiscible fluidics, inertial fluidics are used as the basis... Agent:

20140248627 - Nucleic acid sample preparation: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids... Agent: Biological Dynamics, Inc.

20140248625 - Pcr methods for characterizing the 5' untranslated region of the fmr1 and fmr2 genes: This disclosure relates to methods of determining the presence and position of AGG or interruptor elements within a trinucleotide (for example, CGG) repeat region, and to methods of determining the number of repeats present in this region, by amplifying a set of products with a set of primers of which... Agent: Asuragen, Inc.

20140248623 - System and method for determining copies-per-unit-volume using pcr and flow control of droplets: Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions. Each of the plurality of discrete sample portions comprising a portion of the sample, and a reaction mixture. The method further includes amplifying the plurality... Agent: Life Technologies Corporation

20140248622 - Telomere length measurement in formalin-fixed, paraffin embedded (ffpe) samples by quantitative pcr: Methods of reliably quantifying telomere length in cells or tissues that have been formalin fixed and paraffin embedded (FFPE) samples by quantitative polymerase chain reaction protocol and kits for use with such various methods are provided. The methods of the present invention may be used to predetermine an individual's response... Agent: Geron Corporation

20140248629 - Gold nanoparticle based dipstick nano-biosensor for detecting plasmodium falciparum and plasmodium vivax and mehtod of synthesizing the same: The embodiments herein provide a dipstick nano-biosensor for diagnosing Plasmodium vivax and Plasmodium falciparum. The dipstick biosensor comprises a backing plate coated with a cellulose membrane, nitrocellulose membrane and fibreglass. Gold nanoparticles coated with antidigoxigenin are immobilized on the dipstick along with probes comprising strptavidin, texas red, biotin and fluorescein.... Agent: Pasteur Institute Of Iran

20140248630 - Methods and kits used in the detection of fungus: The invention encompasses method of using quantitative PCR to detect fungal organisms in clinical and environmental samples to generate standards that allow the quantification of fungal organisms in the samples.... Agent: Arizona Board Of Regents On Behalf Of Northern Arizona University

20140248631 - Diagnosis of sepsis and systemic inflammatory response syndrome: The present invention relates a method for the diagnosis, prediction or risk stratification for mortality and/or disease outcome of a subject that has or is suspected to have sepsis, comprising determining the presence and/or level of antitrypsin (ATT) or fragments thereof in a sample taken from said subject and/or determining... Agent:

20140248633 - Leukemia stem cell targeting ligands and methods of use: The present invention is directed to C-type lectin-like molecule-1 (CLL1) specific ligand peptides, comprising the amino acid motif LR(S/T), and methods of their use, e.g., for imaging detection for diagnosis of leukemia and the presence of leukemic stem cells (LSCs) and targeted therapy against leukemia mediated at least in part... Agent: The Regents Of The University Of California

20140248632 - Magnetically induced microspinning for super-detection and super-characterization of biomarkers and live cells: Identification, quantification and characterization of biological micro- and nano-systems is enabled by magnetically spinning these natural, non-magnetic systems with the aid of induced magnetization. Biofriendly magnetic micro- and nano-labels enable magnetorotation in extremely weak electromagnetic fields. The spinning of these micromotors can be observed by a simple, CD-like, optical tracking... Agent: The Regents Of The University Of Michigan

20140248634 - Vimentin as a biomarker for the progression of myeloproliferative neoplasms: The disclosure relates to novel compounds that are capable of modulating Jak2 kinase activities, compounds that have therapeutic use in treating or preventing a subject suffering from or susceptible to a Jak2 mediated disease or disorder, and methods of use and compositions thereof.... Agent: University Of Florida Research Foundation

20140248639 - Assays for identifying compounds that modulate bitter taste: The present invention is based on applicants' discovery, disclosed herein, of agonists for the TAS2R receptors TAS2R1, TAS2R4, TAS2R9, TAS2R13, TAS2R14, TAS2R16, TAS2R44, TAS2R46, and TAS2R60. The assignment of agonists to these receptors makes assays for identifying compounds that modulate bitter taste possible. For example, the present invention provides methods... Agent: Chromocell Corporation

20140248638 - Oxmif as a diagnostic marker: The present invention pertains to the recognition that a specific oxMIF form of MIF is useful as a diagnostic marker in (MIF-related) diseases, in particular for example monitoring of disease progression. The present invention also pertains to the respective use of a diagnostic kit and a respective diagnostic assay and... Agent:

20140248635 - Alpha-tubulin acetyltransferase: Polypeptides with tubulin acetyltransferase activity are described, as are nucleic acids encoding said polypeptides, and methods of use. The invention further provides enhancers and inhibitors of tubulin acetyltransferase activity, as well as cells having altered tubulin transferase activity.... Agent: University Of Georgia Research Foundation, Inc.

20140248636 - Assay for histidinyl hydroxylase activity: The present invention relates to assays for monitoring activity of Mina53 and NO66 activities, in particular, to assays for identifying modulators of Mina53 and NO66 activities. The invention also relates to assays to monitor the histidinyl hydroxylase activity of Mina53 and NO66 on their substrates, the human ribosomal protein Rpl27a... Agent: Isis Innovation Limited

20140248637 - Composition for diagnosis of lung cancer and diagnosis kit of lung cancer: Disclosed is as a biomarker useful in early diagnosis of lung cancer, at least one protein selected from the group including Quescin-sulfhydryl oxidase 1, Fibrillin-1, Isoform A of Lamin-A/C, Latent-transforming growth factor beta-binding protein 2, Galectin-1, highly similar to Dickkopf-related protein 3, Isoform A1-B of Heterogeneous nuclear ribonucleoprotein A1, 14-3-3... Agent: Seoul National University R&db Foundation

20140248642 - Apparatus and method for lateral flow affinity assays: The invention provides apparatus for the quantitative analysis of an analyte in a sample, comprising (i) a solid phase; and (ii) a detector, wherein the surface of the solid phase comprises (a)a first position for sample application, and (b)a second position, distant from the first position, wherein a first molecule... Agent: Bio Nano Consulting

20140248641 - Cloned glucagon-like peptide-2 receptors: The invention relates to nucleotides and amino acid sequences encoding Glucagon-like peptide-2 receptors, recombinant host cells transformed with such nucleotides, and methods of using the same in drug screening and related applications.... Agent: Nps Pharmaceuticals, Inc.

20140248640 - Methods for testing an immune response using cultures of t cells, b cells, dendritic cells and follicular dendritic cells: The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics,... Agent: Sanofi Pasteur Vaxdesign Corporation

20140248643 - Chromatographic process for enrichment and isolation: A chromatographic process for the enrichment of at least one compound of interest from a mixture is proposed, using chromatographic columns, wherein said process involves a sequence of the following steps: (i) a cyclic accumulation phase, in which the chromatographic columns are alternatingly operated in an interconnected phase, followed by... Agent: Chromacon Ag

20140248644 - Highly sensitive cell-based assay to detect the presence of active botulinum neurotoxin serotype-a: The present specification discloses methods for detecting extremely low amounts of botulinum neurotoxin serotype A in samples, including complex matrices like blood, plasma, and serum.... Agent:

20140248645 - Glucose oxidase mutants, compositions, devices, kits and uses thereof: Compositions, devices, kits and methods are disclosed for assaying glucose with a glucose oxidase mutant that has been modified at an amino acid residue involved in the active site. The glucose oxidase mutant has reduced oxidase activity while substantially maintaining its dehydrogenase activity.... Agent: Roche Diagnostics Operations, Inc.

20140248654 - Acidic environment-detecting fluorescent probe: In the formula, R1 and R2 independently represent a hydrogen atom, or an alkyl group which may be substituted (wherein R1 and/or R2 represents an alkyl group which may be substituted); R3, R4, R5, R6, R7 and R8 independently represent a hydrogen atom, a halogen atom, or the like; X... Agent: The University Of Tokyo

20140248646 - Imidazo[1,5-a]pyridinium ion fluorophores, and methods of making and using the same:

20140248647 - Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching: A method for analyzing a blood sample is provided that includes the steps of: providing a blood sample having one or more of each first and second constituents; admixing a colorant with the sample, which colorant is operative to cause the first constituents and second constituents to fluoresce and absorb... Agent: Abbott Point Of Care, Inc.

20140248650 - Method and device for measuring multiple physiological properties of cells: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing... Agent: Seahorse Bioscience

20140248653 - Method for selecting mevalonate synthesis modulators using cells derived from human pluripotent cells: A method for selecting pharmaceutical compounds affecting mevalonate or cholesterol, having a step for putting into contact with the pharmaceutical compounds to be tested, cells of the MSC type obtained by a method for producing cells of the MSC type from human pluripotent cells or from induced stem cells, including... Agent:

20140248649 - Method of studying a cryogenic sample in an optical microscope: The present invention relates to a method of studying a sample using an optical microscope, comprising providing the sample in a sample holder with means to maintain the sample at a temperature below 273 K; providing a microscope objective lens, in a thermally insulating jacket, having an extremal lens element... Agent: Fei Company

20140248652 - Methods for diagnosing and identifying modulators of membrane potentials in bipolar disorder and attention deficit hyperactivity disorder: The present invention provides methods to modulate key elements along the DAG signaling pathway as well as a diagnostic assay, device and methods of using the same to diagnose bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD). Methods to identify diagnostic markers and drug targets for BD and ADHD.... Agent: Psychnostics, LLC

20140248651 - Nutrient medium: The invention relates to a nutrient medium, containing 10 to 20 parts by weight of yeast extract, 15 to 30 parts by weight of peptone, 35 to 75 parts by weight of monosaccharides and disaccharides, up to 3 parts by weight of mineral substances, 0.02 to 1 parts by weight... Agent: Dohler Gmbh

20140248648 - Phripheral diagnostic methods for screening alzheimer's disease using beta amyloid and intercellular communication: The present disclosure relates to a peripheral diagnostic method for screening Alzheimer's disease in patients based on quantitatively measured complexity of skin-sampled fibroblast networks.... Agent: Blanchette Rockefeller Neurosciences Institute

20140248655 - Quantitative soft agar colony formation assay using tetrazolium that generates water-soluble formazan: This invention provides a quantitative assay technique for soft agar colony formation that can be carried out rapidly with high accuracy. Specifically, this invention relates to a method for evaluation of cell survival comprising: a step of overlaying agar at the bottom of a vessel with agar containing cells, overlaying... Agent: Kagoshima University

20140248656 - Analysis and sorting of motile cells: A method for sorting motile cells includes introducing an initial population of motile cells into an inlet port of a microfluidic channel, the initial population of motile cells having a first average motility; incubating the population of motile cells in the microfluidic channel; and collecting a sorted population of motile... Agent: The Brigham And Women S Hospital, Inc.

20140248657 - Method for producing insoluble aggregate of neurodegenerative-disease-related protein: The purpose of the present invention is to develop a method for producing a large amount of an insoluble aggregate that is equivalent to an insoluble aggregate formed in the brain of a patient. A method of producing an insoluble aggregate of a neurodegenerative-disease-related protein according to the present invention... Agent: Tokyo Metropolitan Institute Of Medical Science

20140248658 - Cytoplasmic stain composition: A composition of two cytoplasm stains for use in differentiation of cell nuclei from cell cytoplasmic components and differentiation of specific cytoplasm components by tinctorial contrast. Specifically, the invention relates to two stain compositions utilized as a counter stain in the hematoxylin and eosin procedure for use in histological and... Agent: Hci Sciences, LLC

20140248659 - Tissue processor: A tissue processing system includes a plurality of processing stations. Each processing station includes a plurality of tissue receiving areas that are each configured to accommodate a tissue sample as well as physically isolate that tissue sample from other tissue samples at other receiving areas of the same processing station.... Agent: Rushabh Instruments, LLC

20140248660 - Heterologous intron within a signal peptide: The invention concerns the field of recombinant gene engineering. It concerns novel introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes with heterologous introns, especially genes encoding antibodies and antibody derived fragments, and the production of... Agent: Boehringer Ingelheim International Gmbh

20140248662 - Host cell for the production of a compound of interest: The present invention relates to a recombinant host cell for the production of a compound of interest. The invention further relates to a method for the production of such host cell. The invention further relates to the production of a compound of interest. The invention further relates to isolated polynucleotides... Agent: DsmIPAssets B.v.

20140248663 - Polypeptides having cellobiohydrolase activity and polynucleotides encoding same: Provided are isolated polypeptides having cellobiohydrolase activity, catalytic domains and cellulose binding domains, and polynucleotides encoding the polypeptides, catalytic domains or cellulose binding domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or... Agent:

20140248661 - Zcytor19 polynucleotides, polypeptides, antibodies and methods of use: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor... Agent: Zymogenetics Inc.

20140248666 - Epitopes: Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are provided.... Agent: Amgen Inc.

20140248665 - Novel intron sequences: The invention concerns the field of recombinant gene engineering. It concerns novel introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes with heterologous introns, especially genes encoding antibodies and antibody derived fragments, and the production of... Agent: Boehringer Ingelheim International Gmbh

20140248664 - Readily isolated bispecific antibodies with native immunoglobulin format: A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in the CH3 domain, wherein the differential modifications are non-immunogenic or substantially non-immunogenic with respect to the CH3 modifications, and at least one of the modifications results in a differential... Agent: Regeneron Pharmaceuticals, Inc.

20140248667 - Enhancing spinosyn production with oxygen binding proteins: The invention describes the integration of polynucleotides into chromosomal DNA of S. spinosa species, which are useful for the production of insecticides, integrants thereof, and also to the use of the integrants. The invention includes the stable integration and expression of an oxygen-binding protein, VHb, which results in increased spinosyn... Agent:

20140248668 - Methods and materials for recombinant production of saffron compounds: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express a zeaxanthin cleavage dioxygenase alone or in combination with recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce compounds from saffron such as crocetin, crocetin dialdehyde, crocin, or picrocrocin.... Agent: Evolva Sa

20140248669 - Recombinant microorganism for the production of useful metabolites: Described are recombinant microorganisms characterized by having phosphoketolase activity, having a diminished or inactivated Embden-Meyerhof-Parnas pathway (EMPP) by inactivation of the gene(s) encoding phosphofructokinase or by reducing phosphofructokinase activity as compared to a non-modified microorganism and having a diminished or inactivated oxidative branch of the pentose phosphate pathway (PPP) by... Agent: Scientist Of Fortune, S.a.

