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Chemistry: molecular biology and microbiology

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
07/10/2014 > 120 patent applications in 66 patent subcategories.

20140193798 - Cyclic implant perfusion, cleaning and passivation process and implant produced thereby: This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and... Agent: Rti Surgical, Inc.

20140193799 - Microfabricated artificial lung assist device, and methods of use and manufacture thereof: The invention provides systems and methods for exchanging gas in an oxygenator device, and methods for preparing and using such oxygenator devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient.... Agent: The Charles Start Draper Laboratory, Inc.

20140193800 - Systems and methods for continuous flow pcr systems: A liquid handling system of a PCR system is instructed to obtain a matrix of samples and reagents for a PCR experiment. A fluid pumping system of the PCR system is instructed to maintain a continuous flow of a transport fluid through a plurality of micro-channels that allows the mixture... Agent: Stokes Bio Limited

20140193801 - Schiff-base conjugate of n, n-dibutyl-p-phenylenediamine with pyridoxal 5'-phosphate for improved homocysteine assays using pyridoxal 5'-phosphate-dependent enzymes: A composition, method and kit for performing a two-reagent enzymatic homocysteine assay, wherein a single homocysteinase enzyme and a Schiff-based conjugate of N,N-dibutyl-p-phenyldiamine (DBPDA) with pyridoxal 5′-phosphate (PLP) are used to measure total homocysteine in plasma or serum. The assay measures a chromophore reaction product of H2S and the DBPDA... Agent: Anticancer, Inc.

20140193804 - Biological specimen collection and transport system and method of use: Disclosed are compositions for isolating populations of nucleic acids from biological, forensic, and environmental samples. Also disclosed are methods for using these compositions as one-step formations for killing pathogens, inactivating nucleases, and releasing polynucleotides from other cellular components within the sample, and stabilizing the nucleic acids prior to further processing... Agent: Longhorn Vaccines And Diagnostics, LLC

20140193805 - Hpv e6, e7 mrna assay and methods of use thereof: Provided is an HPV E6, E7 mRNA assay, referenced herein as the “In Cell HPV Assay,” that is capable of sensitive and specific detection of normal cervical cells undergoing malignant transformation as well as abnormal cervical cells with pre-malignant or malignant lesions. The In Cell HPV Assay identifies HPV E6,... Agent: Incelldx, Inc.

20140193802 - Identification of an altered therapeutic susceptibility to anti-hcmv compounds and of a resistance against anti-hcmv compounds: The present invention relates to a method for the detection of an altered therapeutic response of a subject infected by HCMV to a treatment with a 3,4 dihydroquinazoline or N-{3-[({4-[5-(6-aminopyridin-2-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)amino]-5-fluorophenyl}-1-cyanocyclopropanecarboxamide, a method for the detection of a drug resistance of a HCMV to a 3,4-dihydroquinazoline or N-{3-[({4-[5-(6-aminopyridin-2-yl)-1,2,4-oxadiazol-3-yl]phenyl}sulfonyl)amino]-5-fluorophenyl}-1-cyanocyclopropanecarboxamide, and to a... Agent:

20140193803 - Methods, compositions, and kits for determining hepatitus a virus: The present invention relates to compositions, methods, and kits for determining the presence or absence of HAV in a sample.... Agent: Grifols Therapeutics Inc.

20140193806 - Real-time detection of influenza virus: The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection... Agent: Theranos, Inc.

20140193807 - Bead manipulation techniques: The invention provides a method of redistributing magnetically responsive beads in a droplet. The method may include providing a droplet including magnetically responsive beads. The droplet may be provided within a region of a magnetic field having sufficient strength to attract the magnetically responsive beads to an edge of the... Agent: Advanced Liquid Logic, Inc.

20140193814 - Abca1 downregulation in prostate cancer: A method of providing a prognosis or diagnosis of prostate cancer in a subject is described. The method includes obtaining a urine or prostate sample from the subject; determining the level of expression of ABCA1 in the sample; and comparing the level of expression of ABCA1 in the sample to... Agent: The Cleveland Clinic Foundation

20140193822 - Complex sets of mirnas as non-invasive biomarkers for kidney cancer: The present invention relates to non-invasive methods, kits and means for diagnosing and/or prognosing of kidney cancer in a body fluid sample from a subject. Further, the present invention relates to set of polynucleotides or sets of primer pairs for detecting sets of miRNAs for diagnosing and/or prognosing of kidney... Agent: Comprehensive Biomarker Center Gmbh

20140193811 - Culture based screening assay and methods of use thereof to identify agents which modulate tumor development, invasion and differentiation: A 3D organotypic culture which phenocopies aggressive, invasive cancer and methods of use thereof are provided.... Agent: The Trustees Of The University Of Pennsylvania

20140193821 - Exonic splicing enhancers and exonic splicing silencers: Compounds and methods for regulation of exonic splicing enhancers and exonic splicing silencers. Compounds include polynucleotides targeted to aberrant exonic splicing enhancers and exonic splicing silencers. Compounds and methods for the diagnosis of diseases and conditions associated with aberrant exonic splicing enhancers and exonic splicing silencers. Methods for identifying splicing-sensitive... Agent:

20140193813 - Isolation of nucleic acids: Provided herein is technology relating to isolating nucleic acids. In particular, the technology relates to methods and kits for extracting nucleic acids from problematic samples such as stool.... Agent: Exact Sciences Corporation

20140193810 - Liquid injection jig set: A liquid injection jig set includes a chip receiver in which a microchip having a plate shape is received in a case, and a jig that is configured to be fittable to the chip receiver includes a hollow needle that can pierce a side end surface of the microchip, which... Agent: Sony Corporation

20140193819 - Methods and compositions for modulation of amplification efficiency: Provided herein are methods and kits for modulating the amplification efficiency of nucleic acids, which are useful in multiplex reactions where the amplification efficiency of one or more nucleic acids in the mixture are desired to be modulated relative to one or more other nucleic acids. Embodiments relate to molecular... Agent: Becton, Dickinson And Company

20140193817 - Methods and kits useful for detecting an alteration in a locus copy number: A method of identifying an alteration in a locus copy number is provided. The method is effected by determining a methylation state of at least one gene in the locus, wherein a methylation state differing from a predetermined methylation state of the at least one gene is indicative of an... Agent: Trisogen Biotechnology Limited Partnership

20140193809 - Methods for genetic analysis of dna to detect sequence variances: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.... Agent:

20140193815 - Methods of using oligonucleotides comprising a molecular switch: This invention relates to oligonucleotides comprising a molecular switch which may exist in an “open” or “closed” position. The molecular switch portion of the probe is particularly sensitive to the identity of sequences complementary to the molecular switch. Oligonucleotides containing a molecular switch are applicable to all kinds of hybridization... Agent: Gen-probe Incorporated

20140193820 - Nanowire-based system for analysis of nucleic acids: System for detection and/or analysis of nucleic acids using nanowires to detect covalent modification of nucleic acids.... Agent: Applied Biosystems, LLC

20140193808 - Non-invasive detection of fetal genetic traits: Blood plasma of pregnant women contains fetal and (generally>90%) maternal circulatory extracellular DNA. Most of said fetal DNA contains 500 base pairs, said maternal DNA having a greater size. Separation of circulatory extracellular DNA of <500 base pairs results in separation of fetal from maternal DNA. A fraction of a... Agent:

20140193818 - Partition defined detection methods: Methods are disclosed for resolving measurement problems such problems in measuring chromosomal copy number. Some disclosed methods involve first selecting a primary assay element characteristic to partition. Such characteristic may be a source of experimental variability such as the GC content of measured DNA sequences. Additionally, the disclosed methods may... Agent:

20140193812 - Single-cell nucleic acid analysis: The present invention provides methods for analysis of genomic DNA and/or RNA from small samples or even single cells. Methods for analyzing genomic DNA can entail whole genome amplification (WGA), followed by preamplification and amplification of selected target nucleic acids. Methods for analyzing RNA can entail reverse transcription of the... Agent: Fluidigm Corporation

20140193816 - System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs,... Agent: Natera, Inc

20140193824 - High-resolution clonal typing of escherichia coli: The present invention provides methods and compositions for high-resolution clonal typing of Escherichia coli.... Agent:

20140193825 - Modulation of angiopoietin-like 3 expression: Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay,... Agent: Isis Pharmaceuticals, Inc.

