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Chemistry: molecular biology and microbiologyBelow are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 11/13/2014 > 121 patent applications in 72 patent subcategories.
20140335503 - Methods for ascertaining the history of hematological conditions of a human from a single blood sample: A method for analysis of red blood cell production dynamics is disclosed. The method comprises: (ai) separating RBCs in the blood sample into ordered subsets of RBCs based on relative age-related physical parameter of the RBCs, or (aii) obtaining a pair of estimates simultaneously, the pair of the estimates comprising... Agent:
20140335507 - Assays for influenza virus hemagglutinins: The invention quantifies HA using a process which comprises two key steps: HA is captured using a lectin, such as snowdrop lectin; and captured HA is quantified using an immunoassay. This assay can conveniently be performed in an ELISA format. The process is specific, is robust in the face of... Agent:
20140335504 - Human adaptation of h5 influenza: The present invention provides, among other things, technologies and methodologies for detection, treatment, and/or prevention of influenza transmission and/or infection. The present invention also provides technologies for monitoring influenza HA variants with particular degrees of susceptibility to mutation for human adaptation.... Agent: Massachusetts Institute Of Technology
20140335508 - Method for detecting an infection by the hepatitis c virus: The invention relates to a method of in-vitro detection of an infection with a hepatitis C virus (HCV) in a biological sample, comprising the simultaneous detection of the HCV capsid protein, and of an antibody directed against said capsid protein, said method using, for capturing the anti-capsid antibodies, a peptide... Agent:
20140335506 - Modular point-of-care devices, systems, and uses thereof: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods... Agent:
20140335505 - Systems and methods for collecting and transmitting assay results: Systems and methods are provided for collecting, preparing, and/or analyzing a biological sample. A sample collection site may be utilized with one or more sample processing device. The sample processing device may be configured to accept a sample from a subject. The sample processing device may perform one or more... Agent:
20140335511 - Acoustic pressure wave/shock wave mediated processing of biological tissue, and systems, apparatuses, and methods therefor: Methods for preparing a biological tissue specimen for examination, such as microscopic examination, that involves applying acoustic pressure wave/shock wave (APW/SW) energy to the tissue specimen. The APW/SW energy can be applied to the tissue specimen to augment any one or more steps of processing the tissue specimen. In one... Agent:
20140335512 - Enzyme method: The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a RecD helicase. The helicase controls the movement of the target polynucleotide through the pore.... Agent:
20140335509 - Method of determining the nucleotide sequence of oligonucleotides and dna molecules: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown... Agent: Life Technologies Corporation
20140335510 - Nanoparticle sensor for nucleic acid-protein interaction: The present invention provides a sensor for sensing nucleic acid-protein interactions, comprising a noble metal nanoparticle (NP), a double stranded nucleic acid molecule capable of binding with a protein in an aqueous solution and a fluorescent conjugated polymer (CP). The present invention also provides a method for sensing nucleic acid-protein... Agent: Agency For Science, Technology And Research
20140335519 - Capture probes for use in detecting the presence of trichomonas vaginalis in a sample: Oligomers useful for determining the presence of Trichomonas vaginalis in a test sample.... Agent:
20140335517 - Detection and treatment of schizophrenia: The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia... Agent:
20140335520 - Direct nucleic acid analysis: The present disclosure provides methods, systems, and apparatuses for collecting and/or amplifying nucleic acids. In general, provided methods, systems, and apparatuses involve contacting a sample including a nucleic acid with a nucleic acid amplification reagent without purification of nucleic acids from the sample.... Agent: Spartan Bioscience, Inc.
20140335515 - Droplet digital pcr with short minor groove probes: Methods for the detection of ddPCR assay-generated amplicons by short minor groove binder-fluororophore-oligonucleotide-quencher (MGB-Fl-oligo-Q) probes. The short MGB-Fl-oligo-Q probes not only reduce background, but also show improved mismatch discrimination when compared to the same length non-MGB probes for detecting the ddPCR generated targets at room temperature.... Agent: Elitech Holding B.v.
20140335518 - Encapsulated reagents and methods of use: The present invention contemplates use of encapsulated aqueous and non-aqueous reagents, solutions and solvents and their use in laboratory procedures. These encapsulated aqueous or non-aqueous reagents, solutions and solvents can be completely contained or encapsulated in microcapsules or nanocapsules that can be added to an aqueous or non-aqueous carrier solution... Agent:
20140335522 - Enrichment & isolation of microbial cells & microbial nucleic acids from a biological sample: A method for enrichment and isolation of microbial cells and microbial nucleic acids from a biological sample is described. The method comprises (i) adding to an initial volume of biological sample a differential cell lysis solution to obtain a final concentration of 0.1 to 1% of SDS in the sample;... Agent:
20140335523 - Gender-specific identification of sperm cells and embryos using locked nucleic acids: Disclosed are sperm cells and embryos comprising a labeled locked nucleic acid bound to a gender-specific repeat sequence. Methods for identifying and separating sperm cells or embryos containing a labeled locked nucleic acid from sperm cells or embryos not containing the labeled oligonucleotide produce gender-enriched sperm cell or embryo fractions.... Agent:
20140335513 - Hybrid nanopore device with optical detection and methods of using same: The invention is directed to a device comprising a protein nanopore immobilized in a lipid layer within an aperture of a solid phase substrate, which provides a stable platform for using first and second members of one or more FRET pairs to generate optical signals as a labeled analyte translocates... Agent: Quantapore, Inc.
20140335516 - Inducible cell-based model for the study of friedreich's ataxia: Isolated transduced cells exhibiting FRDA characteristics in an inducible fashion are disclosed. Isolated transduced cells comprise an expression vector having a nucleic acid sequence encoding an shRNA for frataxin protein knockdown and a heterologous expression control sequence. Additionally, methods of screening for a candidate therapeutic agent for treating Friedreich's Ataxia... Agent:
20140335524 - Method for controlling the production of sulphites, of hydrogen sulphide and of acetaldehyde by yeasts: The present invention relates to the identification of alleles of the MET2 and SKP2 genes having the effect of reducing the production of sulphites, of hydrogen sulphide and of acetaldehyde by Saccharomyces, and to the use of these alleles in methods for controlling the production of these compounds during alcoholic... Agent:
20140335521 - Method for designing rna binding protein utilizing ppr motif, and use thereof: A method for designing a protein capable of binding in an RNA base selective manner or RNA base sequence specific manner is provided. The protein of the present invention is a protein containing one or more of PPR motifs (preferably 2 to 14 PPR motifs) each consisting of a polypeptide... Agent: Kyushu University, National University Corporation
20140335514 - Methods for detecting nucleic acid sequence variants: The present invention provides methods for detecting the presence or absence of a nucleic acid variant in a target region. These methods include amplifying the target region with a forward primer and a reverse primer in the presence of a selector blocker. The selector blocker includes a sequence complementary to... Agent: Biocept, Inc.
20140335528 - Analyte enrichment methods and compositions: Methods and compositions for enriching a population of particles containing an analyte are disclosed. In one embodiment, enrichment beads are used that are larger in size than the beads used for amplification. A separation device is employed that can retain larger beads with bound amplified beads. The technique finds many... Agent:
20140335531 - Apparatus for detecting nucleic acid amplification product in real time: There is provided an apparatus for detecting a nucleic acid amplification product in real time, which is capable of effectively excluding or reducing apparatus error factors without using a second fluorescence signal used for correction. A plurality of wells 7A are given with temperature cycles and fluorescence strength from a... Agent:
20140335530 - Compositions and methods for modulating an immune response: The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory T cell suppressive activity.... Agent: The Johns Hopkins University
20140335525 - Cutoff point delta ct. method for her2 pcr testing in breast cancer: The present invention is related to an improved method for HER2 gene test by using quantitative real-time PCR (Polymerase Chain Reaction) technique. Our invention streamlines test process, and incorporates quality control for each major step, including sample, reagent, operation, and data report. We eliminate the need for reference genes which... Agent:
20140335532 - Human skin sample methods and models for validating hypotheses for mechanisms driving skin pigmentation: Human skin tissue sample methods and models for validating hypotheses for mechanisms driving skin pigmentation as well as methods for driving skin pigment levels in ex-vivo skin tissue. The method includes providing a first cultured human skin tissue sample and testing the effectiveness of the test agent for driving skin... Agent:
20140335529 - Method of tumor screening: A method for tumor screening using urine of a mammal, the method includes obtaining a total urine nucleic acid (e.g., DNA) from a urine sample of a mammal, extracting a high molecular weight urine nucleic acid (above 1000 bp) by contacting the total urine nucleic acid with an adsorbent in... Agent: The Children's Hospital Of Philadelphia
20140335526 - Quantification of residual host cell dna by real-time quantitative pcr: The present invention relates to a method for quantifying residual host cell genomic DNA in recombinant protein biologics using quantitative real time PCR.... Agent: Confarma France
20140335527 - Systems and methods for mobile device analysis of nucleic acids and proteins: A portable system for extracting, optionally amplifying, and detecting nucleic acids or proteins using a compact integrated chip in combination with a mobile device system for analyzing detected signals, and comparing and distributing the results via a wireless network. Related systems and methods are provided.... Agent: Nanobiosym, Inc.
20140335533 - Method of preparing quality control material for ffpe: This specification relates to Formalin-fixed embedded quality control material for use for validation, verification, and to run controls for molecular assays. The quality control material can be used for a variety of tissues and for a variety of molecular assays. The quality control material can be used in commercial labs... Agent:
20140335534 - Method and system for identifying a biomarker indicative of health condition: By designing a retrogression-progression model in combination with oral microbial community analysis, the present invention provides a method of identifying a biomarker indicative of a subject mammal's condition, wherein the condition is selected from presence of the first disease, severity of the first disease, sensitivity to the first disease, and... Agent: The Procter & Gamble Company
20140335535 - Peptide marker for cancer diagnosis and cancer diagnosis method using the same: The present invention relates to a peptide marker for cancer diagnosis and a cancer diagnosis method using the same, more precisely to a peptide marker for cancer diagnosis screened by the following steps: separating and concentrating glycoproteins including a certain glycan chain related to the occurrence of cancer; hydrolyzing the... Agent: Korea Basic Science Institute
20140335536 - Vaccine for the treatment of mycobaterium related disorders: The invention relates to genes and proteins involved in the sporulation of Mycobacteria and the use thereof in the technical fields of immunology and medicine.... Agent: Marfl Ab
20140335541 - B7-h1 and b7-h4 in cancer: Methods of determining prognosis of a subject with cancer or determining risk of cancer progression by assessing expression of B7-H4, or B7-H1 and B7-H4 in combination.... Agent:
20140335542 - Molecular characterization of circulating tumor cells: The disclosed invention includes methods and kits for the removal of white blood cells from samples of enriched rare cells.... Agent:
20140335543 - Antibodies to clostridium difficile spores and uses thereof: The present invention provides antibodies that bind to the endospore of the bacterium Clostridium difficile, methods of making such antibodies, and methods of using such antibodies, including methods of detecting C. difficile endospores.... Agent: 3m Innovative Properties Company
20140335544 - Method of detecting the presence of an antibody in a sample: Methods for detecting in a sample the presence of an antibody to a conjugate of an antigen associated with a first carrier by a first association are disclosed. The method comprises contacting a conjugate of the antigen associated with a second carrier by a second association with said sample under... Agent:
20140335537 - Devices for performing colorimetric assay with plucked human hair: Apparatuses are disclosed for performing calorimetric assays with plucked human hair using a device adapted for that purpose. This device may include a transparent reaction vessel connected via a capillary tube to a burst pack, and connected via another capillary tube to a funnel, into which a plucked human hair... Agent: Follea International Ltd.
20140335538 - Methods of diagnosing als: The invention relates to an epitope protection assay for use in diagnosis, prognosis and therapeutic intervention in diseases, for example, involving polypeptide aggregation, such as prion infections. The methods of the invention first block accessible polypeptide target epitope with a blocking agent. After denaturation of the polypeptide, a detecting agent... Agent:
20140335545 - Method for detecting compound-binding protein: A method for detecting the interactions of biomaterials by screening a prey that interacts with a bait includes preparing a cell which expresses a first construct including a translocation module, a first labeling material, and a first medium, and a third construct including a prey and a second labeling material;... Agent:
20140335539 - Method for detecting protein-protein interaction: m
20140335540 - Method of diagnosing bacterial infections using bacterial glycoproteins: The present application provides a method of diagnosing bacterial infections using engineered glycoproteins in an immunoassay. The engineered bacterial glycoproteins used in the immunoassay comprise a bacterial antigen covalently attached to a protein via polysaccharyltransferase (PTase)-mediated glycosylation, wherein the bacterial antigen is selected based on the bacterial infection of interest.... Agent:
20140335546 - Devices and methods for determining the risk of developing a serious infection: A device for calculating risk of a patient developing a serious infection, the device comprising: a controller; storage storing electronic program instructions for controlling the controller; a display for displaying a user interface; and input means; wherein the controller is operable, under control of the electronic program instructions, to: receive... Agent:
20140335547 - Marker panels for idiopathic pulmonary fibrosis diagnosis and evaluation: The present invention relates to the discovery that of a panel of serum or plasma markers may be used to diagnose Idiopathic Pulmonary Fibrosis (“IPF”) and distinguish this condition from other lung ailments. It further relates to the identification of markers associated with IPF disease progression.... Agent: University Of Pittsburgh - Of The Commonwealth System Of Higher Education
20140335548 - Spermidine biomarker for the detection of sulfoxidizing activity: The invention refers to a method to evaluate the sulfoxidizing activity in a microbiologic process detecting the presence of the spermidine biomarker produced by the micro organisms that participate in such process.... Agent:
20140335549 - Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using elisa assays: The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic... Agent: Board Of Regents, The University Of Texas System
20140335552 - Method and apparatus for detecting cancer in mammals: The invention provides a method and apparatus for detecting cancer using the measurement of acute-phase proteins (APPs) and the measurement of thymidine kinase activiy level in body fluids. An index is calculated based on the measured data and compared with a pre-established reference that allows a pratitioner to determine a... Agent: Veterinary Diagnostics Institute, Inc.
