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Chemistry: molecular biology and microbiology

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
05/21/2015 > 124 patent applications in 68 patent subcategories.

20150140543 - Compositions and methods for enhancing the viability of animal cells, tissues, and organ explants: Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site... Agent:

20150140545 - Actuation of parallel microfluidic arrays: An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators,... Agent:

20150140544 - Bioreactor system and method for cloning the physiological state of microorganisms: Bioreactor system and method for cloning the physiological state of microorganisms comprises in preferred embodiment of a mother-reactor and one or more daughter-reactors with sensors, stirrers, fluid and gas flow channels, scales, pumps, controllers, computer, software, valves and accessory devices. The bioreactors are inter-connected with culture transfer hose. To achieve... Agent:

20150140546 - Detecting components of a composite fluid: Described are embodiments for determining components of a composite liquid and controlling the flow of the components into containers. In one embodiment, components of whole blood, after separation, are determined and directed to different containers for collection and storage. Embodiments may be implemented on an apparatus configured to separate multiple... Agent: Terumo Bct, Inc.

20150140551 - Device and method for investigating one or a plurality of phase objects: A method for investigating one or a plurality of phase objects is described, in which a grid made up of elements is used, which is illuminated with light of a light source, the coherence length of which is larger than the average spacing of adjacent elements of the grid. A... Agent:

20150140548 - Extraction control for rna: The present invention relates to compounds for use in the control of extraction procedures, in particular in connection with nucleic acid material for use in PCR, in particular RT-PCR and more preferably real-time RT-PCR (quantitative PGR). The extraction control according to the present invention is based on plant virus material... Agent: Vela Operations Pte. Ltd.

20150140547 - Methods and compositions for assessing copy number of target polynecleotides: The present invention relates to methods and compositions for assessing copy number of a target polynucleotide in a sample, methods and compositions for establishing a standard curve for a target polynucleotide, and the uses of the methods and compositions for detecting a pathogen, e.g., human papillomavirus (HPV).... Agent: Ningbo Health Gene Technology Co., Ltd.

20150140550 - Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions: Methods for aiding in the diagnosis of disorders including, but not limited to, PDDs (Pervasive Development Disorders), Dysautonomic disorders, Parkinson's disease and SIDS (Sudden Infant Death Syndrome). In one aspect, a diagnosis method comprises analyzing a stool sample of an individual for the presence of a biological marker (or marker... Agent:

20150140549 - Polymersome encapsulation of hydrophobic fluorescent polymers: Described herein are aqueous soluble polymersomes that encapsulate one or more hydrophobic fluorescent polymers and methods of their preparation and use.... Agent:

20150140552 - Quantitative analyte assay device and method: The present invention related to a quantitative assay device and a method for the determination of an analyte, based on a test strip, which contains a porous test membrane allowing for capillary flow of the analyte and complexes of the analyte, a porous upstream membrane in fluid connection with the... Agent:

20150140553 - High efficiency multiplexed nucleic acid capture in a structured microenvironment: Provided herein is a method for sample analysis. In some embodiments, the method may involve: a) enzymatically attaching a reactive group to nucleic acid molecules in a sample; b) covalently reacting the reactive group with surface exposed reactive sites on a porous support, thereby covalently tethering the nucleic acid molecules... Agent:

20150140560 - Asynchronous magnetic bead rotation (ambr) microviscometer for analysis of analytes: The disclosure provides a label-free viscosity-based analyte detection system using paramagnetic beads as an asynchronous magnetic bead rotation (AMBR) microviscometer. It is disclosed herein that the bead rotation period is linearly proportional to the viscosity of a solution comprising analytes surrounding the paramagnetic bead. Optical measurement of asynchronous microbead motion... Agent:

20150140561 - Compound for sequencing by synthesis: The present invention provides deoxynucleoside tri- or tetraphosphate comprising a 3′ nitrate and a detectable label covalently bound to the oxygen atom of an oxymethyl or oxyallyl or oxypropargyl substitution of a nucleobase. Such compounds provide new possibilities for future Sequencing by Synthesis technologies.... Agent:

20150140554 - Detection methods for target dna: The invention pertains to a safe, quick and reliable method of detecting the presence of a target DNA sequence in a sample. The invention also pertains to a system for detecting presence of a target DNA sequence in a biological sample. The system includes an ITC template that includes a... Agent:

20150140563 - Lab on chip cartridge: A cartridge for an optical analysis, including a supporting body, having a first face and a second face opposite to one another; a plurality of wells adapted to receive a biological solution to be analyzed, the wells extending in the supporting body on the first face; at least one biocompatible... Agent:

20150140562 - Lab on chip image analysis: An optical analyzer, configured to receiving a cartridge for biochemical analyses including a plurality of wells, and carrying out fluorescence analysis of the cartridge, in particular of the wells. The analyzer comprises a control unit (microprocessor and memory) configured to: (a) acquiring an image associated to the fluorescence emitted by... Agent:

20150140555 - Method of identifying foetal erythroblast: There is provided a method for identifying at least one foetal erythroblast the method comprising: (a) detecting the expression of at least one foetal erythroblast specific marker selected from the group consisting of neutral amino acid transporter B (SLC1A5), solute carrier family 3 (activators of dibasic and neutral amino acid... Agent:

20150140558 - Methods of identifying and isolating cells using molecular beacons: Methods are provided for isolating lineage-specific cells from a population of cells using molecular beacons which bind to mRNA markers and then isolating the lineage specific cells from the population of cells based on the label of the molecular beacon.... Agent:

20150140557 - Methods, compositions, and kits for detecting allelic variants: In some embodiments, the present inventions relates generally to compositions, methods and kits for use in discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides for compositions, methods and kits for quantitating rare (e.g., mutant) allelic variants, such as SNPs, or nucleotide (NT) insertions... Agent:

20150140559 - Nucleotides and nucleosides and methods for their use in dna sequencing: The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, photocleavable, enzymatically cleavable, or non-photocleavable groups and methods for their use in DNA... Agent: Lasergen, Inc.

20150140556 - Optical fiber with grating and particulate coating: The present invention provides, in addition to other things, methods, systems, and apparatuses that involve the use of an optical fiber with grating and particulate coating that enables simultaneous heating; optical detection; and optionally temperature measurement. Methods, systems, and apparatuses of the present invention may be used in many applications... Agent:

20150140566 - Inflammation-enabling polypeptides and uses thereof: This present technology relates to the use of inflammation-enabling polypeptides (or their coding sequences) to screen for agents useful for the prevention, treatment and/or alleviations of symptoms associated with an inflammatory disorder, to identify individuals susceptible of developing an exacerbated inflammatory response as well as to determine if a therapeutic... Agent:

20150140565 - Method for digesting biological cells: A method for digesting biological cells in a reaction container includes treating the cells with pressure pulses. The pressure pulses are generated by at least one eddy current actuator in conjunction with an electric conductor arranged on or in the reaction container.... Agent:

20150140567 - Nucleic acid amplification: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases and primers.... Agent:

20150140568 - Reference markers for biological samples: DNA oligomers comprising sequences that are absent from the genome of one or more organisms of interest are used as reference markers (RMs). The RMs are added to biological samples to “tag” and subsequently identify the samples as authentic and to distinguish tagged samples from samples obtained without said markers,... Agent:

20150140564 - Selective-competitive primer and method of use: Disclosed herein is a self-competitive primer for preferentially amplifying a sample nucleic acid based on whether a selected region thereof has a nucleotide variation, in comparison with a selected region of a reference nucleic acid. The self-competitive primer includes a 5′-competing domain and a 3′-elongating domain. Sequences of the 5′-competing... Agent: Mackay Memorial Hospital

20150140571 - Antigen detection method which uses lectin and comprises enzyme treatment step: An antigen detection method detects an antigen having a specific sugar chain in a sample with a lectin that binds to plural kinds of sugar chains including the specific sugar chain. The detection method includes: a first step of bringing the lectin into contact with the sample; a second step... Agent: Konica Minolta, Inc.

20150140572 - Composition for use in mycobacteria diagnosis: The present invention relates to a composition having the activity of degrading the cell wall of a Mycobacterium species comprising: (a) a first fusion protein including (i) a domain with a first enzymatic activity, the enzymatic activity being at least one or more of the following: N-acetyl-b-D-muramidase (lysozyme, lytic transglycosylase),... Agent:

20150140569 - Elispot diagnostic kit for neuromyelitis optica and its application: An ELISpot diagnosis kit for NMO and its application are characterized in that, the polypeptide fragment specific to NMO effector T-cell is obtained through topological conformation analysis of aquaporin-4 (AQP-4), followed by the structural analyses of the related polypeptides after combination and rearrangement so as to screen out the brand-new... Agent:

20150140570 - High-speed two-step incubation method and apparatus for in-vitro diagnostic testing: An incubator including a container having an interior chamber capable of receiving a sample holder having samples, a lower heated surface disposed within the interior chamber of the container, and a movement mechanism coupled to the container and the lower heated surface. In one embodiment, the movement mechanism is configured... Agent:

20150140576 - Cancer specific glycans and use thereof: The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention describes methods to detect cancer specific glycans as well as methods for the production of reagents binding to said glycans. The invention is also directed to the use of... Agent: Glykos Finland Oy

20150140577 - Optical engine for flow cytometer, flow cytometer system and methods of use: An optical engine for use in a bench top flow cytometer, the optical engine comprising a set of lasers; a different set of beam shaping optics for each laser, wherein each set comprises two lenses to adjustably focus light horizontally along an x-axis to a same horizontal position and vertically... Agent:

20150140579 - In vitro diagnosis device and uses thereof: The invention relates to an in vitro diagnosis device (10) for the detection of at least one reaction between an erythrocytic phenotype antigen and an antibody specifically directed against said antigen in a sample of blood or one of the components thereof. The device is characterised in that it comprises:... Agent: Abo Diag

20150140578 - Methods and devices for sample testing and evaluation: Methods and devices for evaluating a sample from a subject for the presence of a mixed population of cells, e.g., a sample having more than one distinct populations of cells, e.g., red blood cells (RBCs). Also included are methods and devices for Coombs crossmatch and DAT testing.... Agent:

20150140573 - Assays for detecting glucosidase activity: The present invention relates to a method of detecting α-(1→6)-glucosidase activity in a sample. The method is for example useful for determining the limit dextrinase activity in a sample. The method involves use of an oligosaccharide substrate of the formula X-(glucoside)n-*(glucoside)m-Z—Y, where X is a blocking group, -* is a... Agent:

20150140574 - Method for producing horseradish peroxidase recombinant protein using filamentous fungus: A modified polynucleotide has a different base sequence in at least one codon from a wild-type base sequence encoding a horseradish peroxidase polypeptide. The usage frequency of the modified codon of the polynucleotide corresponds to the codon usage frequencies of three filamentous fungal species in Humicola, Aspergillus, and Trichoderma. The... Agent: Meiji Seika Pharma Co., Ltd.

20150140575 - Methods for determining ligand binding to a target protein using a thermal shift assay: The invention is directed to a method of determining whether a non-purified sample contains a target protein bound to a ligand of interest comprising the steps of: a) exposing said non-purified sample to a temperature which is capable of causing or enhancing precipitation of the unbound target protein to a... Agent: Evitraproteoma Ab

20150140580 - Antibodies to matrix metalloproteinase 9: The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an... Agent: Gilead Biologics, Inc.

20150140581 - Microfluidic device for generating neural cells to simulate post-stroke conditions: This application provides devices for modeling ischemic stroke conditions. The devices can be used to culture neurons and to subject a first population of the neurons to low-oxygen conditions and a second population of neurons to normoxic conditions. The neurons are cultured on a porous barrier, and on the other... Agent:

20150140582 - Immunological test element with improved control zone: The invention concerns a test element for carrying out an immunological sandwich test for determining an analyte from a liquid sample containing a reagent zone or conjugate zone which contains a conjugate of an analyte binding partner and a label which can be detected directly or indirectly by visual, optical... Agent:

20150140583 - Methods, devices, and systems of detecting microorganisms: A rapid, sensitive method of separating and detecting microorganisms from a sample containing microorganisms, such as but not limited to bacteria, fungi, yeast, viruses, and the like. The method relies on separation techniques to separate and concentrate the cells from the sample, together with chemical techniques to amplify the amount... Agent: Celsis International Limited

20150140584 - Reagent materials and associated test elements: Reagent materials and associated test elements are provided. In one embodiment, a test element having dual functionality includes a first coenzyme-dependent enzyme or a substrate for the first enzyme, a second coenzyme-dependent enzyme or a substrate for the second enzyme, and a coenzyme selected from the group consisting of thio-NAD,... Agent:

20150140585 - Gas biosensors: Microbial biosensors that generate gas outputs in hard-to-image materials using exogenous methyl halide transferase (MHT) genes. By varying the promoter that is fused to the MHT gene, biosensors for different triggers can be made.... Agent:

20150140586 - Device for online measurement of neurotransmitters using enzymatic reactors: The invention relates to a device and a method for measuring neurotransmitters in the brain dialysate of mammals using enzymatic reactors specific to a certain neurotransmitter, which generate fluorescent derivatives when mixed. The mixture is introduced into an incubation chamber and passes through a temperature controlling system in order to... Agent:

20150140587 - Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two... Agent:

20150140588 - Lipase variants and polynucleotides encoding same: The present invention relates to variants with improved activity in an amide-bond reaction. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.... Agent: Novozymes A/s

20150140589 - Automated protein digestion, recovery, and analysis: The present disclosure provides an automated system and method for protein digestion, recovery, and analysis. The present disclosure also provides a buffer solution for use therein.... Agent:

20150140590 - Fluorescent probe for cell observation and method using same: The separase sensor of the present invention has two types of fluorescent proteins different in fluorescence wavelength at both ends of an amino acid sequence containing a separase cleavage site and a localization-targeting sequence targeting to a specific site within a cell. Since timing of activating separase and location of... Agent:

20150140591 - Cell engineering using rnas: The invention concerns the field of cell culture technology. It concerns RNA having a specific sequence, expression vectors encoding said RNA, production host cell lines comprising said RNA, and methods of producing recombinant biopharmaceutical products using engineered host cell with altered levels of said RNAs, such as small non-coding RNAs,... Agent:

20150140592 - Development of microorganisms for hydrogen production: Methods and compositions are provided for engineering microorganisms, which permit enhanced H2 production. The methods and compositions provided include novel chimeric gene constructs encoding H2-forming H2ase and maturation proteins, allowing for generation of H2 continuously in large quantities. In one illustrated embodiment, novel engineered algae are provided with increased levels... Agent:

20150140595 - Formulations for the synthesis of paramagnetic particles and methods that utilize the particles for biochemical applications: A set of paramagnetic particles synthesized by co-precipitation methods wherein an alkaline hydroxide solution is mixed with a metal salt solution. The alkaline hydroxide features ammonium hydroxide, potassium hydroxide, sodium hydroxide, or mixtures thereof. The metal salt solution features at least one ferrous salt and at least one tetravalent metal... Agent:

20150140594 - Human taste cells capable of continuous proliferation: The present invention relates to proliferating human taste cells, wherein the cells are the cells deposited under the DSMZ deposit accession number DSM ACC3169 or taste cells derived thereof. The present invention further relates to the proliferating human taste cells of the invention for use in research. Further, the present... Agent:

20150140600 - Mass spectrometry quantitation of p450 isoforms in hepatocytes: A method for screening a drug for cytochrome P450 (CYP) induction is provided and can include incubating the drug with a microsome-containing biological sample and then quantitating at least one cytochrome P450 isoform. The isoforms can be selected from 2B6, 3A4, 1A2, and 3A5 isoforms. In some embodiments, the method... Agent:

20150140598 - Methods of screening sulfated polysaccharides for therapeutic activity for a glycocalyx-related disease: Methods are disclosed for screening sulfated polysaccharides to identify one or more therapeutic agents that can be used for the treatment of a variety of disorders that affect the glycocalyx of a subject. A glycocalyx disease inhibitor identified by the method may increase the production of heparin sulfate or of... Agent:

20150140596 - Microfluidic device, system, and method for tracking single cells and single cell lineages: The present invention relates to a microfluidic device, a microfluidic system, and methods for tracking single cells, multiple cells, single cell lineages, and multiple cell lineages in series and/or in parallel. The microfluidic device comprises a substrate having one microfluidic channel formed therein or a plurality of microfluidic channels formed... Agent: Cornell University

20150140597 - Novel methods of measuring effective density of nanoparticles in fluids: The invention includes a method of determining the effective density of nanomaterial agglomerates in liquids, such as but not limited to physiological fluids, using volumetric centrifugation. The method of the invention allows for the development of reliable and efficient in vitro dosimetry and methods for toxicological testing of engineered nanomaterials.... Agent:

20150140599 - Plant growth regulator and use thereof: A plant growth regulator containing glutathione allows increasing harvest index. This provides a technique for specifying a control factor for a plant, thereby effectively controlling germination, growth, anthesis etc. of the plant.... Agent:

20150140593 - Retention index standards for liquid chromatography: A homologous series of neutrally charged compounds having at least one functional group bearing a positive charge and at least one functional group bearing a negative charge are advantageous retention index standards for liquid chromatography, especially for liquid chromatography-mass spectrometry (LC-MS) methods, more especially for LC-MS methods employing electrospray (ESI)... Agent:

20150140601 - Fixing tissue samples using nitrogen-containing compounds that release aldehydes: A method (100) for fixing at least one tissue sample (1) is carried out using a tissue processor (10). The tissue sample (1) is introduced at a first temperature level and a first pressure level into a fixing reagent (2) containing at least one nitrogen-containing compound capable of pressure- and/or... Agent:

20150140602 - Methods and microbial cultures for improved conversion of lignocellulosic biomass: The present technology pertains to methods and microbial co-cultures for converting lignocellulosic biomass to biofuels and/or other carbon-based chemicals. Aspects of the present disclosure relate to novel consolidated bioprocessing (CBP) methods by which the efficiency of the production of biofuels and/or other carbon-based chemicals from cellulosic biomass-containing materials can be... Agent:

20150140604 - Immobilized cycloaliphatic peptide acyltransferase and preparation method and uses thereof: Disclosed in the present invention are an immobilized cycloaliphatic peptide acyltransferase and a preparation method and use thereof. The cycloaliphatic peptide acyltransferase is immobilized on a carrier; the cycloaliphatic peptide acyltransferase is derived from natural or artificial mutants or variants thereof, or can be obtained by introducing a foreign cyclic... Agent:

20150140603 - Method for the production of a lysate used for cell-free protein biosyntheses: The invention relates to a method for producing a lysate used for cell-fee protein biosynthesis, comprising the following steps: a) a genomic sequence in an organism, which codes for an essential translation product that reduces the yield of cell-fee protein biosynthesis, is replaced by the foreign DNA located under a... Agent: Rina-netzwerk Rna Technologien Gmbh

20150140605 - One step n-terminal tagging of proteins: The invention includes a selective method of modifying the N-terminus of a protein using an aminoacyl tRNA transferase. In certain embodiments, the method comprises contacting a solution of the protein or peptide with a transferase and a derivative of a molecule, whereby the N-terminus of the protein or peptide is... Agent:

20150140607 - Cho expression system: The present invention is within the field of industrial protein production. The inventors have designed and constructed a new expression system comprising an expression vector coding for a glutamine synthetase of human or dog origin, and a CHO cell line. More specifically, the invention pertains to a combination of (i)... Agent: Sanofi

20150140606 - Method of producing sugar liquid: A method of producing a sugar liquid from cellulose-containing biomass includes (1) to (4): (1) subjecting a cellulose-containing biomass to a dilute sulfuric acid treatment and thereafter separating the treated cellulose-containing biomass into a dilute sulfuric acid-treated liquid and a cellulose-containing solid content; (2) adding a cellulase to the cellulose-containing... Agent:

20150140609 - Anti-alpha(v)beta(6) antibodies: Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Q mediated diseases.... Agent:

20150140608 - Methods related to omalizumab: The present invention relates to the characterization and production of omalizumab.... Agent: Momenta Pharmaceuticals, Inc.

20150140610 - Sulfilimine and sulphoxide methods for producing festinavir: A process for making the compound of Formula I utilizes the starting compound, together with sulfilimine and sulfoxide process steps later on.... Agent:

20150140611 - Portable preparation, analysis, and detection apparatus for nucleic acid processing: The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through... Agent:

20150140612 - Methods for increasing enzymatic hydrolysis of cellulosic material: The present invention relates to methods for increasing hydrolysis of a pretreated cellulosic material, comprising subjecting the pretreated cellulosic material to a cellulolytic enzyme composition; a polypeptide having cellulolytic enhancing activity; a Peroxidase; and a nonionic surfactant and/or cationic surfactant, at conditions suitable for hydrolyzing the pretreated lignocellulosic material. The... Agent:

20150140613 - Enhanced fermentation process using molasses: Described herein are compositions and methods for enhanced fermentation of molasses using transglucosidase.... Agent: Danisco US Inc.

20150140614 - Variants of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase: The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed... Agent: Evonik Degussa Gmbh

20150140615 - Method for preparing organic acid by fed-batch-feeding carbon source substrate and base: The present invention provides a fed-batch culture method comprising a step of fed-batch-feeding a carbon source base and a base in such a manner that the pH level can be maintained at a level suitable for the growth of microorganisms for fermentation of a carbon source. The present invention also... Agent:

20150140616 - Process for making furfural: Processes are described for producing furfural from a mixture of pentoses and hexoses, by dehydrating and cyclizing pentoses to provide furfural using a water-soluble acid at elevated temperatures in the presence of a low-boiling, water-immiscible organic solvent, such as toluene, which is effective for extracting the furfural into an organic... Agent: Archer Daniels Midland Company

20150140617 - Candida tropicalis cells and use thereof: The invention relates to genetically engineered Candida tropicalis cells, use thereof and a method of production of ω-hydroxycarboxylic acids and ω-hydroxycarboxylic acid esters.... Agent: Evonik Degussa Gmbh

20150140618 - Lipase in short-chain esterification of fatty acids: Patatin, a lipase obtainable from potatoes, has been found to have advantages in the esterification reaction of fatty acids to yield fatty acid alkyl esters. Methods for application of this lipase activity are described, as well as the use of patatin in various industrial processes.... Agent:

20150140619 - Use of marine algae for co-producing alkenones, alkenone derivatives, and co-products: A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including an alkenone hydrocarbon mixture of the kerosene/jet fuel range (primarily C10-, C12-, and C17-hydrocarbons) and fucoxanthin, a high-valued carotenoid, from the marine alkenone-producing microalgae Isochrysis.... Agent:

20150140620 - Biosynthetic pathways, recombinant cells, and methods: This disclosure describes engineered biosynthetic pathways, recombinant cells, and methods relating to biosynthesis of esters. The recombinant cells may be modified to exhibit increased biosynthesis of an ester compared to a wild-type control. The recombinant cell may be incubated in medium that includes a carbon source under conditions effective for... Agent: Regents Of The University Of Minnesota

20150140621 - Polyhydroxyalkanoate production and related processes: Embodiments of the invention relate generally to processes for the production and processing of polyhydroxyalkanoates (PHA) from carbon sources. In several embodiments, PHAs are produced at high efficiencies from carbon-containing gases through the utilization of a regenerative polymerization system.... Agent:

20150140622 - Reagents and methods for cyanobacterial production of bioplastics and biomaterials: The present invention provides reagents and methods for biomaterial production from cyanobacteria.... Agent:

20150140623 - Synthesis of diester-based lubricants from enzymatically-directed epoxides: The present invention is generally directed to methods of making diester-based lubricant compositions, wherein formation of diester species proceeds via esterification of epoxide intermediates, and wherein the epoxide intermediates are generated via an enzymatically-driven mechanism. In some embodiments, the methods for making such diester-based lubricants utilize a biomass precursor and/or... Agent: Chevron U.s.a. Inc.

20150140625 - Genetically engineered yeast cell capable of producing lactate, method of producing the same, and method of producing lactate by using the cell: A genetically engineered yeast cell capable of producing lactate having increased TPI activity, a method of preparing the yeast cell, and a method of producing lactate by using the yeast cell.... Agent:

20150140626 - Genetically engineered yeast cell producing lactate including acetaldehyde dehydrogenase, method of producing yeast cell, and method of producing lactate using the same: Provided is a genetically engineered yeast cell with lactate production capacity, including an enzyme that catalyzes conversion of acetaldehyde to acetyl-CoA and an enzyme that catalyzes conversion of pyruvate to lactate, which activities are increased compared to a parent cell of the yeast cell, as well as a method of... Agent:

20150140624 - Production of lactic acid from fermentations using mixed bacterial cultures: A method and system for producing lactic acid from biomass materials uses a mixed bacteria culture of at least one homofermentative lactic acid bacteria and at least one heterofermentative lactic acid bacteria in an integrated production system to increase the productivity and yield of lactic acid.... Agent: Jiangsu University

20150140627 - Method for producing bioproducts using hydrolyzed organic wastes of fermentation: Provided is a method for producing bioproducts, including the steps of: culturing a first microorganism to produce bioalcohol; hydrolyzing the first microorganism; separating the bioalcohol; obtaining wastes from the hydrolyzed bioalcohol fermentation; and inoculating a second microorganism into the wastes from the hydrolyzed bioalcohol fermentation.... Agent:

20150140628 - Volatile organic compound recovery system and method: The present invention provides for passive V0C recovery in the fermentation process that does not affect or minimally affects the conditions within the fermentor vessel and does not affect or minimally affects the conditions within the headspace of the fermentor vessel itself while using the production of CO2 emitted during... Agent:

20150140629 - Alcoholic fermentation process in the presence of a high alcohol tolerant yeast and a maltotriose positive yeast: The invention relates to an alcoholic fermentation process in the presence of one or more high alcohol tolerant yeast and one or more maltotriose positive yeast. The process of the present invention can be a fermentation process for the production of ethanol, for the production of beer, for the production... Agent: Cargill, Incorporated

20150140630 - Manure treatment process with anaerobic digester: A process is provided for converting waste fibers to solid fuel. The process includes providing a supply of animal waste including the waste fibers in a predetermined quantity, subjecting the supply of animal waste to anaerobic digestion, producing a waste byproduct, dewatering the waste byproduct, and compressing the dewatered waste... Agent:

20150140631 - Production of volatile dienes by enzymatic dehydration of light alkenols: Described is a method for generating conjugated dienes through a biological process. More specifically, the application describes a method for producing conjugated dienes (for example butadiene, isoprene or dimethylbutadiene) from light alkenols via enzymatic dehydration, in particular by making use of an alkenol dehydratase.... Agent:

20150140632 - System and method for renewable resource production, for example, hydrogen production by microbial, electrolysis, fermentation, and/or photosynthesis: System and method for sustainable economic development which includes hydrogen extracted from substances, for example, sea water, industrial waste water, agricultural waste water, sewage, and landfill waste water. The hydrogen extraction is accomplished by thermal dissociation, electrical dissociation, optical dissociation, and magnetic dissociation. The hydrogen extraction further includes operation in... Agent:

20150140633 - System and method for proliferation of stem cells in cellular tissue: A method and a system are provided for subjecting organic cells in a region of a subject to an extremely low frequency magnetic field. At least one resonance medium is operably connected to a generator. The generator produces a sinusoidal non-harmonic current signal, having a predetermined frequency of substantially between... Agent:

20150140634 - Method for producing a polymer product from multidimensional aggregated components as barrier or carriers of living microbial cells and biological barriers in plastic and textile: This invention relates to a polymer product comprising the components consisting of a polymer in form of granules; a multidimensional structure containing amphiphilic molecules, such as lipids, surfactants or polymers, wherein said polymer product has an active and/or passive oxygen or CO2 barrier, with an UV blocking activity or with... Agent:

20150140635 - Boronic and borinic acid compound as inhibitors of sulfenic acid-containing proteins: A boronic or borinic acid compound is used to inhibit the activity of a sulfenic acid-containing protein. Thus, a biologically-active sulfenic acid-containing protein is contacted with an activity-inhibiting effective amount of a boronic or borinic acid compound of Formula I or a salt, hydrate or solvate thereof, whose components are... Agent:

20150140636 - Polynucleotides encoding mutant hydrolase proteins with enhanced kinetics and functional expression: The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.... Agent: Promega Corporation

20150140637 - Process for the separation of a mixture of a protein and its reaction product with a polyalkylene glycol: The present invention relates to a process for the separation of a mixture of a protein and its reaction product with a polyalkylene glycol, comprising the steps: a) providing a mixture comprising the protein and the reaction product in a fluid, b) bringing the mixture of step a) into contact... Agent:

20150140638 - Polypeptides having endoglucanase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having endoglucanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent:

20150140639 - Vectors with modified initiation codon for the translation of aav-rep78 useful for production of aav: The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the... Agent:

20150140640 - Process for growing natural or engineered high lipid accumulating strain on crude glycerol and/or other sources of waste carbon for the production of oils, fuels, oleochemicals, and other valuable organic compounds: Disclosed herein are microorganisms capable of growing on crude glycerol and/or glycerol and/or methanol, or combinations thereof. In some embodiments the microorganisms are knallgas bacteria that produce or secrete at least 10% of lipid by weight. Also disclosed are methods of converting crude glycerol and/or glycerol and/or methanol produced as... Agent: Kiverdi, Inc.

20150140641 - Endoglucanase variants: The present invention relates to variant endoglucanases having improved thermoactivity, improved thermostability, and improved viscosity reduction activity over wild-type M. thermophila endoglucanase.... Agent:

20150140642 - Method of promoting growth of green algae: Provided is a method of culturing green algae which promotes the growth of the green algae which is in a state of being a green swarm cell by irradiating the green algae that accumulate astaxanthin with an artificial light, in which the green algae are grown in a liquid medium... Agent: Showa Denko K.k.

20150140643 - Biological odor control system: A biological odor control system includes a vessel and a nutrient tank mounted and attached to an outer surface of the vessel such that the nutrient tank does not extend into a housing of the vessel. The vessel can include a housing, a gas inlet, a gas outlet, a first... Agent:

20150140644 - Treatment of leaf tissue for the recovery of interstitial recombinant proteins by the application of cell wall degrading enzymes: The present disclosure relates to methods of increasing the purity of an apoplast-targeted recombinant protein recovered from a plant tissue, and increasing the yield of recovery of an apoplast-targeted recombinant protein from a plant tissue.... Agent:

20150140645 - Microfluidic analysis system: A thermal cycling device (3) device a number of fixed thermal zones (11, 12, 13) and a fixed conduit (10) passing through the thermal zones. A controller maintains each thermal zone including its section of conduit (10) at a constant temperature. A series of droplets flows through the conduit (10)... Agent:

20150140646 - Systems and methods for detection and quantification of analytes: Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a... Agent:

20150140647 - System for the execution, traceability, monitoring and control of a method of reducing the bacterial count in a confined environment: A system (1) for the execution, traceability, monitoring and control of reducing the bacterial count in a confined environment, includes an environment identification device (2) arranged to contain information relating to the confined environment. A device (3) for micronizing air-dispersed decontaminant substances is arranged to diffuse through a diffuser (9)... Agent:

20150140648 - Disposable chip-type flow cell and flow cytometer using same: The present invention provides an apparatus for analyzing particles in a solution including a unit configured to place a flow cell having a flow path for flowing a sample solution containing the particles; a unit configured to illuminate the sample solution flowing through the flow path of the flow cell;... Agent: On-chip Biotechnologies Co., Ltd.

20150140649 - Nucleic acid extraction device: A nucleic acid extraction device includes: a tube section in which are disposed in this order a first plug formed of oil, a second plug formed of a washing liquid immiscible with oil and for washing a substance adsorbing a nucleic acid, a third plug formed of oil, a fourth... Agent:

20150140650 - Systems and methods for cryopreservation of cells: An auto-nucleating device includes a tube containing a crystalline cholesterol matrix. The ends of the tube are closed by a membrane that is impermeable to the cholesterol but permeable to liquids contained in a cryopreservation vessel. The auto-nucleating device provides a site for ice nucleation during freezing of the liquid... Agent:

20150140655 - Apparatus and methods for sperm separation: Various embodiments of methods and apparatuses for separating sperm, including apparatus having an inlet and an outlet reservoir, and either: i) a radial array of microchannels disposed between the inlet and outlet reservoirs to provide fluid communication therebetween and to direct motile sperm inwardly from the inlet reservoir to the... Agent: The Royal Institution For The Advancement Of Learning/mcgill University

20150140653 - Expanding cells in a bioreactor: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured... Agent: Terumo Bct, Inc.

20150140654 - Expanding cells in a bioreactor: Described are embodiments for expanding cells in a bioreactor. In one embodiment, methods are provided that distribute cells throughout the bioreactor and attach cells to specific portions of a bioreactor to improve the expansion of the cells in the bioreactor. Embodiments may be implemented on a cell expansion system configured... Agent: Terumo Bct, Inc.

20150140651 - Surgical technique for harvesting autogenous symphysis graft: A surgical technique for harvesting an autogenous symphysis bone graft including making a single vertical incision to the symphysis area of a patient and harvesting bone from the symphysis area of the patient's mandible. The single vertical incision is made parallel to muscle fibers of the patient's chin.... Agent:

20150140652 - Vessel for culturing human es cells: Provided are a culture vessel with which an embryonic body can be formed efficiently from human embryonic stem cells, and a method for culturing human embryonic stem cells using the vessel. There is provided a vessel for culturing human embryonic stem cells, the culture vessel having two or more wells... Agent: Sumitomo Bakelite Co., Ltd.

20150140656 - Method of freezing cells: The present invention is a method of freezing cells comprising the steps of incubating said cells in a solution comprising a cryoprotective agent, concentrating the cells resulting from the previous step withdrawing the eluent essentially free of cells, and freezing the resulting concentrated cells. The cells frozen by the invention's... Agent:

20150140658 - Lineage reprogramming to induced cardiac progenitor cells (icpc) by defined factors: Animal cells, notably adult fibroblasts, are advantageously reprogrammed in direct lineage reprogramming methods using defined factors to produce proliferative and multipotent induced cardiac progenitor cells (iCPC). The iCPC thus produced can be differentiated under suitable differentiation conditions to cardiac lineage cells including cardiomyocytes, smooth muscle cells, and endothelial cells, as... Agent:

20150140657 - Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts: This invention provides methods of generating natural killer (NK) cells and dendritic cells (DCs). The methods utilize human hemangioblasts as intermediate cells to generate the NK cells and DCs. In various embodiments, the methods do not require the use of stromal feeder layers.... Agent: Stem Cell & Regenerative Medicine International, Inc.

20150140660 - Hydrogen cyanide-based polymer surface coatings and hydrogels: The present invention provides a process of coating at least a portion of a substrate surface comprising contacting the surface with hydrogen cyanide monomeric units under conditions permitting polymerisation of the hydrogen cyanide monomeric units to form a polymer that coats the surface. Also provided is a substrate coated by... Agent:

20150140659 - Three-dimensional cell culture system and manufacturing method thereof: A three-dimensional cell culture system for an imaging system to observe a cell image includes at least two cell culture layers formed by a solution having a photo-polymerizable monomer, a bio-molecule, an acoustic scattering medium solution and a cell culture medium. After placing a cell into the two cell culture... Agent: National Taiwan University

20150140661 - Method for producing pancreatic hormone-producing cell, pancreatic hormone-producing cell, and differentiation/induction promoter: The method for producing a pancreatic hormone-producing cell according to the present invention is characterized in that a specific differentiation/induction promoter is added to a culture medium in the process of differentiating/inducing of a pluripotent stem cell or a pancreatic tissue stem/progenitor cell into the pancreatic hormone-producing cell. The differentiation/induction... Agent:

20150140662 - Method of producing induced pluripotent stem cells using a dominant negative mutant of p53: Provided is a method of producing an iPS cell, comprising bringing (a) Oct3/4 or a nucleic acid that encodes the same, (b) Klf4 or a nucleic acid that encodes the same, and (c) Sox2 or a nucleic acid that encodes the same, as well as (d1) L-Myc or a nucleic... Agent:

20150140663 - In vitro reconstituted plant virus capsids for delivering rna genes to mammalian cells: The invention provides compositions of matter comprising a cowpea chlorotic mottle virus capsid protein (CCMV CP) and a ribonucleic acid, as well as methods for using such compositions. In such compositions, the cowpea chlorotic mottle virus capsid protein envelops the ribonucleic acid so as to for a capsid that can... Agent:

20150140664 - Large gene excision and insertion: Methods of simultaneously excising large nucleic acid sequences from a target nucleic acid and inserting large foreign nucleic sequences into the target nucleic acid sequence using DNA binding protein nucleases are described.... Agent:

20150140665 - Site-specific integration of transgenes into human cells: Methods for inserting a polynucleotide sequence into the genome of a human cell are provided. The present methods result in insertion of a polynucleotide sequence of interest into the H11 locus in the genome of a human cell. Also provided are nucleic acids that include sequences for integrating a polynucleotide... Agent:

20150140666 - Microbes with controlled adhesive properties: The present invention encompasses a phototrophic microorganism with altered and controlled adhesive properties. One aspect of the present invention encompasses a genetically modified phototrophic microorganism capable of controlled adhesion. The microorganism comprises a recombinant nucleic acid construct, wherein the nucleic acid construct comprises an inducible promoter operably-linked to a nucleic... Agent: Arizona Board Of Regents For And On Behalf Of Arizona State University

  
05/14/2015 > 117 patent applications in 73 patent subcategories.

20150132737 - System for keeping alive and transporting skin biopsies and applications of said system: Disclosed is an in vitro or ex vivo method for preserving and/or keeping alive mammalian, preferably human skin biopsies, enabling to transport it and, if applicable, to culture it. Also disclosed is a skin biopsy thus preserved and obtained by such a method and relates to its use as a... Agent: Genoskin

20150132738 - Method for identification of non-hematogeneous karocytes enriched from body fluid of humans or animals: Disclosed is a method for identification of non-hematogenous karyocytes enriched from body fluid of humans or animals, wherein immunofluorescent staining of antibodies against human leukocytes and fluorescence in situ hybridizationof chromosome are carried out synchronously to distinguish hematogenous karyocytes and the interference produced by the hematogenous karyocytes during the judgement... Agent:

20150132739 - Multilayered blood product: A blood product (10), a method for preparing the blood product, a blood product obtainable by the method and a blood product preparing container means. The blood product comprises components from whole blood, especially fibrin, thrombocytes and leukocytes. The blood product (10) comprises a first layer (21), a second layer... Agent:

20150132741 - Extraction control for dna: The present invention relates to compounds for use in the control of extraction procedures, particular in connection with nucleic acid material for use in PCR and more preferably real time PCR (quantitative PCR), The extraction control according to the present invention is based on non-pathogenic bacterial material which can be... Agent: Vela Operations Pte. Ltd.

20150132740 - Lanthanum-based concentration agents for microorganisms: A concentration agent for microorganisms is provided that contains both lanthanum and carbonate. Additionally, articles that include the concentration agent and methods of concentrating a microorganism using the concentration agent are provided.... Agent:

20150132744 - Methods of detecting cells latently infected with hiv: Disclosed are methods of detecting and isolating CD4+ T cells latently infected with HIV as well as methods of screening for inhibitors of CD4+ T cells latently infected with HIV.... Agent: Oregon Health And Science University

20150132742 - Microfluidic devices formed from hydrophobic paper: Microfluidic devices fabricated from paper that has been covalently modified to increase its hydrophobicity, as well as methods of making and using thereof are provided herein. The devices are typically small, portable, flexible, and both easy and inexpensive to fabricate. Microfluidic devices contain a network of microfluidic components, including microfluidic... Agent:

20150132743 - Proximity assays for detecting nucleic acids and proteins in a single cell: Methods and reagents for detection and analysis of nucleic acids and proteins using proximity extension assays.... Agent:

20150132748 - Integrated microfluidic and solid state pyrosequencing systems: The invention provides for sequencing a nucleic acid molecule based on the detection of base incorporation by the release of pyrophosphate (PPi) using a new enzyme system comprising adenosine diphosphate (ADP)-glucose pyrophosphorylase (AGPase) and its substrate ADP-glucose.... Agent: Agency For Science, Technology And Research

20150132745 - Methods and compositions for generating reference maps for nanopore-based polymer analysis: The present disclosure generally relates to the methods and compositions to efficiently analyze polymer characteristics using nanopore-based assays. Specifically disclosed is a method for generating reference signals for polymer analysis in a nanopore system, wherein the nanopore system has a multi-subunit output signal resolution. The method comprises translocating a reference... Agent: University Of Washington Through Its Center For Commercialization

20150132749 - Methods and kits for isolating nucleic acid from an organism: The invention generally relates to methods and kits for isolating nucleic acids from an organism. In certain embodiments, methods of the invention involve contacting a plurality of lytic enzymes to an organism, thereby lysing a cell wall of the organism to release the nucleic acid, and introducing at least one... Agent:

20150132746 - Sampling medium: Provided herein is technology relating to the collection of biological samples and particularly, but not exclusively, to compositions, methods, and uses related to using a biopolymer substrate to collect biological samples for analysis.... Agent:

20150132747 - Treatment of neurodegeneration and neuroinflammation: Methods of treating a subject having a condition characterized by at least one of neurodegeneration and neuroinflammation are provided. Methods of reducing astrogliosis in a subject having a condition characterized by increased astrogliosis are also provided. Methods of providing neuroprotection to a subject in need thereof are also provided.... Agent:

20150132750 - Compositions and methods for oxygenation of nucleic acids containing 5-methylpyrimidine: 5-methylpyrimidine oxygenases and their use in the modification of nucleic acids are described.... Agent: New England Biolabs, Inc.