20140248670 - Methods for enhancing the degradation of cellulosic material with chitin binding proteins: The present invention relates to methods for degrading or converting a cellulosic material and for producing substances from the cellulosic material.... Agent: Novozymes, Inc.

20140248671 - Methods of increasing secretion of polypeptides having biological activity: The present invention relates to methods for producing a secreted polypeptide having biological activity, comprising: (a) transforming a fungal host cell with a fusion protein construct encoding a fusion protein, which comprises: (i) a first polynucleotide encoding a signal peptide; (ii) a second polynucleotide encoding at least a catalytic domain... Agent: Novozymes, Inc.

20140248672 - Modified ethylenediamine-n,n'-disuccinate:ethylenediamine lyase: The present invention provides a modified ethylenediamine-N,N′-disuccinate:ethylenediamine lyase. The present invention also provides a protein that comprises the amino acid sequence represented by SEQ ID NO: 1; or a protein that comprises an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 by deletion,... Agent: Mitsubishi Rayon Co., Ltd.

20140248673 - Methods of producing 7-carbon chemicals via coa-dependent carbon chain elongation associated with carbon storage: This document describes biochemical pathways for producing pimelic acid, 7-hydroxyheptanoic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the CoA-dependent elongation enzymes... Agent: Invista North America S.&#xe1 R.i.

20140248674 - Polypeptides having peroxygenase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s

20140248675 - Methyl butenol synthase: The present invention provides novels genes encoding methyl butenol (MBO) synthase, methy butenol synthases and their use in methyl butenol production.... Agent: Board Of Trustees Of Michigan State University

20140248676 - Process for recovering salt during a lignocellulosic conversion process: The present invention relates to a process for generating steam and recovering salts during a lignocellulosic conversion process. The process comprises de-salting a still bottoms stream; incinerating a stream comprising lignin and the de-salted still bottoms stream in an incinerator; and utilizing the heat generated from said incinerating to produce... Agent: Iogen Energy Corporation

20140248677 - Gas mix installation and method: Gas mix installation (5) for use in connection with tanks (1) for biogas reactors wherein the gas mix installation comprises:•—a main pump (8) having respectively a suction side and an injection side, where said pump (8) is arranged externally of the tank (1)•—a liquid suction pipe (6) connecting the interior... Agent:

20140248678 - Led component: An LED component and the use thereof. The component comprises a light output spectrum with at least one peak intensity between 600-800 nm wavelength range with a full width at half maximum at least 50 nm; second optional optical light output peak at 200-500 nm wavelength range; and third optional... Agent: Lumichip Limited

20140248679 - Apparatus and methods to enhance field gradient for magnetic rare cell separation: The present invention discloses apparatus and methods to enhance magnetic field gradient for magnetic cell separation. One preferred embodiment in accordance with the invention comprises an electromagnet with an open gap formed between two pole tips and two driving coils with independently controlled electrical current magnitude and direction. In the... Agent:

20140248680 - Compositions and methods for collecting algae: The invention relates to compositions containing Bacillus sp., optionally with magnetite, useful in methods for collecting algae. The invention also relates to methods for collecting algae by contacting algae and bare maghemite and compositions thereof.... Agent:

20140248681 - Microcapsules and concrete containing the same: Microcapsules, for inclusion in concrete, adapted to reduce the area of a defect by at least 45% in said concrete once a quantity of said microcapsules has ruptured, said microcapsules each comprising: a polymeric shell encapsulating a liquid core, wherein the polymeric shell comprises a substantially impermeable polymer layer and... Agent:

20140248682 - Hsa-related compositions and methods of use: Provided are human serum albumin (HSA) compositions with improved properties over native HSA.... Agent: Medimmune, LLC

20140248683 - Hydrogenase isolated from thermococcus spp: The present invention relates to novel hydrogenases isolated from novel hyperthermophilic strains belonging to Thermococcus spp., genes encoding the hydrogenases, and methods of producing hydrogen using strains having the genes. According to the hydrogen production methods of the invention, a large amount of hydrogen can be produced merely by culturing... Agent: Korea Ocean Research & Development Institute

20140248684 - Compositions and methods for the production and use of human cholinesterases: In some aspects, the present invention relates to compositions and methods for the production of human cholinesterases. More particularly, it relates to methods for the production of human cholinesterases using transient expression and vectors for producing the same. In one aspect, the present invention relates to a plant viral vector... Agent: Arizona Board Of Regents For And On Behalf Of Arizona State University

20140248685 - Alpha-amylase mutants: The invention relates to a variant of a parent Termamyl-like α-amylase, which exhibits an alteration in at least one of the following properties relative to said parent α-amylase: i) improved pH stability at a pH from 8 to 10.5; and/or ii) improved Ca2+ stability at pH 8 to 10.5, and/or... Agent: Novozymes A/s

20140248686 - Therapeutic polypeptides with increased in vivo recovery: The present invention relates to the field of modified therapeutic polypeptides with increased in vivo recovery compared to their non-modified parent polypeptide. For example, the invention relates to fusions of therapeutic polypeptides with recovery enhancing polypeptides connected directly or optionally connected by a linker peptide.... Agent: Csl Behring Gmbh

20140248687 - Methods for expressing polypeptides in hyperthermophiles: Provided herein are genetically engineered archaea. A genetically engineered archaea includes a heterologous polynucleotide that has a promoter operably linked to a coding region, where the coding region encodes a polypeptide having optimal activity below the optimum growth temperature (Topt) of the genetically engineered archaeon. Also provided herein are methods... Agent: North Carolina State University

20140248688 - Plant wall degradative compounds and systems: The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications.... Agent:

20140248689 - Glucose-induced inactivation/degradation-resistant transporter gene and use thereof: The present invention relates to a glucose-induced inactivation/degradation-resistant transporter gene and use thereof, and more particularly, to a brewing yeast having excellent assimilation of oligosaccharides (maltose, maltotriose, etc.), an alcoholic beverage prepared using the yeast, a method of producing the alcoholic beverage, etc. More specifically, the present invention relates to... Agent: Suntory Holdings Limited

20140248690 - Liquid reflux high-speed gene amplification device: e

20140248691 - Caps for sample wells and microcards for biological materials: A cover for a biological sample well tray, comprising a cap for sealing a sample well. The cap comprises a well lens for focusing light into the sample well and collecting light from the sample. In another aspect, the cap comprises an elongate portion configured to permit incoming light to... Agent: Applied Biosystems, LLC

20140248693 - Optical systems and methods for biological analysis: An instrument for processing and/or measuring a biological process contains an excitation source, a sample holder, an optical sensor, an excitation optical system, and an emission optical system. The sample holder is configured to receive a plurality of biological samples. The optical sensor is configured to receive an emission from... Agent:

20140248692 - Systems and methods for nucleic acid-based identification: Systems and methods for calculating a predictive index of identity of a nucleic acid sample using polymorphic genetic marker data are provided. In one embodiment, a predictive index of identity of the nucleic acid sample is calculated using a value from a second set of data from a polymorphic genetic... Agent: Life Technologies Corporation

20140248694 - Test strip: The invention includes a base, a working wire, a grounding wire, a first division layer, a second division layer and a cover layer. The base has a reaction area. The working wire is formed with a first measure contact and a first bioreaction contact. The grounding wire is formed with... Agent:

20140248695 - Viral vectors purification system: The present invention relates to a new method for purification of viral vectors particularly those belonging to the Retroviridae family, which is based on the expression in the packaging cell line that produced such vectors of an exogenous gene encoding a cell surface marker. The incorporation of the cell surface... Agent: Molmed, S.p.a.

20140248698 - Method for culturing pluripotency-maintained singly dispersed cells by means of laminar flow: The one aspect of the present invention aims to provide a novel cloning method for human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), which method is based on culture of dispersed single cells without addition of an apoptotic agent. More specifically, the one aspect of the... Agent: Arkray, Inc.

20140248697 - Method for evaluating cell populations: The invention describes specific sialylated structures present on human stem cells and cell populations derived thereof. The invention is especially directed to methods to control the status of stem cells by observing changes in sialylation of the cells; and control of potential contaminations of biological materials; and reagents and methods... Agent: Glykos Finland Oy

20140248696 - Methods of maintaining, expanding, and diffrentiating neuronal subtype specific progenitors: Methods for expanding proliferating populations of neuronal subtype-specific progenitors are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors.... Agent: Wisconsin Alumni Research Foundation

20140248699 - Erythroid cells producing adult-type beta-hemoglobin generated from human embryonic stem cells: Methods and compositions of erythroid cells that produce adult β-hemoglobin, generated by culturing CD31+, CD31+/CD34+ or CD34+ cells from embryonic stem cells under serum-free culture conditions.... Agent: Wisconsin Alumni Research Foundation

20140248700 - Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells: An improved method of producing differentiated progenitor cells comprising obtaining inner cell mass cells from a blastocyst and inducing differentiation of the inner cell mass cells to produce differentiated progenitor cells. The differentiated progenitor cells may be transfected such that there is an addition, deletion or alteration of a desired... Agent: Advanced Cell Technolgy

20140248701 - Dcx mini-promoters: Isolated polynucleotides comprising a DCX mini-promoters are provided. The mini-promoter may be operably linked to an expressible sequence, e.g. reporter genes, genes encoding a polypeptide of interest, regulatory RNA sequences such as miRNA, siRNA, anti-sense RNA, etc., and the like. In some embodiments a cell comprising a stable integrant of... Agent:

20140248702 - Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are... Agent: Massachusetts Institute Of Technology

20140248703 - Method for ordering and introducing multiple genes into a genome: Described is a method of introducing multiple nucleic acid molecules into the genome of a cell. The method includes providing a plurality of nucleic acid molecules, each of the plurality of nucleic acid molecules containing (a) a nucleic acid sequence operatively linked to a promoter sequence at the 5′ end... Agent: Academia Sinica

  
08/28/2014 > 136 patent applications in 73 patent subcategories.

20140242569 - Poultry performance: Methods for increasing breast muscle weight in poultry are disclosed herein. These methods can include delivery of compositions via in ovo administration. The methods disclosed herein also encompass the delivery of proteins. The methods disclosed herein are effective for increasing breast muscle weight in poultry, both in the embryo, and... Agent: Zoetis LLC

20140242570 - Method for picking up cell material and assembly for performing said method: In a method for picking up cell material from a culture dish a picking tool is displaced towards the cell material. Contact between the tool and the cell material is determined by carrying out capacitive measurements. After contact the tool is removed from the cell material. In an assembly for... Agent: Bd Kiestra B.v.

20140242572 - Chromatography method, chromatography kit, and method of producing an insoluble carrier for chromatography: A chromatography method including a step of developing a complex of a specimen and a labeled substance modified by a first bondable substance which can be bonded to the specimen on an insoluble carrier, a step of capturing the complex of the specimen and the labeled substance at a reactive... Agent: Fujifilm Corporation

20140242573 - Optical element, analysis device, analysis method and electronic apparatus: An optical element includes a metal layer having a thickness in a first direction; metallic particles spaced apart from the metal layer in the first direction; and a light transmitting layer separating the metal layer from the metallic particles. The metallic particles are disposed in a lattice shape in a... Agent: Seiko Epson Corporation

20140242571 - Optical element, analysis equipment, analysis method and electronic apparatus: An optical element includes a metal layer in which a first direction is a thickness direction; metallic particles provided to be spaced from the metal layer in the first direction; and a light transmitting layer that separates the metal layer from the metallic particles, in which the size T of... Agent: Seiko Epson Corporation

20140242574 - Codon-optimized gene for mutated shrimp luciferase and method for use thereof: There has been a demand for a codon-optimized gene for the mutated catalytic domain of Oplophorus luciferase, which is capable of efficiently expressing a protein both in a cultured animal cell and Escherichia coli. There has also been a demand for a substrate coelenterazine analogue showing a higher activity than... Agent: Jnc Corporation

20140242575 - Kits and methods for in vitro analyte detection using precipitating compound and polarizers: The invention provides inexpensive kits and methods for determination of an analyte in a sample with very high sensitivity. Analyte can be determined using an analyte binding member such as an antibody or an oligonucleotide, which can be directly or indirectly linked to an enzyme. The kit and method uses... Agent:

20140242576 - Methods for determining nucleotide sequence repeats: The invention relates to methods to reduce the length of a homonucleotide repeat sequence a target DNA sequence. This is done by using an oligonucleotide primer which extends in the unaltered repeat of identical nucleotides of the target polynucleotide, the oligonucleotide primer comprises at the at the 5′ side a... Agent:

20140242583 - Assays, methods and compositions for diagnosing cancer: The present invention provides a method and single-tube assay for identification and quantitative analysis of differentially methylated MLH1 promoter sequences that are associated with certain types of cancer in an individual by obtaining a biological sample comprising DNA from the individual, detecting the presence of and measuring the level of... Agent:

20140242577 - C-probe libraries for dna target enrichment: Provided herein is a method for enriching a target nucleic acid molecule. In one embodiment, the method may involve hybridizing a C-probe to a strand of a target nucleic acid to produce a complex, enzymatically removing any 3′ overhanging end from the target nucleic acid of the complex to produce... Agent:

20140242586 - Chimeric primers with hairpin conformations and methods of using same: Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5′ of the target-specific primer sequence; a tag sequence 5′ of the anti-tag sequence; and a blocker between the anti-tag sequence and... Agent: Luminex Corporation

20140242581 - Compositions and methods for genetic analysis of embryos: The present disclosure provides for compositions and methods for genetic analysis of embryos. Generally, the compositions and methods provide for the acquisition of an sample containing RNA from an embryo, genetic analysis involving various techniques such as sequencing-, hybridization- or amplification-based methods, and the detection of genetic alterations that may... Agent: Reproductive Genetics And Technology Solutions, LLC

20140242582 - Detection of genetic abnormalities using ligation-based detection and digital pcr: The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary... Agent: Ariosa Diagnostics, Inc.