20140335551 - Sulfotransferase assay: A method of detecting sulfotransferase activity including conducting a first reaction comprising, measuring free phosphate produced by the first reaction, and comparing the measured free phosphate to a free phosphate standard curve or equation or to a free phosphate level obtained in a separate reaction. The first reaction includes combining... Agent:
20140335553 - Novel l-amino acid oxidase, method for measuring l-lysin, kit and enzyme sensor: Methods are provided measuring L-lysine using a variant enzyme, an L-lysine measurement kit, and an enzyme sensor. Variant L-amino acid oxidase having a predetermined amino acid mutation, and having oxidase activity that is highly substrate-specific for L-lysine; a method for measuring L-lysine using this variant enzyme; an L-lysine measurement kit;... Agent: Toyama Prefecture
20140335554 - Apparatus and methods for aliquotting frozen samples: A method of obtaining an aliquot of a frozen sample contained in a container includes moving a coring device into the sample and then withdrawing it to obtain a frozen sample core. The location from which the core is taken is selected to be at a radial position where the... Agent: President And Fellows Of Harvard College
20140335555 - Automated vitrification device: The present application relates to devices for the vitrification of biological samples, including embryos, oocytes and biological tissues. Suitably, the devices are automated devices which require little if any operator intervention or sample handling, thereby reducing contamination, improving success rates and increasing efficiency. Also provided are methods of vitrifying a... Agent: University Of Kansas
20140335557 - Apparatus for counting viable particles in liquid in real time, dialysis fluid monitoring system and purified water monitoring system using the apparatus, and method of counting viable particles in liquid in real time: A viable particle counting apparatus 77 includes devices 10, 70, 2. The device 10 radiates a light with a predetermined wavelength toward a liquid containing a detection target. The device 70 reduces a Raman-scattered light emitted from the liquid out of lights emitted due to an interaction of the light... Agent: Rion Co., Ltd.
20140335556 - Mass spectrometric determination of microbial resistances: The invention relates to a mass spectrometric method for determining microbial resistances to antibiotics. The invention provides specific methods comprising cultivation in synthetic media, in which several amino acids, preferably only a single amino acid, are isotopically labeled by incorporating 13C, 15N, 18O or 34S. If several amino acids are... Agent:
20140335558 - Method for the characterization of microorganisms on solid or semi-solid media: The present invention relates to methods and systems for scanning, detecting, and monitoring microorganisms on solid or semi-solid media using intrinsic fluorescence (IF) measurements. The methods are further directed to detection, characterization and/or identification of microorganisms on a solid or semi-solid media using intrinsic fluorescence (IF) measurements that are characteristic... Agent: Biomerieux, Inc.
20140335559 - Method for the detection of acid production by cariogenic bacteria: The present invention relates to a method for the semi-quantitative determination of cariogenic bacteria in a sample of saliva and/or plaque, in which the microorganisms contained in a sample of plaque or saliva are brought into contact with a carbon source that is fermented to acid by the cariogenic bacteria.... Agent: Ivoclar Vivadent Ag
20140335560 - Automated microdissection instrument: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking... Agent: Life Technologies Corporation
20140335561 - Method for producing phosphoserine incorporated proteins by using seprs mutants and ef-tu mutants: According to the invention, a phosphorylated protein can be produced in an amount of mg per liter using the SepRS and EF-Tu mutants. Thus, the invention is useful for the production of various phosphorylated proteins, including phosphorylated enzymes, the production of antibodies, the fabrication of protein chips, and cell-based screening... Agent: Korea Advanced Institute Of Science And Technology
20140335562 - Genetically engineered herbicide resistant algae: Algae transformed with one or more polynucleotides encoding proteins that confer herbicide resistance are provided. The algae can be grown in small or large scale cultures that include one or more herbicides for the production and isolation of various products.... Agent: Sapphire Energy, Inc.
20140335564 - Il-17 binding proteins: Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.... Agent: Abbvie Inc.
20140335565 - Method for production of polypeptide: The present invention provides a method capable of producing a natural or recombinant protein in high yield. The present invention relates to a method of producing a polypeptide, comprising culturing a cell which strongly expresses cysteine sulfinic acid decarboxylase and has a transferred DNA encoding a desired polypeptide and thereby... Agent:
20140335563 - Stabilized human igg2 and igg3 antibodies: It is intended to provide highly stable variants of human antibody IgG2 and IgG3 subclasses. The present invention provides an IgG heavy chain comprising the constant region of a human IgG2 heavy chain having at least a substitution of Y for F at the 300th position, L for V at... Agent: Kyowa Hakko Kirin Co., Ltd
20140335566 - Mobile vessel or carrier for the manufacturing production and purification of biologics: Embodiments described herein relate to mobile biologics production systems that can be transported to a site where a production of biologics is required, and is operable to produce the biologics on-site on demand. A mobile biologics production system can include a mobile carrier configured to be trailered to a biologics... Agent: Biocapacity On Demand, LLC
20140335567 - Lactonase derived from candida bombicola and uses thereof: The present disclosure relates to an enzyme derived from Candida bombicola that is capable of lactonizing or polymerizing carbohydrate-containing compounds, lipids, fatty acids, hydroxylated fatty acids, alcohols, dicarboxylic acids or mixtures thereof. Hence, host cells comprising the latter enzyme can be used, via the formation of intra- or inter-molecular ester-bounds,... Agent: Universiteit Gent
20140335568 - Nucleic acid assembly, vector, cell, methods and kit thereof: The present disclosure relates to a nucleic acid assembly (NAA), comprising sensor domain and handle domain; an assembly interfaceable motif (AIM) sequence optionally along with intracellular targeting motif (ITM) sequence; and an AIM-NAA complex. It also relates to a vector comprising assembly interfaceable motif sequence optionally along with intracellular targeting... Agent: National Centre For Biological Sciences
20140335569 - Method of amplifying nucleic acid sequences: The invention is directed to methods of removing amplicons of non target and/or target nucleic acid sequences having one or more modified (e.g., methylated) nucleotides from a sample wherein the sample comprises the non target nucleic acid and a target nucleic acid sequence to be amplified.... Agent:
20140335571 - Lignin-degrading methods: Disclosed herein are methods that involve degrading materials that include lignin. In one aspect, the method generally includes contacting a lignin sample with a lignin depolymerase and contacting the lignin sample with an auxiliary compound. In another aspect, the method generally includes contacting an auxiliary compound with a sample that... Agent:
20140335570 - Polypeptides having xylanase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes Inc.
20140335573 - Fusion proteins comprising type-ii cohesin modules, multi-enzyme complexes comprising same and uses thereof: Fusion proteins including a type-II cohesin module that are capable of integrating into native and designer cellulosomes. β-glucosidases modified to include a type-II cohesin module and polynucleotides encoding same. Multi-enzyme complexes including the fusion proteins, and methods for biomass degradation utilizing same.... Agent:
20140335572 - Polypeptides having catalase activity and polynucleotides encoding same: Provided are isolated polypeptides having catalase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent:
20140335574 - Mutant acetolactate synthase and a method for producing branched-chain l-amino acids: A mutant bacterial acetolactate synthase (AHAS I) which is resistant to feedback inhibition by L-valine is described. Also described is a method for producing branched-chain L-amino acids using a bacterium from the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by the use of the acetolactate... Agent: Ajinomoto Co., Inc.
20140335575 - Novel amidase: An object of the present invention is to provide a means for producing an optically active tropic acid that is a compound useful as a synthetic raw material or an intermediate for pharmaceutical products and the like. The present invention provides a novel polypeptide having activity to (R)-selectively hydrolyze a... Agent:
20140335576 - Methods for increasing microbial production of isoprene, isoprenoids, and isoprenoid precursor molecules using glucose and acetate co-metabolism: Provided herein are methods for the increased production of intracellular acetyl-CoA, mevalonate, isoprenoid precursors, isoprene and/or isoprenoids by recombinant microorganisms via co-metabolism of substrates with varied oxidation levels.... Agent: The Goodyear Tire & Rubber Company
20140335577 - Use of enzymes having silicase activity: The present invention relates to the use of polypeptides having silicase activity for the modification or synthesis of silica, silicones and other silicium (IV) compounds. The present invention also relates to the use of polypeptides having silicase activity for the modification of glass, sand, asbestos, computer chips, glass wool, fiber... Agent:
20140335579 - Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms: The present invention relates to polynucleotides from Cochliobolus heterostrophus C5, Cyanothece sp. CCY0110, Mycocentrospora acerin and Hyaloperonospora parasitica, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids. The invention furthermore relates to vectors, host cells and transgenic nonhuman organisms which comprise the... Agent:
20140335578 - Integrated biodiesel process: Methods of using crude glycerol to make fatty acids are provided, as well as integrated methods of converting glycerol waste from biodiesel production into more biodiesel. Bacteria and other microbes engineered to produce free fatty acids from glycerol are also provided.... Agent: William Marsh Rice University
20140335580 - Method for enrichment of eicosapentaenoic acid and docosahexaenoic acid in source oils: An simpler, cheaper method for enhancing the percentage of eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) from source oils has been discovered. This method hydrolyzes the oil using the lipase enzyme but does not inactivate the lipase enzyme with either added chemicals or increased temperature. The method relies on centrifugation... Agent: Board Of Supervisors Of Lousiana State University And Agricultural And Mechanical College
20140335581 - Lactic acid extraction: A method for recovering lactic acid from an aqueous mixture including the steps of: providing an aqueous mixture including lactic acid and at least 5 wt. % dissolved magnesium chloride, based on the total weight of water and dissolved material in the aqueous mixture; extracting the lactic acid from the... Agent:
20140335582 - Fermentive production of four carbon alcohols: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.... Agent:
20140335583 - Methods and systems for producing products using engineered iron oxidizing bacteria: Methods and systems for producing a biofuel using genetically modified iron-oxidizing bacteria (IOB) are disclosed. In some embodiments, the methods include the following: providing an IOB that have been genetically modified to enable them to generate a biofuel or chemical; feeding a first source of ferrous iron to the IOB;... Agent:
20140335584 - Increased ethanol production by genetic engineering of microorganisms to express hemoglobin: The present disclosure describes novel bacterial strains which express a pyruvate decarboxylase gene and at least one alcohol dehydrogenase gene from a bacteria of the genus Zymomonas and also express a hemoglobin gene from a bacteria of the genus Vitreoscilla. The present disclosure further describes methods for producing fermentation products... Agent:
20140335585 - Method of reutilization of carbon dioxide from emissions: This invention relates to apparatuses and methods for the reduction of carbon dioxide emissions resulting from combustion using a bioreactor that includes methanogenic bacteria or genetically modified algae.... Agent: Hillwinds Energy Development Corporation
20140335586 - System and method for converting acids to hydrocarbon fuels: Herein disclosed is a method comprising: converting at least a portion of the biomass into medium-chain fatty acids or carboxylic acids ranging from C4 to C9; reacting at least a portion of the medium-chain fatty acids or carboxylic acids in a ketonization reactor to produce a ketonization product; and reacting... Agent: Ee-terrabon Biofuels LLC
20140335587 - Radiofrequency device for increasing intracellular bioactive substance and plant cell culture method using the same: There are provided a radiofrequency device for increasing amount of a bioactive substance in a plant cell and a plant cell culture method for increasing amount of useful intracellular secondary metabolites by using the radiofrequency device. The cell culture method of the present invention makes it possible to increase specific... Agent: Bio-fd&c Co., Ltd
20140335588 - Apparatus and process for production of an encapsulated cell product: A process for production of an encapsulated cell product, the process comprises the steps of concentrating cells from a propagation medium using a tangential flow filtration system. Mixing the concentrated cells with an encapsulation medium to form a cell encapsulation mixture. Polymerizing, gelling, or cross-linking the cell encapsulation mixture to... Agent: Geosynfuels, LLC
20140335589 - Separation of a target substance from a fluid or mixture using encapsulated sorbents: Method and apparatus for separating a target substance from a fluid or mixture. Capsules having a coating and stripping solvents encapsulated in the capsules are provided. The coating is permeable to the target substance. The capsules having a coating and stripping solvents encapsulated in the capsules are exposed to the... Agent:
20140335590 - Methods for promoting cell reprogramming: The present invention is based on the seminal discovery that several kinases play important roles in barrier pathways in somatic cell reprogramming. The present invention provides that modulating expression or activity of these kinases can significantly promote or enhance cell reprogramming efficiency. Key kinases are identified and key regulation networks... Agent: Sanford-burnham Medical Research Institute
20140335591 - Increased production of secreted proteins by recombinant eukaryotic cells: Described herein are methods for increasing the amount of protein secreted by a cell. In one case, a cell is provided which contains a heterologous nucleic acid encoding a protein having unfolded protein response modulating activity and a heterologous nucleic acid encoding a protein of interest to be secreted. In... Agent: Danisco US Inc.