20140193823 - Primer set and a method for identification of meat species: The invention discloses a primer set for identification of meat species. The primer set comprises a pair of outer primers used to amplify a sense strand of DNA fragment of mitochondrial cytochrome b between positions 51 and 507. The pair of outer primers comprises a forward outer primer and a... Agent: National Pingtung University Of Science And Technology

20140193826 - Sample handling system with dosing device and thermal cycler: The invention concerns a sample handling system and a process for the handling of chemical or biological samples, particularly body fluids such as blood, saliva, secretions, etc. or tissue samples, and more specifically for the processing of samples for DNA analysis by means of PCR, comprising a dosing device with... Agent: Hamilton Bonaduz Ag

20140193827 - Characterizing a glatiramer acetate related drug product: e

20140193828 - Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity: The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes... Agent: The Regents Of The University Of California

20140193829 - Monoclonal antibodies against scrapie prion protein: The present invention relates to monoclonal antibodies against PrPSc protein. The anti-PrPSc mAbs produced of this invention can specifically detect PrPSc protein from normal mouse brain homogenates without pre-treatment with protease K, which may be used in developing a diagnostic method and kit for prion disease with high specificity and... Agent: National Yang-ming University

20140193830 - Optical biosensors: Provided are biosensors, compositions comprising biosensors, and methods of using biosensors in living cells and organisms. The biosensors are able to be selectively targeted to certain regions or structures within a cell. The biosensors may provide a signal when the biosensor is targeted and/or in response to a property of... Agent:

20140193835 - Cell-based detection of apf through its interaction with ckap4 for diagnosis of interstitial cystitis: An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to... Agent:

20140193836 - Novel markers for dopaminergic neuron progenitor cells: The present invention provides a method for selecting dopaminergic neuron progenitor cells, which comprises detecting any one or more of markers selected from the group consisting of CD15 (SSEA-1), CD24, CD46, CD47, CD49b, CD57, CD58, CD59, CD81, CD90, CD98, CD147, CD184, Disalogangliosid GD2, SSEA-4, CD49f, SERINC4, CCR9, PHEX, TMPRSS11E, HTR1E,... Agent: Kyoto University

20140193837 - Luminescent nanoparticle compositions: A composition is disclosed which is capable of being used for detection, comprising a noble metal nanoparticle. The inventive compositions exhibit little interaction with serum proteins while exhibiting pH-dependent adsorption onto live cell membranes. The nanoparticles of the claimed invention are capable of interacting with cell membranes, which in turn... Agent: The Board Of Regents Of The University Of Texas System

20140193832 - Detection of prostate cancer using psa glycosylation patterns: The present invention features novel methods for determining if a subject has prostate cancer. The present invention is based on the development of lectin immunosorbant assays which analyze α2,6-linked sialylation of total serum PSA by sambucus nigra lectin (SNA) and α2,3-linked sialylation of total and free serum PSA. These novel... Agent: The Johns Hopkins University

20140193833 - Isolation and detection of cancer cells: Provided are methods of using polycarbonate filters to isolate and detect cancer cells in a biological fluid, particularly biological fluids, such as urine, that contain very low concentrations of cancer cells. The characterization of the isolated cells for the presence or absence of cancer specific proteins is useful for cancer... Agent: The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.

20140193831 - Seed trait prediction by activity-based protein profiling: The present invention relates to a method of predicting a plant seed trait, such as germination rate, vigour, aging and priming, by determining the presence of a target protein, i.e. diagnostic marker, in its active state in a protein sample derived from a plant seed or plant seed lot. Thereby,... Agent: Ninsar Agrosciences Sl

20140193834 - Blood-brain barrier permeable peptide compositions: Blood-brain barrier permeable peptide compositions that contain variable antigen binding domains from camelid and/or shark heavy-chain only single-domain antibodies are described. The variable antigen binding domains of the peptide compositions bind to therapeutic and diagnostic biomarkers in the central nervous system, such as the amyloid-beta peptide biomarker for Alzheimer's disease.... Agent: Icb International, Inc.

20140193844 - Biomarkers for ankylosing spondylitis: There is described herein methods and peptides for detecting autoantibodies to NOG and/or SOST in a patient sample in order to diagnose of prognosticate Ankylosing Spondylitis in the patient.... Agent: University Health Network

20140193840 - Chromatography filter paper-based elisa: A chromatography filter paper-based ELISA includes following steps: providing a chromatography filter paper plate provided with a plurality of independent hydrophilic regions defined by at least one hydrophobic region; immobilizing an antigen of a sample onto one of the hydrophilic regions of the chromatography filter paper plate; and detecting the... Agent: National Tsing Hua University

20140193841 - Fluorogenic semiconductor nanocrystals: Fluorogenic semiconductor nanocrystals and compositions thereof are provided herein, including kits, assay systems and methods for their preparation and use.... Agent: Life Technologies Corporation

20140193838 - Method for measuring sialic acid in immunoglobulin g and immunoglobulin g anti-double-stranded dna antibodies: A method for measuring the amount of sialic acid in immunoglobulin G and immunoglobulin G anti-ds DNA antibodies is disclosed. The method for measuring the amount of sialic acid in immunoglobulin G in the present invention uses culture fluid, blood, plasma, or serum to directly measure the amount of sialic... Agent: Chang Gung Medical Foundation, Linkou Branch

20140193842 - Non-specific reaction inhibitor, method for inhibiting non-specific reaction, and kit: m

20140193839 - Smartphone biosensor: A mobile computing device that includes an image sensor may be used to detect the result of a biomolecular assay. The biomolecular assay may be performed in an optical assay medium that provides an optical output in response to light from a light source, with the optical output indicating result.... Agent: The Board Of Trustees Of The University Of Illinois

20140193843 - Use of basic prolin-rich lacrimal gene products, such as opiorphin, as a biomarker: The present invention relates to the use of Basic Prolin-rich Lacrimal protein (BPLP) gene products, such as Opiorphin, for establishing a prognosis, a diagnosis or the monitoring of a pathological state or of treatment efficacy in a subject and the related method of use.... Agent: Institut Pasteur

20140193845 - Use of sfrp-3 in the assessment of heart failure: Disclosed is a method for assessing heart failure in vitro including the steps of measuring in a sample the concentration of the marker SFRP-3, of optionally measuring in the sample the concentration of one or more other marker(s) of heart failure, and of assessing heart failure by comparing the concentration... Agent: Roche Diagnostics Operations, Inc.

20140193846 - Novel apoc-i isoforms and their use as biomarkers and risk factors of atherosclerotic disease: Novel isoforms of apolipoprotein C-I (apoC-I), namely apolipoprotein C-I1 (apoC-I1) and apolipoprotein C-I1′ (apoC-I1′), both of which have a molecular weight of approximately 90 daltons greater than native apolipoprotein C-I (SEQ ID NO:6) and native apolipoprotein C-I′ (SEQ ID NO:7), are shown to be both biomarkers for diagnosing atherosclerotic disease... Agent: The Texas A&m University System

20140193847 - Glutathione alkylester isotopologue and method for detecting reactive metabolite: [Solution] Provided is a glutathione alkylester isotopologue represented by general formula (1). In formula (1), R1 represents a linear or branched alkoxy group in which at least one of carbon, oxygen, and hydrogen atoms contained therein is isotope-labeled and which has 1 to 8 carbon atoms or a cycloalkoxy group... Agent: Kyorin Pharmaceutical Co., Ltd

20140193851 - Detecting individual analytes by means of magnetic flow measurement: In a magnetic flow measurement, such as flow cytometry, individual analytes are detected in the through-flow. The analytes (e.g., cells) are marked with magnetic labels directly in the medium surrounding the analytes. The analytes are transported through the flow channel of a measuring device including at least one magnetic sensor.... Agent:

20140193849 - Glucose-peg conjugates for reducing glucose transport into a cell: There is provided a glucose-PEG conjugate comprising a PEG moiety conjugated to a linear glucose moiety at the C1 position of the glucose moiety. The glucose-PEG conjugate may be used to reduce glucose transport into a cell and may be used to treat a proliferative disorder.... Agent: Agency For Science, Technology And Research

20140193850 - Holographic method and device for cytological diagnostics: The present invention discloses a method for analyzing a liquid cell sample, comprising the steps of: a) providing at least one liquid cell sample in a sample vial; b) obtaining data linked to the cells in the sample by performing differential digital holographic microscopy on said liquid cell sample in... Agent: Ovizio Imaging Systems Nv/sa

20140193848 - Sample vial cap and sample vial for use in preparing cytological specimen and method of preparing cytological specimen: A cap configured for use with a specimen container includes a cap body having a top surface defining an opening therethrough, a torque pattern disposed on the top surface of the cap body, and a pierceable and self-resealing membrane disposed across the opening, where, when the membrane is intact or... Agent: Hologic, Inc.

20140193852 - Adipose tissue collection and pre-processing devices for use in liposuction procedure: Devices and methods are described for pre-processing tissue samples containing cells of interest for various therapeutic procedures. Fibrous material may be extracted from the tissue sample through a shredding and separating device, resulting in a non-fibrous sample containing the cells of interest, which may then be washed and centrifuged to... Agent:

20140193853 - Bioprocessing: Bioreactors are provided that include a vessel and a jet mixer disposed in the vessel. Methods that utilize the bioreactors are provided, involving placing a microorganism or cells and a fluid medium in the bioreactor.... Agent: Xyleco, Inc.