20140242590 - Flt3 mutations associated with drug resistance in aml patients having activating mutations in flt3: The invention provides methods and compositions for identifying acute myeloid leukemia (AML) patients that have an increased likelihood of a relapse following treatment with AC 220.... Agent: The Regents Of The University Of California

20140242585 - Genetic test for the identification of carriers of complex vertebral malformations in cattle: Genetic markers for identifying bovine carriers of complex vertebral malformation (CVM) disease gene are described. The genetic markers, including the microsatellite markers BM4129, INRAA003, BMS2790, ILSTS029, INRA123, BM220, HUJ246, BMS862, BMS937, BL1048, BMS2095 and BMS1266 and the bovine SLC35A3 gene, are located on bovine chromosome BTA3. The G/T polymorphism at... Agent: Viking Genetics Fmba

20140242584 - Genomic dna extraction reagent and method: The present invention is directed to a genomic DNA extraction reagent and method for improved extraction of DNA from biological tissue. The extraction reagent of the invention is mixed with disrupted biological tissue to form a DNA extraction solute which is incubated in a DNA extraction step. The extraction reagent... Agent: Syngenta Participations Ag

20140242589 - Hybridization compositions and methods: The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, utilize a of cyclic and/or non-cyclic solvent that is non-toxic and may eliminate or reduce the amount of formamide in the hybridization composition.... Agent: Dako Denmark A/s

20140242580 - Method for predicting response or prognosis of lung adenocarcinoma with egfr-activating mutations: The invention provides a method for predicting the response of an EGFR-activating mutant subject suffering from a lung adenocarcinoma and receiving treatment with epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and a method for predicting prognosis in an EGFR-activating mutant subject suffering from a lung adenocarcinoma and receiving treatment... Agent: National Taiwan University

20140242588 - Methods and processes for non-invasive assessment of genetic variations: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.... Agent: Sequenom, Inc

20140242587 - Rapid and reliable detection of infectious agents: The present invention is directed to devices, systems and methods that enable the detection of low copy numbers of bacterial polynucleotides in a sample without having to use multiple species specific primer sequences.... Agent:

20140242579 - Reversible terminator molecules and methods of their use: The present invention relates generally to methods of sequencing of polynucleotides and compounds, compositions and kits useful for sequencing of polynucleotides. The chemical compounds include nucleotide and nucleoside analogs which possess a blocking group covalently attached to the 3′ hydroxyl of the sugar moiety. The blocking group may optionally be... Agent:

20140242578 - Simultaneous detection of multiple mirnas using capillary electrophoresis system equipped with plural laser-induced fluorescence detectors: The present invention relates to a method for simultaneously detecting multiple miRNAs present in a sample and a kit for detecting same. According to the present invention, two or more miRNAs existing in trace amounts in a sample can be analyzed through only one measurement. The detection method of the... Agent: Korea Institute Of Science And Technology

20140242592 - Allele-specific amplification: The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, but having a 3′-terminal nucleotide complementary to only one variant of the target sequence and having at least one nucleotide with a base covalently... Agent: Roche Molecular Systems, Inc.

20140242595 - Hepatocyte production via forward programming by combined genetic and chemical engineering: The present invention provides methods comprising both genetic and chemical means for the production of hepatocytes from a variety of cell sources, particularly pluripotent stem cells.... Agent: Cellular Dynamics International, Inc.

20140242591 - Method of diagnosing and preventing pneumococcal diseases using pneumococcal neuraminidases: A method of providing protection against pneumococcal infection in a subject is disclosed. The method includes steps of administering to the subject a composition that includes combination of three recombinant pneumococcal neuraminidases: NanA, NanB, and NanC of S. pneumoniae strains CGSP14, wherein administration of the recombinant pneumococcal neuraminidases elicits an... Agent: Chang Gung Medical Foundation, Linkou Branch

20140242594 - Methods and compositions for preparation of nucleic acids: A method for isolating genomic DNA (gDNA) from a biological material. In some embodiments, the method includes (a) contacting a sample that contains gDNA with a solution of hydroxide and a detergent under conditions and for a time sufficient to degrade a cell wall, a cell membrane, a nuclear membrane,... Agent: Syngenta Participations Ag

20140242598 - Multiplex pcr-based testing of cutaneous squamous cell carcinoma and pseudoepitheliomatous hyperplasia and methods for distinguishing the same: Methods for differentiating squamous cell carcinoma from pseudoepitheliomatous hyperplasia in a biological sample using KRT9 and C15orf48, methods of using differentially expressed genes as prognostic markers for squamous cell carcinoma, methods of using molecular pathways as targets for the treatment of squamous cell carcinoma, and diagnostic kits therefor.... Agent:

20140242597 - Predicting tumor response to anti-erbb3 antibodies: A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from... Agent: Aveo Pharmaceuticals, Inc.

20140242593 - Sample chamber array and method for processing a biological sample: A sample chamber array is provided. The sample chamber array may comprise at least one reservoir in fluid communication with at least one sample chamber, and a movable portion defining the sample chamber. The reservoir is fillable with a liquid biological sample. The movable portion may be movable with respect... Agent: Applied Biosystems, LLC

20140242596 - Systems and methods for biological analysis: A case for containing a plurality of biological samples contains a base, a substrate and a cover. The substrate is attached to the base and comprises a plurality of reaction regions configured to receive one or more biological samples. The cover comprises an inner surface and is configured to be... Agent:

20140242599 - Materials and methods for determining sensitivity potential of compounds: The invention concerns in vitro proteomic analysis of cells to determine the sensitizing potential (including allergic potential) of compounds on said cells. Several protein markers are provided that allow assays to be performed to determine whether a chemical has a sensitizing potential of contact sensitizers.... Agent: Electrophoretics Limited

20140242600 - Imaging the heterogeneous uptake of radiolabeled molecules in single living cells: A radioluminescence microscopy system and method for imaging the distribution of radiolabeled molecules in live cell cultures and tissue sections. Cells are grown and incubated with radiolabeled molecules on a scintillator plate or a scintillator plate is placed adjacent to the cells after incubation. Scintillation light produced by decay of... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20140242605 - Heat-transfer resistance based analysis of bioparticles: A bio-sensing device suitable for the detection and/or characterization of target bioparticles and corresponding method is described. The bio-sensing technique is based on the impact on the heat transfer resistivity value of bioparticles binding in binding cavities of a structured substrate. By sensing temperatures and determining a heat transfer resistivity... Agent: Imec

20140242603 - Methods and apparatus for target cell magnetic enrichment, isolation and biological analysis: Disclosed here are methods and apparatus for target cell magnetic enrichment, isolation, and biological analysis. The target cells are labeled with magnetic nano-particles in a separate tube, container or in a device with soft magnetic collectors but not activated during the labeling period. Labeled biological samples will be used for... Agent:

20140242601 - Molecularly imprinted polymer-based passive sensor: Systems and methods for the detection of one or more target molecules emitted from microbial sources are described. The systems and methods may include a molecularly imprinted polymer film; a strain sensitive surface, wherein the molecularly imprinted polymer film comprises a polymer host with one or more binding sites for... Agent: Freshair Sensor Corporation

20140242604 - Ultra-fast pathogen toxin detection assay based on microwave-accelerated metal-enhanced fluorescence: The present invention provides for a system and method to detect low levels of the anthrax protective antigen (PA) exotoxin in biological fluids, wherein the system uses a metal-enhanced fluorescence (MEF)-PA assay in combination with microwave-accelerated PA protein surface absorption. Microwave irradiation rapidly accelerates PA deposition onto the surface adjacent... Agent: University Of Maryland, Baltimore County

20140242602 - Uses of labeled hsp90 inhibitors: The disclosure provides evidence that the abundance of this particular “oncogenic HSP90” species, which is not dictated by HSP90 expression alone, predicts for sensitivity to HSP90 inhibition therapy, and thus is a biomarker for HSP90 therapy. The disclosure also provides evidence that identifying and measuring the abundance of this oncogenic... Agent: Sloan-kettering Institute For Cancer Research

20140242609 - Diagnosis and treatment of kidney stones, methods and compositions therefor: Methods of detecting, diagnosing, monitoring and treating kidney stones are disclosed. In some embodiments, methods of detecting, diagnosing or monitoring kidney stones comprise contacting a urine sample with anti-Claudin-14 antibody, and detecting quantity of a complex comprising Claudin-14 and the antibody, wherein an increase compared to control levels is diagnostic... Agent: Washington University

20140242610 - Methods and compositions for cytometric detection of rare target cells in a sample: The present disclosure provides cytometric methods for the detection of rare target cells in a sample. In certain aspects, the methods and compositions may facilitate the detection of rare target cells, such as circulating tumor cells (CTCs), in a biological sample such as blood. Aspects of the methods include contacting... Agent: Becton, Dickinson And Company

20140242611 - Method for detecting and/or quantifying an analyte at the surface of a cell: The invention relates to a method for quantifying a protein of interest expressed at the surface of a cell or else present in a tissue sample, said method comprising the use of two ligands capable of binding specifically to a domain of said protein.... Agent: Cisbio Bioassays

20140242612 - System and method for integration of mobile device imaging with microchip elisa: A system and method for analyzing a biomarker in a biological sample is provided. A biological sample is loaded onto a microchip and an enzyme-linked immunosorbent assay specific to the biomarker is performed on the microchip. A color image of the microchip is generated using a mobile device and a... Agent:

20140242613 - Rapid identification of organisms in bodily fluids: There is provided a lateral flow assay that can provide an indication of Gram negative (GN) or Gram positive (GP) infection (or both) within 30 minutes, and desirably in less than 15 minutes. The immediate result would signal the presence of Gram negative bacteria, Gram positive bacteria, both Gram negative... Agent: Kimberly-clark Worldwide, Inc.

20140242607 - Antibody for detecting epithelial ovarian cancer marker and method for diagnosing epithelial ovarian cancer: It is intended to find a highly specific epithelial ovarian cancer marker and to provide an antibody capable of specifically recognizing and detecting the marker or a fragment of the antibody. The present invention provides an anti-β1,6-N-acetylglucosaminyltransferase 5B antibody for diagnosis of epithelial ovarian cancer, i.e., an antibody for detection... Agent: National Institute Of Advanced Industrial Science And Technology

20140242606 - Probe for ifret and use thereof: The present invention relates to a probe for iFRET and use thereof. Specifically, the present invention relates to a novel probe for iFRET, a method for preparing the probe for iFRET, a method for searching a target protein-specific binding site or a molecule having the binding site using the probe... Agent: Korea Research Institute Of Bioscience And Biotechnology

20140242608 - Composition for diagnosis of lung cancer and diagnosis kit for lung cancer: The present invention provides serum paraoxonase 1 protein as a biomarker useful for early diagnosis of lung cancer.... Agent: Seoul National University R&db Foundation

20140242619 - Equine parasite detection: The present invention provides a method of diagnosing a cyathostomin infection, said method comprising the step of identifying a level of anti-cyathostomin larval antigen antibodies in a sample, wherein a level of anti-cyathostomin larval antigen antibodies is indicative of a cyathostomin infection.... Agent: Moredun Research Institute

20140242616 - Free ngal as a biomarker for cancer: Uncomplexed neutrophil gelatinase associated lipocalin (NGAL) is present at increased levels in individuals with atypical ductal hyperplasia (ADH), a major risk factor for future breast cancer development; in individuals that have ovarian cancer; and in individuals that have breast cancer, both invasive and noninvasive. Accordingly, the present invention is directed... Agent: Children's Medical Center Corporation

20140242617 - Immunoassay for detecting kratom, its constituents and their use: The invention relates to the field of drug detection and describes antibody-based components methods and kits for the detection and quantification of alkaloids of the plant kratom. The invention is underpinned by novel antibodies which specifically bind to mitragynine alkaloids found in the kratom plant and their metabolites.... Agent: Randox Laboratories Limited

20140242614 - Magnetic aggregating and washing device for in vitro assays and methods of use thereof: Provided herein are magnetic aggregating and washing devices. Further provided herein are methods using magnetic aggregation to aggregate and wash sample molecules in an in vitro assay.... Agent: Plexbio Co., Ltd.

20140242620 - Method of inhibiting non-specific binding in step of detecting substance in biological sample, and agent for use in the method: in the step of detecting, a substance capable of specifically binding to the substance to be detected is immobilized to a carrier through binding between biotin and the biotin-binding protein before or after binding of the substance to be detected to the substance capable of specifically binding to the substance... Agent: Japan Tobacco Inc.

20140242615 - Methods and reagents for determining isomeric analytes: Methods include determining in a sample an amount of a first isomeric analyte and a second isomeric analyte. A first measurement value and a second measurement value are determined. The first measurement value represents a total amount of the first isomeric analyte and the second isomeric analyte. The second measurement... Agent: Siemens Healthcare Diagnostics Inc.

20140242618 - Ritalinic acid immunoassay: The invention provides novel antibodies which specifically bind to the methylphenidate metabolite, ritalinic acid, enabling an immunoassay that can detect methyphenidate in biological samples for an extended period following its ingestion. The invention also describes novel conjugates and kits incorporating the antibodies.... Agent: Randox Laboratories Limited

20140242621 - Method for determining protein s activity: The invention relates to a method for determining the protein Ca-cofactor activity of protein S, wherein the protein Ca-cofactor activity of protein S is measured in a first reaction volume in the absence of a protein S inhibitor and in a second reaction volume in the presence of a protein... Agent: Siemens Healthcare Products Diagnostics Gmbh

20140242622 - Methods of detecting test elements having degraded test chemicals as well as apparatuses incorporating the same: An analytical apparatus is disclosed for detecting at least one analyte in a sample, where in an analyte measurement at least an electrical or optical property changeable by presence of the analyte at least one test chemical of a test element is recorded, and where the analytical apparatus also can... Agent: Roche Diagnostics Operations, Inc.