20140335592 - Tal effector-mediated dna modification: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.... Agent: Regents Of The University Of Minnesota
20140335593 - Cytotoxic ribonuclease variants: This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the ribonuclease inhibitor while still retaining catalytic properties. While earlier work had identified some... Agent:
20140335594 - Method for the removal of virus from a protein solution: The present invention relates to a method for selectively removing virus and/or virus DNA from a solution comprising a target protein, whereby acetone is used as a precipitation agent to precipitate virus and/or virus DNA as well as the target protein.... Agent:
20140335595 - Streptomyces strain that decomposes proteins recalcitrant to proteolysis: The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and... Agent:
20140335596 - Subtilase variants and polynucleotides encoding same: The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.... Agent:
20140335597 - Single-use vertical wheel bioreactors: A pneumatic bioreactor includes a vessel containing a fluid to be mixed and at least one mixing device driven by gas pressure. A first embodiment includes a floating impeller that rises and falls in the fluid as gas bubbles carry it upward to the surface where the gas is then... Agent:
20140335599 - Method for rapidly and efficiently harvesting green algae using cationic organoclay: The present invention relates to aminoclay, for harvesting algae, which is prepared by fixing aminosilane around cationic metal ions through a sol-gel reaction. Also, the present invention relates to a method for harvesting algae using the aminoclay according to any one selected from the above methods.... Agent:
20140335598 - Reaction casing for a photosynthetic reactor and associated photosynthetic reactor: Reaction casing (1) for a photosynthetic reactor suitable for cultivating photosynthetic microorganisms, in particular algae, said reaction casing (1) being designed for both floating on an expanse of water and defining a path for a gas/liquid culture medium to flow in two phases between a first and a second opening... Agent:
20140335600 - Cell collection method: A method for collecting cells that have been cultured by using a cell culture kit in which, at least, a culture container for cultivating cells, a cell collection container for collecting cells after cultivation and a waste liquid container for collecting a culture medium after cultivation are linked to one... Agent:
20140335601 - Chemical oxidation and biological attenuation process for the treatment of contaminated media: A method for the removal of semi-volatile organic compounds in soils, sludges, groundwater, process water, and wastewater is presented. Oxidation and biological attenuation processes utilize persulfates and other oxidants with trivalent metals, such as ferrous iron or Mn3+, as activators. The resulting chemical oxidation process yields degradation compounds which facilitate... Agent: Innovative Environmental Technologies, Inc.
20140335602 - Chemical oxidation and biological attenuation process for the treatment of contaminated media: A method for the removal of semi-volatile organic compounds in soils, sludges, groundwater, process water, and wastewater is presented. Oxidation and biological attenuation processes utilize peroxide, persulfates, percarbonates, and/or other oxidants with trivalent metals, such as ferric iron (Fe3+) or manganic ion (Mn3+) as activators. The resulting chemical oxidation process... Agent: Innovative Environmental Technologies, Inc.
20140335603 - Method for signal amplification in biosensor-based system for rapidly detecting infectious agents: A system for detecting infectious agents in biological samples in real time that includes a sample to be tested for at least one specific infectious agent; and a biosensor, wherein the biosensor is operative to detect a specific infectious agent in the sample to be tested; and wherein the biosensor... Agent: Applied Biomolecular Technologies
20140335604 - Device for staining suspended cells: A device for staining suspended cells composed of a cannula (1), a pushrod (2), a plunger sealing pad (3), and a capture membrane (4), wherein the plunger sealing pad (3) is located at an upper part within the cavity of the cannula (1), the capture membrane (4) is located at... Agent: Wuhan Cell Marker & Machine Tech. Co., Ltd.
20140335605 - Anti-microrna oligonucleotide molecules: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.... Agent:
20140335608 - Cell culture kit, and method of using cell culture kit: A cell culture kit for cultivating cells in a closed system that comprises at least one or more of each of: a culture container for cultivating cells; a culture medium storage container for storing a culture medium or the like; a cell injection container for injecting cells; and a cell... Agent:
20140335607 - Methods and compositions relating to restricted expression lentiviral vectors and their applications: The present invention provides HIV-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise promoters active to promote expression specific to cell types or... Agent: Research Development Foundation
20140335606 - Purification of stem cell-derived cardiomyocytes using molecular beacons targeting cardiomyocyte specific mrna: This disclosure is in the area of research and therapeutics. In certain embodiments, it provides methods to assist in the purification of cell mixtures, e.g., cardiomyocytes, using molecular beacons targeting cell-type specific RNA, e.g. mRNA.... Agent:
20140335609 - Protein expression from multiple nucleic acids: The current invention reports a method for the recombinant production of a secreted heterologous immunoglobulin in a CHO cell comprising the following steps: i) providing a CHO cell, which is adapted to growth in suspension culture, adapted to growth in serum-free medium, mycoplasma free, and virus free, ii) providing a... Agent: Hoffmann-la Roche Inc.
20140335610 - Cell culture substrate, and method for manufacturing same: A cell culture substrate is used comprising a photopolymerization initiator immobilized on a surface of the cell culture substrate, and a linear polymer immobilized on a part or the entirety of the surface via the photopolymerization initiator, and wherein the photopolymerization initiator is thioxanthone. Thereby, advantageously, a single type or... Agent: Tokyo Women's Medical University
20140335613 - Cell growth-promoting peptide and use thereof: The pharmaceutical composition provided by the present invention comprises at least one pharmaceutically acceptable carrier, and an active ingredient including an artificially synthesized peptide comprises: (A) an amino acid sequence constituting a cell-penetrating peptide and (B) an amino acid sequence constituting the signal peptide in amyloid precursor protein (APP) or... Agent:
20140335611 - Compositions and methods for promoting the generation of pdx1+ pancreatic cells: Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic... Agent: The General Hospital Corporation
20140335612 - Supports and methods for promoting integration of cartilage tissue explants: The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage tissue pieces derived from donor or engineered tissue. The methods and supports described herein promote cell migration and integration of neighboring tissue pieces in... Agent:
20140335614 - Method and devices for cryopreservation of biomaterials: Improved methods for cryopreservation of cells result when cells are cooled at controlled rates in devices that ensure a constant rate of cooling of less than 10° C.... Agent:
20140335615 - Methods of using mechanical force with somatic and pluripotent cells: Provided are methods useful in increasing efficiency of biotransport, reprogramming or altering a cell's state of differentiation, and maintenance of cells in an undifferentiated state.... Agent:
20140335616 - Defined systems for epithelial cell culture and use thereof: The present invention provides cell culture media formulations which support the in vitro cultivation of animal epithelial cells. The media comprise at least one fibroblast growth factor (FGF) and at least one agent that induces increased intracellular cAMP levels, and optionally comprise ascorbic acid. The present invention also provides methods... Agent: Life Technologies Corporation
20140335617 - Controlling surface wettability of ultrahigh surface area hierarchical supports: The subject innovation is directed to hierarchical structures characterized by ultrahigh surface area and methods of fabricating the same, as well as attachment of functional species to these structures to alter interactions of these hierarchical structures with their environments, such as by making them permanently or reversibly hydrophilic. One such... Agent: Wright State University
20140335618 - Tal effector-mediated dna modification: Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided.... Agent: Iowa State University Research Foundation, Inc.
20140335619 - Human pluripotent stem cells produced by somatic cell nuclear transfer: Human pluripotent embryonic stem cells produced by somatic cell nuclear transfer as well as methods of making and using said human pluripotent embryonic stem cells are disclosed.... Agent: Oregon Health & Science University
20140335620 - Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation: The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme.... Agent: Massachusetts Institute Of Technology
20140335621 - Gene targeting vector, and method for using same: Provided is a gene targeting vector that enables highly efficient gene targeting. The gene targeting vector has a structure comprising a positive selection marker flanked by a DNA homologous to a 5′-upstream region of a target site and a DNA homologous to a 3′-downstream region of the target site, wherein... Agent:
20140335622 - Expression vector and method for producing protein: Provided are: an expression vector for secreting a protein (Z) to be recovered or a fusion protein having the protein (Z) moiety therein; a method for producing a transformant using the expression vector; the transformant; and a method for producing a protein using the transformant. An expression vector comprising an... Agent: Asahi Glass Company, Limited
20140335623 - Methods and compositions for generating sporulation deficient bacteria: The present invention relates to methods and compositions for engineering sporulating bacterial cells, particularly a cell of the class Clostridia. In particular, the present invention relates to the generation of sporulation deficient bacteria for the generation of industrial superior phenotypes.... Agent: Northwestern University11/06/2014 > 108 patent applications in 60 patent subcategories.
20140329219 - Critical point drying systems and methods for in situ tissue preservation: Methods and systems for preserving tissues in situ using critical point drying are disclosed. Such methods and systems are particularly applicable to the preservation of a deceased body, such as a deceased person or animal, with or without removal of internal tissues or organs. A fixative can be perfused through... Agent:
20140329220 - Cannula with floating clamping member: A cannula has a longitudinal base member having a first clamping end and a longitudinal arm member pivotally attached to the longitudinal base member and having a second clamping end, the cannula being in a closed position when the first and second clamping ends are brought together. A first clamp... Agent: Lifeline Scientific, Inc.
20140329221 - Reperfusion protection solution and uses thereof: In various embodiments a reperfusion protection solution (RPS) is provided along with methods of use thereof. Illustrative reperfusion protection solutions include, but are not limited to a buffer; one or more substrates for the synthesis of adenosine triphosphate (ATP) under anaerobic conditions; citrate-phosphate-dextrose (CPD); and one or more amino acids... Agent:
20140329222 - Increasing the viability and stress tolerance of viable biological material: The present invention relates to a method for improving viability and/or stress tolerance of viable biological material and using the said material comprising applying hydrostatic pressure to said biological material; keeping the said viable biological material at the hydrostatic pressure for a predetermined time period; releasing the hydrostatic pressure; and... Agent: Applied Cell Technology Kft.
20140329224 - Biotechnological apparatus comprising a bioreactor, exhaust gas temperature control device for a bioreactor and a method for treating an exhaust gas stream in a biotechnological apparatus: This patent document relates to the field of biotechnological apparatuses. It relates particularly to a biotechnological apparatus comprising a bioreactor, an exhaust gas temperature control device and a method for treating an exhaust gas stream. This patent document further relates to a connection device for a sterile single-use fluid conduit... Agent:
20140329223 - Photobioreactors, solar energy gathering systems, and thermal control methods: The present invention provides photobioreactors, solar energy gathering systems, and methods for thermal control of a culture medium containing a phototrophic organism in a photobioreactor, that allow temperature control in a cost effective manner, reducing the energy required for temperature control of a culture medium containing phototrophic microorganisms in a... Agent: Joule Unlimited Technologies, Inc.
20140329229 - Absorbent dried biofluid collection substrates: A new device and methods that allow for improved sequestration and preservation of harvested analytes and bio-molecules from biofluid samples is defined. The new device and methods relate to an improved dried biofluid collection substrate that is absorbent and contains a plurality of affinity ligands located within defined sample collection... Agent:
20140329228 - Fluorescence immunoassay using polypeptide complex containing fluoro-labeled antibody variable region: (c) calculating the amount of the antigen contained in the sample or visualizing the antigen using the positive correlation between the antigen concentration and the fluorescence intensity of the fluorescent dye(s) as an indicator, thereby measuring the concentration of the target antigen existing in the test substance.... Agent: Ushio Denki Kabushiki Kaisha
20140329231 - Liquid medium and sample vial for use in a method for detecting cancerous cells in a cell sample: The current invention concerns a method for determining the presence of a (pre)cancerous cell in a liquid cell sample, comprising the steps of: —suspending and preserving a cell sample obtained from a subject in a sample vial comprising a liquid medium, said liquid medium comprises means for labeling cells or... Agent:
20140329226 - Method for identifying markers: The invention is a method for identifying markers associated with the presence of a predetermined characteristic comprising accumulating spectral data from a sample known to have a predetermined characteristic, identifying a spectral feature which is indicative of the predetermined characteristic, and identifying a marker associated with the spectral feature.... Agent: Seroptix, Inc.