20140193854 - Method for mass-producing antifreeze protein derived from polar yeast: The present invention relates to a method for mass-producing an antifreeze protein derived from a polar yeast, and more particularly, to a method for mass-producing an antifreeze protein derived from Leucosporidium sp., which is the polar yeast, for synthesizing a recombinant polynucleotide by optimizing and altering a gene, which codes... Agent: Korean Ocean Research And Development Institute

20140193855 - Methods and compositions for determining the purity of chemically synthesized nucleic acids: This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such... Agent: North Carolina State University

20140193856 - Control of gene expression: The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention utilizes recombinant DNA technology to post-transcriptionally modify... Agent: Commonwealth Scientific And Industrial Research Organisation

20140193857 - Centrifuge tube droplet generator: A centrifuge tube droplet generator includes a centrifugally generated droplet system which accommodates a sample volume of below 20 microliters and below. The system has virtually no dead volume, is simple and inexpensive and can therefore be realized in a disposable unit. The system can be tailored to fit the... Agent: Cypho, Inc.

20140193858 - Production of viral vectors: The present invention relates to methods and compositions for the production of viral vectors. In particular, the present invention provides methods and compositions for faster, higher titer and higher purity production of viral vectors (e.g. adenoviral vectors). In some embodiments, the present invention provides gutted and helper viruses with identical... Agent: The Regents Of The University Of Michigan

20140193859 - Temperature-dependent insertion of genetic material into genomic dna: The present invention provides improved methods and reagents for insertion of genetic material into genomic DNA.... Agent:

20140193860 - Low sequence bias single-stranded dna ligation: The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin)... Agent: The Penn State Research Foundation

20140193865 - Methods of producing 7-carbon chemicals from long chain fatty acids via oxidative cleavage: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis... Agent: Invista North America S.&#xe1 R.i.

20140193861 - Methods of producing 7-carbon chemicals via aromatic compounds: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoate, 7-hydroxyheptanoate, heptamethylenediamine, or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate produced from chorismate or benzoate. These pathways, metabolic engineering and cultivation strategies described herein rely on the... Agent: Invista North America S.&#xe1 .r.l.

20140193863 - Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming one or two terminal functional groups, each comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the... Agent: Invista North America S.&#xe1 R.i.

20140193862 - Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the carbon chain elongation... Agent: Invista North America S.&#xe1 R.i.

20140193864 - Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation: This document describes biochemical pathways for producing one or more of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol by forming one or two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C7 aliphatic backbone substrate produced from succinate semialdehyde or pyruvate. These pathways, metabolic... Agent: Invista North America S.&#xe1 R.l.

20140193866 - Compositions and methods for making and modifying oils: The invention provides novel methods for making or modifying oils, e.g., plant animal or microbial oils, such as vegetable oils or related compounds, that are low in a particular fatty acid(s), for example, low linoleic oils, linolenic oils, low palmitic oils, low stearic oils or oils low in a combination... Agent: DsmIPAssets B.v.

20140193867 - Microbial odd chain fatty acids: Engineered bacteria that produce a predominance of odd-chain free fatty acids.... Agent:

20140193868 - Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms: The present invention is in the field of biosynthesis of polyhydroxyalkanoates (PHA). The invention relates to a genetically engineered microorganism having at least one gene involved in the metabolism, preferably in the production, of polyhydroxyalkanoates (PHA). This microorganism is useful in commercial production of polyhydroxyalkanoates. The present invention further relates... Agent:

20140193869 - Cell-free system for converting methane into fuel and chemical compounds: The present disclosure relates, in some aspects, to cell-free methods and systems for large-scale conversion of methane to isobutanol, comprising combining, in a bioreactor at elevated pressure, methane, oxygen, and cell lysates containing methane monooxygenase, methanol dehydrogenase, and enzymes that catalyze the conversion of formaldehyde to isobutanol, to form a... Agent: Greenlight Biosciences, Inc.

20140193870 - Extracellular aldonolactonase: The present disclosure relates to hydrolysis of hexose-δ-lactones by use of an S. thermophile extracellular aldonolactonase. In particular the present disclosure relates to compositions including a S. thermophile extracellular aldonolactonase and methods of use thereof.... Agent: The Regents Of The University Of California

20140193871 - Method for enhancing carbon biofixation: At least one product chosen from acids and alcohols is produced by a microbial fermentation process comprising: providing a gaseous substrate and a liquid medium to a microorganism, wherein the liquid medium comprises lactic acid and/or salts thereof, and wherein the gaseous substrate comprises at least one carbon source chosen... Agent:

20140193872 - Process for the conversion of cellulosic feedstock materials: A process for converting a cellulosic feedstock to chemical compound, such as an alcohol, or mixture of chemical compounds, wherein one or more process streams can be used in one or more of the other process steps.... Agent:

20140193873 - Method for preparing a hydrocarbon: A method for preparing a hydrocarbon comprising contacting a fatty acid substrate with at least one fatty acid reductase and at least one fatty aldehyde synthetase and at least one fatty acyl transferase, wherein the fatty acid substrate is a fatty acid, a fatty acyl-ACP, or a fatty acyl-CoA or... Agent: Shell Oil Company

20140193874 - Novel biomarker for diagnosis of lung cancer: Disclosed are a composition for diagnosis of lung cancer including an antibody specific to GPI specific phospholipase D1 (GPLD1) protein, which is an effective biomarker for early diagnosis of lung cancer, and a composition for diagnosis of lung cancer including a primer or probe specific to a nucleic acid encoding... Agent: Seoul National University R&db Foundation

20140193875 - Porous polymeric resins: Porous polymeric resins, reaction mixtures and methods that can be used to prepare the porous polymeric resins, and uses of the porous polymeric resin are described. More specifically, the polymeric resins typically have a hierarchical porous structure plus reactive groups that can be used to interact with or react with... Agent: 3m Innovative Properties Company

20140193876 - Methods of purification of native or mutant forms of diphtheria toxin: The present invention relates to the use of hydroxyapatite chromatography and multimodal chromatography, for punfication of diphtheria toxin, or a mutant form thereof, from a mixture, for example, a host cell fermentation mixture containing impurities such as host cell proteins and DNA. This invention further relates to the integration of... Agent:

20140193877 - Thermus brockianus nucleic acid polymerases: The invention provides nucleic acids and polypeptides for nucleic acid polymerases from a thermophilic organism, Thermus brockianus. The invention also provides methods for using these nucleic acids and polypeptides.... Agent: Applied Biosystems, LLC

20140193879 - Dfpase enzymes from aplysia californica: The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.... Agent: Novozymes A/s

20140193878 - Mrna interferase from myxococcus xanthus: A regulated deployment of a toxin gene for developmental programmed cell death in bacteria is described. M. xanthus is demonstrated to have a solitary mazF gene that lacks a cotranscribed antitoxin gene. Deletion of mazF results in elimination of the obligatory cell death during development causing dramatic reduction in spore... Agent: University Of Medicine And Dentistry Of New Jersey

20140193880 - Modified factor viii and factor ix genes and vectors for gene therapy: The present invention relates to a modified and optimized Factor VIII or Factor IX nucleic acid for inclusion in a chimeric virus vector. Use of such vector can be used for treatment of hemophilia.... Agent: Asklepios Biopharmaceutical, Inc.

20140193881 - Novel adamts-13 mutant: An enhanced disintegrin-like domain, and metalloprotease, with an isolated human thrombospondin type 1 motif, member 13 (ADAMTS-13) that includes substitutions at one or more positions in the isolated human ADAMTS-13.... Agent: The Chemo-sero-therapeutic Research Institute

20140193882 - Novel strains of bacteriophages for the treatment of bacterial infections, particularly by strains of drug-resistant bacteria of the genus stenotrophomonas: Bacteriophage strains and their use in the production of preparations for use in the treatment of bacterial infections, particularly by strains of drug-resistant bacteria of the genus Stenotrophomonas, particularly those belonging to the species Stenotrophomonas maltophilia... Agent: Instytut Immunologii I Terapii Doswiadczalnej Pan

20140193883 - Gas exhaust filter device for a bioreactor: A gas exhaust filter device for a bioreactor with reduced blockage by condensed liquid is disclosed, which comprises a housing with a filter medium, a gas inlet and a gas outlet and also further comprises a plurality of ribs extending from at least one inner wall of the housing in... Agent: Ge Healthcare Bio-sciences Ab

20140193885 - Production of itaconic acid: The invention relates to a nucleic acid sequence encoding an Aspergillus mitochondrial tricarboxylic acid transporter that can be used in the production of itaconic acid in micro-organisms. Preferably said transporter protein is the protein encoded by the nucleic acid which is located on a chromosome segment of A. terreus that... Agent: Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek

20140193884 - Steady state anaerobic denitrifying consortium for application in in-situ bioremediation of hydrocarbon-contaminated sites and enhanced oil recovery: Enriched steady state microbial consortiums for microbial enhanced oil recovery and in situ bioremediation of hydrocarbon-contaminated sites, under anaerobic denitrifying conditions, are disclosed.... Agent: E I Du Pont De Nemours And Company

20140193888 - Fabric and home care products: This invention relates to fabric and home care products comprising one or more cold water proteases and processes for making and using such products. Such compositions provide improved cleaning and freshness. Such cold water proteases may be derived from parent enzymes, including BPN′ subtilisin and subtilisin derived from Bacillus lentus,... Agent: The Procter & Gamble Company

20140193886 - Surfactants that improve the cleaning of lipid-based stains treated with lipases: Described are compositions and methods relating to the removal of oily stains from fabrics and other surfaces using a lipase in combination with a selected surfactant to mediate the release of fatty acids generated by the lipase. The compositions and methods have application in, e.g., laundry cleaning and dishwashing.... Agent: Danisco US Inc.