20140242624 - Intact mass determination of protein conjugated agent compounds: The present invention provides methods and systems for the rapid determination of the intact mass of non-covalently associated antibody heavy chains (HC) and light chains (LC) which result from the attachment of drug conjugates to interchain cysteine residues. By analyzing the antibody-drug conjugate (ADC) using native desalting conditions, the intact-bivalent... Agent: Seattle Genetics, Inc.

20140242623 - Signal-responsive plastics: We disclose methods and compositions for preparation of stimuli-responsive plastics that are capable of responding to chemical and/or physical signals in their environment. In one embodiment the plastics consist of patterned mixtures of poly(phthalaldehyde) polymers in which each polymer contains a different end-capping group (also called a “trigger”), responsive to... Agent:

20140242625 - Analytical method for fab and fab' molecules: A method of measuring acidic species generated by degradation of a Fab or Fab′ component of a Fab-PEG or a Fab′-PEG is provided. The method involves: a) cleaving PEG and a linker from the Fab-PEG or Fab′-PEG with an enzyme; b) optionally separating the PEG and linker from the Fab... Agent: Ucb Pharma, S.a.

20140242628 - Analytical method and device for malic acid: Analytical methods and devices according to the present disclosure may be used to assay the concentration of malic acid, or related species, in a sample, e.g., preparations of fruit, vegetables, juice, and/or wine. Liquid samples are combined with a reaction mixture, incubated, and a parameter characteristic of the resulting incubated... Agent: Sportsman Consulting, LLC

20140242626 - Nitrite-reductase (nirb) as potential anti-tubercular target and a method to detect the severity of tuberculosis disease: The present invention discloses functional nitrite reductase as a potential drug target for anti-tubercular drug development. The present invention also relates to the development of an easy method for identification of nitrite in clinical samples as well as its correlation with the severity of the disease. Presence of active as... Agent:

20140242627 - Stabilized formulation for luminescent detection of luciferase and nucleoside phosphates: Methods, kits and compositions containing a mixture of D-luciferin and L-luciferin for light generation with luciferase are disclosed that have improved stability when stored over time. The mixture of D-luciferin and L-luciferin can be used to detect the presence or amount of ATP or of luciferase in a sample.... Agent: Promega Corporation

20140242632 - Hydrogel patterning and transferring method of cells, and cell-based biosensor using same: Provided are a hydrogel-encapsulated cell patterning and transferring method comprising: preparing a substrate having a hydrogel-encapsulated cell patterning comprising a first cell and an alginate hydrogel; preparing an agarose hydrogel substrate comprising agarose hydrogel and any one of a second cell and a physiological active substance; and disposing the substrate... Agent: Unist Academy-industry Research Corporation

20140242630 - Laser microdissection method and apparatus: Systems and methods for automated laser microdissection are disclosed. In one variation, targeted biological material is manually or automatically selected and a transfer film is placed in juxtaposition to the location of an interior of a cut path. In another variation, a sample of biological material is mounted onto a... Agent: Life Technologies Corporation

20140242629 - Modulation of angiogenesis: The invention provides methods for treating pathological conditions that can be improved by providing angiogenesis. The invention is generally directed to provide angiogenesis by administering cells that express and/or secrete one or more pro-angiogenic factors. The invention is also directed to drug discovery methods to screen for agents that modulate... Agent: Abt Holding Company

20140242631 - New and greener process to synthesize water-soluble mn2+-doped cdsse(zns) core(shell) nanocrystals for ratiometric temperature sensing, nanocrystals, and methods implementing nanocrystals: Novel Mn2+-doped quantum dots are provided. These Mn2+-doped quantum dots exhibit excellent temperature sensitivity in both organic solvents and water-based solutions. Methods of preparing the Mn2+-doped quantum dots are provided. The Mn2+-doped quantum dots may be prepared via a stepwise procedure using air-stable and inexpensive chemicals. The use of air-stable... Agent:

20140242633 - Urine sample analyzer and sample analyzing method: A urine analyzer capable of operating in a urine measurement mode and a body fluid measurement mode, the urine analyzer includes a specimen preparing section configured to prepare a measurement specimen and a detecting section configured to derive signals of particles in the measurement specimen supplied from the specimen preparing... Agent: Sysmex Corporation

20140242634 - Methods and compositions for hematoxylin and eosin staining: The present invention provide for solutions of a defined composition useful in a staining protocol, such as a hematoxylin and eosin staining protocol, when used at certain points of the staining protocol. The formulations of these defined solutions are such that carry-over of the solutions will not negatively impact, or... Agent:

20140242635 - Fermentation process for the production of diphtheria toxin: The present invention relates to a fermentation process comprising a fermentation step of growing a strain of Corynebacterium diphtheriae in medium in a fermenter under conditions of agitation sufficient to maintain a homogenous culture and limited aeration such that pO2 within the culture falls to less than 4% for the... Agent: Glaxosmithkline Biologicals S.a.

20140242636 - Regulatable promoter: A method of producing a protein of interest (POI) by culturing a recombinant eukaryotic cell line comprising an expression construct comprising a regulatable promoter and a nucleic acid molecule encoding a POI under the transcriptional control of said promoter, comprising the steps a) cultivating the cell line with a basal... Agent: Lonza Ltd.

20140242637 - Artificial introns: The invention concerns the field of recombinant gene engineering. It concerns novel artificial introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes, especially genes encoding antibodies and antibody derived fragments, and the production of various polypeptides... Agent: Boehringer Ingelheim International Gmbh

20140242638 - Transcription unit and use thereof in (yb2/0) expression vectors: A transcription unit constituted by a polynucleotide including the hCMVie virus enhancer, the enhancer having the nucleotide sequence SEQ ID NO: 1, or a nucleotide acid having at least 70% sequence identity with the sequence SEQ ID NO: 1 and essentially having transcription activation properties, and the promoter region of... Agent:

20140242639 - Construction of bifunctional short hairpin rna: A method for designing a bi-shRNA expression cassette encoding a bi-shRNA comprising: selecting one or more target site sequences; providing a backbone sequence comprising a first and a second stem-loop structure, inserting a first passenger strand and a second passenger strand and providing for synthesis of the bi-shRNA expression cassette.... Agent: Gradalis, Inc.

20140242641 - Method for obtaining an open phototrophic culture with improved storage compound production capacity: In accordance with the invention, a starting culture is submitted to selective pressure, thus giving a competitive advantage to storage compound producing species, by subjecting said starting culture to a cycle of alternating dark phases and light phases and providing limitation of availability of essential growth nutrients in one or... Agent: Technische Universiteit Delft

20140242640 - Methods of making nanotechnological and macromolecular biomimetic structures: The present invention is in the fields of nanotechnology and biomimetics. In particular, the present invention relates to the use of modified ribosomes to produce biomimetic structures. These biomimetic structures, also known as directed element polymers, are not produced by traditional industrial means but instead are produced by living systems... Agent:

20140242642 - Dual cofactor specific ribitol dehydrogenase and use thereof: There are provided a novel ribitol dehydrogenase, a residue determining double coenzyme specificity, and a method for preparing L-ribulose using the same, and more particularly, to a ribitol dehydrogenase producing rare sugars, nucleic acid molecules encoding the same, a vector including the nucleic acid molecules, a transformant including the vector,... Agent: Konkuk University Industrial Cooperation Corp.

20140242643 - The use of phosphoketolase for producing useful metabolites: The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention... Agent: Ajinomoto Co., Inc.

20140242645 - Process for making beta 3 agonists and intermediates: The present invention is directed to a process for preparing a compound of formula I-11 through multiple-step reactions.... Agent:

20140242644 - Process for the enzymatic synthesis of (7s)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid and application in the synthesis of ivabradine and salts thereof: e

20140242646 - Oxidation and amination of primary alcohols: The present invention relates to a method comprising the steps a) providing a primary alcohol of the formula HO—(CH2)x—R1, wherein R1 is selected from the group consisting of —OH, —SH, —NH2 and —COOR2, x is at least 3 and R2 is selected from the group consisting of H, alkyl and... Agent: Evonik Degussa Gmbh

20140242647 - In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes: The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme... Agent: California Institute Of Technology

20140242649 - Hybrid organic-inorganic system for producing biofuels: The present invention provides for a system for converting CO2 and H2 to one or more biologically derived compounds. In some embodiments, the system comprises a host cell comprising one or more nucleic acids encoding genes for a recombinant surface display protein which is capable of tethering an electrocatalyst molecule,... Agent: The Regents Of The University Of California

20140242648 - Protein having activity to promote fatty acid chain elongation, gene encoding same and use thereof: The present invention relates to a protein having an activity to promote fatty acid chain elongation, a polynucleotide encoding the same, etc. The present invention provides, for example, a polynucleotide containing the nucleotide sequence shown in SEQ ID NO: 1 or 4, a polynucleotide encoding a protein which consists of... Agent: Suntory Holdings Limited

20140242651 - Enzymatically catalyzed method of preparing mono-acylated polyols: The present invention relates to a biocatalytic method of preparing a mono-acylated polyol catalyzed by triacylglycerol lipase mutants, as for example derived from Candida antarctica lipase B (CALB); a biocatalytic method of enantioselectively preparing an asymmetric mono-acylated polyol, catalyzed by the same enzyme mutants; as well as the use of... Agent: Basf Se

20140242652 - Method for producing succinic acid: e

20140242650 - Recominant ralstonia eutropha capable of producing polyactic and acid or polylatic acid polymer, and method for producing polyactic acid or polylatic acid copolymer using the same: Provided are a recombinant Ralstonia eutropha capable of producing polylactate or a hydroxyalkanoate-lactate copolymer, and a method of preparing polylactate or a hydroxyalkanoate-lactate copolymer using the same. The recombinant Ralstonia eutropha, which is prepared by introducing a gene of an enzyme converting lactate into lactyl-CoA and a gene of a... Agent: Lg Chem, Ltd.

20140242653 - Method for producing pyruvic acid from alginic acid: A method for producing pyruvic acid from polysaccharide alginic acid that is contained in large amounts in brown algae using the ability to assimilate alginic acid possessed by a lactate-dehydrogenase-gene-deficient Sphingomonas sp. A1 strain (ldh strain) is provided. The method for producing pyruvic acid comprises culturing the lactate-dehydrogenase-gene-deficient Sphingomonas sp.... Agent: Kyoto University

20140242654 - Butyrate producing clostridium species, clostridium pharus: A clostridia bacterial species Clostridium pharus, is provided. Under anaerobic conditions Clostridium pharus can convert ethanol and/or acetate to butyric acid.... Agent: Coskata, Inc.

20140242655 - Bioconversion process for producing nylon-7, nylon-7, 7 and polyesters: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7,... Agent: Invista Technologies S.a R.l.

20140242656 - Method for producing alcohols and/or solvents from paper pulps with recycling of the non-hydrolysated plant material in a regeneration reactor: b

20140242657 - Process for the production of alcohols and/or solvents from papermaking pulps with recycling of non-hydrolyzed vegetation:

20140242659 - Method for producing renewable fuels: According to the present invention, organic material is converted to biogas through anaerobic digestion and the biogas is purified to yield a combustible fluid feedstock comprising methane. A fuel production facility utilizes or arranges to utilize combustible fluid feedstock to generate renewable hydrogen that is used to hydrogenate crude oil... Agent: Iogen Corporation

20140242658 - Method for production of isoprenoid compounds: The present invention is directed to variant squalene synthase enzymes, including Saccharomyces cerevisiae squalene synthase enzymes, and to nucleic acid molecules encoding these variant enzymes. These variant enzymes produce squalene at a lower rate than the wild-type enzyme, allowing more farnesyl pyrophosphate to be utilized for production of isoprenoid compounds,... Agent:

20140242660 - Chimeric isoprenoid synthases and uses thereof: Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of... Agent:

20140242661 - Process control method: A process control method, the method comprising the steps of: (i) Passing a portion of a biomass containing liquid from a first reactor (12) in which a batch anaerobic digestion of organic material is being or has been conducted to a liquid storage vessel (14), methane being produced in both... Agent: Anaeco Limited

20140242662 - Manipulation of cells on a droplet actuator: A method of growing cells on a droplet actuator is provided. The method may include providing a droplet actuator including a cell culture droplet including a cell culture medium and one or more cells; and maintaining the droplet at a temperature suitable for causing the cells to grow in the... Agent: Advanced Liquid Logic

20140242663 - Magnetic separation of algae: Described herein are methods and systems for harvesting, collecting, separating and/or dewatering algae using iron based salts combined with a magnetic field gradient to separate algae from an aqueous solution.... Agent: Los Alamos National Security, LLC

20140242664 - Engineering of systems, methods and optimized guide compositions for sequence manipulation: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are... Agent: Massachusetts Institute Of Technology

20140242665 - Phenyl xanthene dyes: Fluorescent phenyl xanthene dyes are described that comprise any fluorescein, rhodamine or rhodol comprising a particular C9 phenyl ring. One or both of the ortho groups on the lower C9 phenyl ring is ortho substituted with a group selected from alkyl, heteroalkyl, alkoxy, halo, haloalkyl, amino, mercapto, alkylthio, cyano, isocyano,... Agent: Applied Biosystems, LLC

20140242666 - Vaccine for shigella: u

20140242667 - Amylase variants:

20140242668 - Polysaccharide lyases: The present invention relates to a variant of a mature polysaccharide lyase having a beta helix structure, wherein said variant comprises an N- and/or C-terminal truncation and consists essentially of at least 90% of the beta helix structure of the mature polysaccharide lyase.... Agent: Biomay Ag

20140242669 - Production of infectious rna viruses in yeast: The method described herein provides a novel platform utilizing yeast as a biological non-host system to express and assemble whole viruses for use as attenuated or killed vaccines.... Agent:

20140242670 - Production of poliovirus at high titers for vaccine production: Described is a process for producing poliovirus, the process comprising: a) providing a serum-free suspension culture of cells, which are primary human retina (HER) cells that have been immortalized by expression of adenovirus E1 sequences, b) infecting the cells with poliovirus, at a cell density of between 2×106 cells/ml and... Agent: Crucell Holland B.v.