20150132751 - Detecting single nucleotide polymorphism using overlapped primer and melting probe: Methods for the detection of the presence or absence of a single nucleotide polymorphism (SNP) in a target nucleic acid in a biological or non-biological sample are described. The methods can include performing an amplifying step using primers, a hybridizing step utilizing a melting probe, and a detecting step, wherein... Agent: Roche Molecular Systems, Inc.

20150132758 - Magnetic nanocomposite retrieval of nucleotide sequence: Disclosed is a process for retrieval of nucleotide sequence. The process includes mixing iron chloride tetrahydrate with iron (III) chloride hexahydrate in solution; adding ammonium hydroxide to the mixture and stirring to form maghemite nanoparticles; stirring the maghemite nanoparticles in a solution with an inorganic acid, a surfactant and a... Agent:

20150132752 - Method for determining hla-a*24 group: The method of the present invention is a method for determining an HLA-A*24 group, which includes determining the HLA-A*24 group on the basis of the results of the typing of (a) a 211st base and (b) a 395th base, in which A (adenine) in the initiation codon for an HLA... Agent: Toppan Printing Co., Ltd.

20150132754 - Method for increasing accuracy in quantitative detection of polynucleotides: Disclosed is a method for improving the sensitivity and accuracy of quantitative detection of polynucleotides in a sample, such a clinical specimen, by a method that utilizes a two- or three-step process of tagging/labeling target molecules and adding an adapter sequence for adding a universal primer for efficient amplification of... Agent: Cb Biotechnologies, Inc.

20150132757 - Method of detecting and identifying circulating antigens in human biological samples: Disclosed herein is a method of detecting and identifying antigens that are shed into human bodily fluids during infection. The disclosed method allows circulating antigens associated with a particular infection to be detected within minutes or hours from testing as compared to days required with the current methods. Methods of... Agent: The Board Of Regents Of The Nevada System Of Higher Education, On Behalf Of The Univ. Of Nevada

20150132760 - Methods of detecting charcot-marie tooth disease type 2a: Methods are described for screening a subject for risk of Charcot-Marie-Tooth Disease Type 2A or for diagnosing Charcot-Marie-Tooth disease or a predisposition for developing Charcot-Marie-Tooth disease in a subject, by detecting the presence or absence of a mutation in the mitofusin gene in a biological sample collected from the subject.... Agent: Duke University

20150132753 - Microfluidic devices for multi-index biochemical detection: In one aspect, a microfluidic device for multiple reactions is provided, which comprises a reaction channel comprising multiple reaction chambers connected to a closed chamber or an elastic balloon outside of the microfluidic device, wherein a wall of the closed chamber is an elastic membrane; and a control channel comprising... Agent:

20150132755 - Multiwell plate: An assembly for processing a sample is provided. The assembly comprises a first body having a plurality of spaced-apart conduits and a second body having a plurality of chambers wherein each conduit is fluidically connected to a separate chamber. The assembly forms a plurality of liquid flow paths, each flow... Agent: 3m Innovative Properties Company

20150132756 - Polymerase idling method for single molecule dna sequencing: A method for sequencing a nucleic acid is provided. In certain embodiments the method comprises obtaining a duplex comprising a nucleic acid and a primer, wherein the primer has a nuclease resistant 3′ end, combining the duplex with a chain terminator nucleotide and a proof-reading polymerase to produce a reaction... Agent:

20150132759 - Solid support assay systems and methods utilizing non-standard bases: Solid support assays using non-standard bases are described. A capture oligonucleotide comprising a molecular recognition sequence is attached to a solid support and hybridized with a target. In some instances, the molecular recognition sequence includes one or more non-standard bases and hybridizes to a complementary tagging sequence of the target... Agent:

20150132764 - Bag3 as biochemical serum and tissue marker: l

20150132763 - Compositions and methods for identification of a duplicate sequencing read: The present invention provides methods, compositions and kits for detecting duplicate sequencing reads. In some embodiments, the duplicate sequencing reads are removed.... Agent:

20150132762 - Method and apparatus for shearing of genomic material using acoustic processing: Method and apparatus for controlling acoustic treatment of a sample including a liquid. A processing volume in which the sample is acoustically treated may be controlled, e.g., by using a bead positioned in the sample that helps to enhance the shearing effects of acoustic energy on genomic fragments.... Agent: Covaris, Inc.

20150132761 - Method for rapidly evaluating performance of short interfering rna with novel chemical modifications: It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It... Agent:

20150132765 - System and method for measuring flourescence of a sample: The present disclosure provides a system and a method for measuring fluorescence of a sample. The sample may be a polymerase-chain-reaction (PCR) array, a loop-mediated-isothermal amplification array, etc. LEDs are used to excite the sample, and a photodiode is used to collect the sample's fluorescence. An electronic offset signal is... Agent:

20150132768 - Anti-pancreatic cancer antibodies: Described herein are compositions and methods of use of anti-pancreatic cancer antibodies or fragments thereof, such as murine, chimeric, humanized or human PAM4 antibodies. The subject antibodies show a number of novel and useful therapeutic characteristics, such as binding with high specificity to pancreatic and other cancers, but not to... Agent:

20150132767 - Erg/tff3/hmwck triple immunostain for detection of prostate cancer: This invention relates to a triple immunostaining assay (ERG/TFF3/HMWCK) for sensitive and specific detection of prostate cancer. Positive staining for at least one of ERG or TFF3 combined with negative staining of HMWCK in a sample such as prostate tissue sample is indicative of cancer.... Agent: Cornell University

20150132766 - Imaging cell sorter: The present invention provides a cell enrichment/purification device having a function of continuously enriching cells, a function of locating the cells in a particular area of a flow path in a continuous array after the cell enrichment, a function of recognizing the shape of the cells and fluorescence emission from... Agent: Kanagawa Academy Of Science And Technology

20150132774 - Fluorescent protein voltage sensors for measuring membrane potential and imaging high-frequency neuronal electrical activity: Fluorescent protein voltage sensors for measuring membrane potential and imaging high-frequency neuronal electrical activity are disclosed. In particular, the invention relates to engineered protein voltage sensors that comprise a voltage-sensing domain comprising four transmembrane domains linked to a circularly permuted fluorescent protein, which is inserted into the extracellular loop between... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20150132773 - Identification of atypical antibodies in human blood and blood products: A method identifies atypical antibodies in blood or blood product manufacturing processes that may produce false positives in quality control testing on intermediate or final products.... Agent:

20150132775 - Method and device for determining concentration, crosstalk and displacement fluorescence cross correlation spectroscopy: The present invention provides a FCCS method for determining the concentration and/or the diffusion coefficient of at least a first labeled species, a second labeled species and/or a complex between said first and second labeled species, in a system, wherein the method comprises the steps of determining a cross-talk parameter... Agent: Apiconisis Ab

20150132776 - Kits, compositions and methods for detecting a biological condition: The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one composition in a kit for a predetermined period of time to form at least one reaction product, when the subject... Agent:

20150132777 - Non-heating detection method for dermatophyte: The present invention provides a method of detecting dermatophyte, including a step of extracting a dermatophyte component from a sample with a treatment liquid containing a non-ionic surfactant or a zwitterionic surfactant, and a kit for diagnosing dermatophyte infection, containing a treatment liquid comprising the above surfactant, and an antibody... Agent:

20150132769 - Biomarker for determining mitochondrial damage in friedreich's ataxia: Compositions and methods for screening for a disease or a disorder associated with a deficiency in frataxin in a subject using biomarkers for diseases or disorders associated with a deficiency in frataxin are disclosed. The compositions and methods include determining the acetylation status of mito-chondrial proteins. Also disclosed are methods... Agent:

20150132771 - Combination of spla2 activity and lp(a) cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event: The present invention related to a method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, comprising: —measuring, in a sample obtained from said subject, at least two cardiovascular risk factors: a) s PLA2 activity and b) Lipoprotein(a), —combining said... Agent:

20150132772 - Determination of neutrophil gelatinase-associated lipocalin (ngal) as a diagnostic marker for renal disorders: Methods for diagnosing renal disorders by measuring human neutrophil gelatinase-associated lipocalin (NGAL) are provided.... Agent:

20150132770 - Pregnancy-associated plasma protein-a2 (papp-a2) polynucleotides: The present invention provides pregnancy associated plasma protein A2 (PAPP-A2), its nucleotide and amino acid sequences, antisense molecules to the nucleotide sequences which encode PAPP-A2, expression vectors for the production of purified PAPP-A2, antibodies capable of binding specifically to PAPP-A2, hybridization probes or oligonucleotides for the detection of PAPP-A2-encoding nucleotide... Agent:

20150132778 - Methods and kits for diagnosing heparin-induced thrombocytopenia: Provided herein are methods for diagnosing heparin-induced thrombocytopenia (HIT) in a subject. The methods comprise (a) contacting a PF4-heparin complex with a biological sample from the subject; (b) contacting the composition of part (a) with an HIT-like antibody; and (c) measuring the amount of bound HIT-like antibody. In one embodiment,... Agent: The Trustees Of The University Of Pennsylvania

20150132780 - Melittin peptide conjugates and methods employing same: Methods and reagents are disclosed for conducting assays for IgE specific for honey bee venom allergen. A reagent comprises a conjugate of a small molecule linked to a terminal glycine amino acid of a synthetic 26 amino acid melittin peptide. In the method a combination is provided that comprises a... Agent: Siemens Healthcare Diagnostics Inc.

20150132779 - Method for determining ubiqutin chain length: Protein ubiquitylation, an essential post-translational modification, regulates almost every cellular process including protein degradation, protein trafficking, signal transduction, and DNA damage response in eukaryotic cells. The diverse functions of ubiquitylation are thought to be mediated by distinct chain topologies resulting from eight different ubiquitin linkages, chain lengths, and complexities. Currently,... Agent:

20150132782 - Method for diagnosing cancer by detecting gpc3: Provided is a method for diagnosing cancer by detecting a novel cancer marker. Cancer can be diagnosed by detecting soluble glypican 3 in a test sample.... Agent:

20150132781 - Multiplexed chromatography-immunoassay method for the characterization of circulating immune complexes: Thus, herein is reported a method for analyzing/characterizing circulating immune complexes (CICs) formed in vivo comprising a size-exclusion chromatography of a sample obtained from a mammal to which the drug had been administered at least once for determining the weight/size of the immune complexes, optionally a second non-SEC chromatography, and... Agent: Hoffmann-la Roche Inc.