20140193887 - Use of secondary paraffin sulfonates for increasing the cleaning capacity of enzymes: An improvement for boosting the cleaning capacity of one or more enzymes includes providing one or more secondary paraffin-sulfonates to a cleaning composition. The method is particularly effective for textiles at low washing temperatures.... Agent: Clariant International Ltd.

20140193889 - Enzymatic antimicrobial and antifouling coatings and polymeric materials: Disclosed herein are a coating, a textile finish, a wax, elastomer, a filler, an adhesive, or a sealant, as well as polymeric materials such as a plastic, a laminate, a composite, that includes an enzyme that degrades cell wall or cell membrane components (e.g., a lysozyme, lytic transglycosylase) alone or... Agent: Reactive Surfaces, Ltd.

20140193890 - Thermostable enzymes and methods of making and using the same: Provided herein are compositions and methods for enhancing enzyme activity, half-life and/or thermostability. Also provided herein are compositions and methods including the enhanced enzymes. Also provided herein are methods and compositions related to improved pectinolytic enzymes, such as pectate lyase, which exhibit enhanced activity, thermostability and/or longer half-life.... Agent: University Of Calcutta

20140193893 - Genetic test system: There is provided a genetic test system provided with a dispensing means for dispensing a sample and a reagent to a reaction vessel and a vessel conveyance means for conveying the reaction vessel. The system further includes a plurality of nucleic acid amplification detection units, each including a temperature control... Agent: Hitachi High-technologies Corporation

20140193892 - Image analysis and measurement of biological samples: Methods, devices, apparatus, and systems are provided for image analysis. Methods of image analysis may include observation, measurement, and analysis of images of biological and other samples; devices, apparatus, and systems provided herein are useful for observation, measurement, and analysis of images of such samples. The methods, devices, apparatus, and... Agent: Theranos, Inc.

20140193891 - Methods for detection of biological substances: Methods and compositions are provided for detection of biological substances in nasal specimen.... Agent:

20140193894 - Sensor and package: A fluid sensor comprises a formed plastic body and a reagent. The body has a top face with an integral first surface. The body also has a bottom face opposed to the first surface and a sidewall that extends from the periphery of the top face. The first surface is... Agent: Bayer Healthcare, LLC

20140193895 - Automated tissue engineering system: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation... Agent:

20140193896 - High efficiency and high precision microfluidic devices and methods: New high density microfluidic devices and methods provide precise metering of fluid volumes and efficient mixing of the metered volumes. A first solution is introduced into a segment of a flow channel in fluidic communication with a reaction chamber. A second solution is flowed through the segment so that the... Agent: Fluidigm Corporation

20140193897 - Bioreactor container and integrity check method for bioreactor containers: A bioreactor container comprising has an at least locally flexible wall and at least one container opening. The wall of the bioreactor container has a fluid-tight inner sheet, and an at least locally fluid-permeable or structured outer sheet. A method for testing the integrity of the bioreactor container also is... Agent: Sartorius Stedim Biotech Gmbh

20140193898 - System for producing a biogas: A method for producing a biogas is provided. The method includes the steps of providing a polyculture of aquatic plants to a growth system; continuously providing water, carbon dioxide, air and nutrients to the polyculture contained within the growth system; growing the polyculture for a time sufficient to produce an... Agent: Ssb International, LLC

20140193899 - Monoclonal antibodies to fibroblast growth factor receptor 2: The present invention is directed toward a monoclonal antibody to fibroblast growth factor receptor 2, a pharmaceutical composition comprising same, and methods of treatment comprising administering such a pharmaceutical composition to a patient.... Agent: Galaxy Biotech, LLC

20140193900 - Device for washing suspended cells or particles: A device and method are disclosed to enable fluid manipulations without disturbing or removing particles or cells. By engineering assay compartment geometries to take advantage of fluid mechanical effects, the flow velocity may be diminished around particles or cells. This technology may be used to process particles or cells of... Agent:

20140193901 - Large scale cell harvesting method for pack-bed culture device: A large scale cell harvesting method for a pack-bed culture device by providing cell growing space that is loosely packed with a plurality of porous matrixes and/or matrix means. When a cell detaching step at least comprising shaking or spinning the culture chamber is performed, the unoccupied space is large... Agent: Cesco Bioengineering Co., Ltd.

20140193905 - Expansion of definitive endoderm cells: Disclosed herein are cell cultures comprising expanded definitive endoderm cells as well as methods for expanding definitive endoderm cells in culture.... Agent: Viacyte, Inc.

20140193903 - Microcarriers for stem cell culture: We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50... Agent: Agency For Science, Technology And Research

20140193902 - Pdx1 expressing endoderm: Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of... Agent:

20140193904 - Pdx1 expressing endoderm: Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of... Agent: Viacyte, Inc.

20140193906 - Screening methods for spinal muscular atrophy: Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.... Agent:

20140193907 - Particle based biologically active molecule delivery systems: Described here are devices and methods for the delivery of molecules, including biologically active molecules, into tissues. The devices and methods are generally particle based, and devised to deploy the molecules into a target tissue in a controlled manner to minimize tissue damage. The devices and methods may further be... Agent: Bay Genomics, LLC

20140193908 - Sequential antibody therapy: The invention provides a blocking ligand specific for CTLA-4 and a vascular targeting ligand/IL-2 complex, for sequential use in inhibiting the growth of tumour cell... Agent: Philogen S.p.a.

20140193909 - Direct differentiation of cardiomyocytes from embryonic stem cells: The present invention relates to the induction of differentiation in human embryonic stem (hES) cells to cardiomyocytes and factors such as prostaglandin I2 (PGI2), Fgf 9, Bmp6, Bmp4, Scf, Igf2, and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of... Agent: Es Cell International Pte Ltd

20140193910 - Methods for producing pancreatic precursor cells and uses thereof: The present invention is directed to methods for readily propagating somatic pancreatic precursor cells. The methods comprise isolating cells from intact pancreatic samples and enhancing guanine nucleotide (GNP) biosynthesis in cultures comprising these cells, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses asymmetric cell kinetics in the cells,... Agent:

20140193911 - Thermoresponsive cell culture supports: The present invention relates to a cell culture support comprising a substrate and a thermoresponsive polymeric blend layer, wherein the polymeric blend layer comprises at least one thermoresponsive polymer and at least one network forming adhesion promoter. The present invention further relates a method of making a cell culture complex... Agent: The University Of Akron

20140193912 - Method for increasing the efficiency of inducing pluripotent stem cells: The present invention relates to a method for increasing the efficiency of inducing pluripotent stem cells by utilizing genes Jhdm1a that modify histone. By utilizing Jhdm1a, and a stem cell inducing factor, the present invention increases the efficiency of inducing pluripotent stem cells and increases the quality of induced pluripotent... Agent: Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences

20140193913 - Methods and compositions for homologous recombination in human cells: The methods and compositions described herein are based, in part, on the discovery of a stem cell state in human cells that resembles the morphology observed in murine-derived stem cells. Induction of such a state in human stem cells permits an increase in the efficiency of homologous recombination. Thus, the... Agent: The General Hospital Corporation

20140193914 - Introduction of modular vector elements during production of a lentivirus: Methods and kits for lentiviral production are provided. By separating certain components of the vector including but not limited to promoter, reporter and selection marker preference components from the genetic content of interest, one can create libraries that allow for the efficient generation of custom selected lentiviral vectors.... Agent: Thermo Fisher Scientific Biosciences Inc.

20140193915 - Compositions and methods for custom site-specific dna recombinases: The invention relates to biotechnology and provides novel compositions and methods for sequence-specific or sequence-directed transcription activator-like effector recombinases. The invention also provides novel plant transformation vectors and expression cassettes, which include novel combinations of chimeric recombinases with plant expression and transformation elements. Methods for gene-targeting, DNA sequence removal, and... Agent: Monsanto Technology, LLC

20140193916 - Electrotransformation of clostridium pasteurianum: By this invention, for the first time, a method for high-efficiency genetic transformation of the anaerobic bacterium Clostridium pasteurianum is provided. Clostridium pasteurianum is a bacterium of substantial industrial importance, due to its selectivity and high productivity of the biofuel and biochemical n-butanol, and its ability to grow on a... Agent: Algaeneers Inc.

20140193917 - Modulation of meiotic recombination: The invention provides methods of modifying the level of expression or functional activity of factors such as enzymes or other catalytic proteins or structural proteins, alone or in concert, to modify the frequency of meiotic homologous recombination involving the exchange of genetic information between non-sister chromatids from homologous maternal and... Agent: Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agr

  
07/03/2014 > 141 patent applications in 74 patent subcategories.