20140329232 - Method for the detection of nucleic acid synthesis and/or amplification: The present invention relates to a method for the detection of nucleic acid synthesis and/or amplification, characterised in that the method includes adding at least one colorimetric metal indicator and at least one bland magnesium chelator to a reaction mixture for nucleic acid amplification. The present invention further relates to... Agent:
20140329230 - Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma: Methods and kits for diagnosing and determining prognosis of head and neck squamous cell carcinoma are described. An exemplary method for diagnosing head and neck squamous cell carcinoma (HNSCC) in a subject may comprise assaying a saliva sample from the subject for the presence of total protein, solCD44, and HPV,... Agent:
20140329227 - Methods of reducing or eliminating protein modification and degradation arising from exposure to uv light: Methods of inactivation of a virus in a sample comprising a protein component are provided. Also provided are methods of reducing protein degradation or modification in to the presence of a reactive species, such as a reactive species generated as a result of UV exposure, are also provided. In another... Agent:
20140329225 - Target detection with nanopore: Provided are methods for detecting a target molecule or particle suspected to be present in a sample, comprising (a) contacting the sample with (i) a fusion molecule comprising a ligand capable of binding to the target molecule or particle and a binding domain, and (ii) a polymer scaffold comprising at... Agent:
20140329234 - Fluorescent labeling of transfer rna and study of protein synthesis: Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or... Agent: The Trustees Of The University Of Pennsylvania
20140329237 - Means and methods for assessing sperm nuclear dna structure: The present invention is directed to a method for determining nuclear DNA (nDNA) in sperm sample by means of Raman micro-spectroscopy. In particular, the method is useful to determine the presence of intact and/or damaged nDNA in a sperm. Further, the present invention is directed to a method for screening... Agent: Westfä Lische Wilhelms-universitä T Mü Nster
20140329233 - Methods, compositions and kits for a one-step dna cloning system: Methods and kits for joining two or more polynucleotides to form a product polynucleotide are provided. A mixture contains a first polynucleotide comprising a selectable marker. The mixture further contains a second polynucleotide comprising a first typeIIs recognition sequence and a second typeIIs recognition sequence. The second polynucleotide is other... Agent: Dna Twopointo, Inc.
20140329236 - Non-natural nucleosides as theranostic agents: A theranostic agent for inhibiting translesion DNA replication comprises natural adenine ribose analog having formula I.... Agent:
20140329235 - Sensor housing and reagent chemistry: A sensor comprises a sensor housing, having a channel; a porous substrate, in the channel; an analysis chemistry reagent, on the porous substrate; and a nozzle, in fluid connection with the channel. The porous substrate fills a cross section of the channel, and the cross-sectional area of the channel at... Agent:
20140329242 - Characterizing multiple sclerosis: A method for characterizing multiple sclerosis in a subject involves comparing ratios of expression levels of genes in a biological sample from a subject to references, wherein the multiple sclerosis is characterized based on a difference in the ratios of the expression values of genes in the biological sample from... Agent:
20140329240 - Chip-based sequencing nucleic acids: A system for fast DNA sequencing by amplification of genetic material within microreactors, denaturing, demulsifying, and then sequencing the material, while retaining it in a PCR/sequencing zone by a magnetic field. One embodiment includes sequencing nucleic acids on a microchip that includes a microchannel flow channel in the microchip. The... Agent:
20140329238 - Detection of gene duplications: Methods of detecting a candidate genetic anomaly such as a candidate duplication in a genome are disclosed. The methods comprise quantifying fluorogenic assays for alleles of a genetic locus from a plurality of individual genomes, identifying ranges of fluorescent intensities indicative of individual genomes homozygous for a first allele, homozygous... Agent: Applied Biosystems, LLC
20140329239 - Digital analyte analysis: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from... Agent: Raindance Technologies, Inc.
20140329241 - Hydrolase enzyme substrates and uses thereof: The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions and methods that provide highly sensitive assay methods for such hydrolytic enzymes.... Agent:
20140329243 - Method for characterizing circulating tumor cells, and use thereof in diagnosis: Disclosed is a method for characterization, in a biological sample, of circulating tumour cells (CTCs) bearing at least one marker characteristic of the tumorous nature of the cell, the marker being selected from the groups constituted by: the oncogenic proteins characteristic of the CTCs, with the exception of the proteins... Agent: Institut Gustave Roussy
20140329246 - Amplification methods to minimise sequence specific bias: Methods for amplifying nucleic acids are provided. The methods can be used to minimise sequence specific bias caused by the preferential amplification of certain nucleic acid sequences. Methods are described which can lower the efficiency of AT rich templates relative to GC rich templates, thereby minimising GC bias during amplification... Agent: Illumina Cambridge Limited
20140329244 - Apparatus for amplification of nucleic acids: Described herein is a chip-based apparatus for amplifying nucleic acids, a cartridge housing the apparatus, and methods of using the apparatus for amplification of nucleic acids. More specifically, this invention provides integrated semiconductor chip, manufactured with standard semiconductor manufacturing process, with on-chip circuitry to perform thermal management and optical sensing... Agent: Anitoa Systems, LLC
20140329248 - B7-h1 and survivin in cancer: Methods of determining prognosis of a subject with cancer by assessing expression of B7-H1 and survivin in combination.... Agent:
20140329245 - Methods and compositions for pcr using blocked and universal primers: Provided herein are methods and compositions for performing PCR with primers with blocked 3′-ends that are unblocked when these primers anneal to the template. The multiplexed PCR can be used as real-time qPCR, for end-point detection or as enrichment method for next generation sequencing (NGS). Also described herein are methods... Agent: Unitaq Bio
20140329247 - Methods for multiplexing amplification reactions: A two-step multiplex amplification reaction includes a first step which truncates the standard initial multiplex amplification round to “boost” the sample copy number by only a 100-1000 fold increase in the target. Following the first step the product is divided into optimized secondary single amplification reactions, each containing one of... Agent:
20140329249 - Selective release of sub-group of biological units: A method of individually releasing from an entity one or more members of a sub-group of biological units included in a heterogeneous group of biological units is provided. The method includes binding the group of biological units including the sub-group of biological units to the entity via a linker. Following... Agent: Roche Molecular Systems, Inc.
20140329250 - Calcium-binding photoprotein: The invention provides calcium-binding photoproteins which can detect light emission with a higher sensitivity. The proteins of the invention comprising the amino acid sequence of SEQ ID NO: 2 can be used for the detection and measurement of calcium ions. The proteins of the invention are useful as reporter proteins,... Agent:
20140329251 - Ltbp2 as a biomarker for lung injury: The application discloses LTBP2 as a new biomarker for pulmonary injury; methods for the diagnosis, prediction, prognosis and/or monitoring of said pulmonary injury based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing said methods.... Agent:
20140329252 - Methods and kits for diagnosing and/or prognosing osteoarthritis: A method of determining whether a subject is at risk of developing osteoarthritis (OA), said method comprising: determining the cellular localization of a Prohibitin-1 (PHB1) polypeptide and/or Small Ubiquitin-like Modifier (SUMO) polypeptide and/or UBC9, in a cell sample from said subject; and determining whether said subject is at risk of... Agent:
20140329253 - Monoclonal antibody for the detection of snap/clip tag: A monoclonal antibody that binds specifically to the SNAP motif and to the CLIP tag comprising CDRs with the amino acid sequences SEQ ID Nos. 3, 4, 5, and 8, 9, 10.... Agent: Fraunhofer-gesllschaft Zur Foerderung Der Angewandten Forschung E.v.
20140329254 - Biosensor using redox cycling: The present invention relates to a biosensor using dual amplification of signal amplification by means of enzymes coupled with signal amplification by means of redox cycling, and to the use of a technology that maintains a slow reaction state between redox cycling materials without the use of redox enzymes, and... Agent: Pusan National University Industry-university Cooperation Foundation
20140329256 - Urinary biomarkers for predicting long-term dialysis: This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the... Agent:
20140329257 - Detection of hydrogen peroxide: The present invention provides compounds useful for detection of hydrogen peroxide and methods of using same.... Agent:
20140329258 - Self-contained test sensor: A test strip to assist in determining the concentration of an analyte in a fluid sample comprises a base, at least one tab and a break line. The base includes a capillary channel and a test element. The capillary channel is in fluid communication with the test element. The test... Agent:
20140329260 - Method of diagnosis of fibrotic diseases: The present invention relates to a new diagnosis method in the field of hepatology, combining measurement of serum markers and of liver elasticity.... Agent: Biopredictive
20140329259 - Systems and methods of sample processing and fluid control in a fluidic system: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.... Agent: Theranos, Inc.
20140329261 - Treatment of cancer by inhibition of the myd88/erk map kinase interaction: A method for selecting in vitro compounds is capable of potentiating the effect of a DNA damage inducing chemotherapy agent for the treatment of cancer, and includes selecting compounds inhibiting the interaction between MyD88 and ERK MAP KINASE.... Agent: Centre National De La Recherche Scientifique (cnrs)
20140329262 - Testing system and method for testing: This invention relates to a testing system for assessing the level of a biochemical marker, comprising a disposable device (2) with a sample inlet (4) and a at least one visible detection compartment (5A, 5B), arranged with composition including a chemical means (Y) for direct detection of said biochemical marker,... Agent:
20140329263 - Stabilization of labile analytes in reference materials: Provided herein are assay control materials comprising stable analytes and lyophilized unstable analytes, and methods of making and using the same.... Agent: Bio-rad Laboratories, Inc.
20140329268 - Arrangement for detection of hemolysis: The following invention relates to a device for visual detection of hemolysis in a whole blood sample from a pierceable container, said device comprising at least one visible detection compartment and a transfer passage connected to said visible detection compartment, said device further comprising means for passing through the container... Agent: Hemcheck Sweden Aktiebolag
20140329264 - Fibroblast growth patterns for diagnosis of alzheimer's disease: Methods of diagnosing Alzheimer's disease are provided. At least five methods of diagnostic measurements are presented: Method 1: Integrated score; Method 2: Average aggregate area per number of aggregates; Method 3: Cell migration analysis; Method 4: Fractal analysis; Method 5: Lacunarity Analysis. In certain embodiments, a sample of a subject's... Agent: Blanchette Rockefeller Neurosciences Institute
20140329265 - Flowcell, sheath fluid, and autofocus systems and methods for particle analysis in urine samples: The present disclosure relates to apparatus, systems, compositions, and methods for analyzing a sample containing particles. A particle imaging system or analyzer can include a flowcell through which a urine sample containing particles is caused to flow, and a high optical resolution imaging device which captures images for image analysis.... Agent: Iris International, Inc.
20140329267 - Self-healing material and method for the preparation thereof: It is provided a self-healing polymer network comprising transition metal thiolates, particularly thiolates of a transition metal that is able to self-assemble by metallophilic attractions, and more particularly Au(1), Ag(1), Cu(1) thiolates, or a mixture thereof, and, optionally, disulfide bonds, thiol and other thiolate groups. It is also provided several... Agent:
20140329270 - Automated system and method of treating tissue samples on slides: An automated method and system for treating one or more tissue samples disposed on slides, the system comprising: a controller, a plurality of slide treatment modules arranged to receive ones of the slides; at least one fluid dispensing robot configured by the controller to dispense a plurality of reagents to... Agent: Leica Biosystems Melbourne Pty Ltd
20140329269 - Devices, systems, and methods for extracting a material from a material sample: Devices, systems, and associated methods for selectively extracting a material from a sample are provided. In one aspect, for example, a method for selectively extracting biological material from a biological sample can include identifying a region of biological material to be extracted from a biological sample disposed on a substantially... Agent:
20140329273 - Apparatus for collecting donated stool: Disclosed are an apparatus for the collection of donated stool, a collection chamber for depositing (or collecting), processing and harvesting stool from a donor and a process for the preparation of a composition comprising donated stool and a pharmaceutically acceptable carrier.... Agent: Pl&y LLC
20140329274 - Metabolic flux measurement, imaging and microscopy: Provided herein are methods for measuring molecular flux rates of molecules of interest in a tissue sample in spatially-organized manner and generating output (e.g., an image, a heat map, a contour map, a table or a database) representing the molecular flux rates of each spatially-defined location of the sample. Provided... Agent: The Regents Of The University Of California
20140329272 - Metal-based covalent viability reagent for single cell analysis: The present invention provides a robust viability stain for methods utilizing elemental analysis. A population of cells is contacted with an effective dose of a non-chelated biomacromolecule-reactive metal derivative, which selectively crosses the plasma membrane of non-viable cells, and which covalently modifies a biological macromolecule within the cell, for a... Agent:
20140329271 - Screening for nitrogen fixation: An essentially glutamine-free medium comprising a whole-cell glutamine biosensor, comprising a glutamine auxotrophic E. coli and a Lux reporter gene, for detecting glutamine in an analyte. The medium is useful in methods to detecting, screening, identifying and selecting nitrogen-fixing microbes and in methods of determining the nitrogen state of plants,... Agent:
20140329275 - Biocatalysis cells and methods: In one aspect, the invention provides a recombinant microbial cell modified to exhibit increased biosynthesis of a biosynthetic product compared to a wild-type control. In some cases, the biosynthetic product can be isocaproate; in other cases the biosynthetic product can be isovalerate. In another aspect, the invention provides methods of... Agent:
20140329276 - Methods for increasing n-glycan occupancy and reducing production of hybrid n-glycans in pichia pastoris strains lacking alg3 expression: Methods for increasing the yield and N-glycosylation site occupancy of paucimannose or complex N-glycans of recombinant glycoproteins produced in a recombinant host cell lacking dolichyl-P-Man:Man5GlcNAc2-PP-dolichyl alpha-1,3 mannosyltransferase (Alg3p) activity are disclosed. In particular, recombinant host cells are provided that comprise a disruption of the expression of an OS-9 family gene... Agent: Merck Sharp & Dohme Corp.