20150132783 - Neuroprotective chemicals and methods for identifying and using same: Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. These compounds can be used to treat various diseases, disorders, or conditions associated with, for example, unwanted cell death.... Agent: University Of Iowa Research Foundation

20150132784 - Methods and kits for detecting a xerophilic microorganism or an osmophilic microorganism: A method for detecting a xerophilic microorganism is provided. The method comprises providing a sample to be tested, an aqueous diluent comprising about 1.0 to about 10.2 weight percent glycerol, and a thin film culture device comprising a cold water-reconstitutable medium to facilitate the growth of a microorganism. The method... Agent:

20150132785 - Protease assay: The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell. The assays are comprised of two particles linked via an oligopeptide linkage that comprises a consensus sequence... Agent:

20150132786 - Method for measuring glycosylated hemoglobin, measurement reagent, and measurement kit: Described is a method for accurately and highly sensitively measuring glycated hemoglobin in a hemoglobin-containing sample without being influenced by hemoglobin. It is related to a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising: reacting hemoglobin-containing sample with a protease in the presence of a surfactant; and then... Agent:

20150132788 - Establishing the viability of biological samples: The invention relates to a method, a use and a kit for establishing the viability (ability to live) of biological samples using ageladine A. The invention is advantageously suitable for establishing the viability of biological samples which can otherwise be dyed in an intra-cellular manner by fluorescence dyes other than... Agent: Ovamed Gmbh

20150132787 - Method for producing ciliary marginal zone-like structure: The invention provides a method for producing a cell aggregate containing a ciliary marginal zone-like structure by culturing a cell aggregate containing a retinal tissue in which Chx10 positive cells are present in a proportion of 20% or more of the tissue in a serum-free medium or serum-containing medium, each... Agent: Riken

20150132792 - Methods of assaying sensitivity of cancer stem cells to therapeutic modalities: The present invention is directed to methods of measuring the proliferative ability of individual patient cancer stem cells. The present invention provides a method for treating a cancer patient according to an assay of the individual patient's tumor's cancer stem cell sensitivity, by measuring the proliferative ability of cancer stem... Agent: The Research Foundation For The State University Of New York

20150132789 - Optical imaging system and methods for using the same: Aspects of the present disclosure include methods and systems for assaying a sample for an analyte. Methods according to certain embodiments include illuminating a sample with a slit-shaped beam of light, detecting light transmitted through the sample, determining absorbance of the transmitted light at one or more wavelengths and calculating... Agent:

20150132791 - Sample analyzer and computer program product: A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample,... Agent: Sysmex Corporation

20150132790 - Screen to identify agents that can modulate heme transporter: Provided are compositions and methods related to heme transporters and high-throughput methods of identifying agents that can modulate heme transporters. An approach for identifying a modulator of a eukaryotic heme transporter involves adding a toxic heme analog and at least one test agent to a culture of cells, wherein the... Agent:

20150132793 - Method for filtering a biological sample: A method for filtering a sample comprising the steps of: (a) providing a sample with eukaryotic cells and containing or suspected to contain a micro-organism; (b) performing a selective lysis of the eukaryotic cells to obtain a lysed sample; (c) filtering the lysed sample obtained in step (b) through a... Agent: Biocartis Nv

20150132796 - Kit for detecting biofilms: The invention relates to a kit for detecting biofilms, which is in particular compatible with the agri-food industry and comprises a biofilm staining solution containing a stain in solution in a dilution phase compatible with the agri-food industry, wherein said stain is Coomassie blue, and a cleaning solution comprising said... Agent:

20150132794 - Method of manufacturing sample containers: A method of manufacturing a batch of sample containers optimized for culturing particular animal cells or binding particular proteins under particular growth conditions. When a customer requires a batch of sample containers, an appropriate surface is first selected by a testing process. A test container is provided which has a... Agent: Sony Dadc Austria Ag

20150132795 - Systems and methods for detection of cells using engineered transduction particles: Systems and methods for detecting and/or identifying target cells (e.g., bacteria) using engineered transduction particles are described herein. In some embodiments, a method includes mixing a quantity of transduction particles within a sample. The transduction particles are associated with a target cell. The transduction particles are non-replicative, and are engineered... Agent: Geneweave Biosciences, Inc.

20150132797 - Composition, method and kit for reducing background staining: Compositions, methods and kits are disclosed for improved staining of a cell or tissue with a dye-conjugate that binds specifically to a particular component of the cell or tissue. The compositions, methods and kits include a polymeric material that reduces non-specific binding of a dye-conjugate to components of the cell... Agent:

20150132798 - Integrated sequential sample preparation system: The invention provides an integrated sequential sample preparation system using a sequential centrifuge for preparing samples for analysis. Methods of more efficiently preparing discrete samples sequentially for subsequent analysis are also provided. The apparatus and methods for sequentially preparing discrete samples provide improved operating efficiencies over conventional preparation processes that... Agent:

20150132799 - Methods to increase and harvest desired metabolite production in algae: Enhanced yields of photosynthetically fixed carbon produced by hypersaline photosynthetic algae are provided by co-culturing with a halophilic archaea. Further, methods are provided to control harvesting of desired metabolic products from hypersaline photosynthetic algae by controlling caspase activity.... Agent:

20150132800 - Trichoderma hydrophobin production: The invention relates to a method for maximizing expression of a biosurfactant, such as hydrophobin, in a microorganism, in particular a Trichoderma production host.... Agent: Danisco US Inc.

20150132802 - Alkaline feed: A method for cultivating a bacterial cell comprising the addition of an amino acid in an alkaline solution used for pH regulation. Also an aspect is a method for producing a polypeptide comprising the steps of a) providing a bacterial cell comprising a nucleic acid encoding the polypeptide, b) cultivating... Agent: Hoffmann-la Roche Inc.

20150132801 - Low acidic species compositions and methods for producing and using the same: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα... Agent:

20150132803 - Polypeptide for improving protein production in microorganisms of the phylum labyrinthulomycota: The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.... Agent:

20150132804 - Instruments and method relating to thermal cycling: The present invention relates to a device for thermal cycling of biological samples, a heat sink used in such a device and a method. The heat sink comprises a base plate designed to fit in a good thermal contact against a generally planar thermoelectric element included in the device, and... Agent:

20150132805 - Composition for producing microrna precursors as drugs for enhancing wound healing and production method of the microrna precursors: This invention generally relates to a composition and its production method useful for developing drugs and/or therapies for enhancing wound healing, in particular scarless wound healing. Particularly, the present invention teaches the essential processes necessary for producing and purifying embryonic stem cell (ESC)-specific RNA compositions, such as messenger RNAs (mRNA),... Agent: Mello Biotech Taiwan Co., Ltd.

20150132806 - Ketoreductase polypeptides: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme including the capability of reducing 5-((4S)-2-oxo-4-phenyl(1,3-oxazolidin-3-yl))-1-(4-fluorophenyl)pentane-1,5-dione to (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the... Agent:

20150132807 - Engineered imine reductases and methods for the reductive amination of ketone and amine compounds: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.... Agent:

20150132808 - Method for producing 1,5-pentamethylenediamine, mutant lysine decarboxylase, method for producing 1,5-pentamethylene diisocyanate and method for producing polyisocyanate composition: A mutant lysine decarboxylase is produced by replacing at least one of the amino-acids in the amino acid sequence shown in sequence ID No. 4 of the sequence listing with another amino-acid.... Agent:

20150132809 - Systems and methods for enhancing gene expression: The present invention provides for a system for increasing the production of a compound using an artificial positive feedback loop (APFL). In some embodiments, the system diverts a compound produced in a first metabolic pathway into a second metabolic pathway in order to produce a compound of interest.... Agent: The Regents Of The University Of California

20150132810 - Integrated processes for anaerobically bioconverting hydrogen and carbon oxides to oxygenated organic compounds: Integrated processes are provided for the bioconversion of syngas to oxygenated organic compound with the ability to recover essential compounds for the fermentation and recycle the compounds to the fermentation.... Agent: Coskata, Inc.

20150132811 - Deactivation of urushiol and method of treament and prevention of contact dermatitis: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an... Agent:

20150132812 - Two-stage process for producing oil from microalgae: A process for production of biofuels from algae can include cultivating an oil-producing algae by promoting sequential photoautotrophic and heterotrophic growth. The method can further include producing oil by heterotrophic growth of algae wherein the heterotrophic algae growth is achieved by introducing a sugar feed to the oil-producing algae. An... Agent:

20150132813 - Biosynthetic pathways, recombinant cells, and methods: This disclosure describes, generally, recombinant cells modified to exhibit increased biosynthesis of pentanoic acid, methods of making such recombinant cells, and methods of inducing the cells to produce pentanoic acid. This disclosure also describes, generally, recombinant cells modified to exhibit increased biosynthesis of 2-methylbutyric acid, methods of making such recombinant... Agent:

20150132814 - Process for fermenting sugars containing oligomeric saccharides: Sugar mixtures containing nonfermentable oligomers are fermented in the presence of certain enzymes that depolymerise the oligomers simultaneously with the fermentation process.... Agent: Cargill, Incorporated

20150132815 - Processes for enhancing the performance of large-scale, tank anaerobic fermentors: Processes are disclosed for the low energy, anaerobic bioconversion of hydrogen and carbon monoxide in a gaseous substrate stream to oxygenated organic compounds such as ethanol by contact with microorganisms in a deep, tank fermentation system with high conversion efficiency of both hydrogen and carbon monoxide. Gas feed to the... Agent: Coskata, Inc.

20150132816 - Microbial production of branched medium chain alcohols, such as 4-methylpentanol: The invention relates to recombinant cells and their use in the production of branched medium-chain alcohols such as 4-methyl-1-pentanol.... Agent:

20150132817 - Alcoholic fermentation yeast and method for producing ethanol using same: [Problem] To provide an alcoholic fermentation yeast having resistance to limonene, which is a fermentation inhibitor, and a method for producing ethanol using the alcoholic fermentation yeast. [Solution] An alcoholic fermentation yeast Saccharomyces cerevisiae (Deposition No. NITE BP-890), which has resistance to limonene and can grow in the presence of... Agent:

20150132818 - Glycosylation method of algae or agricultural by-products comprising high-pressure extrusion pulverization step: Disclosed is a method of saccharifying biomass, such as algae or agricultural by-products by performing a high-pressure extrusion pulverization process for the biomass, such as algae or agricultural by-products, and more particularly to a method of saccharifying biomass, which includes homogenizing and crushing algae or agricultural by-products, and extruding the... Agent: Dae-a Intellectual Property Consulting

20150132819 - Thermococcus onnurineus mc02 and method of hydrogen production using thereof: The present invention provides Thermococcus onnurineus MC02 strain (accession no. KCTC12511BP) having increased hydrogen production ability, wherein the expression of rchA gene of the strain increases. Also, the present invention provides a method for producing the strain belonged to the genus Thermococcus having increased hydrogen production ability comprising, increasing the... Agent:

20150132820 - Thermostable catalase: A recombinant microorganism capable of efficiently expressing thermostable catalase can be provided by obtaining a DNA necessary for efficiently producing it as a recombinant protein, and the thermostable catalase can be efficiently produced at low cost by cultivating the obtained recombinant microorganism. Hydrogen peroxide can be efficiently decomposed at low... Agent: Meiji Seika Pharma Co., Ltd.

20150132821 - Systems and methods for improving nuclease specificity and activity: Endonucleases play an essential role in genetic engineering and molecular biology. A major barrier to the clinical adoption of nucleases and engineered nucleases remain the overall lack of specificity and activity. Off-site cleavage, cleavage at loci other than the target loci, typically occurs resulting in mutations, unexpected gene-knockouts, or translocations.... Agent:

20150132822 - Polypeptides having xylanase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent:

20150132823 - Alpha-amylase variants: The invention relates to a variant of a parent Termamyl-like alpha-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an alpha-amylase variant of... Agent:

20150132824 - Polypeptides having xanthan degrading activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having xanthan degrading activity, catalytic domains and polynucleotides encoding the polypeptides and catalytic domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides and catalytic domains.... Agent:

20150132825 - Compositions and methods comprising serine protease variants: The present invention provides methods for protein engineering and serine protease variants produced there from. Specifically, the present invention provides serine protease variants having one or more substitutions as compared to a reference serine protease. In addition, the present invention provides compositions comprising these serine protease variants. In some embodiments,... Agent: Danisco US Inc.

20150132826 - Chimeric truncated tissue plasminogen activator (t-pa) resiatant to plasminogen activator inhibitor-1 and improved biochemical properties: The present invention discloses a thrombolytic therapy for acute myocardial infarction by t-PA. A chimeric truncated form of t-PA is designed and expressed in Pichia pastoris. The new variant t-PA comprises of a finger domain of Desmoteplase, an epidermal growth factor (EGF) domain, a kringle 1 domain, a kringle 2... Agent:

20150132827 - Emulsifier centrifuge tube fermenter: A centrifuge tube fermenter for culturing cells in a nutrient medium wherein the centrifuge tube fermenter is comprised of a top end, a bottom end, a vertical cylindrical outer wall positioned between the top end and the bottom end, and an inner wall positioned inside the outer wall, the bottom... Agent:

20150132828 - Bacterial host strain comprising a mutant spr gene and having reduced tsp activity: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and... Agent:

20150132829 - Induction of flocculation in photosynthetic organisms: The present invention provides compositions and methods for producing flocculation moieties in photosynthetic organisms. The photosynthetic organisms are genetically modified to effect production, secretion, or both, of the flocculation moieties. Also provided are methods of flocculating organisms.... Agent: Sapphire Energy, Inc.

20150132830 - Trap type carbon replenishing device for culturing microalgae of opened pool and carbon replenishing method thereof: The invention relates to the field of microalgae culture and specifically relates to a trap-type carbon supplement device and carbon supplement method for cultivating microalgae in an open pond. The trap-type carbon supplement device for cultivating microalgae in an open pond, comprises a trap-type container, a partition plate and a... Agent: Institute Of Process Engineering, Chinese Academy Of Sciences

20150132831 - Compositions comprising lipase and methods of use thereof: The invention relates to a cleaning composition comprising a lipase with at least 75% identity to SEQ ID NO: 2, and a surfactant, wherein said composition is more effective in removing lipid stains present at a surface in comparison with an equivalent composition lacking the lipase.... Agent:

20150132832 - Multiuse, enzymatic detergent and methods of stabilizing a use solution: Stabilized use solutions of low phosphorus, alkali metal carbonate detergents employing enzymes for cleaning compositions are disclosed. In particular, the present invention is a composition for, and method of, removing soils, preventing redeposition of protein soils and reducing foam, using stabilized enzyme cleaning compositions, namely use solutions of the same.... Agent:

20150132833 - Multiuse, enzymatic detergent and methods of stabilizing a use solution: Stabilized use solutions of low phosphorus, alkali metal carbonate detergents employing enzymes for cleaning compositions are disclosed. In particular, the present invention is a composition for, and method of, removing soils, preventing redeposition of protein soils and reducing foam, using stabilized enzyme cleaning compositions, namely use solutions of the same.... Agent:

20150132834 - Method for removal of triglycerides in lipoproteins other than low-density lipoproteins: Disclosed is a method for selectively eliminating triglycerides in lipoproteins other than low density lipoprotein, which method allows one to provide a method for directly and differentially quantifying LDL-TG in a sample with excellent simplicity, specificity and accuracy using an automated analyzer or the like without performing a laborious operation... Agent: Denka Seiken Co., Ltd.