20140242671 - Cell line for production of adeno-associated virus: This invention relates to a HEK293 cell line that grows under animal component-free suspension conditions. The cell line is ideal for rapid and scalable production of adeno-associated virus (AAV) and supports production of all serotypes and chimera of AAV.... Agent:

20140242672 - Lactobacillus mutant, nucleotide sequence for lactobacillus mutant and primers for nucleotide sequence of lactobacillus mutant: Sammlung von Mikroorganismen and Zellkulturen GmbH (DSMZ, Inhoffenstr. 7B, D-38124 Braunschweig, Germany) on Nov. 18, 2013, wherein the accession number of Lactobacillus paracasei subsp. paracasei NTU 101 is DSM 28047. In the present invention, a nucleotide sequence for NTU 101 and the primers for the nucleotide sequence are proposed in... Agent:

20140242673 - Chemically defined culture medium for fermentation to produce succinic acid and application thereof: This invention belongs to the technical field of industrial microorganism fermentation and relates to a type of chemical defined medium used for succinic acid production by fermentation and its application. The chemical defined medium of this invention used for succinic acid production by fermentation includes conventional compositions and critical growth... Agent:

20140242675 - Monascus purpureus mutant, nucleotide sequence for monascus purpureus mutant and primers for nucleotide sequence of monascus purpureus mutant: The present invention relates to a mutant of Monascus purpureus NTU 568, a nucleotide sequence for Monascus purpureus NTU 568 and primers for nucleotide sequence of Monascus purpureus NTU 568, wherein the Monascus purpureus NTU 568 having the nucleotide sequence of SEQ ID NO 1, SEQ ID NO 2 or... Agent:

20140242674 - Pentose fermentation by a recombinant microorganism: The present invention provides recombinant nucleic acid constructs comprising a xylose isomerase polynucleotide, a recombinant fungal host cell comprising a recombinant xylose isomerase polynucleotide, and related methods.... Agent: Codexis, Inc.

20140242676 - Artificial leaf-like microphotobioreactor and methods for making the same: Described herein are algae carbon capture systems and biomass production systems, and more specifically, algal based microphotobioreactors (μPBRs) comprising a biocompatible polymer (e.g., hydrogel) containing algae, inorganic carbon, light-frequency shifting agents (e.g., quantum dots and/or dyes of fluorescent proteins) and methods for making such μPBRs.... Agent: Los Alamos National Security, LLC

20140242677 - Photobioreactor: A method of operating a closed photobioreactor for cultivation of phototrophic microorganisms. The photobioreactor comprises a culture liquid and is partially or completely surrounded by water of a water body. A density difference between the culture liquid and the surrounding water is provided so that the position of the photobioreactor... Agent: Aveston Grifford Ltd.

20140242678 - Apparatus and method for a lysis of a sample, in particular for an automated and/or controlled lysis of a sample: The present invention provides an apparatus and a method for a lysis procedure, in particular for an automated and/or controlled lysis procedure of a sample, in particular a biological sample. The apparatus comprises at least one rotation disc (31), at least one vial holder (90) which is configured to receive... Agent:

20140242679 - Method for producing hypoallergenic peanut products: A peanut food product with reduced levels of allergenic proteins such as Ala h1/h2/h3 is produced by initiating the germination process in raw peanuts, holding the peanuts in moist conditions to initiate germination and then treating with bromelain.... Agent:

20140242680 - Emissions control of spent air from cumene oxidation: Methods and systems for removing volatile organic compounds from spent air are provided. The method can include oxidizing cumene in the presence of an oxidant to produce an oxidized product containing methanol and a spent air, separating the spent air from the oxidized product, contacting the spent air with an... Agent: Kellogg Brown & Root LLC

20140242681 - Photobioreactor: A photobioreactor system may include a one or more fluidly connectable tubes for growing or producing microorganisms or biomass such as microalgae. The system may include either a single tube loop or an array of tubes. A first fluid may be held in the tube or tubes, and an inlet... Agent:

20140242683 - Apparatus for selective excitation of microparticles: Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more reagents, selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the... Agent: Lightspeed Genomics, Inc.

20140242682 - Salivary diagnostic systems: Salivary diagnostic systems are provided for improved disease diagnosis and overall health care. Salivary diagnostic systems are provided for the plurality of steps required in salivary diagnostic processes. The salivary diagnostic systems are interchangeably coupled by various methods and steps and include a collection system, a filter system, an evaluation... Agent: Beam Technologies, LLC

20140242685 - Inlet valve for chamber systems and sample containers, and chamber systems and sample containers with such inlet valves: An inlet valve charges an inner chamber of a system or sample container with liquid and has a first pipetting axis, an inlet opening, it supplies liquid by a laboratory pipette that is automatically reclosed and also has a valve body with a blocking element, a pressing part and a... Agent: Tecan Trading Ag

20140242684 - System for hydrolyzing a cellulosic feedstock slurry using one or more unmixed and mixed reactors: Provided is a system for hydrolyzing a cellulosic feedstock slurry. The system comprises one or more unmixed reactors for receiving and partially hydrolyzing the cellulosic feedstock slurry so as to produce a mixture of partially hydrolyzed slurry. The unmixed reactors may be plug flow reactors. One or more mixed reactors... Agent: Iogen Energy Corporation

20140242686 - Trash composting apparatus: A system for decomposing materials includes a main container and a drum container housed within the main container. The drum container includes a central longitudinal axis about which the drum container rotates. The drum container also includes at least one partition extending transverse to the central longitudinal axis of the... Agent:

20140242687 - Photobioreactor: A photobioreactor system may include a one or more fluidly connectable tubes for growing or producing microorganisms or biomass such as microalgae. The system may include either a single tube loop or an array of tubes. A first fluid may be held in the tube or tubes, and an inlet... Agent:

20140242688 - Photobioreactor: Provided herein is a transgenic bacteria engineered to accumulate carbohydrates, for example disaccharides. Also provided is a photobioreactor for cultivating photosynthetic microorganisms comprising a non-gelatinous, solid cultivation support suitable for providing nutrients and moisture to photosynthetic microorganisms and a physical barrier covering at least a portion of the surface of... Agent: Proterro, Inc.

20140242689 - Vortex bioreactor: The invention relates biotechnology. The vortex bioreactor comprises a cylindrical tank with a lid, a device for agitating a medium, said device being located in the tank and consisting of a bladed wheel secured horizontally on a vertical shaft in the upper portion of the tank and a horizontal annular... Agent: Obschestvo S Ogranichennoi Otvetsvennostju "tsentr Vikhrevykh Tekhnology

20140242690 - Cystic fibrosis treatment: The present invention relates to medicaments for the treatment of cystic fibrosis. Also provided are methods of preparing such medicaments so that they can be used in a treatment regime for cystic fibrosis. The present invention also provides a kit of parts including the medicament of the invention, as well... Agent:

20140242691 - Neural progenitor cell populations: This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates differentiation, and establishes the neural progenitor population. The progenitors can be further differentiated in... Agent: Asterias Biotherapeutics, Inc.

20140242692 - Mammalian genes involved in toxicity and infection: The present invention relates to cellular proteins that are involved in toxicity and infection or are otherwise associated with the life cycle of one or more pathogens.... Agent:

20140242693 - Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells: The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation.... Agent: Janssen Biotech, Inc.

20140242694 - Composition containing complex cytokines derived from ebv-infected b cells for inducing the maturation of dendritic cells: A composition for deriving the maturation of dendritic cells includes complex cytokines generated by the simulation, the expression of which is induced on EBV-infected B cells. The dendritic cell maturation process, which conventionally takes approximately 7 days, can be shortened to 2 days, thereby producing dendritic cells in a more... Agent: Inje University Industry-academic Cooperation Foundation

20140242695 - Protein-induced pluripotent cell technology and uses thereof: A method of generating protein-induced pluripotent stem cells by delivering bacterially expressed reprogramming proteins into nuclei of starting somatic cells using the QQ-protein transduction technique, repeating several cell reprogramming cycles for creating reprogrammed protein-induced pluripotent stem cells, moving the reprogrammed cells into a feeder-free medium for expansion, and expanding and... Agent: Wayne State University

20140242696 - Thermally induced gelation of collagen hydrogel and method of thermally inducing gelling a collagen hydrogel: The present invention relates to collagen hydrogels. Particularly, the invention relates to hydrogels comprising a telopeptide collagen (“telo-collagen”) and an atelopeptide collagen (“atelo-collagen”); hydrogels comprising collagen and chitosan; methods of making the hydrogels; methods of reducing gelation of a hydrogel mixture at room temperature; methods of reducing compaction of cells;... Agent: Medtrain Technologies, LLC

20140242697 - Thermally induced gelation of collagen hydrogel and method of thermally inducing gelling a collagen hydrogel: The present invention relates to collagen hydrogels. Particularly, the invention relates to hydrogels comprising a telopeptide collagen (“telo-collagen”) and an atelopeptide collagen (“atelo-collagen”); hydrogels comprising collagen and chitosan; methods of making the hydrogels; methods of reducing gelation of a hydrogel mixture at room temperature; methods of reducing compaction of cells;... Agent: Medtrain Technologies, LLC

20140242698 - Medical records storage system: Electronic medical records have to evolve from the isolated hospital systems or insurance company owned storage data silos based on a binary code accessed by patients through portals to the patient themselves becoming the data silo with portals to which all hospital systems or insurance companies send data for storage... Agent: Complete Consent, LLC

20140242701 - Chimeric antigen receptor: Provided are a chimeric antigen receptor comprising an extracellular domain capable of binding to an antigen, a transmembrane domain and at least one intracellular domain, the chimeric antigen receptor being characterized in that an intracellular domain of a glucocorticoid-induced tumor necrosis factor receptor (GITR) is contained as the intracellular domain;... Agent: Takara Bio Inc.

20140242699 - Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are delivery systems and tissues or organ which are targeted as sites for delivery. Also provided are vectors and vector systems some of which encode one or... Agent: The Broad Institute Inc.

20140242700 - Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation: The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme.... Agent: The Broad Institute, Inc.

20140242702 - Methods and compositions for enhancing nuclease-mediated gene disruption: Methods and compositions for increasing nuclease-mediated genomic modification using DNA repair inhibitors are provided.... Agent:

20140242703 - Methods for transferring molecular substances into plant cells: Provided are methods for introducing a molecule of interest into a plant cell comprising a cell wall. Methods are provided for genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall.... Agent: Dow Agrosciences LLC

20140242704 - Pef-ts expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Basf Se

  
08/21/2014 > 150 patent applications in 78 patent subcategories.

20140234827 - Ssat mrna translation repression and activation: The invention provides an isolated nucleic acid having a sequence encoding a spermidine/spermine acetyltransferase (“SSAT”), wherein translation of an mRNA comprising the encoded SSAT has increased basal translation and increased stimulated translation, compared to a wild-type mRNA encoding SSAT. Methods of use for the nucleic acid are also provided. Methods... Agent: Temple University - Of The Commonwealth System Of Higher Education

20140234828 - Method for separating blood, separation container for a blood centrifuge, system for filling a freezer container: The invention relates to a method for separating blood, to a separation container and to a system, wherein different blood fractions—erythrocytes (64), buffy coat (65) and blood plasma (66)—are obtained, wherein blood is introduced into a separation container (1) and is then centrifuged into different superimposed, fluidically connected sections of... Agent:

20140234829 - Separating composite liquids: Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In... Agent: Terumo Bct, Inc.

20140234830 - Direct amplification and detection of viral and bacterial pathogens: Provided are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Further provided are reagent mixtures that allow... Agent: Quest Diagnostics Investments Incorporated

20140234831 - Packaging or other materials comprising a biosensor and methods of their use: Provided herein is a composition for detection of a microbial product in a sample comprising a polydiacetylene (PDA) and a packaging polymer, wherein the sample contacts the PDA and a change of PDA color indicates detection. Also provided herein are methods of making a packaging material comprising a PDA and... Agent:

20140234832 - Methods and compositions for inhibiting undesired cleaving of labels: The invention provides methods and compositions, including, without limitation, algorithms, computer readable Media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that... Agent: Intelligent Biosystems, Inc.

20140234833 - Sperm staining and sorting methods: A method of sex sorting sperm is disclosed. The sperm may be stained with a DNA selective fluorescent dye, which fluoresces when excited, a dead quenching dye, which selectively quenches fluorescence emitted by the DNA selective fluorescent dye within the membrane of compromised sperm, and a split enhancing dye. The... Agent: Inguran, LLC

20140234841 - Compositions, methods and kits to detect dicer gene mutations: In one aspect, the disclosure provides isolated nucleic acids, polypeptides, primers, and probes for the detection of mutations in a nucleic acid sequence for a DICER1 polypeptide.... Agent: The Washington University In St. Louis

20140234837 - Epigenetic marker for the identification of natural killer cells: The present invention relates to a method, in particular an in vitro method for identifying a subgroup of natural killer cells of a mammal, preferably CD3−, non T-lymphocyte derived NK cells, which often express the surface proteins CD56 and/or CD16, comprising analyzing the accessibility of the genomic DNA for OSBPL,... Agent: Epiontis Gmbh

20140234844 - Hybridization compositions and methods using formamide: The invention provides methods and compositions for hybridizing at least one molecule to a target. The composition comprises at least one nucleic acid sequence, formamide, and a hybridization solution, wherein the concentration of formamide is less than or equal to 25%.... Agent: Dako Denmark A/s

20140234834 - Method for quantifying human dna: The invention provides for a method for quantifying one or more nucleic acids of a genome in a sample comprising the steps of (a) amplifying a first nucleic acid to be quantified, (b) determining the amount of said first nucleic acid by comparison of the amount of amplification product from... Agent: Qiagen Gmbh

20140234839 - Method for the cytological analysis of cervical cells: The invention provides for a diagnostic test to monitor cancer-specific genetic abnormalities to diagnose cervical cell disorders and predict which patients might progress to cancer. Genetic abnormalities are detected by identification in chromosomal copy number of chromosome 3 and chromosome 5 using FISH analysis of probes targeted to 3q and/or... Agent: Neodiagnostix

20140234843 - Methods and compositions for expanding cells and improving engraftment: Methods of expanding FCs or stem cells are provided herein, as are methods of screening for compounds that increase expression of DOCK2 or decrease expression of Arhgap18, either of which improves engraftment.... Agent:

20140234840 - Molecular markers linked to ppo inhibitor tolerance in soybeans: This invention relates generally to the detection of genetic differences among soybeans. More particularly, the invention relates to soybean quantitative trait loci (QTL) for tolerance to protoporphyrinogen oxidase inhibitors, to soybean plants possessing these QTLs, which map to a novel chromosomal region, and to genetic markers that are indicative of... Agent: E. I. Du Pont De Nemours And Company

20140234836 - Mutation detection assay: A method of sample analysis is provided. In certain embodiments, the method involves: a) amplifying a product from a sample that comprises both wild type copies of a genomic locus and mutant copies of the genomic locus that have a point mutation relative to said wild type copies of the... Agent: Exact Sciences Corporation

20140234842 - Mutations associated with cystic fibrosis: The present invention provides novel mutations identified in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that can be used for a more accurate diagnosis of cystic fibrosis (CF) and CF related disorders. Methods for testing a sample obtained from a subject to determine the presence of one or more... Agent:

20140234835 - Rare clonotypes and uses thereof: The invention is directed to a method of selecting disease-correlated clonotypes that have a reduced likelihood of producing a false positive signal of relapse when used to monitor minimal residual disease. In accordance with the invention, candidate correlating clonotypes are obtained from a patient, the rarity of each is determined... Agent: Sequenta, Inc.