20140186819 - Liquid to liquid biological particle concentrator: A rapid one-pass liquid filtration system efficiently concentrates biological particles that are suspended in liquid from a dilute feed suspension. A sample concentrate or retentate suspension is retained while eliminating the separated fluid in a separate flow stream. Suspended biological particles include such materials as proteins/toxins, viruses, DNA, and/or bacteria... Agent:

20140186822 - Methods for the detection of biologically relevant molecules and their interaction characteristics: Methods for the detection of biologically relevant molecules that comprise concentrating such molecules into microscopic holes in a sheet of chemically inert material, restricting the openings, and measuring the electric current through the holes or the fluorescence near the hole openings. The electric current or fluorescence will change as the... Agent:

20140186820 - Micro-fluidic device for the analysis of a fluid sample: Use of a programmable device with capacitive touch screen for the analysis of a fluid sample as interface between a micro-fluidic device, this micro-fluidic device comprising at least one electrode and at least one micro-channel comprising an input for the introduction of the sample, and the processor of said programmable... Agent:

20140186821 - Noninterfering multipurpose compositions for collecting, transporting and storing biological samples: The invention is directed to compositions and methods for collecting, transporting, and storing microorganisms obtained from samples of biological, clinical, forensic, and environmental origin. Compositions preserve the viability of the collected organisms, permit long-term storage, and are compatible with subsequent manipulation including propagation and culture of collected microorganisms, or isolation,... Agent: Longhorn Vaccines And Diagnostics, LLC

20140186824 - Dynamic biochemical tissue analysis assays and compositions: Described herein is a method, and compositions useful with the method, of analyzing a tissue from a subject. The method includes contacting a probe conjugate (10) including a probe molecule (12), to a biological tissue 146 from a subject. The probe conjugate (10) is contacted with the biological tissue (14)... Agent: Ohio University

20140186825 - Labeled nucleotide analogs: Labeled reactant compositions, and particularly labeled nucleic acid reaction compositions that include structural components including double-stranded nucleic acids. In some embodiments, the structural components maintain potentially damaging labeling components sufficiently distal from the reactant portion of the molecule such that damaging effects of the label group on other reaction components,... Agent: Pacific Biosciences Of California, Inc.

20140186823 - Mutant pores: The invention relates to mutant forms of Msp. The invention also relates to nucleic acid characterisation using Msp.... Agent: Oxford Nanopore Technologies Limited

20140186827 - Assays for the detection of genotype, mutations, and/or aneuploidy: The present invention provides amplification-based methods for detection of genotype, mutations, and/or aneuploidy. These methods have broad applicability, but are particularly well-suited to detecting and quantifying target nucleic acids in free fetal DNA present in a maternal bodily fluid sample.... Agent: Fluidigm, Inc.

20140186833 - Cc2d2a gene mutations associated with joubert syndrome and diagnostic methods for identifying the same: The present invention provides a method of screening a subject for mutations in the CC2D2A gene that are associated with Joubert syndrome, an autosomal recessive form of mental retardation. The present invention also provides proteins that are associated with Joubert syndrome including proteins that includes an amino acid sequence that... Agent: Centre For Addiction And Mental Health

20140186839 - Compositions and methods for diagnosing autism spectrum disorders: The invention generally relates to compositions and methods for diagnosing autism spectrum disorders. In certain embodiments, the invention provides a method for diagnosing presence or increased risk of developing an autism spectrum disorder in a subject.... Agent:

20140186836 - Diagnosis marker, diagnosis method and therapeutic agent for amyotrophic lateral sclerosis, and animal model and cell model developing amyotrophic lateral sclerosis: Provided are a diagnosis marker, a diagnosis method, and a therapeutic agent suitable for diagnosing and treating amyotrophic lateral sclerosis (ALS). Also provided are an animal model and a cell model suitable for developing a therapeutic agent and a treatment method for ALS. The diagnosis method for ALS includes: an... Agent:

20140186835 - Identification of the causative mutation for inherited connective tissue disorders in equines and methods for testing for same: Provided is a description of a mutation which is positively correlated with Warmblood Fragile Foal Syndrome Type 1 (WFFST1). The mutation is a G to A change at a specific location in the equine lysyl hydroxylase 1 (LH1) gene. Compositions and methods for use in diagnosing WFFST1 are provided.... Agent: Cornell University

20140186834 - Mecp2e1 gene: The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders.... Agent: The Hospital For Sick Children

20140186829 - Method for predicting insulinopenic type 2 diabetes: The present invention relates to an in vitro method, for predicting a risk of onset of type 2 diabetes in a subject, which method comprises the steps of: a) measuring the concentration of bacterial 16S rDNA in a biological sample of said subject; and b) comparing said measured concentration of... Agent: Institut National De La Sante Et De La Recherche Medicale (inserm)

20140186826 - Method of judging risk for onset of drug-induced granulocytopenia: e

20140186830 - Methods for analyzing short tandem repeats and single nucleotide polymorphisms: Methods for genotyping a sample comprising nucleic acid are provided. The methods comprise analyzing STR and SNP loci.... Agent: Applied Biosystems, LLC

20140186828 - Methods for determining cell viability using molecular nucleic acid-based techniques: The present invention relates to novel methods, and kits, for selectively excluding dead cells from a mixture containing live and dead cells, such as microbe cells in clinical samples, blood products, medical/biotechnology products and food products where subsequent interrogation of the selected live cells are an indicator of the presence... Agent:

20140186837 - Methods for diagnosing cancer: Methods and kits for the detection of cancer and for pre-cancer screening based on the expression of genes associated with altered metabolism and apoptosis in cancerous cells, particularly the expression of a mitochondrial antiviral-signaling (MAVS) or a voltage-dependent anion channel 1 (VDAC1) protein or mRNA in combination with additional genes... Agent: Ben-gurion University Of The Negev Research And Development Authority

20140186838 - Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity: The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes... Agent: The Regents Of The University Of California

20140186832 - Selective ultrasonic lysis of blood and other biological fluids and tissues: The present invention features methods for selective lysis of endogenous cells in a biological sample. In preferred embodiments, the methods of the invention comprise contacting the biological sample with lysis solution, and subjecting the mixture to ultrasound, thereby selectively lysing the endogenous cells in the biological sample. The invention also... Agent:

20140186831 - Solid phases optimized for chemiluminescent detection: Solid supports for chemiluminescent assays are provided. The solid support includes a plurality of probes covalently or physically attached to the support surface and a chemiluminescent enhancing moiety incorporated onto the surface or into the bulk of the support. The solid support can be a multi-layered support including an upper... Agent: Life Technologies Corporation

20140186846 - Dna chip with micro-channel for dna analysis: Provided is a DNA chip with micro-channel for DNA analysis, which has a structure in which a silicon layer (chip A) and a plastic layer (chip B) are laminated, wherein the chip A includes at least two PCR reactors connected in series in a micro-channel, and a filter between the... Agent: Panasonic Corporation

20140186847 - Endonuclease-enhanced helicase-dependent amplification: The invention provides methods and compositions for enhancing the speed and sensitivity of helicase-dependent amplification through the use of an endonuclease.... Agent: Biohelix Corporation

20140186845 - Methods for determining the expression level of a gene of interest including correction of rt-qpcr data for genomic dna-derived signals: The present invention relates to methods for determining the expression level of a gene of interest in a nucleic acid sample by RT-qPCR. More specifically, procedures for determining the impact of a gDNA contamination on the measured total signal have been developed allowing the correction of the signal originating from... Agent: Inserm (institut National De La Sante Et De La Recherche Medicale)

20140186843 - Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof: Disclosed are locational or positional methods concerning CRISPR-Cas systems, and apparatus therefor.... Agent: The Broad Institute, Inc.

20140186842 - Nannochloropsis spliced leader sequences and uses therefor: The present invention relates to the culture and manipulation of microorganisms for biotech applications, and is based on the discovery and characterization of spliced leader sequences identified in transcripts from Nannochloropsis species. In particular, the invention provides nucleic acid compositions comprising a SL sequence operably linked to a protein-encoding gene.... Agent: Synthetic Genomics, Inc.

20140186844 - Polynucleotide primers and probes: The present disclosure provides a novel technology that involves improved primer design. These primer pairs have a wide range of applications and provide high sensitivity and specificity.... Agent: Swift Biosciences, Inc.