20150132835 - Devices, systems, and methods for diagnostic testing: The present disclosure relates to devices, systems, and methods for performing diagnostic tests. The disclosed diagnostic devices are capable of performing analytic tests and communicating with a portable multifunctional device (PMD) or other computing device. Through input and manipulation of materials within the diagnostic device, a large range of tests... Agent:

20150132836 - Method and system for detecting lymphosarcoma in cats using biomarkers: The invention provides a method and system for developing and using diagnoses of lymphosarcoma in feline subjects using Thymidine kinase (TK) and haptoglobin (HP) as biomarkers. The invention provides a method for obtaining the level of each biomarker and computing an index for a feline subject. The invention provides predefined... Agent:

20150132837 - Microfluidic devices for reliable on-chip incubation of droplets in delay lines: The present invention relates generally to droplet creation, fusion and sorting, and incubation for droplet-based microfluidic assays. More particularly, the present invention relates to delay-lines, which allow incubation of reactions for precise time periods. More particularly, the present invention relates to delay lines for incubations up to three hours, while... Agent:

20150132838 - Ventilation unit for flow reversal: A ventilation unit is arranged to effect flow reversal, according to two opposite directions, of a gas flow generated by a fan without reversing the rotation direction of the fan. The ventilation unit includes a fan, at least a first piping arrangement through which a gas flow is intended to... Agent:

20150132839 - Systems and methods for bio-mass energy generation: A closed loop system for generating energy is described herein. The closed loop system can include a solar collector, a tank, and the combustor. The solar collector can collect electromagnetic energy from a light source including, the sun. This electromagnetic energy can be transported from the solar collector to the... Agent:

20150132840 - Single-use bioreactor and head plate, and a process for manufacturing same: A single-use bioreactor, suitable in particular for use in a parallel bioreactor system for applications in cell culture and/or microbiology, a head plate for such a single-use bioreactor and a process for manufacturing the single-use bioreactor and the head plate. The single-use bioreactor comprises a head plate, a dimensionally stable... Agent:

20150132841 - Vessel holder and cap assembly: A vessel holder assembly is provided. A vessel holder, for receiving one or more vessels, includes a first set of attachment features. A cap assembly, for covering the vessel(s) includes a second set of attachment features. Respective attachment features of the vessel holder and the cap assembly may be complementary,... Agent: Covaris, Inc.

20150132842 - Package for cell-containing material and package containing cell-containing material: A package for cell-containing material includes an inner and outer bag. The periphery of the inner bag except an opening is sealed. The periphery of the outer bag except an opening is sealed. The outer bag contains the inner bag so the opening faces outward. A portion of the opening... Agent:

20150132843 - Processes for the preparation of highly pure plasmid compositions: The present disclosure generally relates to processes for preparing highly pure plasmid compositions. The processes generally involve treating a composition comprising plasmid DNA with a polypeptide to digest colanic acid. The treated plasmid DNA is then separated from the treated composition.... Agent:

20150132844 - Dendritic cell compositions and methods: Methods are provided for the production of dendritic cells from monocytes that have been incubated at a temperature of 1° C.-34° C. for a period of approximately 6 to 96 hours from the time they are isolated from a subject. After the incubation period, the monocytes can then be induced... Agent:

20150132845 - Device and method for continuous cell culture and other reactions: Devices, systems, and methods for continuous cell culture and other reactions are generally described. In some embodiments, chambers (e.g., cell growth chambers) including at least a portion of a wall formed of a flexible member are provided. A retaining structure can be incorporated outside and proximate to the chamber such... Agent: Massachusetts Institute Of Technology

20150132846 - Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.... Agent:

20150132847 - Encapsulation and cardiac differentiation of hipscs in 3d peg-fibrinogen hydrogels: The present invention relates to the production of cell cultures and tissues from undifferentiated pluripotent stem cells using three-dimensional biomimetic materials. The resultant cell cultures or tissues can be used in any of a number of protocols including testing chemicals, compounds, and drugs. Further, the methods and compositions of the... Agent:

20150132848 - High complexity sirna pools: The present invention relates to a method for producing pools of siRNA molecules suitable for RNA interference.... Agent:

20150132849 - Ex vivo maturation of islet cells: The invention relates to methods for promoting maturation of islet cells from pre-weaned mammals for the purpose of optimizing the islets for their use as donor tissue for xenotransplantation. The method of the invention removes the pancreas from donor animals and reduces the pancreas tissue to fragments that are greater... Agent: Islet Sciences, Inc.

20150132850 - Stem cells from the mammalian neural plate: The present invention relates to methods for deriving novel stem cells from the mammalian early neural plate.... Agent:

20150132851 - Systems and methods for processing cells: The present invention efficiently and cost-effectively extracts and collects cells from a tissue. The inventors have discovered that the tissue can be effectively fragmented and the resulting cells can be purified using a system or kit with multiple components. An advantage of the present invention is that tissue processing takes... Agent:

20150132852 - Tissue culturing method, culturing method of ferns and explant obtained therefrom: A tissue culturing method includes following steps: providing a chopped gametophyte, generating calluses by culturing the chopped gametophyte, and performing apogamic regeneration of sporophytes, by culturing the calluses in a culture fluid to develop the sporophytes from the calluses. The present invention also provides a tissue culturing method of ferns... Agent: Chunghwa Picture Tubes, Ltd.

20150132853 - Cytoplasmic transfer to de-differentiate recipient cells: Methods for de-differentiating or altering the life-span of desired “recipient” cells, e.g., human somatic cells, by the introduction of cytoplasm from a more primitive, less differentiated cell type, e.g., oocyte or blastomere are provided. These methods can be used to produce embryonic stem cells and to increase the efficiency of... Agent: Advanced Cell Technology, Inc.

  
05/07/2015 > 114 patent applications in 62 patent subcategories.

20150125847 - Method of blood pooling and storage: The disclosure provides methods of making a cell-containing product having a uniform amount of cells therein. The method comprises pooling red blood cells from a plurality of blood units, and inactivating any pathogen contained therein. A storage solution added to the cellular component results in a cell-containing product that is... Agent:

20150125848 - Methods related to alemtuzumab: The present invention relates to the characterization and production of alemtuzumab.... Agent: Momenta Pharmaceuticals, Inc.

20150125849 - Eukaryotic expression system and use thereof: Provided are a eukaryotic expression system and its applications. The eukaryotic expression system has a recombinant plant cell. The recombinant plant cell includes a first vector and a second vector. The first vector expresses a fusion protein containing an Asia tospoviral common epitope. The fusion protein containing Asia tospoviral common... Agent: National Chung Hsing University

20150125852 - Method for evaluation of viability of viruses with lymphotropism properties: Methods and techniques to increase the reliability of detecting virus infections, particularly lymphotropism, to eliminate false negative reactions in testing blood for the presence of lymphotropic viruses during enzyme immunoassay (EIA) and polymerase chain reaction (PCR) testing, and to better detect viruses with lymphotropism in biological materials having a concentration... Agent: Obschestvo S Ogranichennoi Otvetstvennostyu

20150125850 - Novel rapid and highly sensitive cell based system for the detection and characterization of hiv: The invention pertains to a novel cell line, an HIV tat-rev dependent GFP-Gaussia luciferase Reporter cell line, known henceforth as the GGR cell line, that detects pseudotype and replication competent HIV (cloned or uncloned isolates, in cell media or human serum) rapidly and with high sensitivity. This GGR cell line... Agent:

20150125851 - Optical sensor and manufacturing method thereof, and detection method utilizing same: An optical sensor is configured to be used with trappers specifically bound to an object substance to detect whether the object substance exists or not in a specimen. The optical sensor includes a first metal layer made of gold having a lower surface and an upper surface which is configured... Agent:

20150125853 - Trend analysis and statistical process control using multitargeted screening assays: Aspects of the present invention provide novel multi-targeted microbiological screening and monitoring methods having substantial utility for monitoring and control of microbial growth and contaminants, microbiological processes, predictive microbiology, and for exposure and risk assessment. Microbial markers shared by both target and index microbes are used in novel methods for... Agent:

20150125854 - Methods and compositions for performing analytical operations: Methods for performing analytical reactions and compositions for use in such methods, where the methods have reduced signal levels deriving from non-specific adsorption of detected reagents to other components of the analytical method, e.g., other reagents, solid phase components, vessels, etc.... Agent: Pacific Biosciences Of California, Inc.

20150125856 - Assays for resistance to echinocandin-class drugs: Nucleic acid amplification assays for mutations to two short sections of the fungal gene FKS1. Mutations in these target sequences have been shown to correlate with resistance to echinocandin-class drugs. Assays may include detection by sequencing or by labeled hybridization probes. Also, primers, probes and reagent kits for performing such... Agent:

20150125857 - Cancer patient selection for administration of wnt signaling inhibitors using rnf43 mutation status: Disclosed are biomarkers, methods and assay for the identification of cancer patients who are predicted to benefit from the therapeutic administration of Wnt antagonist. The biomarkers include detection of RNF43 and ZNRF3 gene deletion, reduced RNF43 and ZNRF3 mRNA expression, reduced RNF43 and ZNRF3 protein expression, RNF43 and ZNRF3 inactivation... Agent: Irm LLC

20150125863 - Cxcl5 as a marker of hormone escape in prostate cancer: The invention relates to the use of CXCL5 as a marker for assessing hormone escape in prostate cancer cells. The invention further provides diagnostic methods and kits for assessing hormone escape in prostate cancer cells, and CXCL5 antagonists for use in the treatment or prevention of prostate cancer and/or hormone... Agent:

20150125858 - Determining prostate cancer recurrence using polymorphisms in angiogenesis-related genes: In particular, disclosed is a method for treating a patient with prostate cancer that involves genotyping a nucleic acid sample from the subject for one or more single nucleotide polymorphism (SNP) alleles in one or more genes angiogenesis, comparing the one or more SNP alleles to control allele frequencies to... Agent:

20150125862 - Isolation of rna-protein complexes using cross-linking reagents and oligonucleotides: Provided herein is a method of sample analysis. In certain embodiments, the method comprises: a) cross-linking protein of a cell using a first compound to produce a first cross-linked product comprising cross-linked protein, and RNA; b) contacting the first cross-linked product and a second compound under conditions by which an... Agent:

20150125855 - Method of snp detection by using gene detection technique in bead-based microfluidics: The present invention provides a method of SNP detection by using gene detection in bead-based microfluidics comprising following steps: (a) preparing a microbead with a duplex DNA; (b) inserting a dye into the duplex DNA; (c) delivering the microbead into a microchannel with a temperature gradient region; (d) heating the... Agent: National Taiwan University

20150125860 - Methods and compositions for detecting aspergillus terreus, aspergillus niger, and mycotoxins: The invention relates to a method of identifying an Aspergillus terreus or an Aspergillus niger fungal species in patient tissue or body fluid and to primers and probes for use in such a method.... Agent:

20150125861 - Methods and compositions for identifying sulfur and iron modifying bacteria: The invention relates to methods and compositions for identifying specific bacterial species, which are sulfur and iron oxidizers and/or reducers, from wall board (e.g., dry wall) and/or a patient tissue or body fluid. The method comprises the steps of extracting and recovering DNA of the bacterial species from the wall... Agent:

20150125859 - Nucleic acid chromatography method, composition for nucleic acid chromatography and kit containing same: Provided is a nucleic acid chromatography method ensuring a stable detection state, and a composition and kit for use in nucleic acid chromatography. For this purpose, the nucleic acid chromatography method is provided with a step of performing chromatography by supplying a chromatography liquid containing a target nucleic acid to... Agent: Ngk Insulators, Ltd.

20150125867 - Aptamers for clostridium difficile diagnostics: The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to toxins produced by Clostridium difficile; diagnostic kits and methods comprising such aptamers; and methods of making and using such aptamers.... Agent:

20150125868 - Asxl1 as a new diagnostic marker of myeloid neoplasms: The present invention relates to a method for diagnosing a myeloid cancer in a subject, which comprises the step of analyzing a biological sample from said subject by determining the presence or the absence of a mutation in the ASXL1 (additional sex combs like 1) gene coding for the polypeptide... Agent: Inserm (institut National De La Sant&#xe9 Et De La Recherche M&#xe9 Dicale)

20150125870 - Method for electrochemically identifying target nucleotide sequences: A method and assembly for electrochemically identifying target nucleotide sequences. The method includes supplying a biological sample that may contain a predetermined target nucleotide sequence; supplying activatable amplification materials comprising free nucleotides to form replicated target nucleotide sequences; supplying an oxido-reducible compound capable of being inserted during replication between the... Agent: Centre National De La Recherche Scientifique (cnrs)

20150125866 - Method for selecting donors and recipients for transplantation: The present invention discloses a method for determining a suitable donor for a recipient in need of transplant based on identifying short tandem repeat allele length differences.... Agent:

20150125865 - Methods and apparatuses for droplet mixing: Methods and systems are provided for merging a droplet with a volume of fluid in a microfluidic system. In particular, the methods of the invention use a microfluidic structure designed to merge a fluid with a droplet in order to dilute, add volume, or add selected reagents, biological materials, or... Agent:

20150125869 - Methods for multiplexing amplification reactions: A two-step multiplex amplification reaction includes a first step which truncates the standard initial multiplex amplification round to “boost” the sample copy number by only a 100-1000 fold increase in the target. Following the first step the product is divided into optimized secondary single amplification reactions, each containing one of... Agent:

20150125864 - Methods of stabilizing a vesicle in a sample: Provided is a method of stabilizing vesicles in a sample by combining a sample comprising a vesicle with a chelating agent and a composition used in the stabilizing the vesicle in the sample.... Agent:

20150125871 - Methods for decontaminating circuits for producing glucose polymers and hydrolysates of glucose polymers: The present invention concerns a method for determining the impact of a production step or a purification step on the presence or nature of pro-inflammatory contaminating molecules in glucose polymers or the hydrolysates of same by using an in vitro test of inflammatory response using cell lines. It further concerns... Agent: Roquette Freres

20150125872 - Fet sensing cell and method of improving sensitivity of the same: The present disclosure provides a device, such as a FET sensing cell, which includes a first dielectric layer over a substrate, an active layer over the first dielectric layer, a source region in the active layer, a drain region in the active layer, a channel region in the active layer... Agent: Taiwan Semiconductor Manufacturing Company Limited

20150125873 - Method and device for detecting an analyte: According to the invention there is provided a method of detecting an analyte including the steps of: i) providing a sample which contains the analyte and magnetic nanoparticles, in which the magnetic nanoparticles include a magnetic body portion which acts as a signalling vector and at least one receptor moiety... Agent:

20150125875 - Methods for isotopically labeling biomolecules using mammalian cell-free extracts: Methods for producing an isotope-labeled mammalian, including a human, biomolecule, such as polypeptides and proteins, in a cell-free protein synthesis system. A biomolecule standard is produced having at least one isotope different in abundance than that of the naturally occurring isotopes in the biomolecule. Methods for quantifying biomolecules standards expressed... Agent: Pierce Biotechnology, Inc.