20140234838 - Square wave thermal cycling: Embodiments disclosed herein relate to methods and systems for analysis of melting temperatures, and particularly to analysis of duplex nucleic acids.... Agent: Becton, Dickinson And Company

20140234848 - Cryptographic methods using nucleic acid codes: Novel methods and systems for encoding cryptographic information are disclosed. A message can be encoded through a sequence of nucleic acids by assigning a binary value to a pair of nucleic acids, while other nucleic acids can be used for spacing. Unique organisms can also be used for identification. The... Agent: California Institute Of Technology

20140234850 - Dna fragment detection method, dna fragment detection kit and the use thereof: The disclosure claims a cleaved Deoxyribonucleic acid (DNA) detection method, a DNA fragment detection kit and use thereof. Wherein, the method includes the steps of: designing primers according to a test site or a test region of the DNA fragment; cyclizing the DNA fragment to obtain acyclized DNA; implementing Polymerase... Agent: Berry Genomics Co., Ltd

20140234847 - High throughput genome-wide translocation sequencing: Provided are methods for high-throughput screening to determine locations of double-stranded DNA breaks (DSBs) and translocations in genomes caused by different agents, such as enzymes.... Agent: Children's Medical Center Corporation

20140234849 - Oligonucleotide sequences that identify species of animal: The present invention provides a method for identifying animal species, said method comprises a step of amplifying a DNA fragment by PCR using a DNA in a sample as a template and animal-specific DNA sequences as a primer pair, wherein the animal-specific DNA sequences are derived from a ATP synthase... Agent: National Institute Of Agrobiological Sciences

20140234845 - Organism identification panel: Methods and containers are provided for identifying a species, illustratively a bacterial species. Illustrative methods comprise amplifying various genes in the nucleic acid from the bacterial species in a single reaction mixture using pairs of outer first-stage primers designed to hybridize to generally conserved regions of the respective genes to... Agent:

20140234846 - Recombinase polymerase amplification: This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling... Agent: Alere San Diego, Inc.

20140234852 - Human keratinocytes ptch1 cell line: A cellular model is described for targeting dysregulation or inappropriate activation of the Sonic Hedgehog/Patched (SHH/PTCH) pathway. Also described, is a screening method using this cellular mod& to screen for pharmacological compounds that can treat or prevent skin cancer and, in particular, Basal Cell Carinoma (BCC) lesions.... Agent: Cnrs

20140234851 - Modular extracellular sensor architecture for cell-based biosensors: The present invention provides modular extracellular sensors, nucleic acids encoding such sensors, and cells expressing such sensors, and methods of employing such sensors and cells for detecting extracellular ligands. In certain embodiments, the extracellular sensors comprise a ligand binding domain, a transmembrane domain, a protease domain, a protease cleavage site,... Agent: Northwestern University

20140234853 - Nucleotide transient binding for sequencing methods: Provided herein are compositions and systems for use in polymerase-dependent, nucleotide transient-binding methods. The methods are useful for deducing the sequence of a template nucleic acid molecule and single nucleotide polymorphism (SNP) analyses. The methods rely on the fact that the polymerase transient-binding time for a complementary nucleotide is longer... Agent: Life Technologies Corporation

20140234855 - Chromophore compositions and methods of making and using the same: Chromophore compositions and methods of making and using the same are provided. Aspects of the chromophore compositions include a chromophore component having a chromophore, such as a fluorescent dye moiety, stably associated with a prosthetic group binding cavity of a metalloprotein. Also provided are methods of making, methods of use,... Agent:

20140234857 - Compositions and methods for toxigenicity testing: The present invention relates to compositions and methods for testing agents (e.g., Clostridium botulinum neurotoxin (BoNT) detection and analysis). In particular, the present invention relates to the use of Human induced pluripotent stem (hiPS) derived cells for agent detection and analysis.... Agent:

20140234858 - Hsf1 as a marker in tumor prognosis and treatment: In some aspects, the invention relates to Heat Shock Protein-1 (HSF1) gene and HSF1 gene products. In some aspects, the invention provides methods of tumor diagnosis, prognosis, treatment-specific prediction, or treatment selection, the methods comprising assessing the level of HSF1 expression or HSF1 activation in a sample obtained from the... Agent:

20140234854 - Method for evaluation of presence of or risk of colon tumors: The disclosed methods are used to predict or assess colon tumor status in a patient. They can be used to determine nature of tumor, recurrence, or patient response to treatments. Some embodiments of the methods include generating a report for clinical management. The methodology provided herein is intended to detect... Agent: Applied Proteomics, Inc.

20140234856 - Sensor for detecting analytes: A sensor for detecting an analyte can include a photoluminescent nanostructure embedded in a sensor hydrogel. The sensor hydrogel can be supported by a substrate hydrogel.... Agent: Massachusetts Institute Of Technology

20140234859 - Controlled platelet activation to monitor therapy of adp antagonists: A method is provided of determining whether an individual has reduced ability to form platelet thrombi due to inhibition of platelet activation initiation, signal transduction and/or GPIIb/IIIa blockade. A blood sample is obtained from the individual being assessed. The blood sample is mixed in combination with 1) an anticoagulant; 2)... Agent: Accumetrics, Inc.

20140234865 - Instrument and method for optical particle sensing: Devices for detecting particle sizes and distributions using focused light scattering techniques, by passing a sample through a focused beam of light, are disclosed. In one embodiment, the devices include one or more lasers, whose light is focused into a narrow beam and into a flow cell, and dispersions are... Agent:

20140234864 - Magnetic removal or identification of damaged or compromised cells or cellular structures: A method for magnetic cellular manipulation may include contacting a composition with a biological sample to form a mixture. The composition may include a plurality of particles. Each particle in the plurality of particles may include a magnetic substrate. The magnetic substrate may be characterized by a magnetic susceptibility greater... Agent:

20140234867 - Antibodies specific to heterodimers of bcl-2 family and uses thereof: Isolated antibodies specifically binding to heterodimers of the Bcl-2 family and uses thereof for detecting presence of Bcl-2 heterodimers in a patient.... Agent: Eutropics Pharmaceuticals, Inc.

20140234869 - Cadherins as cancer biomarkers: Methods of isolating, enriching, capturing, identifying, or detecting the presence of, cancerous cells in a sample, e.g., a blood sample from a subject, by detecting the presence of one or more cancer cell surface markers selected from the group consisting of cadherin 1 (CDH1), CDH2, CDH3, CDH4, CDH5, CDH9, CDH11,... Agent:

20140234866 - Ex vivo flow cytometry method and device: t

20140234868 - Use for glycolipoprotein gintonin, isolated and identified from ginseng, as a natural medical-plant derived ligand: The present invention relates to glycolipoprotein gintonin, isolated and identified from ginseng, as a natural medicinal-plant-derived ligand acting on LPA1 (lysophosphatidic acid; 1- or 2-acyl-sn-glycerol-3-phosphate), LPA2, LPA3, LPA4 and LPA5 receptors whose efficacy is exhibited physiologically/pharmaceutically via an interaction with subset receptors [LPA1(edg-2), LPA2(edg-4), LPA3(edg-7), LPA4, PLA5] in the EDG... Agent: Konkuk University Industrial Cooperation Corp.

20140234860 - Measurement of pka for cancer characterization: A method for characterizing a carcinoma in a subject. The method comprises assaying a sample of a bodily fluid derived from the subject for extracellular PKA activity and comparing the activity to a reference value. In the assay, a reaction mixture is prepared comprising the previously unfrozen sample, a PKA... Agent:

20140234861 - Method for diagnosis, prognosis or treatment of acute coronary syndrome (acs) comprising measurement of plasma concentration of macrophage migration inhibitory factor (mif): A method for diagnosing acute coronary syndrome (ACS) in a subject, the method comprising measuring plasma macrophage migration inhibitory factor (MIF) concentration in a sample from the subject, and diagnosing ACS when the subject plasma MIF concentration is greater than a reference plasma MIF concentration, wherein the sample is taken... Agent:

20140234870 - Nik inhibitors cell-based screening assay: The present invention relates to a cell-based assay for the screening and the identification of inhibitors of NIK protein. The method according to the present invention allows the identification of compounds that inhibit NIK activity related to the phosphorylation of IKK1. The assay combines the use of transfected Human Embryonic... Agent: Merck Patent Gmbh

20140234862 - Compositions and methods for quantitatively monitoring lipids: Provided herein are fluorescent lipid binding proteins (FLBPs). The FLBPs comprise a lipid binding domain linked to a fluorophore, whereby the fluorophore's fluorescence emission undergoes a spectral change upon lipid binding.... Agent: The Board Of Trustees Of The University Of Illinois

20140234863 - Immunoassay methods: The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid from said mammalian subject wherein said antibody is a biological marker of a disease state or disease susceptibility, the... Agent: Oncimmune Ltd.

20140234873 - Apparatus for processing a sample in a liquid droplet and method of using the same: A device for processing a sample in a liquid droplet containing a hydrophilic liquid is described. The device includes: a circumferential wall and a base including an immobilisation member. The circumferential wall and the base define a reservoir adapted to accommodate a hydrophobic medium immiscible with the liquid droplet. The... Agent: Agency For Science, Technology And Research

20140234874 - Compositions and methods for in vitro diagnostic tests including sulfonic acid: The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be... Agent: Surmodics, Inc.

20140234876 - Method and system for detection of natural high intensity sweeteners that contain hydroxyl groups: The present invention provides a hapten derivative and conjugate of a natural high intensity sweetener containing hydroxyl groups. The conjugate can be used to produce antibodies specific against the natural high intensity sweetener. The present invention further provides a kit and method for detecting and quantifying the natural high intensity... Agent: Purecircle Sdn Bhd

20140234877 - Method for detecting a beta-specific antibodies in a biological sample: Disclosed is a method for detecting Aβ-specific antibodies in a biological sample comprising the following steps:—contacting the sample with Aβ-aggregates or with particles comprising Aβ-aggregate like surfaces and allowing the Aβ-specific antibodies to bind to the Aβ-aggregates, and -detecting the Aβ-specific antibodies bound to the Aβ-aggregates by a single particle... Agent: Affiris Ag

20140234871 - Method of extraction of an enzyme from plant or animal tissue: This invention provides a method for the extraction and detection of a peptide from transgenic plant tissues wherein a non-immunogenic solubility-promoting compound is used to release the enzyme into the solution fraction during the purification process. In some embodiments, this invention provides a method for the extraction and detection of... Agent: Syngenta Participations Ag

20140234875 - Methods predicting risk of an adverse clinical outcome: Provided are methods for evaluating the risk of an adverse clinical outcome in a subject, deciding whether to discharge or continue treating a subject (e.g., treatment on an inpatient basis), or to initiate or terminate treatment, selecting a subject for participation in a clinical study, and selecting a therapeutic treatment... Agent: Critical Care Diagnostics, Inc.

20140234872 - Target of the phosphoinositide 3-kinase pathway: The present disclosure generally relates to tyrosine phosphorylation sites of an Akt enhancer, and methods for the detection of the phosphorylated tyrosine residues. In particular, anti-phosphotyrosine antibodies and binding proteins find use in the compositions and methods of the present disclosure.... Agent: The Regents Of The University Of California

20140234878 - Composition for diagnosing acute myocardial infarction, kit for diagnosing acute myocardial infarction comprising same, and method of diagnosing acute myocardial infarction: Provided are compositions for diagnosing acute myocardial infarction including a preparation for measuring an amount of a substance P (SubP) or neuropeptide Y (NpY), kits for diagnosing acute myocardial infarction comprising the composition, and methods of diagnosing acute myocardial infarction based on the amount of the substance P or the... Agent: Korea Institute Of Science And Technology

20140234879 - Dynamic of sflt-1 or endoglin/plgf ratio as an indicator for imminent preeclampsia and/or hellp syndrome: Diagnostic methods and tools relating to diagnosing whether a pregnant subject is at risk for developing preeclampsia and/or early-onset preeclampsia within a short period of time. The methods include determining the amounts of the biomarkers sFlt-1 or Endoglin and PIGF in a first and a second sample of said subject,... Agent: Roche Diagnostics Operations, Inc.