20140186840 - Pyrophosphorolysis-activated polymerization (pap) using ribonucleic acid (rna) template: A new method of RNA-PAP was developed that can directly amplify RNA template without additional treatment. RNA-PAP brings in a new mechanism for amplification of RNA template in which RNA-dependent DNA pyrophosphorolysis and RNA-dependent DNA polymerization are serially coupled using 3′ blocked primers. Due to this serial coupling, RNA-PAP has... Agent:

20140186848 - Quantification of adaptive immune cell genomes in a complex mixture of cells: Compositions and methods are described for highly sensitive quantification of the relative representation of DNA from adaptive immune cells (e.g., T and/or B lymphocytes) in DNA extracted from complex mixtures of cells that include cells which are not adaptive immune cells. Included are methods for determining the relative presence in... Agent: Adaptive Biotechnologies Corporation

20140186841 - Sensing and identifying biological samples on microfluidic devices: A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the... Agent:

20140186849 - Fluorescent detector systems for the detection of chemical perturbations in sterile storage devices: System and method for detecting and measuring chemical perturbations in a sample. The system and method are useful for non-invasive pH monitoring of blood or blood products sealed in storage bags.... Agent: Blood Cell Storage, Inc.

20140186850 - Reagents and methods for bispecific antibody-based binding of target molecules: The invention provides methods for delivery of payloads to targets in samples using non-sterically hindered complexes. The invention further provides reagents and kits for practicing the methods of the invention. The invention also provides methods for preparation of reagents for use in the methods of the invention.... Agent: Akrivis Technologies, LLC

20140186851 - Method of analyzing binding efficiency of adhesive nanoparticles: Provided is a method of analyzing binding efficiency of adhesive nanoparticles. The method includes (a) injecting a solution containing nanoparticles into a first chamber slide, (b) evaporating only the solution from the first chamber slide into which the solution containing the nanoparticles is injected, and measuring a saturation temperature using... Agent: Korea Institute Of Science And Technology

20140186855 - Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto: Methods, assays, and apparatus are disclosed for testing of antigens associated with intestinal and/or blood-brain barrier permeability. For example, blood, saliva or other bodily fluid can be tested for binding (1) to a bacterial toxin (preferably a lipopolysaccharide), and (2) binding to tissue antigens selected from at least one of... Agent: Cyrex Laboratories, LLC

20140186854 - Method using a nonlinear optical technique for detection of interactions involving a conformational change: A nonlinear optical technique, such as second or third harmonic or sum or difference frequency generation, is used to detect binding interactions, or the degree or extent of binding, that comprise conformational change. In one aspect of the present invention, the nonlinear optical technique detects a conformational change in a... Agent: Biodesy, LLC

20140186856 - Observation apparatus and observation method: An observation apparatus and an observation method are provided. The observation apparatus includes a light source that emits illumination light used to observe a specimen to which a fluorescent substance that specifically binds to or is expressed in a stimulus target has been supplied, an illumination optical system that radiates... Agent: Olympus Corporation

20140186857 - Fluorescent label for biological substance detection method: The present invention provides a fluorescent label that can be used for carrying out a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation... Agent: Konica Minolta, Inc.

20140186858 - Composition for high stringency cell treatment and antigen retrieval: The present invention relates to a cell treatment composition for the permeabilization of fixed blood cells, to the use of said composition, to a method for the treatment of a biological sample comprising fixation of said sample and subsequently contacting said biological sample with said cell treatment composition. The invention... Agent: Beckman Coulter, Inc.

20140186859 - Autofocus method for imaging a biological sample and cartridge for use therein: A method of automatically focusing a microscope on a specimen is carried out by capturing an image from each of a plurality of focal planes in or on said specimen, calculating a focus score for each of said images, selecting the focal plane corresponding to the image having the best... Agent:

20140186852 - Biomarkers for myocardial ischemia: This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular... Agent: The Johns Hopkins University

20140186853 - Method for analyzing mucin 1 using probe capable of binding to 3'-sulfonated core 1 carbohydrate chain, and method for detecting or monitoring breast cancer: The purpose can be achieved by a method for analyzing the mucin 1 having a Sulfo-3Galβ1-3GalNAc-R carbohydrate chain, including: a step of bringing a 3′ sulfonated core 1 carbohydrate chain binding probe capable of binding to the Sulfo-3Galβ1-3GalNAc-R carbohydrate chain into contact with a sample to be tested; a step... Agent: Tokyo Institute Of Technology

20140186863 - Method for detecting pancreatic disease marker: The present invention relates to a method for detecting a marker for pancreatic disease for obtaining highly reliable results while reducing the risk of complications. It also relates to a method for a detecting a marker for pancreatic disease comprising: measuring the concentration of a marker for pancreatic disease in... Agent: Olympus Corporation

20140186860 - Novel immunogenic proteins of leptospira: The invention provides novel immunogenic proteins LigA and LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits.... Agent: Cornell University

20140186861 - Soluble treponema pallidum protein tp0453, tp0453-tp0326 fusion protein, and use in syphilis diagnosis: The present application provides methods of producing soluble Treponema pallidum protein Tp0453 (such as the fragment shown in SEQ ID NO: 3). For example, the protein can be expressed from the pET28a vector in a cell and the resulting soluble Tp0453 protein isolated from the cell. Also provided are the... Agent: Uvic Industry Partnerships Inc.

20140186862 - Systems and methods for determining the percentage of glycated hemoglobin: Described herein are systems and methods for assaying a sample to quantitatively determine the percentage of glycated hemoglobin in the sample.... Agent: Relia Diagnostic Systems, Inc.

20140186864 - Method for identifying a malodor inhibitor: Provided is a method for identifying a malodor inhibitor based on a response of an olfactory receptor. The present invention provides a method for identifying a malodor inhibitor including: adding a test substance and a malodor-causing substance to at least one olfactory receptor selected from the group consisting of OR5P3,... Agent: Kao Corporation

20140186865 - Method for assaying plasminogen in a liquid medium, associated compositions and kit: o

20140186866 - Glucose control test strip: A control test strip for glucose that includes a cover that forms a fluid path when affixed to the test strip substrate. The fluid path includes a glucose deposit area formed by drying a glucose solution on to the cover or onto the test strip substrate. The control test strip... Agent: General Electric Company

20140186867 - Composition comprising antibody that binds to domain ii of her2 and acidic variants thereof: A composition comprising a main species HER2 antibody that binds to domain II of HER2 and acidic variants thereof is described. Pharmaceutical formulations comprising the composition, and therapeutic uses for the composition are also disclosed.... Agent: Genentech, Inc.

20140186868 - Method for adapting a hydrolytic enzyme to a component that stabilizes the hydrolytic enzyme: The stabilization of a hydrolytic enzyme in a liquid preparation is to be improved through a component that stabilizes the hydrolytic enzyme. This is accomplished by a method for adapting a hydrolytic enzyme to a component that stabilizes the hydrolytic enzyme, comprising the following method steps: a) providing a hydrolytic... Agent: Henkel Ag & Co., Kgaa

20140186869 - Method for inhibiting protease in biological sample containing pancreatic juice components: This method for inhibiting protease in a biological sample containing pancreatic juice components inhibits protease enzyme activity in the biological sample by adding at least one type of protease inhibitor having a sulfonyl fluoride group to the biological sample containing pancreatic juice components. In addition, this protease inhibitor for a... Agent: Olympus Corporation

20140186870 - In vivo proteomics: The application discloses methods, materials, and compositions for the labeling of molecules, for example, proteins, in living cells or in subcellular compartments of living cells. In particular, the application relates to proteomic analysis methods; materials and compositions and means based on direct tagging of unknown proteins with tagging enzymes (such... Agent: Massachusetts Institute Of Technology

20140186872 - Bisacodyl and its analogues as drugs for use in the treatment of cancer: The present invention provides compounds having the formula A: (A) or pharmaceutically acceptable salt thereof, wherein W, R1, R2 and R5 are as defined in classes and subclasses herein, and pharmaceutical compositions thereof, as described generally and in subclasses herein, which compounds are useful as cytotoxic agents towards proliferating and/or... Agent: Universite De Strasbourg

20140186876 - Cell analysis apparatus and method: Devices and methods that measure one or more properties of a living cell culture that is contained in liquid media within a vessel, and typically analyzes plural cell cultures contained in plural vessels such as the wells of a multiwell microplate substantially in parallel. The devices incorporate a sensor that... Agent: Seahorse Bioscience

20140186871 - Compositions and methods for optimizing drug hydrophobicity and drug delivery to cells: Methods to determine drug hydrophobicity and to quantify changes in drug hydrophobicity that optimize drug function by means of differential scanning calorimetry of an endothermic phase transition of a base protein-based polymer, specifically of an elastic-contractile model protein, to which is attached the drug to be evaluated for its hydrophobicity... Agent:

20140186877 - Compositions and methods for the biosynthesis of 1-alkenes in engineered microorganisms: Various 1-alkenes, including 1-nonadecene and 1-octadecene, are synthesized by the engineered microorganisms and methods of the invention. In certain embodiments, the microorganisms comprise a recombinant alpha-olefin-associated enzyme. This enzyme may be expressed in combination with a recombinant alkene synthase pathway-related gene. The engineered microorganisms may be photosynthetic microorganisms such as... Agent: Joule Unlimited Technologies, Inc.

20140186874 - Immature platelet enumeration systems and methods: Embodiments of the present invention encompass automated systems and methods for analyzing immature platelet parameters in an individual based on a biological sample obtained from blood of the individual. Exemplary techniques involve correlating aspects of direct current (DC) impedance, radiofrequency (RF) conductivity, and/or light measurement data obtained from the biological... Agent: Beckman Coulter, Inc.