20140329278 - Amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders: The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides, to methods for preparing such amino acid sequences and polypeptides, to host cells expressing or capable of expressing such amino acid sequences or polypeptides, to compositions, and in particular to pharmaceutical compositions, that comprise such amino... Agent: Ablynx N.v.
20140329279 - Compositions for cell culture and methods of using the same: Supplementation of the bioflavonoids such as epigallocatechin gallate, rutin, naringin, or genistein into mammalian cell culture media are shown to be effective in reduction of acidic species variants on recombinant antibodies. The demonstrated reduction in acidic species through the use of bioflavonoids, facilitates the manufacturing of a less heterogeneous product... Agent:
20140329277 - Method for culturing cells in order to produce substances: The invention concerns a method for culturing cells in order to produce substances. According to the invention a cell line producing substances is cultured while feeding a nutrient medium in such a manner that glucose limitation occurs in the culture solution. The degree of glucose limitation DGL=qGlc/qGlcmax (qGlc=observed current specific... Agent: Hoffmann-la Roche Inc.
20140329280 - Processing biomass: Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful products, such as fuels. For example, systems can use feedstock materials, such as cellulosic and/or lignocellulosic materials and/or starchy or sugary materials, to produce ethanol and/or butanol, e.g., by fermentation.... Agent: Xyleco, Inc.
20140329281 - Recombinant production of steviol glycosides: Recombinant microorganisms, plants, and plant cells are disclosed that have been engineered to express recombinant genes encoding UDP-glycosyltransferases (UGTs). Such microorganisms, plants, or plant cells can produce steviol glycosides, e.g., Rebaudioside A and/or Rebaudioside D, which can be used as natural sweeteners in food products and dietary supplements.... Agent:
20140329282 - Closed nucleic acid structures: The invention provides compositions and methods for making closed nucleic acid structures in which one or both strands are continuous. The closed nucleic acid structures can be used as sequencing templates among other applications.... Agent: Gen-probe Incorporated
20140329283 - Enzymes: The present invention relates to new enzymes with improved properties and to compositions comprising these enzymes suitable for use in the production of a food, feed, or malt beverage product, such as in a brewing process.... Agent: Dupont Nutrition Biosciences Aps
20140329284 - Chimeric polypeptides having beta-glucosidase activity and polynucleotides encoding same: The present invention relates to chimeric polypeptides having beta-glucosidase activity. The present invention also relates to polynucleotides encoding the chimeric polypeptides; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the chimeric polypeptides... Agent:
20140329285 - On-farm integrated high-solids processing system for biomass: A method for on-farm processing a biomass feedstock into a useful industrial chemicals includes the steps of (a) delignifying the biomass feedstock to produce a delignified biomass, (b) subjecting the delignified biomass to cellulase production, (c) subjecting the delignified biomass with attached cellulase to simultaneous cellulolytic and solventogenic reactions to... Agent: The University Of Kentucky Research Foundation
20140329286 - Equol concentration increasing agent containing psicose as active ingredient: The present invention relates to a processed food composition containing, as an active ingredient, psicose, which is a saccharide having the function of stimulating a daidzein conversion into equol by an intestinal microorganism in the human body.... Agent:
20140329287 - Compositions and methods for lipid production: Described herein, inter alia, are compositions, oleagnious organisms, and methods useful for producing lipids, lipid precursors, and/or oleochemicals.... Agent: Board Of Regents, The University Of Texas System
20140329288 - In vivo conversion of light energy into hydrogen gas: The present disclosure provides isolated phototrophic cells for producing hydrogen and methods for use thereof. The methods involve inducing endo-hydrogenase expression in the phototrophic cells through the use of a regulatable promoter and harvesting light energy for hydrogen production. In preferred embodiments the hydrogenase is a member of the Hyq... Agent: The Regents Of University Of California
20140329289 - Anti-fh aptamers, method for producing same, and uses thereof: The invention relates to nucleic acid aptamers binding specifically to factor H, to a method for obtaining same, and to the uses thereof, in particular for the purposes of purifying factor H.... Agent: Laboratoire Francais Du Fractionnement Et Des Biotechnologies
20140329290 - Novel branched polyethylene glycol and use thereof: The present invention allows formation of covalent bonds in a bioactive compound having at least one amino group so as to efficiently provide the compound modified with PEG. The present invention thus provides a functionalized polyethylene glycol having a structure that allows reaction of two aldehyde groups with one amino... Agent:
20140329291 - D4 desaturases and d5 elongases: Disclosed are methods and compositions related to ONC-T18, D4-desaturases, D5 elongases, their isolation, characterization, production, identification, and use for fatty acid production, as well as organisms containing these compositions and organisms expressing them.... Agent: Dsm Nutritional Products Ag
20140329292 - Novel fungal enzymes: This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such enzymes, compositions, recombinant and genetically modified host cells, and methods of use are described. The invention also relates to a method... Agent: Dyadic International, Inc.
20140329293 - Polypeptides having cellobiohydrolase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s
20140329294 - Cell culture medium for adamts protein expression: The present invention provides culture mediums that are useful for the expression of ADAMTS proteins, such as ADAMTS13. Methods for the expression and purification of ADAMTS proteins are also provided. In some embodiments, the mediums and methods of the invention are useful for the expression of ADAMTS proteins having high... Agent: Baxter Healthcare Sa
20140329295 - Method for forming and extracting solid pellets comprising oil-containing microbes: A process including: (a) mixing a microbial biomass, comprising oil-containing microbes, and at least one grinding agent capable of absorbing oil, to provide a disrupted biomass mix; (b) blending at least one binding agent with said disrupted biomass mix to provide a fixable mix capable of forming a solid pellet;... Agent:
20140329296 - Novel extreme thermophilic bacteria of the genus caldicellulosiruptor: The present disclosure pertains to novel isolated cellulolytic extreme thermophilic bacterial cells belonging to the genus Caldicellulosiruptor, mutants thereof, isolated strains, microbial cultures and microbial compositions. The novel bacteria are in particular suitable for the production of fermentation products such as ethanol and lactic acid from lignocellulosic biomass.... Agent: Direvo Industrial Biotechnology Gmbh
20140329297 - Polymeric thin-film tube connectors, bioreactors, systems and methods: Polymeric thin-film tube connectors, bioreactors, systems and methods are described, the connectors allowing connection of a polymeric thin-film tube of a bioreactor chamber with a complementary part, typically, rigid port of flange of the bioreactor or bioreactor system. Further, bioreactors having a thin-film reactor chamber and one or more connectors... Agent:
20140329298 - Solid waste digestion system: A system for digesting biodigestible feed that preferably includes the steps of comminuting the feed, introducing feed, an oxygen-containing gas, an accelerant, and bacteria into a digestion zone, the bacteria being suitable for digesting the feed under aerobic, anaerobic, and anoxic conditions. The contents of the digestion zone can be... Agent: Ecologico-logic, Inc.
20140329299 - Method and plant for separating carbon dioxide from crude gases containing methane: A method for removing carbon dioxide from methane-containing crude gases, especially biogas, by pressure scrubbing, using a physical solvent, includes circulating the contaminated scrubbing solution after regeneration. A plant suitable for carrying out the method considerably reduces the methane loss which arises through methane slippage and improves the overall energy... Agent:
20140329300 - Device for analyzing a sample and method of using the same: This disclosure is directed to a device and method of using the device to analyze a sample. The sample may be a suspension, a portion of the suspension, a particular component of the suspension, or the like. For example, the suspension may be blood, the portion may be buffy coat,... Agent: Rarecyte, Inc.
20140329303 - In-vitro contact lens testing: Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate... Agent:
20140329301 - Multiplexed diagnostic detection apparatus and methods: Disclosed herein are devices configured for the amplification and detection of multiple targets from a sample, and methods of using the same. The devices disclosed herein comprise microfluidic cartridges have a first stage (amplification) and a second (detection) stage. The two-stage design of the cartridges enables testing for multiple targets... Agent: Handylab, Inc.
20140329302 - Wireless based marine pathogens detection system: Embodiments of the present invention provide antibody functionalized high electron mobility transistor (HEMT) devices for marine or freshwater pathogen sensing. In one embodiment, the marine pathogen can be Perkinsus marinus. A sensing unit can include a wireless transmitter fabricated on the HEMT. The sensing unit allows testing in areas without... Agent:
20140329304 - Rapid peptidoglycan-based assay for detection of bacterial contamination: The invention relates to a colorimetric method for detecting bacterial or fungal pathogens by detecting peptidoglycan or (1-3)-β-D-glucan in a sample.... Agent: Immunetics, Inc.
20140329305 - Devices, methods, and systems for nucleic acid amplification: A microfluidic device comprising a first surface portion and a first sample retaining element, which have differing affinities to a fluid, and a method comprising supplying a sample to such a device. In some embodiments, the differing affinity is a result of plasma, ion embedding, surface charging, chemical, optical, electronic... Agent: Applied Biosystems, LLC
20140329306 - Anaerobic digester service device with a separation curtain: A digester tank has a servicing device that allows access to the interior of the digester tank. The sealing device may have a movable retention wall adapted to resist the pressure of the gas inside the digester by one or more of a) increasing the bending resistance of the retention... Agent:
20140329307 - Method and device for conducting biochemical or chemical reactions at multiple temperatures: Methods and devices for conducting chemical or biochemical reactions that require multiple reaction temperatures are described. The methods involve moving one or more reaction droplets or reaction volumes through various reaction zones having different temperatures on a microfluidics apparatus. The devices comprise a microfluidics apparatus comprising appropriate actuators capable of... Agent: Advanced Liquid Logic, Inc.
20140329308 - Platform for immobilization and observation of subcellular processes: A method of immobilizing matter for imaging that includes providing an array of nanofibers and directing matter to the array of the nanofibers. The matter is immobilized when contacting at least three nanofibers of the array of nanofibers simultaneously. Adjacent nanofibers in the array of nanofibers may be separated by... Agent: Ut-battelle, LLC
20140329309 - Ribosomal promoters for production in microorganisms: The present invention provides methods and compositions of improved expression systems in microorganisms. The methods and compositions comprise a ribosomal promoter derived from a Bacillus species microorganism, such a ribosomal RNA or a ribosomal protein promoter.... Agent:
20140329310 - Activated t cells: Provided are compositions comprising activated T cells and activated T cells armed with bispecific antibodies directed at cancer antigens which are poor responders to alloantigen, and methods of using the compositions to help engraftment and improve anti-tumor effects.... Agent:
20140329311 - Induction of human embryonic stem cell derived cardiac pacemaker or chamber-type cardiomyocytes by manipulation of neuregulin signaling: The present invention is directed to methods of producing cardiomyocytes having a nodal/pacemaker phenotype and cardiomyocytes having an atrial/ventricular phenotype. Isolated populations of nodal/pacemaker and atrial/ventricular cardiomyocytes are also disclosed. Methods of treating a subject having cardiac arrhythmia and a subject in need of cardiac tissue repair using the isolated... Agent:
20140329312 - Method for producing human monoclonal immunoglobulin g antibodies: The present invention a method for producing a human immunoglobulin G (IgG) antibody using a prime-boost regime in a Bone Marrow Liver Thymic (BLT) mouse.... Agent:
20140329313 - Expression in insect cells of genes with overlapping open reading frames, methods and compositions therefor: The present teachings disclose nucleic acid cassettes for expressing in an insect cell a plurality of polypeptides encoded by a gene comprising overlapping open reading frames (ORFs). A cassette comprises, in 5′ to 3′ order, a) a first insect cell-operable promoter, b) a 5′ portion of a gene comprising a... Agent: Virovek, Inc.