20140234880 - Methods of detection of cancer using peptide profiles: The disclosed methods address the identification and monitoring of cancer in a subject using serum peptide profiles. Such profiles allow the detection of the differential presence of certain serum peptide markers in comparison with controls. The profiles can be determined employing mass spectrometry.... Agent: Memorial Sloan-kettering Cancer Center

20140234881 - Lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of... Agent: President And Fellows Of Harvard College

20140234882 - Oxygenase-based biosensing systems for measurement of halogenated alkene concentrations: A biosensing system that measures the concentration of halogenated alkenes is disclosed.... Agent: Colorado State University Research Foundation

20140234883 - Use of photocleavable compounds: Use of photochemically cleavable compounds in course of one or multi-photon irradiation experiments.... Agent: Femtonics Kft

20140234884 - Fluorogenic substrates, methods of making the substrates, and methods of detecting glycosidase activities: Fluorogenic substrates, methods of making the fluorogenic substrates, and methods of detecting glycosidase activities (EC3.2.1) are provided. The fluorogenic substrates are composed of a sugar covalently bonded to the 7-hydroxy position of a substituted coumarin sulfonated fluorophore is provided. The fluorogenic substrates include sodium β-D-cellobioside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; sodium β-D-glucoside 6,8-difluoro-7-hydroxycoumarin-4-methanesulfonate; sodium... Agent: Ets J. Soufflet

20140234887 - Fluorogenic peptidase substrate: u

20140234885 - Methods for optimizing domain stability of binding proteins: Provided are methods for measuring the inherent stability of intrachain disulphide-containing domains (e.g., antibody variable domains) and for optimizing the positioning of intrachain disulphide-containing domains within a protein (e.g., a multispecific binding protein, e.g., a DVD-Ig). Also provided are methods of making multispecific binding proteins (e.g., DVD-Ig molecules) comprising two... Agent: Abbvie, Inc.

20140234886 - Novel fructosyl peptide oxidase: o

20140234888 - Method for improved selection of therapeutic agents: The current invention comprises a method of selection of therapeutic agents for treatment of a particular disease in humans or other mammals in which the ratio of the concentrations of thiol (—SH) and disulfide (—SS—) groups is determined in the blood. The therapeutic agent to be tested may be used... Agent:

20140234889 - Method for neutralization of antibiotics in a culture medium: The present invention is directed to a method and means for the neutralization, binding, and/or inactivation of antimicrobials in a test sample. The invention is also directed to a method of detecting the presence of one or more microorganisms in a test sample by culturing the test sample in a... Agent: Biomerieux, Inc.

20140234890 - Methods for purifying biological cells: This invention relates to devices and methods for purifying biological cells. For example, viable tumor, stem, immune and sperm cells can be purified from a complex biological sample using a pipette tip column. Methods of the invention can aid research, diagnosis and treatment of cancer.... Agent:

20140234891 - Cards for sample storage and delivery comprising sintered porous plastic: This application discloses cards comprising sintered porous plastic which may be employed in liquid sample collection, storage, transport and/or delivery to an analytical device. Sintered porous plastic materials provide a unique porous structure, an inert substrate, precise liquid holding capability, are quick drying, and easy to cut and handle.... Agent: Porex Corporation

20140234892 - Microfluidic device for separating cells from a fluid: A microfluidic device for separating one or more cells having a diameter and a first surface energy from a bulk fluid having a second surface energy. The microfluidic device has a base portion having a capillary gap with an inlet capillary, an outlet capillary, a bottom surface, a gap height... Agent: Siemens Healthcare Diagnostics Inc.

20140234893 - Heterologous intron within an immunoglobulin domain: The invention concerns the field of recombinant gene engineering. It concerns novel introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes with heterologous introns, especially genes encoding antibodies and antibody derived fragments, and the production of... Agent: Boehringer Ingelheim International Gmbh

20140234894 - Method for measuring a biological value of a liver: The present invention relates to a method for measuring a biological value Vb in a liver wherein said method comprises the steps of: a/ applying an infrared radiation having at least a first wave number range between 2800 cm−1 and 3000 cm−1 to one or more portions, pi, of a... Agent:

20140234895 - Ultra-rapid diagnostic tissue preparation as an alternative to frozen section: Improved methods and systems for processing of solid tissue are described. The method may be performed manually or automatically. The system may have modules such as (i) a grossing module where a fresh tissue is sliced to prepare a tissue specimen, (ii) a hardening module that hardens the tissue specimen,... Agent:

20140234896 - Growing organisms: A photo bioreactor for the growth of photosynthetic organisms comprising a tank (2) for holding a liquid medium, six rotational agitators (3a-3f) for agitating the liquid medium. Each agitator is arranged to agitate about a substantially vertical axis (6a-6f) by sweeping out, upon rotation, a substantially circular path (C) that... Agent: Algae Health Limited

20140234897 - Polypeptides having cellobiohydrolase activity and polynucleotides encoding same: Disclosed are isolated polypeptides having cellobiohydrolase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate binding domains. Furthermore, nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or carbohydrate binding domains... Agent:

20140234899 - Process for antibody g1 glycoform production: The current invention comprises a method for producing an immunoglobulin or immunoglobulin fragment or immunoglobulin fusion with G1 glycostructure comprising incubating with a galactosyltransferase, a sialyltransferase, a beta-1,4-galactosidase and a sialidase, whereby the galactosyltransferase is added in more than one aliquot during the incubating.... Agent: Hoffmann-la Roche Inc.

20140234898 - Protein and peptide libraries: Provided herein are, inter alia, methods for linking an mRNA molecule to a polypeptide (e.g., a peptide or a protein) by linking the mRNA molecule to a linking amino acid in the polypeptide, or by linking the mRNA molecule to a linking tRNA to which the polypeptide is attached, via... Agent: The General Hospital Corporation

20140234903 - Biosynthetic gene cluster for the production of peptide/protein analogues: A novel gene cluster encoding polypeptides involved in the generation of bio synthetically unique peptide-based compounds is described. In addition, new methods for biosynthetic engineering and production of modified peptides and proteins are disclosed. Furthermore, new tools for identification of homologue polypeptides and precursor peptides in other species are provided.... Agent: Eth Zurich

20140234904 - Method for harvesting photosynthetic unicells using genetically induced flotation: Methods for the harvesting of photosynthetic unicellular organisms are provided, including the formation and expression or overexpression of gas vesicles or vacuole proteins in photosynthetic unicellular organisms. DNA constructs as well as methods for integration of the DNA constructs into the genomes of photosynthetic unicellular organisms for the formation and... Agent: University Of Wyoming

20140234901 - Method for secretory production of protein: A novel technique for improving ability for secretory production of a multimeric protein of a coryneform bacterium is provided, and thereby a method for secretory production of a multimeric protein is provided. A multimeric protein is produced by secretory production utilizing a coryneform bacterium having an ability to produce a... Agent: Ajinomoto Co., Inc.

20140234902 - Methods for producing modified glycoproteins: Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower... Agent: Glycofi, Inc.

20140234900 - Methods for the release of virus-like particles: The present invention relates to methods for the release of baculovirus-expressed Virus-like Particles (VLP's) of non-enveloped viruses from insect cells.... Agent:

20140234906 - Alpha-amylase variants and polynucleotides encoding same: The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.... Agent:

20140234905 - Cell culture improvements: The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.... Agent: Abbvie Inc.

20140234907 - Polypeptides having endoglucanase activity and polynucleotides encoding same: Provided are isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes Inc.

20140234908 - Use of non-subtype b gag proteins for lentiviral packaging: The invention encompasses a lentiviral packaging vector comprising a non-subtype B gag-pol sequence, particularly a subtype D gag-pol sequence. The invention further encompasses methods for making and using these vectors. The invention further encompasses lentiviral vector particles comprising HIV-1 non-subtype B Gag and/or Pol proteins.... Agent:

20140234909 - Dna polymerases with increased 3'-mismatch discrimination: Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Roche Molecular Systems, Inc.

20140234910 - Methods for nucleic acid manipulation: A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity... Agent:

20140234914 - Aspergillus fumigatus cellulolytic enzyme compositions and uses thereof: The present invention relates to recombinant Trichoderma host cells producing Aspergillus fumigatus cellulolytic enzyme compositions and methods of producing and using the compositions.... Agent: Novozymes, Inc.

20140234915 - Cellulolytic enzyme compositions and uses thereof: The present invention relates enzyme composition comprising a cellulolytic preparation and an acetylxylan esterase (AXE); and the used of cellulolytic enzyme compositions for hydrolyzing acetylated cellulosic material. Finally the invention also relates to processes of producing fermentation products from acetylated cellulosic materials using a cellulolytic enzyme composition of the invention.... Agent:

20140234912 - Method for generating human milk oligosaccharides (hmos) or precursors thereof: A method for generating human milk oligosaccharides (HMOs) or precursors thereof, compounds obtainable by the method, and uses and compositions involving such compounds. The method comprising the steps of a) providing at least one donor selected from the group of compounds of any of formulae 5 to 10, b) providing... Agent: Glycom A/s

20140234913 - Process for treating a substrate with an enzyme: In a process for hydrolyzing plant material in aqueous solution or suspension with an enzyme, the enzyme is delivered in solid form (e.g., as a spray-dried powder) in closed containers (such as paper bags or cardboard boxes), which are added directly in the process (i.e., addition of whole boxes/bags). The... Agent: Novozymes A/s

20140234911 - Systems and methods for hydrolysis of biomass: Systems and methods are disclosed for treating lignocellulosic biomass to be supplied to a fermentation system for production of a fermentation product. The systems and methods comprise pre-treating the biomass into pre-treated biomass and separating the pre-treated biomass into a liquid component comprising sugars and a solids component comprising cellulose... Agent:

20140234916 - Method for producing monatin using an l-amino acid aminotransferase: The present invention provides a methodology for improving a yield of 2R,4R-Monatin. Specifically, the present invention provides a method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R-IHOG with an L-amino acid aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin; a method for producing 2R,4R-Monatin... Agent: Ajinomoto Co., Inc.

20140234917 - Enzymatic preparation of diols: The invention relates to enzymatic methods for hydroxylation in position 2 or 3 of two ends of a substituted or unsubstituted, linear or branched aliphatic hydrocarbons.... Agent: Novozymes A/s

20140234918 - Polypeptides having peroxygenase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s

20140234919 - Simultaneous saccharification and fermentation(ssf) of lignocellulosic biomass for single cell oil production by oleaginous microorganisms: Methods and systems for producing lipids which may be used as biofuel are provided. Sugars produced by pretreatment of lignocellulosic biomass are utilized by heterotrophic oleaginous fungi or yeast to increase their biomass and to produce lipids without prior detoxification of the pretreated biomass. After the fungi/yeast are cultured with... Agent: Washington State University Research Foundation

20140234920 - Variant thioesterases and methods of use: The present invention relates to variant thioesterases and their use in plants, e.g., to increase enzymatic activity and to promote increased production of mid-chain length fatty acids (e.g., 8 to 14 carbons) and at desired ratios. Further disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel... Agent: Solazyme, Inc.

20140234921 - Novel cutinases, their production and uses: The present invention relates to novel polypeptides, or fragments of polypeptides, genes encoding them and means for producing said polypeptides. In detail the invention relates to polypeptides having esterase, suberinase and/or cutinase activity at low pH. This invention relates also to compositions containing the polypeptides and methods of using the... Agent: Teknologian Tutkimuskeskus Vtt

20140234922 - System and method for the production of alkyl esters: A method of producing alkyl esters including processing a high free fatty acid feedstock including a mixture of triglycerides and free fatty acids to remove water and solids to create a processed feedstock. The processed feedstock is introduced and mixed into a reaction vessel, the reaction vessel includes water, at... Agent: Viesel Skunk Works, LLC

20140234923 - Fermentation of glycerol to organic acids: The present invention is in the field of producing organic acids and other useful chemicals via biological fermentation using glycerol as a source of carbon. Novel microorganisms and fermentation processes are described that are capable of converting glycerol to useful organic acids in high yield and high purity.... Agent: Myriant Corporation

20140234924 - Variants of glycerol dehydrogenase having d-lactate dehydrogenase activity and uses thereof: The present invention provides methods of designing and generating glycerol dehydrogenase (GlyDH) variants that have altered function as compared to a parent polypeptide. The present invention further provides nucleic acids encoding GlyDH polypeptide variants having altered function as compared to the parent polypeptide. Host cells comprising polynucleotides encoding GlyDH variants... Agent:

20140234925 - Methods for improving malic acid production in filamentous fungi: The present invention relates to methods of producing a C4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a C4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous... Agent: Novozymes, Inc.

20140234927 - Production method for organic acid using coa-transferase: The present invention relates to a method of producing organic acids, comprising biochemical synthesis of organic acid-CoA using acetyl-CoA as a substrate and conducting CoA elimination reaction of the organic acid-CoA using CoA transferase in the presence of acetic acid, in which organic acid is obtained by culturing transformed microorganisms... Agent: Showa Denko K.k.

20140234926 - Recombinant anaerobic acetogenic bacteria for production of isoprene and/or industrial bio-products using synthesis gas: This invention provides for recombinant anaerobic acetogenic bacterial cells having one or more nucleic acids whereby isoprene, mevalonate and/or other industrial bio-products are produced in a substantially oxygen-free culture condition using synthesis gas as energy and/or carbon source.... Agent: Danisco US Inc

20140234928 - Production of carotenoids in oleaginous yeast and fungi: The present invention provides systems for producing engineered oleaginous yeast or fungi that express retinolic compounds.... Agent: DsmIPAssets B.v.

20140234929 - Processes and systems for alcohol production and recovery: The present invention relates to processes for recovering butanol produced in a fermentative process using, for example, an ethanol production plant which has been reversibly-retrofitted for butanol production, that is, the ethanol production plant may be converted for butanol production, but can also revert to an ethanol production. The present... Agent: Butamax Advanced Biofuels LLC

20140234930 - Sorghum with increased sucrose purity: The invention relates to materials and methods for increasing the sucrose purity and total sugar content in stalks of sorghum plants at maturity. The methods involve an inbred or an F1 hybrid transgenic sorghum plant containing transgenes that affect developmental stages such as spikelet meristem identity, establishment of floral meristem... Agent:

20140234931 - Bgl6 beta-glucosidase and nucleic acids encoding the same: The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl6, and the corresponding BGL6 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL6, recombinant BGL6 proteins and methods for producing the same.... Agent: Danisco US Inc.