20140186875 - Novel optical labeling molecules for proteomics and other biological analysis: The invention relates to compositions and methods useful in the labeling and identification of changes in protein levels, changes in enzyme activity, and changes in protein modification. The invention provides for highly soluble optical labeling molecules which are optionally cleavable after separation of mixtures of labeled proteins into components. These... Agent: Montana State University

20140186873 - Synthesis and use of isotopically labeled macrocyclic compounds: Disclosed herein are isotopically labeled antifungal antibiotics and related compounds. Also disclosed are methods for synthesizing these isotopically labeled molecules and using the same to study the distribution of these compounds in the biosphere as well as the products formed by the breakdown of these isotopically labeled compounds.... Agent:

20140186878 - Fluorogenic or fluorophoric compounds and uses thereof: Compounds are provided that are either fluorogenic or fluorophoric. Compositions and articles that include the compounds are also provided. Additionally, methods of detecting a microorganism using the compounds are provided. The compounds are fluorinated and can be used advantageously under acidic conditions.... Agent: 3m Innovative Properties Company

20140186879 - Methods for separation, characterization and/or identification of microorganisms using spectroscopy: The present invention is directed to a method for separating, characterizing and/or identifying microorganisms in a test sample. The method of the invention comprises an optional lysis step for lysing non-microorganism cells that may be present in a test sample, followed by a subsequent separation step. The method may be... Agent: Biomerieux Inc.

20140186881 - Method and system for detection and/or characterization of a biological particle in a sample: The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample whereby the method may be accomplished non-invasively by utilizing a time-dependent spectroscopic technique to obtain at least two measurements of a growth composition comprising a sample and... Agent: Biomerieux, Inc.

20140186880 - Salmonella and/or e. coli enzyme test and/or liquid drop test for biological substances, on non-human samples: A test kit and test apparatus are provided for the detection of enzymes excreted by broken or ruptured bacteria cells in various environments, such as in the field, soil extracts, produce washing, slaughter houses, food preparation area's and other related or non-related areas where a quick test or rapid test... Agent:

20140186882 - Method for fixing a histological sample: The disclosure relates to a method for fixing a histological sample, in which a target fixing time for the sample is defined and the sample is exposed to the action of a fixative, the exposure start time being stored in a memory associated with the sample. The sample is no... Agent: Leica Biosystems Nussloch Gmbh

20140186883 - Processor for processing histological samples: The disclosure relates to a processor for processing histological samples. The processor comprises an inlet for insertion of a closed fixing container having the samples present therein.... Agent: Leica Biosystems Nussloch Gmbh

20140186884 - Xylose isomerases and their uses: This disclosure relates to novel xylose isomerases and their uses, particularly in fermentation processes that employ xylose-containing media.... Agent: Bp Corporation North Americca Inc.

20140186885 - Process for preparing genetically transformed yeasts capable of producing a molecule of interest at a high titre: The subject of the present invention is a process for preparing a genetically modified yeast by multicopy integration of at least four expression cassettes, allowing the production of a molecule of interest at high titre. The subject of the present invention is also yeasts transformed according to said process, and... Agent: Sanofi

20140186886 - In vivo de-glycosylation of recombinant proteins by co-expression with pngase f: Materials and methods for in vivo de-glycosylation of recombinant N-glycosylated proteins by co-expression with bacterial PNGase F (Peptide: N-glycosidase F) in plants, using a transient expression system are described. Methods are described which, for example, produce recombinant proteins of interest in plants in a non-glycosylated form. A method of expressing... Agent: Ibio, Inc.

20140186888 - Method for enhancing the production yield of human papillomavirus l1 protein: This invention is a method for improving production yield of HPV L1 protein including the phase of culturing cell expressing HPV L1 protein in a medium containing high concentration of carbon source. According to the culture method using a medium containing highly concentrated carbon source of this invention, the production... Agent: Chung-ang University Industry-academic Cooperation Foundation

20140186887 - Receptor activator of nf-kappab: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.... Agent: Immunex Corporation

20140186889 - Antibody generation from plasmacytoma-prone transgenic animals: Certain transgenic animals which are prone to the rapid cell division of their antibody-secreting cells have superior properties for the generation of monoclonal antibodies. Not only can their antibody producing cells can be made into hybridomas with superior growth to hybridomas from non-prone animals, but the antibody producing cells themselves... Agent: Abeome Corporation

20140186892 - Monoclonal antibodies against glypican-3: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are... Agent:

20140186891 - Polynucleotides encoding il-31 monoclonal antibodies: The invention provides humanized mouse anti-human IL-31 antibodies and antibody fragments that are capable of binding IL-31 and thereby neutralizing, inhibiting, limiting, or reducing the proinflammatory or pro-pruritic effects of IL-31.... Agent: Zymogenetics, Inc.

20140186890 - Selection of host cells expressing protein at high levels: Provided is a DNA molecule comprising a multicistronic transcription unit coding for i) a selectable marker polypeptide functional in a eukaryotic host cell, and for ii) a polypeptide of interest, the polypeptide of interest having a translation initiation sequence separate from that of the selectable marker polypeptide, wherein the coding... Agent: Chromagenics B.v.

20140186894 - Isolated dna polymerases, kits and applications thereof: Isolated DNA polymerase and the mutant DNA polymerases thereof are provided. The DNA polymerases have good thermostability.... Agent: Industrial Technology Research Institute

20140186893 - Linear amplification of short nucleic acids: The present teachings provide novel methods for amplifying short nucleic acids. In some embodiments, the present teachings provide novel methods for linearly amplifying a collection of micro RNAs by using temperature cycling during a reverse transcription reaction. The cycling can comprise at least 20 cycles of an annealing temperature segment... Agent: Applied Biosystems, LLC

20140186895 - Peptide with the enzymatic activity of a dicer-like protein, a method for preparing short rna molecules, and use thereof: The subject of the invention is a peptide with the enzymatic activity of a Dicer-like protein, a method for preparing short RNA molecules, and use thereof. The purpose of the solution was to develop a new method of producing short RNA molecules, using a new, MtDCL1pepA peptide of a Dicer... Agent: Instytut Chemii Bioorganicznej Pan

20140186899 - Biomass fractionation processes employing sulfur dioxide: The present invention provides a process for fractionating lignocellulosic biomass, comprising: contacting biomass with SO2, water, and optionally a first solvent, to produce intermediate solids; then contacting the intermediate solids with SO2, water, and a second solvent, to produce cellulose-rich solids and a liquid phase comprising hemicelluloses and lignin. The... Agent: Api Intellectual Property Holdings, LLC

20140186898 - Processes for fractionating whole plants to produce fermentable sugars and co-products: The invention provides processes for producing fermentable sugars from whole biomass that includes cellulose, hemicellulose, lignin, and non-lignocellulosic sugars. Some variations fractionate the whole feedstock in the presence of sulfur dioxide, a solvent for lignin, and water, to produce a liquor containing hemicellulose, cellulose-rich solids, lignin, and the non-lignocellulosic sugars.... Agent: Api Intellectual Property Holdings, LLC

20140186897 - Transformant of yeast of genus schizosaccharomyces, method for producing same, method for producing ß-glucosidase, and cellulose degradation method: To provide a transformant of a yeast of the genus Schizosaccharomyces which can produce a modified-type β-glucosidase with improved glucosidase activity, a method for producing such a transformant, a method for producing the modified-type β-glucosidase, and a cellulose degradation method using the modified-type β-glucosidase. A transformant of a yeast of... Agent: Asahi Glass Company, Limited

20140186896 - Use of glycoside hydrolase 61 family proteins in processing of cellulose: The invention provides recombinant GH61 proteins obtained from Myceliophtora thermophila, and nucleic acids that encode such proteins. The invention also provides protein fractions isolated from M. thermophila supernatant that have GH61 protein activity. These preparations can be used to increase yield of products from reactions in which a cellulose-containing substrate... Agent: Codexis, Inc.

20140186900 - Production of fungal extracellular immune stimulating compounds: A process is described for the production of an immunostimulant by submerged cultivation of Ganoderma lucidum in which mycelium from agar plates or a fermentation broth is added to a liquid medium in a shake flask or a bioreactor containing nutrients such as malt extract, yeast extract, peptone and glucose... Agent: Glycanova As

20140186901 - Processes and apparatus for producing fermentable sugars, cellulose solids, and lignin from lignocellulosic biomass: In some variations, the invention provides a process for fractionating biomass, comprising: fractionating the biomass in the presence of a solvent for lignin, sulfur dioxide, and water, to produce a liquor containing hemicellulose, cellulose-rich solids, and lignin; hydrolyzing the hemicellulose contained in the liquor, to produce hemicellulosic monomers; hydrolyzing the... Agent: Api Intellectual Property Holdings, LLC

20140186902 - Methods of producing 6-carbon chemicals via coa-dependent carbon chain elongation associated with carbon storage: This document describes biochemical pathways for producing adipic acid, caprolactam, 6-aminohexanoic acid, 6-hydroxyhexanoic acid, hexamethylenediamine or 1,6-hexanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl groups, in a C6 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on CoA-dependent elongation enzymes... Agent: Invista North America S. A R.l.