20140329314 - Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells: The invention provides methods for depleting extraneous phenotypes from a mixed population of cells comprising the in vitro differentiated progeny of primate pluripotent stem cells, The invention also provides cell populations enriched for target cell populations which are the differentiated in vitro progeny of primate pluripotent stem cells.... Agent:
20140329318 - Isolated human lung progenitor cells and uses thereof: Provided herein are methods and compositions relating, in part, to the generation of human progenitor cells committed to the lung lineage and uses of such cells for treatment of lung diseases/disorders or injury to the lung. Whether an adult stem cell can be isolated from human adult lung remains controversial... Agent:
20140329317 - Method for culturing pluripotent stem cell: (ii) fragmenting the cell aggregates obtained by step (i) into cell aggregates having a uniform average diameter of about 80-about 120 μm. In step (i), a suitable viscosity is conferred to the medium to prevent movement of floating cell aggregates and adhesion and fusion of cell aggregates. In step (ii),... Agent:
20140329315 - Methods for producing insulin-secreting beta cells from human pluripotent stem cells: A method of culturing human pluripotent stem cells to produce pancreatic lineage, the method comprising the steps of (a) culturing the stem cells in the presence of a chemically defined medium comprising an effective amount of FGF, Activin A, and BMP; (b) culturing the cells from step (a) in the... Agent: Wisconsin Alumni Research Foundation
20140329316 - Tissue repair with multipotent cells: The invention relates to the field of medical science, in particular to technology directed at repairing defects in living, preferably human, tissue. The present invention provides a method for inducing differentiation of multipotent cells to a desired cell type, as well as a method for repairing a tissue defect in... Agent:
20140329319 - Apparatus and method for the immunocamouflage of biological cells: A device and method for polymer modification of biological cells includes pumping a first liquid mixture comprising biological cells from a first reservoir to a mixing chamber and a second liquid mixture comprising activated polymer from a second reservoir to the same mixing chamber, independently controlling an output volume of... Agent: Canadian Blood Services
20140329320 - Nanoantibodies, binding chlamydia trachomatis antigen, method for inhibition of infection induced by chlamydia trachomatis: A nanoantibody specifically binding surface antigen of Chlamydia trachomatis and having SEQ ID NO:2 amino acid sequence is disclosed. A nanoantibody specifically binding surface antigen of Chlamydia trachomatis and having SEQ ID NO:4 amino acid sequence is disclosed. A nanoantibody with SEQ ID NO:2 amino acid sequence inhibits development of... Agent:
20140329322 - Method of differentiating glioblastoma cells: A method of increasing differentiation of a cell line of glioblastoma cells is disclosed. A platelet-rich plasma (PRP) composition is prepared. The glioblastoma cells are cultured in the PRP composition for a time period sufficient for differentiation of the glioblastoma cells.... Agent:
20140329321 - Methods and compositions for culturing endoderm progenitor cells in suspension: Provided herein are methods for the in vitro differentiation of induced pluripotent stem cells, which have been expanded and/or maintained under defined conditions, into endodermal precursor cells (EPCs) that are capable of producing mono-hormonal beta cells.... Agent: Cellular Dynamics International, Inc.
20140329323 - Three-dimensional nanostructured hybrid scaffold and manufacture thereof: A method of making a three-dimensional biocompatible scaffold capable of supporting cell activities such as growth and differentiation, the method includes providing a supporting grid that forms an open network and provides mechanical support of a second biocompatible material. The second biocompatible material has interconnected cavities that allow nutrients, metabolites... Agent:
20140329324 - Functional unlimited culture medium having a natural bio-composite inducer: A culture medium with natural inducer for biocomposites. In a general aspect the present disclosure is an indefinite functional culture medium with a natural inducer for biocomposites comprising: i) biomass plant incorporating high copper content, vitamins and trace minerals; and ii) a natural inducer, that is vegetable vinegar.... Agent: Universidad De Antioquia
20140329325 - Optofluidic microdevice for in-vitro laser surgery and transfection involving cells and microorganisms: A device for use in laser optical transfection of biological targets including an optofluidic microdevice and a piece of optical glass. The optofluidic microdevice has a central vertical outlet and a microchannel network that includes a plurality of entrapping channels with narrowings. The microchannel network is fused with the optical... Agent:
20140329326 - Synthetic gene clusters: Methods for making synthetic gene clusters are described.... Agent: The Regents Of The University Of California10/30/2014 > 118 patent applications in 73 patent subcategories.
20140322696 - Functional recovery of human lungs for transplantation: The vasculature of a donor lung is perfused with a lung preserving fluid to preserve its structure. At the same time, a decellularization fluid is perfused through the airways, which strips away donor cells. The decellularized region is then seeded with pulmonary cells of the transplant recipient, which regenerate the... Agent: The Trustees Of Columbia University In The City Of New York
20140322698 - Materials and methods for hypothermic collection of whole blood: The present invention relates to materials and methods for hypothermic collection of whole blood, and components thereof, which can extend the holding time of blood beyond the current usable limit. Additionally, blood can be drawn directly into a hypothermic preservation solution without the addition of standard anticoagulants. This is enabled... Agent: Biolife Solutions, Inc.
20140322697 - Polymer test cartridge mixer for cell lysis: A multiple polymer layer test cartridge includes an input to receive a sample containing cells, multiple lysing channel structures on alternate layers of the multiple layer test cartridge coupled to each other to pass the sample in sequence between the lysing channel structures, and a test chamber to receive the... Agent: Honeywell International Inc.
20140322699 - Affinity-based analytical purification of biotherapeutics for bioprocess monitoring: The invention as disclosed herein provides a method for purifying a non-antibody protein from solution, comprising a chromatography step wherein the solution is passed over an affinity construct containing an affinity ligand-coupled solid support, wherein the affinity construct is associated with a bioprocess unit operation, and isolating the non-antibody protein... Agent: Genzyme Corporation
20140322700 - Method for determining the concentration of virus particles/virus antigens: The invention provides a method for determining the concentration of virus particles and/or virus antigens in a sample. In particular, the invention relates to determining the concentration of influenza virus particles/influenza virus antigens in a sample. The invention further relates to the use of an ion-exchange matrix for the determination... Agent: Novartis Vaccines And Diagnostics, Inc.
20140322702 - Detection of west nile virus nucleic acids in the viral 3' non-coding region: Methods for detecting flavivirus nucleic acids. Particularly described are methods for detecting West Nile virus nucleic acids in the 3′ non-coding region.... Agent: Gen-probe Incorporated
20140322704 - Hepatitis virus culture systems using stem cell-derived human hepatocyte-like cells and their methods of use: The invention relates to the discovery that DHH derived from stem cells are permissive for infection by hepatitis viruses (HV), such as hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV) and hepatitis E virus (HEV). Included in the invention are HV-permissive DHHs... Agent:
20140322703 - Measuring range extension of chromatographic rapid tests: A method for the quantitative determination of an analyte in a sample is provided comprising: (a) providing an analyte-specific substance which is able to undergo a reaction which generates a detectable signal when it is contacted with an analyte; (b) providing at least two calibration graphs which have been generated... Agent:
20140322701 - Miniaturized, automated in-vitro tissue bioreactor: In one embodiment, a system includes a bioreactor coupled to a substrate. The bioreactor includes: a plurality of walls defining a reservoir; a plurality of fluidic channels in at least some of the walls; a fluidic inlet in fluidic communication with the reservoir via, the fluidic channels; a fluidic outlet... Agent: Lawrence Livermore National Security, LLC
20140322705 - Cancer diagnostic and cancer therapeutic: This invention relates to methods and kits for making a prognosis of disease course in a neoplastic disease patient by determining the level, expression and/or activity of a biomarker.... Agent: Thomas Jefferson University
20140322707 - Composition and methods related to modification of 5-methylcytosine (5-mc): The present invention relates to methods and compositions for detecting, evaluating, and/or mapping 5-methyl-modified and/or 5-hydroxylmethyl-modified cytosine bases within a nucleic acid molecule.... Agent: The University Of Chicago
20140322710 - Device and methods for epigenetic analysis: Provided herein are methods and devices for single object detection. The methods and devices can be used to identify a plurality epigenetic markers on a genetic material, or a chromatin, encompassing fragments thereof. The invention provides for the characterization of the genetic material flowing through a channel in a continuous... Agent: Cornell University
20140322712 - Diagnosis and treatment of macular degeneration: The present invention relates generally to biomarkers for macular degeneration. In particular, the biomarkers and related compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications.... Agent: The Regents Of The University Of Michigan
20140322706 - Integrated multipelx target analysis: This invention provides biochip cartridges and instrument devices for the detection and/or analysis of target analytes from patient samples.... Agent:
20140322708 - Method for measuring somatic dna mutational profiles: Methods are provided for determining if an agent causes somatic mutations in a genome, and kits, systems and computer-readable medium therefor.... Agent: Albert Einstein College Of Medicine Of Yeshiva University
20140322709 - Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities: The invention generally relates to methods for detecting fetal nucleic acids and methods for diagnosing fetal abnormalities. In certain embodiments, the invention provides methods for determining whether fetal nucleic acid is present in a maternal sample including obtaining a maternal sample suspected to include fetal nucleic acids, and performing a... Agent: Sequenom, Inc.
20140322714 - Methods of detecting mutations and epigenetic changes: Disclosed are methods for assessing the methylation and mutation status of nucleic acid in a sample. The methods provide for methylation-dependent modification of the nucleic acid in a sample, and subsequently nucleic acid amplification processes to distinguish between mutated and non-mutated target sequence.... Agent: Mdxhealth Sa
20140322713 - Polymethine compounds and their use as fluorescent labels: The present disclosure relates to new polymethine compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.... Agent: Illumina Cambridge Limited
20140322711 - Spinocerebellar ataxia type 8 and methods of detection: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat... Agent: Regents Of The University Of Minnesota
20140322715 - New method and kit for prediction success of in vitro fertilization: The invention comprises a method to determine the chance of a successful pregnancy based on the ratio of said ratio indicated as a formula that uses the presence of Lactobacillus and Staphylococcus bacteria in relation to the total amount of bacteria in a sample of a subject, preferably a urine... Agent: Erasmus University Medical Center Rotterdam
20140322717 - Selective amplification and detection of mutant gene alleles: The present invention provides methods for selectively amplifying a mutant allele of a gene. These methods include (a) contacting a sample containing a mutant and a normal allele of a gene with at least one primer that selectively modifies the normal allele of the gene and causes further amplification of... Agent:
20140322716 - Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set: Compositions and methods are disclosed for uniquely tagging each rearranged gene segment that encodes a T cell receptor (TCR) and/or an immunoglobulin (Ig), in a DNA (or mRNA or cDNA reverse transcribed therefrom) sample from lymphoid cells. These and related embodiments permit accurate, high throughput quantification of distinct TCR and/or... Agent:
20140322718 - Competence stimulating peptide: The present invention concerns a new competence stimulating peptide identified in Firmicutes, in particular Streptococcus, and more preferably S. thermophilus and methods of producing transformation competent Firmicutes, in particular Streptococcus, and more preferably S. thermophilus bacteria.... Agent:
20140322719 - Method for detecting nucleosome adducts: The invention relates to a method for detecting and measuring the presence of nucleosome-protein adducts and the use of such measurements for the detection and diagnosis of disease. The invention also relates to a method of identifying nucleosome adduct biomarkers for the detection and diagnosis of disease and to biomarkers... Agent:
20140322720 - Composition for diagnosing, treating, and preventing age-related macular degeneration and method for diagnosing age-related macular degeneration: There is provided a composition for diagnosing, treating, and preventing an age-related macular degeneration and a method for diagnosing an age-related macular degeneration.... Agent: Konkuk University Industrial Cooperation Corp.
20140322722 - Compositions and methods for detection of defensins in a patient sample: Methods, devices and compositions for diagnosing, predicting and monitoring a urinary tract infection in a subject are described. The detection, prediction and monitoring of a urinary tract infection in a subject by detection of HD5 in the urine of a subject is described.... Agent: The Research Institute At Nationwide Children's Hospital
20140322723 - Diabetes diagnosis through the detection of glycated proteins in urine: The invention involves methods, compositions, and kits for detecting glycated proteins in a sample (e.g., urine or other bodily fluid) from a subject. Also provided are methods, compositions, and kits for diagnosing or following a diabetic condition of the subject or screening for a diabetic condition in a population of... Agent:
20140322724 - Homogeneous competitive lateral flow assay: A patient or animal side method and assay for eliminating the hook effect in the detection of a target analyte such as an acute phase protein in a bodily fluid in which the target analyte comprises a member of a specific binding pair comprising applying the sample to a solid... Agent:
20140322721 - Markers for preeclampsia: This document provides methods and materials related to determining whether or not a pregnant mammal (e.g., a pregnant human) has preeclampsia. For example, methods and materials related to the use of urinary podocytes to determine whether or not a pregnant human has preeclampsia are provided.... Agent:
20140322730 - Botulinum neurotoxin e receptors and uses thereof: An isolated polypeptide comprising an amino acid sequence selected from amino acids 506-582 of SV2A, wherein position 573 is N and is glycosylated, or amino acids 449-525 of SV2B, wherein position 516 is N and is glycosylated. The present invention also provides an antibody that binds specifically to the polypeptide,... Agent: Wisconsin Alumni Research Foundation
20140322726 - Monoclonal antibody specifically recognizing asparagine synthetase: It is an object of the present invention to provide a monoclonal antibody, which is suitable for the quantitative analysis of asparagine synthetase in a cell. The present invention provides a monoclonal antibody which specifically recognizes asparagine synthetase that is present in a cell.... Agent:
20140322725 - Sensors and assays for ubiquitin or ubiquitin-like proteins: The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine... Agent: Colorado State University Research Foundation
20140322727 - Assay: The present invention discloses an assay device (1) for detecting active enzyme in a sample. Said assay device (1) comprises the following components:—(a) a placement region (10) onto which the sample can be placed; (b) a matrix (20) operably connected to said placement region (10) such that the sample when... Agent: Dupont Nutrition Biosciences Aps
20140322728 - Compositions and methods for assessing gastrointestinal health: The present invention relates to kits designed for the collection of stool samples and methods of analyzing those samples for biological markers of maldigestion, inflammation, and imbalanced gut flora.... Agent: Genova Diagnostics, Inc.