20140234932 - Bgl7 beta-glucosidase and nucleic acids encoding the same: The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL7, recombinant BGL7 proteins and methods for producing the same.... Agent: Danisco US Inc.

20140234933 - Egvii endoglucanase and nucleic acids encoding the same: The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same.... Agent: Danisco US Inc.

20140234934 - Process for producing high value products from biomass: A process for converting biomass into high value energy products is provided comprising the steps of: debarking, chipping, and screening wood; separating a plurality of hemicellulose from a plurality of cellulose and lignin; hydrolyzing the plurality of hemicellulose into monosaccharides; fermenting the monosaccharides using immobilized Pachysolen tannophilus; removing the lignin... Agent: Geosynfuels, LLC

20140234935 - Method for producing ethanol using cellulosic biomass as raw material: According to the method of the present invention, a cellulosic biomass slurry whose concentration of cellulosic biomass between 1% and 5% by mass is hydrothermally treated at a temperature of between 140° C. and 200° C. a pressure of between 1 MPa and 5 MPa to saccharify/decompose hemicellulose into C5... Agent: Kawasaki Jukogyo Kabushiki Kaisha

20140234936 - Method for producing ethanol using cellulosic biomass as raw material: In the present disclosure, after a volatile organic acid is added as a catalyst to a slurry and the hydrolytic saccharification reaction of hemicellulose is performed, the volatile organic acid (including one added to the slurry and one produced as a by-product) contained in a C5 saccharified solution can be... Agent: Kawasaki Jukogyo Kabushiki Kaisha

20140234937 - Compositions and methods for the production of isoprene: The present disclosure describes compositions and methods for production of isoprene from lignocellulosic plant biomass using a genetically engineered strain of a saprophytic bacteria.... Agent: Aemetis, Inc.

20140234938 - Harmonic generation for activation of species and/or delivery of species to a target environment: Systems and methods for the activation of species and/or the delivery of species to a target environment using harmonic generation materials are generally described.... Agent: Massachusetts Institute Of Technology

20140234939 - Benzamide compounds and related methods of use: Benzamide compounds and derivatives thereof, as can be used for selective inhibition of the SIRT2 enzyme and/or therapeutic use in the treatment of Huntington's disease.... Agent: Northwestern University

20140234940 - Mutant rb69 dna polymerase: Provided herein are mutant DNA-dependent polymerases which are derived from, or otherwise related to, wild type RB69 DNA polymerase. These mutant polymerases are capable of selectively binding labeled nucleotides. These mutant polymerases are also capable of incorporating a variety of naturally occurring and modified nucleotides, including, for example, terminator nucleotides.... Agent: Life Technologies Corporation

20140234941 - Phosphatidic acid phosphatase gene: The present invention provides a novel phosphatidic acid phosphatase gene. The object of the present invention can be solved by providing a nucleic acid comprising the nucleotide sequence set forth in SEQ ID NO: 1, SEQ ID NO: 4, or SEQ ID NO: 5; a protein comprising the amino acid... Agent: Suntory Holdings Limited

20140234942 - Substrates and methods for collection, stabilization and elution of biomolecules: A solid substrate for the extraction, stabilization, and storage of proteins is provided. The substrate includes: a polysaccharide, such as melezitose under a substantially dry state. The substrate is configured to extract proteins from a sample and stabilize the extracted proteins in a dry format under ambient conditions for a... Agent: General Electric Company

20140234943 - Viruses lacking epithelial cell receptor entry: The document provides nucleic acids, polypeptides, and viruses containing nucleic acids and/or polypeptides. The document also provides methods for using viruses to treat cancer patients. Specifically, the document provides nucleic acid molecules encoding viral hemagglutinin (H) polypeptides, viral H polypeptides, and viruses containing nucleic acids and/or H polypeptides. Such viruses... Agent: Mayo Foundation For Medical Education And Research

20140234944 - Green process for producing polyhydroxyalkanoates and chemicals using a renewable feedstock: Disclosed are organisms genetically engineered to make useful products when grown on ethanol as a carbon source. The organisms are genetically engineered to produce various useful products such as polyhydroxyalkanoates, diols, diacids, higher alcohols, and other useful chemicals.... Agent: Metabolix, Inc.

20140234945 - Transthyretin variants: The present invention provides a means for increasing the serum half-life of a selected biologically active agent by utilizing transthyretin (TTR) as a fusion partner with a biologically active agent. Specifically, the present invention provides substantially homogenous preparations of TTR (or a TTR variant)-biologically active agent fusions and PEG-TTR (PEG-TTR... Agent: Amgen Inc.

20140234946 - Carbon sequestration methods and systems, and compositions produced thereby: Aspects of the invention include methods of removing carbon dioxide (CO2) from a CO2 containing gas. In some instances, the methods include contacting CO2 containing gas with a bicarbonate buffered aqueous medium under conditions sufficient to produce a bicarbonate rich product. Where desired, the resultant bicarbonate rich product or a... Agent: Blue Planet, Ltd.

20140234947 - Treatment of lignocellulosic material: Method and apparatus for making biofuels such as biodiesel and bioethanol or animal foodstuff by treating lignocellulosic material by subjecting the material to microwave radiation at the resonant frequency of the lignin to dissociate the lignin.... Agent: Biofuels Wales, Ltd.

20140234948 - Molecular motor: A molecular motor in which multiple concentric cylinders (or nested cones) rotate around a common longitudinal axis. Opposing complementary surfaces of the cylinders or cones are coated with complementary motor protein pairs (such as actin and myosin). The actin and myosin interact with one another in the presence of ATP... Agent: The Usa, As Represented By The Secretary, Dep. Of Health And Human Services

20140234949 - Systems and methods for fluid and component handling: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that... Agent: Theranos, Inc.

20140234950 - Culture containers with internal top coating over gas barrier coating and associated methods: A container for culturing a test sample includes a molded monolithic single layer polymeric container body having an upwardly extending, visually transmissive wall with an inner surface and a wall thickness that is between about 0.2 mm and 10 mm. The container also has a thin gas barrier coating comprising... Agent:

20140234952 - Diagnostic apparatus: There is described a diagnostic apparatus (1) for analysing a blood sample, the apparatus comprising a luminometer (9) for generating a “luminescence curve” and white blood cell counters (5,7) for determining a lymphocyte count and a neutrophil count, and processing means (10) to determine a physical condition of the subject... Agent:

20140234951 - Mixing bag with integral sparger and sensor receiver: A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.... Agent: Pall Technology Uk Limited

20140234953 - Fabrication of vascularized tissue using microfabricated two-dimensional molds: Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold... Agent: The Charles Stark Draper Laboratory

20140234954 - Methods and apparatus for independent control of product and reactant concentrations: A microreactor with a reaction chamber comprising two sub-chambers with reconfigurable volumes, an input conduit with input valve, an un-filtered output conduit with first output valve, and a filtered output conduit with a second output valve is used to perform a method to control a different dilution rate for cells... Agent: Pharyx, Inc

20140234955 - Cell culture device: There is provided a cell culture device including a cell chip receiving part coupled to a cell chip and having at least one passage through which a liquid-type medium is circulated, and a vortex generation part formed in the passage to generate a vortex in the liquid-type medium.... Agent: Samsung Electro-mechanics Co., Ltd.

20140234956 - Living cell cryopreservation tool: A living cell cryopreservation tool has a living cell holding member having a body part and a living cell holding part and a tubular accommodation member, closed at one end thereof, which is capable of accommodating the living cell holding member. The living cell holding part has a long and... Agent:

20140234957 - Engineered cellular pathways for programmed autoregulation of differentiation: The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type. A quorum sensing systems that regulates the expression of cell fate regulators is introduced into... Agent: The Trustees Of Princeton University

20140234958 - Gene delivery system and method of use: A recombinant replication competent retrovirus for gene deliver and gene therapy is provided. The recombinant retrovirus has a heterologous nucleic acid sequence, a sequence encoding a cell- or tissue-specific ligand or a sequence for transcriptional targeting, or a combination of both a cell- or tissue-specific ligand and a cell- or... Agent: University Of Southern California

20140234959 - Method and device for removing particles from liquid and placing them into a holding device: Methods, devices, and systems are disclosed for collecting or gathering samples, such as zebrafish or zebrafish eggs or embryos, dispersed in a liquid and transferring the collected or gathered samples into discrete receptacles of a holding fixture (e.g. the wells of a multi-well plate, a Petri dish, or any other... Agent:

20140234960 - Methods and compositions for mesenchymal stem cell proliferation: Provided is a method for increasing proliferation of mesenchymal stem cells. The method entails contacting the cells with 6-bromoindirubin-3′-oxime (BIO). This results in robust proliferation and “sternness” in a dose-dependent fashion, as indicated by the gene expression of two stem cell genes: Sox2 and Nanog.... Agent: University Of Rochester

20140234962 - Ligands modified by circular permutation as agonists and antagonists: The present invention provides fusion polypeptides comprising polypeptide ligands that are modified by circular permutation and fused to at least one polypeptide fusion partner wherein such fusion polypeptides have new, improved or enhanced biological functions or activities. Such improvements include, but are not limited to, increased binding affinity, increased activity,... Agent: Alkermes, Inc.

20140234961 - Synthetic single chain variable domain (scfv) immunoglobulin fragment vehicle containing fusion proteins for targeted introduction of sirna: A fusion protein and process are provided by which double-stranded RNA containing small interfering RNA nucleotide sequences is introduced into specific cells and tissues. A cell surface receptor specific synthetic single chain variable domain (scFv) immunoglobulin fragment vehicle specific to a cell surface receptor of the cell and having a... Agent:

20140234963 - Efficient induction of definitive endoderm from pluripotent stem cells: The present invention relates to a method to differentiate pluripotent stem cells to a primitive streak cell population, in a stepwise manner for further maturation to definitive endoderm.... Agent: Novo Nordisk A/s

20140234964 - Novel methods and formulations for orthopedic cell therapy: Aspects of the present invention include methods and compositions related to the production and use of clonal lineages of embryonic progenitor cell lines derived from differentiating cultures of primordial stem cells, in particular, said methods and compositions relate to methods of differentiating cells in the presence of BMP family mambeis... Agent:

20140234965 - Triazine derivatives as differentiation catalysts: A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (I), wherein X is independently —NR4— or —O—, R4 is hydrogen or C1-6-alkyl; R1 is hydroxy, C1-6-alkyl, C1-6-alkoxy, carboxy, C1-6-alkoxycarbonyl, halo, cyano, nitro, formyl, amino, C1-6-alkylamino, or di-C1-6-alkylamino,... Agent: Technische Universitaet Wien

20140234966 - Albumin formulation and use: The invention relates to a new formulation of albumin, a method for producing the albumin formulation and to uses of the albumin formulation, for example in cell culture such as mammalian cell culture and particularly in stem cell culture.... Agent: Novozymes Biopharma Dk A/s

20140234967 - Method to trigger rna interference: A method to generate siRNAs in vivo is described, as are constructs and compositions useful in the method. The method does not depend on the use of DNA or synthetic constructs that contain inverted duplications or dual promoters so as to form perfect or largely double-stranded RNA. Rather, the method... Agent: State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Stat

20140234968 - Production of parthenogenetic stem cells and patient-specific human embryonic stem cells using somatic cell nuclear transfer: Immunocompatible pluripotent stem cells (pSCs), which include cells compatible with different patient populations or patient-specific cells, find wide application in regenerative medicine therapies. Described herein are immunocompatible pSCs generated using techniques such as parthenogenesis resulting in cells possessing desired haplotypes of reduced zygosity, antigenically compatible with multiple patient populations, or... Agent: Sung Kwang Medical Foundation

20140234969 - Methods for enhancing genome stability and telomere elongation in embryonic stem cells: The disclosure provides methods for increasing genome stability of an embryonic stem (ES) cell or induced pluripotent stem (iPS) cell, increasing telomere length in an ES or iPS cell, or both, for example by contacting an ES or iPS cell with an agent that increases expression of Zscan4 in the... Agent: The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv

20140234970 - Modulation of stem cells using zinc finger proteins: Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stem cells into the desired phenotype, propagating stem cells and/or facilitating cloning.... Agent: Sangamo Biosciences, Inc.

20140234972 - Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are... Agent: The Broad Institute, Inc.

20140234971 - Induction of hemogenic endothelium from pluripotent stem cells: Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hPSCs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hPSCs of a combination of transcription factors as described herein.... Agent: Wisconsin Alumni Research Foundation

20140234973 - Generation of induced pluripotent stem cells from small volumes of peripheral blood: Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from peripheral blood cells, such as human blood progenitor cells, using episomal reprogramming and feeder-free or xeno-free conditions. In certain embodiments, the invention provides novel... Agent: Cellular Dynamics International, Inc.

20140234974 - Use of gene regulatory network logic for transformation of cells: Described herein is a gene regulatory network based focused approach to cell transformation. The methods described herein allow for identification of circuit and sub-circuit repertoires for which modification in a starting cell type can result in generation of a transformed cell type in a durable and persistent manner, without requiring... Agent: California Institute Of Technology

20140234975 - Method for increasing the efficiency of double-strand-break induced mutagenesis: The present invention relates to a method for increasing double-strand-break induced mutagenesis at a genomic locus of interest in a cell, thereby giving new tools for genome engineering, including therapeutic applications and cell line engineering. More specifically, the present invention concerns the combined use of TALEN or meganucleases with TREX2,... Agent: Cellectis

20140234976 - Compositions and methods for conferring herbicide resistance: The present invention provides a protein, specifically Parietochloris incisa acetohydroxyacid synthase, and methods for producing branched-chain amino acid in a cell. The present invention further provides polypeptides and polynucleotides useful for conferring herbicide resistance in a cell or an organism. In particular, the present invention discloses a mutated acetohydroxyacid synthase... Agent: Ben-gurion University Of The Negev Research And Development Authority

  
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