20150125874 - Transient flow assay: Described herein are assays for determining total suspended solids (TSS) in liquids. Here TSS can be determined by flowing turbid liquid samples in a porous medium. Using such an assay, TSS can be determined with small volumes of liquid and in short times without the need for dedicated optics and... Agent:

20150125878 - Antibodies against cd106 (vcam-1): The invention provides an antibody or fragment thereof that specifically binds to human endothelial vascular cell adhesion molecule-1 (VCAM-1), wherein the antibody or fragment thereof binds to the extracellular domain of VCAM-1, and wherein the antibody or fragment thereof binds to VCAM-1 when expressed on endothelial cells, wherein the antibody... Agent:

20150125879 - Biodegradable layer-by-layer (lbl) films for cell capture and release: Compositions and methods for providing devices comprised of a substrate and a Layer-By-Layer (LBL) film coated on at least a surface of the substrate, which LBL film comprises binding agents that specifically interact with cells. Such devices are useful, for example, in various cell isolation applications. Among other advantages, such... Agent:

20150125880 - Methods for induction of antigen-specific regulatory t cells: The present invention relates to methods to elicit immature antigen-presenting cells loaded with apoptotic cells or apoptotic bodies. The present invention also relates to methods of obtaining antigen-specific regulatory T cells in vitro or in vivo. Cells loaded with apoptotic bodies/cells and regulatory T cells are obtainable by inducing apoptosis... Agent:

20150125881 - Methods of assessing the immunomodulatory potential of a multipotent stromal cell (msc) population, and systems and kits for practicing the same: Methods of assessing the immunomodulatory potential of a multipotent stromal cell (MSC) population are provided. Aspects of the methods include evaluating the amount of CD54/IL-6 associated with an MSC in a sample of the MSC population to obtain a CD54/IL-6 result and providing an assessment of the immunomodulatory potential of... Agent:

20150125882 - Microfluidic devices, and methods of making and using the same: The present disclosure provides methods and systems for assaying a sample. A microfluidic device to perform an assay of a sample (e.g., biological sample) is described having a sample application site, a porous component and a flow channel. The porous component provides for uniform dissolution of a reagent and mixing... Agent:

20150125883 - Method of isolating and characterizing microorganisms that are targets of host immune responses: The present invention encompasses methods of isolating, identifying, and characterizing microorganisms present in a microbial community occupying a body habitat/surface of a healthy or unhealthy human or animal. More particularly, the invention relates to methods of isolating and identifying viable microorganisms that interact with a host's immune system.... Agent:

20150125884 - Magnetic labeling of bacteria: The present invention provides novel methods of magnetically labeling a bacterial cell by contacting the call with an affinity ligand and subsequently contacting the cell with a magnetic agent, where the affinity ligand and magnetic agent include bioorthogonally reactive groups that can react with each other to form a covalent... Agent:

20150125876 - Biomarker for cognitive dysfunction diseases, and method for detection of cognitive dysfunction diseases using the biomarker: The present invention aims to provide methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising... Agent: Mcbi Inc.

20150125877 - Weak affinity chromatography: The present invention provides methods for analyzing a target compound from a biological sample. In one aspect, a method for analyzing a target compound in a biological sample can comprise delivering a biological sample through an affinity column, the affinity column having a binding ligand coupled to a stationary structural... Agent:

20150125885 - Rtn4b polypeptide, monoclonal antibody thereof, monoclonal antibody-producing hybridoma cell strain, and, preparation and application thereof: The present invention relates to a RTN4B-related polypeptide, a monoclonal antibody thereof, a monoclonal antibody-producing hybridoma cell strain, and, preparation and applications thereof The RTN4B polypeptide comprises an amino acid sequence presented by SEQ ID NO: 1. The invention further discloses a monoclonal antibody, a hybridoma cell strain to produce... Agent:

20150125886 - Compositions and methods for modulating the immune system: A novel class of embryo derived peptides are described (Preimplantation factor) that were generated synthetically and were tested on peripheral blood immune cells and shown to block activated but not basal immunity, inhibiting cell proliferation and creating a TH2 type cytokine bias, in addition PIF enhance endometrial receptivity by increasing... Agent: Biolncept, LLC

20150125887 - Method for establishing the anti-diabetic potential of bitter melon: A method is disclosed for determining the hypoglycemic potential of Momordica charantia (bitter melon) extracts through an in vitro test representative of the range of serum blood sugar typical of normal and diabetic subjects. The in vitro assay provides information on the functional activity of bitter melon extracts for regulating... Agent:

20150125888 - One step enzymatic process for producing alkyl furanosides: A process for enzymatically converting a furanoside substrate in a product of interest, includes contacting the substrate with an enzyme in presence of an alcohol acceptor, wherein the enzyme is preferably Araf51, and wherein the product is preferably an alkyl furanoside. The mutant Araf51 enzyme showing improved transglycosylation activity in... Agent: Centre Natioanal De La Recherche Scientifique (cnrs)

20150125889 - In vitro detection of microorganisms with azoreductase activity: The present invention relates to the use of at least one azo compound for detecting at least one microorganism in a sample. More precisely, the present invention relates to a process for detecting, in a biological sample, at least one microorganism with azoreductase activity, including the steps: placing the sample... Agent:

20150125892 - Fused cyclooctyne compounds and their use in metal-free click reactions: The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as... Agent: Synaffix B.v.

20150125890 - Imaging and evaluating embryos, oocytes, and stem cells: Methods, compositions and kits for determining the developmental potential of one or more embryos or pluripotent cells and/or the presence of chromosomal abnormalities in one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20150125891 - Monolayer protected nanoclusters and methods of making and using thereof: Monolayer protected nanoclusters (MPCs) are described herein. The MPCs contain a cluster of atoms or molecules (e.g. core) having bound thereto a plurality of ligands (e.g., monolayer). The ligands can be bound covalently or semi-covalently bound to the cluster. The ligands are generally in the form of a monolayer or... Agent: Georgia State University Research Foundation, Inc.

20150125893 - Transporter biosensors: The invention provides fusion proteins comprising at least one fluorescent protein that is linked to at least one transporter protein that changes three-dimensional conformation upon specifically transporting its substrate. The transporter protein may be a nitrate transporter, a peptide transporter, or a hormone transporter. The invention provides fusion proteins comprising... Agent:

20150125894 - Whole cell assays and methods: The disclosure provides methods for analysis of disease cell response to a therapeutic agent. In embodiments, a method comprises administering the therapeutic agent to a disease cell sample from the subject in a device that measures at least one physiological parameter of a cell; determining whether a change occurs in... Agent:

20150125896 - Cell binding peptides for diagnosis and detection: Cell binding peptides are provided for binding to cells including urothelial and thyroid follicular cells. The peptides are useful for detection and diagnosis of cancer including bladder and thyroid cancer. A device and method for using the device for capturing cells is provided, the device includes a support having attached... Agent:

20150125895 - Formulations and process for isolating viable microorganism from positive blood cultures: Various embodiments disclosed herein provide for reagents and methods for rapidly isolating viable microbial cells, including S. pneumoniae, from positive blood culture samples. The resulting microbial pellet can be used for both identification and growth-based methods such as antimicrobial susceptibility testing. The buffers described herein may contain a base solution,... Agent: Becton, Dickinson And Company

20150125898 - Compositions and kits for diagnosing infections: The present invention is directed to the use of isotopically labeled citrulline for diagnosing the presence or absence of a bacterial infection in the lungs of a patient.... Agent:

20150125897 - Fast thermo-optical particle characterisation: The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles,... Agent: Ludwig Maximilians Universit&#xe4 T M&#xfc Nchen

20150125899 - Fluorescence-assisted counting apparatus for qualitative and/or quantitative measurement of fluorescently tagged particles: A fluorescence-assisted counting apparatus for quantitative and/or qualitative assessments of a population of fluorescently stained particles in a specimen device retaining fluorescently stained particles, wherein the apparatus includes a detector module and a light source. The detector module includes a lens, a first optical filter and a detector, wherein the... Agent:

20150125900 - Sample analyzer and computer program product: A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample,... Agent: Sysmex Corporation

20150125901 - Bioconversion processes and apparatus: Bioconversion processes are disclosed in which two or more biocatalysts including microorganisms or isolated enzymes that are substantially irreversibly retained in the interior of an open, porous, highly hydrophilic polymer are used in a common aqueous medium. In one exemplary embodiment, one biocatalyst produces a chemical product that is a... Agent:

20150125903 - Fungal xylanases and xylosidases: The present invention provides fungal xylanase and/or xylosidase enzymes suitable for use in saccharification reactions. The present invention provides xylanase and xylosidase enzymes suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce xylanase(s) and/or xylosidase(s), as well as enzyme mixtures exhibiting enhanced... Agent:

20150125902 - Polypeptides having glucoamylase activity and polynucleotides encoding same: Provided are isolated polypeptides having glucoamylase activity, catalytic domains, and polynucleotides encoding the polypeptides, catalytic domains. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains.... Agent: Novozymes A/s

20150125904 - Probe incorporation mediated by enzymes: Compositions (e.g., lipoic acid ligase polypeptides and lipoic acid analogs) and uses thereof in the Probe Incorporation Mediated By Enzymes (PRIME) methods both in vitro and in vivo. Also described herein are kits for performing the PRIME method and vectors/kits for expressing the lipoic acid ligases.... Agent: Massachusetts Institute Of Technology

20150125905 - Cell culture improvements: The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.... Agent:

20150125906 - Methods of hydrolyzing oligomers in hemicellulosic liquor: The present invention relates to methods of degrading or converting biomass material enriched with hemicellulosic material into fermentable sugars.... Agent:

20150125909 - Compositions comprising a polypeptide having cellulolytic enhancing activity and an organic compound and uses thereof: The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and an organic compound. The present invention also relates to methods of using the compositions.... Agent:

20150125908 - Method of producing sugar liquid: A method of producing a sugar liquid from cellulose-containing biomass includes (1) to (3): (1): subjecting a cellulose-containing biomass to hydrothermal treatment and thereafter separating the treated cellulose-containing biomass into a hydrothermally-treated liquid and a cellulose-containing solid content; (2): adding a filamentous fungus-derived cellulase to the cellulose-containing solid content obtained... Agent:

20150125907 - Methods for increasing sugar yield with size-adjusted lignocellulosic biomass particles: A method of increasing sugar yield in a bioproduct production process is provided comprising pretreating one or more size-adjusted lignocellulosic biomass (LCB) particles with a pretreatment, such as an ammonia pretreatment, wherein the one or more size-adjusted LCB particles form a substrate, with the one or more particles having an... Agent:

20150125910 - Ketoreductase polypeptides for the production of (r)-3-hydroxythiolane: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.... Agent:

20150125913 - Integrated ethanol and biodiesel facility: An integrated facility for the co-production of ethanol and biodiesel fuel is provided. Ethanol and corn oil, the primary product and a by-product from the ethanol plant, are utilized as feedstocks for a biodiesel plant operating within the same general facility as the corn ethanol plant. By-products of the biodiesel... Agent:

20150125911 - Method for producing oxo fatty acid and rare fatty acid: The present invention provides a production method of oxo fatty acid, as well as rare fatty acids such as conjugated fatty acid, hydroxylated fatty acid, partially saturated fatty acid and the like, which uses 4 kinds of enzymes (fatty acid-hydratase, hydroxylated fatty acid-dehydrogenase, oxo fatty acid-isomerase, oxo fatty acid-enone reductase)... Agent:

20150125912 - Multi-stage synthesis method with synthesis gas: e

20150125914 - Tailored oils: Recombinant DNA techniques are used to produce oleaginous recombinant cells that produce triglyceride oils having desired fatty acid profiles and regiospecific or stereospecific profiles. Genes manipulated include those encoding stearoyl-ACP desaturase, delta 12 fatty acid desaturase, acyl-ACP thioesterase, ketoacyl-ACP synthase, and lysophosphatidic acid acyltransferase. The oil produced can have enhanced... Agent:

20150125917 - D(-) lactic acid production: A process for producing D(-) lactic acid in high enatiopurity from lignocellulosic material includes providing a hydrolysate of cellulose polymers prepared from the lignocellulosic material, which includes hexose and pentose sugars and contacting the hydrolysate with the bacterium Lactobacillus coryniformis subsp. Torquens, strain 30 (ATCC 25600) in a fermentation reaction.... Agent:

20150125916 - Method for producing l(+) - lactic acid using bacillus strains: A process for producing L(+) lactic acid in high enatiopurity from lignocellulosic material which includes providing a hydrolysate of cellulose polymers prepared from said lignocellulosic material and comprising hexose and pentose sugars and contacting said hydrolysate with the bacterium Bacillus coagulans (ATCC 23498) strain designation M-39 in a fermentation reaction.... Agent:

20150125915 - Method for producing lactic acid: It is intended to provide a fungus of the genus Rhizopus having improved ability to produce lactic acid and a method for producing lactic acid using the fungus. The present invention provides a method for improving the lactate dehydrogenase activity of a fungus of the genus Rhizopus, comprising germinating a... Agent: Kao Corporation

20150125918 - Acid-resistance in kluyveromyces marxianus by engineering transcriptional factor: A microorganism with improved acid-resistance. A microorganism capable of efficiently producing 3-HP, and methods for producing an organic acid.... Agent:

20150125919 - Microorganism with increased iron-regulated abc transporter activity and method of producing hydroxycarboxylic acid by using the microorganism: A recombinant microorganism having increased iron-regulated ABC transporter activity and increased hydroxycarboxylic acid production, as well as a method of producing a hydroxycarboxylic acid using the recombinant microorganism, and a method of producing the recombinant microorganism.... Agent:

20150125920 - Enhanced pyruvate to acetolactate conversion in yeast: A high flux in conversion of pyruvate to acetolactate was achieved in yeast through expression of acetolactate synthase in the cytosol in conjunction with reduction in pyruvate decarboxylase activity. Additional manipulations to improve flux to acetolactate are reduced pyruvate dehydrogenase activity and reduced glycerol-3-phosphate dehydrogenase activity. Production of compounds having... Agent:

20150125921 - Use of anaerobic digestion to destroy antibiotics in organic waste: The invention relates to systems and methods for using the anaerobic digestion (AD) process, especially thermophilic anaerobic digestion (TAD), to destroy biohazard materials including antibiotics.... Agent: Himark Biogas Inc.

20150125922 - Apparatus for preparing enzyme-immobilized beads and method for preparing enzyme-immobilized beads using same: The present invention relates to an apparatus for preparing enzyme-immobilized beads used for preparation of tagatose, and a method for preparing enzyme-immobilized beads using the same. More specifically, the present invention relates to an apparatus for preparing enzyme-immobilized beads, comprising a nozzle with an inside diameter of 0.1-1 mm having... Agent:

20150125923 - Composition and method for delivery of substances in a dry mode having a surface layer: The present invention generally relates to compositions and methods of delivering substances in a dry mode, wherein the compositions include a surface layer disposed on the outer surface of the composition that is permeable to carbon dioxide and oxygen. The compositions may be used to deliver microorganisms to remove contaminates,... Agent: Drylet LLC

20150125924 - Covalent tethering of functional groups to proteins and substrates therefor: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two... Agent:

20150125925 - Compositions and methods comprising serine protease variants: The present invention provides consumer products comprising a serine protease variant, more specifically subtilisin variants produced there from. Specifically, the present invention provides consumer products comprising a serine protease variant, more specifically a subtilisin variant having one or more substitutions as compared to a reference serine protease. In addition, the... Agent: The Procter & Gamble Company

20150125926 - Transporter protein-coupled nanodevices for targeted drug delivery: A tripartite nanodevice comprising a targeting portion, a carrier portion, and at least one molecule to be delivered is provided. In particular, a gold nanoparticle linked to a targeting protein and capable of delivering a stimulant for the treatment of respiratory or disease is described. A method of making and... Agent:

20150125927 - Compositions relating to a mutant clostridium difficile toxin and methods thereof: In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the... Agent:

20150125928 - Nitrilases, nucleic acids encoding them and methods for making and using them: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.... Agent:

20150125929 - Use of charged fluorocarbon compositions in methods for purification of biomolecules: The present invention relates to novel and improved methods for the purification of biomolecules. In particular, the present invention relates to methods of protein purification which employ a porous solid support modified with a charged fluorocarbon composition.... Agent:

20150125930 - Collapsible bag with flexible vortex breaker: A generally cylindrical collapsible mixing vessel, comprising: a) a flexible plastic film side wall, a top wall and a bottom wall, wherein both the top wall and the bottom wall are attached to the side wall and the side, top and bottom walls define an inner volume of the vessel;... Agent:

20150125931 - Method for processing of stable emulsions from whole-cell biotransformations by means of phase inversion: A method processes a stable emulsion having components from whole-cell biotransformations such as cells, soluble cell components, organic solvents and/or water. In this connection, the emulsion, which is stable after the biotransformation, is mixed with further parts of organic phase, and subsequently the mixture is continuously stirred until a catastrophic... Agent: Technische Universitaet Dortmund

20150125932 - Modified organisms for producing gums: The production of a diutan polysaccharide exhibiting increased viscosity properties as compared with previously produced polysaccharide of the same type of repeating units. Such an improved diutan polysaccharide is produced through the generation of a derivative of Sphingomonas sp. ATCC 53159 that harbors a multicopy broad host-range plasmid into which... Agent:

20150125934 - Method for selectively culturing microorganism using phosphite dehydrogenase gene as marker: A simple and inexpensive method for selectively culturing a microorganism which method makes it possible to selectively culture a microorganism of interest even without using a sterilization operation or an antibiotic substance is provided. The method according to the present invention selectively culturing a microorganism includes the step of culturing,... Agent:

20150125933 - Production of fatty acids and derivatives thereof having improved aliphatic chain length and saturation characteristics: The invention relates to compositions, including polynucleotide sequences, amino acid sequences, recombinant microorganisms, and recombinant microorganism cultures that produce compositions of fatty acids and derivatives having target aliphatic chain lengths and/or preferred percent saturation. Further, the invention relates to methods of making and using the compositions. The compositions and methods... Agent: Ls9, Inc.

20150125935 - Microbial growth enhancement from a dry film additive: A hyperbranched polymer based on one or more repeating units of an ABx type monomer, wherein A and B are functional groups and x is greater than or equal to 2, wherein A reacts with, or substantially reacts with, B, wherein B is fractionally functionlized with a plurality of functional... Agent:

20150125936 - Laccases for bio-bleaching: Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins and other phenolic and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions... Agent:

20150125937 - Infectious disease detection system: A method and apparatus for managing a zone. Information is obtained about an environment in the zone with a sensor system. A determination is made by an analyzer system as to whether a contagious condition is present in the zone using the information from the sensor system. An action is... Agent:

20150125940 - Container cleaning device, discharge member for container cleaning device, and analyzer: Disclosed is a container cleaning device which cleans a container for holding a sample. The device comprises: a container holding section for holding the container which has a substantially spherical inner bottom; a discharge section which is inserted into the container; and a cleaning nozzle which discharges a cleaning liquid... Agent:

20150125941 - Detection system of test substance: A detection system of a test substance, includes: a magnetic body that is modified by a first substance capable of being bound to the test substance at a first binding site of the test substance; a marker that is modified by a second substance capable of being bound to the... Agent: Tokyo Institute Of Technology

20150125938 - Liquid sample measuring system and measuring device: An liquid sample measuring system includes a measuring device including a measuring section which measures biological information from liquid sample of a living subject within a housing in which a biosensor, on which the liquid sample of the biological body is deposited, is detachably mounted and a movement measuring section... Agent: Panasonic Healthcare Co., Ltd.

20150125939 - Reagent delivery system: A delivery apparatus for selectively delivering one or more liquid reagents into a reaction or test chamber (2), especially of an assay apparatus, the apparatus comprising: one or more respective storage chambers (5,6) for containing the one or more liquid reagents and arranged generally above the reaction or test chamber... Agent:

20150125942 - Devices, systems, and methods for targeted plating of materials in high-throughput culture plates: Devices, systems, and methods for facilitating placement of cells and materials in culture plates configured for high-throughput applications are provided. A culture system is provided with a culture plate having a lid for guiding placement of cells and materials in each individual culture well of a culture plate. The lid... Agent:

20150125945 - Centrifuge configurations: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that... Agent:

20150125943 - Light field image sensor, method and applications: An angle-sensitive pixel (ASP) device that uses the Talbot effect to detect the local intensity and incident angle of light includes a phase grating disposed above a photodiode assembly or a phase grating disposed above an analyzer grating that is disposed above a photodiode assembly. When illuminated by a plane... Agent: Cornell University

20150125944 - Submersible flow imager: Submersible technology capable of sampling and evaluating suspended particulate materials, including living and dead organisms, is disclosed herein. In addition to fluorescent imaging and analysis, the invention provides automated cell staining, cell sorting, particulate concentration, and organism recovery and preservation. These new technologies may be incorporated into a traditional “fully... Agent:

20150125946 - Horizontal immersion cover type carbon supplement device and carbon supplement method used for microalgae culture in open pond: The invention relates to the field of mass cultivation of microalgae and specifically relates to a horizontal submerged cover type carbon supplement device and carbon supplement method for cultivating microalgae in an open pond. The horizontal submerged cover type carbon supplement device for cultivating microalgae in an open pond, comprises:... Agent: Institute Of Process Engineering ,chinese Academy Of Sciences

20150125947 - Microfluidic device: The invention provides a new microfluidic device and method for performing operations on droplets. The invention extends to microfluidic systems comprising one or more of the microfluidic devices.... Agent: Scope Fluidics Sp Z O.o.

20150125948 - Acoustophoresis device with modular components: An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a... Agent:

20150125949 - Steganographic embedding of information in coding genes: The present invention relates to the storage of items of information in nucleic acid sequences. The invention also relates to nucleic acid sequences in which desired items of information are contained, and to the design, production or use of such sequences.... Agent:

20150125950 - Umbilical cord mesenchymal stem cell exosomes: We describe a method of cell culture of an umbilical mesenchymal stem cell (MSC). The method comprises the steps of providing an umbilical mesenchymal stem cell (MSC) and culturing the umbilical mesenchymal stem cell in a cell culture medium under hypoxic conditions. The umbilical mesenchymal stem cell may be transformed... Agent: Agency For Science, Technology And Research (a*sta (a*star)

20150125951 - Mutant alpha-synuclein, and methods using same: The present invention relates to a mutant human alpha-synuclein with increased toxicity compared to wild-type alpha-synuclein, or a homologue thereof, wherein the mutant alpha-synuclein or homologue thereof comprises at least one amino acid substitution selected from the group consisting of a substitution at the alanine at position 56 (A56), at... Agent:

20150125953 - Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells: Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells derived from pluripotent cells by modulating TGFβ, BMP, and FGF signaling pathways under defined culture conditions. Also described are methods for obtaining non-otic placodal... Agent:

20150125954 - Substrate unit, preservation device and method for the cryopreservation of a biological sample: The invention relates to a substrate unit (100), in particular for the cryopreservation of a biological sample (1) containing biological cells (2, 2.1, 2.2), comprising a substrate platform (10) having a front side and a back side, wherein the front side of the substrate platform (10) has a cultivation surface... Agent:

20150125952 - Systems and method for engineering muscle tissue: The present invention generally relates to the field of cell growth and tissue engineering, in particular, tissue engineered compositions comprising a nanotextured substrate which is structurally configured for growth of cells in an anatomically correct adult phenotype in vitro. In particular, described herein are nanotextured substrates which are structurally configured... Agent:

20150125955 - Pd-1 modulation and uses thereof for modulating hiv replication: Methods, uses, compositions and kits for modulating HIV replication based on PD-1 modulation are disclosed. Methods, uses, compositions and kits useful for the elimination of latent HIV reservoirs based on PD-1 inhibition are also disclosed. Methods and kits useful for identifying agents useful for modulating HIV replication are also disclosed.... Agent: Oregon Health & Science University

20150125957 - Cellular response to surface with nanoscale heterogeneous rigidity: An elastomeric substrate comprises a surface with regions of heterogeneous rigidity, wherein the regions are formed by exposing the elastomeric substrate to an energy source to form the regions such that the regions include a rigidity pattern comprising spots.... Agent:

20150125956 - Composition for maturing dendritic cells, and method for preparing antigen-specific dendritic cells using same: The present invention relates to a composition for maturing dendritic cells, comprising, as a maturation-promoting factor, Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Tumor necrosis factor-α (TNF-α), Interferon-γ (IFN-γ), Prostaglandin E2 (PGE2), Picibanil (OK432) and/or Poly IC. The composition for maturing dendritic cells of the present invention may have the effects of not... Agent: Jw Creagene Inc.

20150125958 - Methods for controlling stem cell differentiation: Disclosed herein are methods for controlling stem cell differentiation through the introduction of transgenes having Xic, Tsix, or Xite sequences to block differentiation and the removal of the transgenes to allow differentiation. Also disclosed are small RNA molecules and methods for using the small RNA molecules to control stem cell... Agent:

20150125959 - Bacterial mutants with improved transformation efficiency: Provided herein are Lactobacillus mutants having improved transformation efficiency, comprising a disruption to an endogenous gene encoding a restriction modification system protein. Also described are methods for producing the mutants, methods for generating transformants using the mutants, and methods for producing a polypeptide or fermentation product using the mutants.... Agent:

20150125960 - Ultrasound mediated delivery of substances to algae: Embodiments provided herein generally relate to methods and materials for ultrasound-mediated introduction of exogenous substances into microorganisms. Some embodiments relate to methods of introducing an exogenous material into a microorganism such as an algae. The methods can include, for example, providing a microorganism (e.g., algae); providing a population of bubbles... Agent:

  
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