20140322729 - Sers, fluorescence, absorption, and luminescence detection with flow-through multi-hole capillaries: 3-dimensional surface-enhanced Raman scattering (SERS), as well as absorption/fluorescence/luminescence detection is carried out using a platform based on nanoparticle-functionalized flow-through multi-hole capillaries for rapid analyte detection. The configuration provides an increased active area and fluidic channels for efficient sample delivery, and also confines and transmits light for a large signal... Agent: The Regents Of The University Of Michigan
20140322731 - Amyloid beta-derived diffusible ligands (addls), addl-binding molecules, and uses thereof: The invention herein comprises amyloid beta-derived diffusible ligands (ADDLs), compositions comprising ADDLs, ADDL-surrogates, ADDL-binding molecules, and methods of using any of the foregoing compounds and compositions. ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of... Agent: Northwestern University
20140322732 - Method for biomarker and drug-target discovery for prostate cancer diagnosis and treatment as well as biomarker assays determined therewith: The invention relates to a method for the determination of a cancer diagnostic/therapeutic biomarker assay and drug-targets including the following steps: (a) identification of potential candidate protein/peptide biomarkers and drug-targets based on the measurement of protein/peptide constituent concentrations in tissue sample proteomes as well as serum, plasma or any other... Agent: Eth Zurich
20140322733 - Optical method and device for identifying and quantifying analytes: A method for analysing a metalloprotein and/or the interaction with its environment comprising the following steps: (a) Providing a medium that enhances the detection of the electromagnetic cross-section signal of metalloproteins, (b) Incorporating a metalloprotein to analyse into said medium, (c) Contacting said medium with electromagnetic radiation, (d) Obtaining the... Agent:
20140322734 - Biomarkers for prediction, diagnosis, and monitoring of parkinson's disease: A method for the risk detection, early diagnosis, prognosis, and monitoring of Parkinson's disease in an individual by measuring the amount of specific biomarkers present in a bodily fluid and comparing them to a reference level of biomarkers in a sample from a healthy person, a person previously diagnosed with... Agent:
20140322735 - Method to measure endogenous enzymatic serum/plasma cholesterol esterification by lcat (lecithin:cholesterol acyltransferase) assay: The present invention provides a method for the assessment of cholesterol esterification through physiologically relevant pathways and incorporates the function of individual subject's endogenous HDL particles. This ex vivo approach avoids the use of an artificial substrate and provides for determination of LCAT activity that includes both the contribution of... Agent: Vascularstrategies LLC
20140322736 - Method for the production of human thrombin and uses thereof: The present invention disclosed the cloning and the purification of a mutant of prethrombin-2, which contains a thrombin cleavage site instead of a factor Xa cleavage site. The stable mutant prethrombin-2 is able to convert itself autocatalytically into active α-thrombin in the absence of ecarin or factor Xa. The new... Agent: AsociaciÓ N Centro De InvestigaciÓ N Cooperative En Biomateriales - Cic Biomagune
20140322737 - Fast reaction kinetics of enzymes having low activity in dry chemistry layers: The present invention concerns a method for determining an analyte as well as a diagnostic element suitable therefore. In one particular form, a method for determining an analyte includes contacting a sample containing the analyte with a diagnostic element comprising a dry reagent layer. The dry reagent layer contains a... Agent:
20140322739 - Methods and compounds for detecting beta-lactamase activity: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective... Agent:
20140322738 - Substrates for covalent tethering of proteins to functional groups or solid surfaces: The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for... Agent: Promega Corporation
20140322741 - Cell free cd4 quantitation and methods of use: The present invention provides a low-cost cell-free assay, the α-test, that provides point-of-care CD4 enumeration using a single platform assay thereby eliminating the need for high-end instrumentation, calibrated pipetting, and specialized technical training. The number of CD4 T cells in blood is driven by the concentration of the protein α1... Agent:
20140322740 - Psa peptidase activity (ppa) as a prostate cancer biomarker: The present invention is directed to the diagnosis of cancer associated with enzymatically active PSA in samples.... Agent: Ohmx Corporation
20140322744 - Clonable tag for correlative light and electron microscopy labeling: The present invention relates to a new clonable label for Correlative Light and Electron Microscopy based on the combination of modified metallothionein and lanthanides.... Agent: Centre National De La Recherche Scientifique
20140322742 - Methods and a device for the formation of three-dimensional multicellular assemblies: The present invention relates to devices and associated methods for forming three-dimensional multicellular assemblies in vitro. Specifically, the present invention relates to devices comprising at least one three-dimensional multicellular assembly immobilised on a two-dimensional adhesive pattern, wherein said three-dimensional multicellular assembly has an organised structure with a normalised polarity and... Agent: Consejo Superior De Investigationes Cientifcas
20140322743 - Polymer microfiltration devices, methods of manufacturing the same and the uses of the microfiltration devices: A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A microfilter comprising two or more polymer layers formed from epoxy-based photo-definable dry film, and a plurality of apertures or open areas each extending through the polymer... Agent: Creatv Microtech, Inc.
20140322745 - Optical method for controlling the movement of a sampling tool: m
20140322746 - Multi-way sorter system and method: Provided herein are improved multi-way cell sorter systems and methods. For example, provided are systems and methods for the collection of cells that are sorted in multiple directions. The systems and methods allow for the construction of a multi-way sorter (e.g., a ten-way sorter in the space that currently only... Agent: Becton, Dickinson And Company
20140322747 - Object selecting device and object selecting method: An object selecting device includes a container configured to store liquid, a plate configured to support a selection object by being immersed into the liquid stored in the container, and a holder configured to hold the plate in a state where a bottom surface of the plate and an inner... Agent: Yamaha Hatsudoki Kabushiki Kaisha
20140322748 - System and method to improve yield of sorted particles: Provided herein are systems and methods for improving yield of sorted particles. In one embodiment, for example, there is provided a system including: (a) a flow cytometer to analyze a sample, wherein the flow cytometer provides a parameter plot based on the analysis of the sample; (b) a user-interface, wherein... Agent:
20140322749 - Method for measuring color change of oxidation-reduction indicator: Provided is a method for measuring a color change of an oxidation-reduction indicator, which method is applicable to measurement of the cariogenic bacterial count and the like. A color change of an oxidation-reduction indicator is measured by a method for measuring a color change of an oxidation-reduction indicator, the method... Agent: Arkray, Inc.
20140322750 - Blood analyzer, blood analysis method and hemolytic agent: This blood analyzer includes a sample preparation portion preparing a measurement sample free from a labeling substance from a blood sample and a hemolytic agent free from a labeling substance, a light information generation portion generating fluorescent information and at least two types of scattered light information from the measurement... Agent: Sysmex Corporation
20140322751 - Mutant pyrrolysyl -trna synthetase, and method for production of protein having non-natural amino acid integrated therein by using the same: Method for incorporating a lysine derivative (particularly an Nε-benzyloxycarbonyl-lysine (Z-Lys) derivative) having useful functional group such as heavy atom, selenium, reactive functional group, fluorescent group or crosslinker, which is suitable as a non-natural amino acid, into a desired protein in a site-specific manner. A mutant pyrrolysyl-tRNA synthetase has substitution of... Agent: Riken
20140322754 - Method for highly expressing recombinant protein of engineering bacteria and use thereof: Provided are methods for highly expressing recombinant protein of engineering bacteria and the use thereof. The method comprises the following steps: (1) engineering bacteria of Escherichia coli with pET system are transfected with recombinant mutated plasmid to obtain positive monoclonal colonies; (2) the positive monoclonal colonies are enriched to obtain... Agent:
20140322753 - Polypeptides having endoglucanase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent:
20140322752 - Refolding transforming growth factor beta family proteins: Compositions and methods for folding proteins belonging to the transforming growth factor beta superfamily are disclosed. The compositions and methods allow for the folding of such proteins when produced in an expression system that does not yield a properly folded, biologically active product.... Agent: Biogen Idec Ma Inc.
20140322755 - Chemically modified sophorolipids and uses thereof: The present disclosure provides a sophorolipid composition that can be used for inducing protein expression in a fermentation host. The sophorolipid composition described herein can be prepared from a natural sophorolipid mixture. Acid treatment of the natural sophorolipid mixture results in a mixture of monoacetylated, deacetylated, and/or diacetylated sophorolipids. The... Agent:
20140322757 - Antibodies that bind colony stimulating factor 1 receptor (csf1r): Antibodies that bind CSF1R are provided. Antibody heavy chains and light chains that are capable of forming antibodies that bind CSF1R are also provided. Polynucleotides encoding antibodies to CSF1R are provided. Polynucleotides encoding antibody heavy chains and lights chains are also provided. Methods of treatment using antibodies to CSF1R are... Agent: Five Prime Therapeutics, Inc.
20140322756 - Method for making multispecific antibodies having heteromultimeric and common components: The invention relates to a method of preparing heteromultimeric polypeptides such as bispecific antibodies, bispecific immunoadhesins and antibody-immunoadhesin chimeras. The invention also relates to the heteromultimers prepared using the method. Generally, the method provides a multispecific antibody having a common light chain associated with each heteromeric polypeptide having an antibody... Agent: Genentech, Inc.
20140322758 - Addition of iron to improve cell culture: The present invention provides, among other things methods of increasing cell density, viability and/or titer in a cell culture including steps of adding a composition comprising iron to the cell culture.... Agent:
20140322759 - Phi29 dna polymerase mutants having increased thermostability and processivity: Mutants of bacteriophage phi29 DNA polymerase with increased protein stability and increased half-life, compared to wild type DNA polymerase. The disclosed mutants are more stable in reaction mixtures with or without DNA. The inventive phi29 DNA polymerase mutants generate more amplification product. The inventive phi29 DNA polymerase mutants amplify genomic... Agent:
20140322761 - Method of preparing sample for nucleic acid amplification reaction, nucleic acid amplification method, and reagent and microchip for solid phase nucleic acid amplification reaction: Provided is a method of preparing a sample for nucleic acid amplification reaction, including: a procedure of dissolving a solid phase reagent at least containing DNA polymerase, cyclodextrin, and a binder, in a liquid containing a nucleic acid.... Agent: Sony Corporation
20140322760 - Method for producing virus vector for gene transfer: The present invention discloses a cell system, as a host cell to be infected with an F gene-deficient virus, which can constitutively and stably express the F protein, and a method for producing an F gene-deficient virus by utilizing the cell. A non-proliferative human parainfluenza type 2 virus vector is... Agent: Mie University
20140322763 - C1-c2 organic acid treatment of lignocellulosic biomass to produce acylated cellulose pulp, hemicellulose, lignin and sugars and fermentation of the sugars: A process for production of C5 and C6 sugar enriched syrups from lignocellulosic biomass and fermentation products therefrom is described. A lignocellulosic biomass is treated with a C1-C2 acid (e.g., acetic acid) with washing thereof with a C1-C2 acid miscible organic solvent, (e.g., ethyl acetate). A soluble hemicellulose and lignin... Agent: Archer Daniels Midland Company
20140322765 - Enhanced processive cellulases: Nucleic acid sequences encoding chimeric polypeptides that exhibit enhanced cellulase activities are disclosed herein. These nucleic acids may be expressed in hosts such as fungi, which in turn may be cultured to produce chimeric polypeptides. Also disclosed are chimeric polypeptides and their use in the degradation of cellulosic materials.... Agent:
20140322764 - Mutant xylanase, manufacturing method and use therefor, and method for manufacturing saccharified lignocellulose: What is aimed at is provision of an inexpensive and efficient saccharification method for lignocellulose using a thermostable xylanase and provision of a mutant xylanase that has a substitute amino acid residue, and that exhibits stable activity even under severe conditions in which enzymes easily inactivate, and that provides an... Agent:
20140322762 - Treatment of cellulosic material and enzymes useful therein: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme... Agent: Roal Oy
20140322766 - C1-c2 organic acid treatment of lignocellulosic biomass to produce acylated cellulose pulp, hemicellulose, lignin and sugars and fermentation of the sugars: A process for production of C5 and C6 sugar enriched syrups from lignocellulosic biomass and fermentation products therefrom is described. A lignocellulosic biomass is treated with a C1-C2 acid (e.g., acetic acid) with washing thereof with a C1-C2 acid miscible organic solvent, (e.g., ethyl acetate). A soluble hemicellulose and lignin... Agent: Archer Daniels Midland Company
20140322767 - Droplet microreactor: The present invention relates to a droplet microreactor, i.e. a microreactor consisting of a droplet of a specific liquid, the microreactor being wall-less, wherein the interface of the specific liquid with the ambient environment and with the support on which the droplet is deposited defines the limits of the microreactor.... Agent:
20140322768 - Polypeptides having peroxygenase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having peroxygenase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent:
20140322769 - Biocatalysts for the preparation of hydroxy substituted carbamates: The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.... Agent:
20140322770 - Polypeptides having peroxygenase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having peroxygenaseactivity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent:
20140322771 - Lipid production: The invention relates to methods for producing lipids and in particular methods for producing glycerolipids suitable for use in generating biofuels. The glycerolipids are produced through the modification of a cell so as to increase phosphatidic acid via the inhibition of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway. The invention further relates... Agent: The University Of Queensland
20140322772 - Production of carboxylates and methane from biomass waste: Methods and systems for producing and removing C6 and/or C8 carboxylates and/or methane from carbohydrate containing biomass, an alcohol, and mixtures of microorganisms under an anaerobic environment. The C6 and/or C8 carboxylates are removed continuously or in-line. Methanogenesis is not inhibited and very little input carbon is lost as carbon... Agent: Cornell University
20140322773 - Method for producing lactic acid: A method for producing lactic acid, which comprises subjecting glucose to lactic acid fermentation by using a fission yeast having a lactic acid fermentation ability and recovering lactic acid produced thereby, characterized in that a fermentation liquor created from an aqueous glucose solution by lactic acid fermentation is replaced with... Agent: Asahi Glass Company, Limited
20140322774 - Microbial production of n-butyraldehyde: Microorganisms and methods of producing n-butyraldehyde with enhanced yields are presented in which a microorganism is engineered to enhance the conversion of a carbon source into n-butyraldehyde. The n-butyraldehyde is recovered by way of a gas stripping process that occurs during the conversion process, providing significantly greater product yield than... Agent:
20140322775 - Method for producing scyllo-inositol: It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia... Agent: Hokko Chemical Industry Co., Ltd.
20140322776 - Overexpression of genes that improve fermentation in yeast using cellulosic substrates: The invention relates to recombinant yeast host cells that overexpress proteins to improve glucose utilization, pentose sugar utilization and/or production of a fermentation product in a fermentation reaction.... Agent: Codexis, Inc.
20140322779 - Eukaryotic organisms and methods for increasing the availability of cytosolic acetyl-coa, and for the producing 1,3-butanediol: Provided herein are non-naturally occurring eukaryotic organisms that can be engineered to produce and increase the availability of cytosolic acetyl-CoA. Also provided herein are non-naturally occurring eukaryotic organisms having a 1,3-butanediol (1,3-BDO) pathway, and methods of using such organisms to produce 1,3-BDO.... Agent:
20140322777 - Process of separating components of a fermentation broth: A process of isolating 1,4-butanediol (1,4-BDO) from a fermentation broth includes separating a liquid fraction enriched in 1,4-BDO from a solid fraction comprising cells, removing water from said liquid fraction, removing salts from said liquid fraction, and purifying 1,4-BDO. A process for producing 1,4-BDO includes culturing a 1,4-BDO-producing microorganism in... Agent: Genomatica, Inc.
20140322778 - Production of isopropanol by improved recombinant strains: The expression vector includes: the nucleic acids coding for the polypeptides forming a polypeptide complex having an enzyme activity allowing acetoacetyl-CoA to be converted to acetoacetate; optionally, at least one nucleic acid coding for a polypeptide having an enzyme activity allowing acetoacetate to be converted to acetone; and at least... Agent: Stichting Dienst Landbouwkundig Onderzoek
20140322780 - Methylbutanol as an advanced biofuel: This invention describes genes, metabolic pathways, microbial strains and methods to produce methylbutanol and other compounds of interest from renewable feedstocks.... Agent: Synthetic Genomics, Inc.
20140322781 - Catalytic conversion of alcohols to hydrocarbons with low benzene content: A method for converting an alcohol to a hydrocarbon fraction having a lowered benzene content, the method comprising: converting said alcohol to a hydrocarbon fraction by contacting said alcohol, under conditions suitable for converting said alcohol to said hydrocarbon fraction, with a metal-loaded zeolite catalyst catalytically active for converting said... Agent: Ut-battelle, LLC
20140322783 - Engineering an increase in ethanol production by altering cofactor specificity: The present invention provides for the manipulation of cofactor usage in a recombinant host cell to increase the formation of desirable products. In some embodiments, the invention provides for a recombinant microorganism comprising a mutation in one or more native enzymes such that their cofactor specificity is altered in such... Agent:
20140322782 - Method and apparatus for bio-fuel seeding: A method and apparatus is provided for microbial seeding and amendment of traditional alternative fuels production systems and processes using immobilized microbe bioreactors. The system addition utilizes attachment of yeast or other microbial consortia to a substrate to enhance alternative fuels production in fermentation processes. The system allows for the... Agent:
20140322784 - Systems and methods for magnetic guidance and patterning of materials: Systems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some embodiments, systems and methods for magnetic guidance and patterning of cells and materials are discussed. Some specific applications of these systems and methods may include levitated culturing of cells... Agent:
20140322785 - Continuous flow bioreactor for magnetically stabilized three-dimensional tissue culture: The invention provides methods for rapid, continuous generation of cells and cell products using magnetically stabilized three-dimensional tissue culture. The invention also pertains to a continuous flow self-regulating closed system bioreactor system for magnetically stabilized three-dimensional tissue culture. The methods described here do not use traditional solid scaffolding for cell... Agent: Worcester Polytechnic Institute
20140322786 - Polymer modified substrates, their preparation and uses thereof: Provided are polymer modified substrates which comprise a) a substrate, b) a binding layer covalently attached to the surface of the substrate and covering at least a part of this surface; and c) a polymer brush formed by a plurality of polymer chains, each of which is covalently attached at... Agent: Apceth Gmbh & Co Kg
20140322787 - Method for manufacturing in vitro vascularized tissue: The present invention relates to a method for manufacturing an in vitro vascularized tissue, which enables obtaining the in vitro vascularized tissue by inducing in vitro angiogenesis in a tissue using vascular cells, for use in in vitro research of diseases in vascularized tissues and developing a treatment. The method... Agent:
20140322789 - Linker-bridged gene or domain fusion reverse transcriptase enzyme: The present invention relates to combinations of a linker bridged gene or domain fusion reverse transcriptase enzyme, and more particularly, combinations of a linker bridged gene or domain fusion reverse transcriptase enzyme and their fusion construction utilizing for more efficient and quality DNA synthesis in reverse transcription. The composition of... Agent:
20140322788 - Method for increasing protein thermal stability: The invention provides a simple and effective method for increasing thermal stability of a wide range of proteins, comprising fusing a self-assembling amphipathic peptide to the C- or N-terminal of target proteins. The fusion protein can have a half life up to 26 times longer than that of the wild... Agent:
20140322790 - Methods, peptides and biosensors useful for detecting a broad spectrum of bacteria: Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the α1-proteinase inhibitor. In the... Agent: Woundchek Laboratories
20140322791 - Process to prepare a stable thrombin composition: The stable thrombin composition comprises purified thrombin, human albumin and a neutral salt, the resulting product being stable when stored as a lyophilisate or frozen and is adjusted to a nominal strength of 500 IU of thrombin or more per ml of solution, the human albumin being in a concentration... Agent:
20140322792 - Cytochrome p450 oxygenases: Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having... Agent: The California Institute Of Technology
20140322793 - Novel dna polymerases: c
20140322794 - Substrates for covalent tethering of proteins to functional groups or solid surfaces: The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for... Agent: Promega Corporation
20140322795 - Alpha-amylase variants: The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant exhibits altered properties, in particular reduced capability of cleaving a substrate close to the branching point, and improved substrate specificity and/or improved specific activity relative to the parent alpha-amylase.... Agent:
20140322796 - Cellobiohydrolase variants: The invention relates to recombinant expression of variant forms of C1 CBH1a and homologs thereof, having improved thermostability, low-pH tolerance, specific activity and other desirable properties. Also provided are methods for producing ethanol and other valuable organic compounds by combining cellobiohydrolase variants with cellulosic materials.... Agent: Codexis, Inc.
20140322797 - Method for removing endotoxin from proteins: Disclosed is a method for removing endotoxin from proteins. Also disclosed are products made by using the method. The method may be used, for example, to produce endotoxin-free lactoferrin. Bovine milk-derived lactoferrin may be produced in commercial quantities by the method, and endotoxin-free bovine lactoferrin may be used for a... Agent:
20140322798 - Inhibition of methane production during anaerobic reductive dechlorination: This method of restricting methane production in methanogenic bacteria, by the use of the enzyme and coenzyme inhibitors, works during anaerobic reductive dechlorination. Various compounds such as, but not limited to, red yeast rice, vitamin B10 derivatives, and ethanesulfonates are utilized to disrupt these different enzyme and coenzyme systems responsible... Agent: Innovative Environmental Technologies, Inc.
20140322799 - Metabolically enhanced cyanobacterium with sequentially inducible production genes for the production of a first chemical compound: This invention provides a metabolically enhanced cyanobacterium for the production of a chemical compound of interest, having at least two first production genes encoding first biocatalysts for the production of the first chemical compound. One of the two first production genes is under the transcriptional control of a first promoter... Agent: Algenol Biofuels Inc.
20140322800 - Oxidized cardiolipin and uses to detect cardiolipin antibodies: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized... Agent: Arlington Scientific, Inc.
20140322801 - Optical imaging based on viscoelastic focusing: An apparatus arranged for examining particles, comprising: a cartridge having at least one microchannel, a viscoelastic fluid flowing in the microchannel, the fluid comprising a suspension of particles, thereby effecting alignment of the particles in at least one-dimensional array parallel to the fluid flow, and an optical magnifying means generating... Agent: Pixcell Medical Technologies Ltd.
20140322802 - Apparatus for measuring blood cells and immunity from whole blood: In conventional apparatuses for measuring blood cells and immunity from whole blood, the CRP cell is used for the final cleaning of a nozzle, and CRP measurement—cleaning of the CRP cell—final cleaning of nozzle are performed in this order in the CRP cell. In contrast, in the present invention, an... Agent: Horiba, Ltd.
20140322803 - Carbon sequestration methods and systems, and compositions produced thereby: Aspects of the invention include methods of removing carbon dioxide (CO2) from a CO2 containing gas. In some instances, the methods include contacting CO2 containing gas with a bicarbonate buffered aqueous medium under conditions sufficient to produce a bicarbonate rich product. Where desired, the resultant bicarbonate rich product or a... Agent: Blue Planet, Ltd.
20140322804 - Photobioreactors and culture bags for use therewith: There is provided a culture bag for use in a photobioreactor. The bag can comprise at least one wall having at least one inlet disposed at a first end portion of the at least one wall or adjacently thereto. The at least one wall defines an internal chamber for receiving... Agent:
20140322805 - System and method for using a pulse flow circulation for algae cultivation: A device for generating a pulsed flow in a channel containing a circulating algal culture can include a plate that is pivotably mounted on the channel and an activator. A pulsed flow is generated in the channel by first positioning the plate to impede the flow of circulating algal culture... Agent: General Atomics
20140322806 - Spheroid cell culture well article and methods thereof: d
20140322807 - Method for extracting nutrients from organic materials: Processes for extracting and recovering nutrients from organic wastes to create a cell culture broth for microorganisms involve the main steps of mixing, solid/liquid separation, optimization, and sterilization. In an embodiment, the method for converting organic waste material into a cell culture broth or growth media includes: (a) mixing an... Agent: Innovative Bios L.L.C.
20140322808 - Populations of hematopoietic progenitors and methods of enriching stem cells therefor: There is described herein a method of enriching a population of stem cells for hematopoietic progenitors. The method comprises inducing hematopoietic differentiation in a population of human embryonic stem cells or human induced pluripotent stem cells; sorting the population based on expression of CD43 and at least one of CD34,... Agent: University Health Network
20140322809 - Use of a rock inhibitor to sustain primary human keratinocytes in a proliferative state: Disclosed herein is the finding that treatment with a ROCK inhibitor increases proliferation and induces immortalization of primary keratinocytes. Accordingly, provided is a method of immortalizing primary keratinocytes by exposure to a ROCK inhibitor. Also provided are immortalized primary keratinocytes produced by the described method, as well as organotypic tissue... Agent: Georgetown University
20140322810 - Natural and synthetic compounds for treating cancer and other diseases: This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, CNS, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an... Agent:
20140322811 - Medium composition for rejuvenating stem cells: The present invention relates to a medium composition for transforming stem cells from an aged person into young stem cells, and more particularly to a medium composition for culturing stem cells, which is used to rejuvenate stem cells from an aged person so as to have characteristics similar to those... Agent:
20140322812 - Mutant receptors and their use in a nuclear receptor-based inducible gene expression system: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a... Agent: Intrexon Corporation
20140322813 - Methods and compositions for enhancing the efficacy and specificity of rna silencing: The present invention provides methods of enhancing the efficacy and specificity of RNA silencing. The invention also provides compositions for mediating RNA silencing. In particular, the invention provides siRNAs, siRNA-like molecules, shRNAs, vectors and transgenes having improved specificity and efficacy in mediating silencing of a target gene. Therapeutic methods are... Agent:Previous industry: Education and demonstration
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