20140186903 - Processes and apparatus for producing furfural, levulinic acid, and other sugar-derived products from biomass: In some variations, the invention provides a process for producing furfural, 5-hydroxymethylfurfural, and/or levulinic acid from cellulosic biomass, comprising: fractionating the feedstock in the presence of a solvent for lignin, sulfur dioxide, and water, to produce a liquor containing hemicellulose, cellulose-rich solids, and lignin; hydrolyzing the hemicellulose contained in the... Agent: Api Intellectual Property Holdings, LLC

20140186905 - Biotechnological synthesis process of organic compounds with the aid of an alkl gene product: Subject matter of the invention is a biotechnological process for the production of organic compounds with the aid of at least one alkL gene product.... Agent: Evonik Degussa Gmbh

20140186904 - Methods of producing 7-carbon chemicals via methyl-ester shielded carbon chain elongation: This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting... Agent: Invista North America S.&#xe1 R.l.

20140186908 - Enzymatic transesterification/esterification processes employing lipases immobilized on hydrophobic resins in the presence of water solutions: Disclosed are processing systems and processes for carrying out enzymatic batchwise or continuous process for the production of fatty acid alkyl esters for use in the biofuels, food and detergent industries.... Agent: Trans Biodiesel Ltd.

20140186909 - Flexible photobioreactors, systems and methods: The present invention provides a photobioreactor for a phototrophic microorganism, and culture medium therefor, comprising a capsule, the capsule comprising an elongated body comprised of a first, flexible polymer film that is at least partially transparent to light of a wavelength that is photosynthetically active in a phototrophic microorganism and... Agent:

20140186907 - Oil composition and method of recovering same: The present invention generally relates to oil compositions and methods of producing such oil compositions. More particularly, the present invention relates to an oil composition recovered from a fermentation product as well as methods of recovering such oil compositions for use in various processes such as bio-diesel production as well... Agent: Poet Research, Inc.

20140186906 - Recombinant microbial cells that produce at least 28% eicosapentaenoic acid as dry cell weight: Recombinant microbial cells are disclosed herein that produce an oil comprising at least 28 percent eicosapentaenoic acid (EPA) measured as a weight percent of dry cell weight. These cells may comprise a polynucleotide sequence encoding an active acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT) comprising at least one amino acid mutation in a membrane-bound... Agent: E I Du Pont De Nemours And Company

20140186910 - Dhad variants for butanol production: Dihydroxy-acid dehydratase (DHAD) variants that display increased DHAD activity are disclosed. Such enzymes can result in increased production of compounds from DHAD requiring biosynthetic pathways. Also disclosed are isolated nucleic acids encoding the DHAD variants, recombinant host cells comprising the isolated nucleic acid molecules, and methods of producing butanol.... Agent: Butamaxtm Advanced Biofuels LLC

20140186911 - Recombinant host cells and methods for producing butanol: Provided herein are recombinant yeast cells comprising a deletion or disruption in an endogenous gene encoding Amn1 and a heterologous gene encoding Amn1. Also provided are recombinant yeast cells comprising a heterologous gene encoding Amn1 and an engineered butanol biosynthetic pathway. Further provided are methods of producing isobutanol comprising providing... Agent: Butamax Advanced Biofuels LLC

20140186912 - Methods for improved ethanol production: Some embodiments provide a process for the production of ethanol. The process includes performing liquefaction, saccharification, and fermentation steps to produce ethanol from an organic material. In one embodiment, the liquefaction step may include disposing a carbon-containing material within a first vessel, adding at least one enzyme to the first... Agent:

20140186915 - Method for producing alkane and recombinant microorganism capable of synthesizing alkane: A method for producing alkane and a recombinant microorganism with good alkane productivity in a reaction system for synthesizing alkane by alkane synthase activity are provided. Alkane productivity is significantly improved in a system for synthesizing alkane by alkane synthase in the presence of ferredoxin. Specifically, the method for producing... Agent: Toyota Jidosha Kabushiki Kaisha

20140186913 - Methods for biosynthesis of isobutene: The document provides methods for biosynthesizing isobutene using one or more isolated enzymes such as one or more of an enoyl-CoA dehydratase, a 2-hydroxyacyl-CoA dehydratase, an isovaleryl-CoA/acyl-CoA dehydrogenase and a mevalonate diphosphate decarboxylase, or using recombinant host cells expressing one or more such enzymes.... Agent: Invista North America S.&#xe1 R.l.

20140186914 - Production of volatile dienes by enzymatic dehydration of light alkenols: Described is a method for generating conjugated dienes through a biological process. More specifically, the application describes a method for producing conjugated dienes (for example butadiene, isoprene or dimethylbutadiene) from light alkenols via enzymatic dehydration, in particular by making use of an alkenol dehydratase.... Agent: Scientist Of Fortune, S.a.

20140186916 - Articles and methods for administering co2 into plants: Methods and articles are provided for reducing the amount of water consumed by a plant over a period of time, sequestering CO2, and producing electricity, where each method includes providing the plant with a composition including at least about 0.1 (wt./wt. or vol./vol.) % CO2 and/or at least about 0.1... Agent: Elwha LLC

20140186917 - Compositions for diagnosis and therapy of diseases associated with aberrant expression of futrins (r-spondins) and/or wnt: The present invention relates to a composition useful for the diagnosis of diseases associated with aberrant expression of the genes encoding the secreted proteins Futrin 1, 2, 3 and/or 4(=R-Spondin 2, 3, 1 and 4, respectively), e.g. in connection with tumors or diseases of the muscle, kidneys or bones. The... Agent: Deutsches Krebsforschungszentrum

20140186918 - Luciferase mutant: A recombinant protein having luciferase activity and at least 60% similarity to a wild-type luciferase wherein in the sequence of the enzyme, the amino acid residue corresponding to residue 357 in Photinus pyralis luciferase is mutated as compared to the corresponding wild-type luciferase, such that the luciferase enzyme is able... Agent: Promega Corporation

20140186919 - Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation: The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme.... Agent:

20140186920 - Materials and methods for using an acyl-acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis: A method of increasing production of fatty acids comprising introducing into a host and expressing therein an acyl-acyl carrier protein (ACP) thioesterase (TE) from Bryantella formatexigens or a mutant thereof; a method of making a mutant B. formatexigens acyl-ACP TE; a method of making a chimeric Cuphea viscosissima acyl-ACP TE;... Agent: Iowa State University Research Foundation, Inc.

20140186921 - Low ph protein purification process: The invention relates to a process for recovering and purifying bile salt-stimulated lipase (BSSL) in a solution which contains impurities, said process comprising the steps: (i) applying BSSL to a hydrophobic interaction chromatography (HIC) resin; (ii) removing impurities by washing said HIC resin with a wash composition having a pH... Agent: Swedish Orphan Biovitrum Ab (publ)

20140186922 - Proteases producing an altered immunogenic response and methods of making and using the same: The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention... Agent: Danisco US Inc.

20140186923 - Compounds and methods for purification of serine proteases: Disclosed herein are compounds, compositions, methods and kits for purifying a serine protease and serine proteases purified with the compounds, compositions and methods.... Agent: Portola Pharmaceuticals, Inc.

20140186924 - Methods for transforming tarwi and for producing molecular farming products in transgenic tarwi seed: The present disclosure describes reproducible methods for the Agrobacterium-mediated production of stable, genetically transformed, fertile tarwi plants (Lupinus mutabilis Sweet) having seed-specific expression of human adenosine deaminase enzyme (hADA) or a functional variant thereof. The method involves slicing a tarwi seed embryo to produce an explant; infecting the explant in... Agent: Prairie Plant Systems Inc.

20140186925 - Enzyme produced by arthrobacter globiformis: Task: There are provided a highly safe epimerase usable in food industry, and a method for producing a ketose. Resolution: The epimerase is a ketose 3-epimerase obtainable from a microorganism of the genus Arthrobacter, and having (1) substrate specificity whereby a D- or L-ketose is epimerized at position 3 to... Agent: Matsutani Chemical Industry Co., Ltd.

20140186926 - Baculoviral vectors comprising repeated coding sequences with differential codon biases: The present invention relates to production of proteins in insect cells whereby repeated coding sequences are used in baculoviral vectors. In particular the invention relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral rep proteins that increase... Agent: UniqureIPB.v.

20140186927 - Process for the production and utilization of chlamydospore rich slurry inoculum: The process for the production of a chlamydospore rich slurry inoculum begins with a substrate colonized with a desired Basidiomycete fungus capable of producing chlamydospores during vegetative growth. The colonized substrate is treated to increase the chlamydospore production and content in said spawn and thereafter combined with water at rate... Agent:

20140186928 - Recombinant microorganism and methods of production thereof: The invention relates, inter alia, to novel genetically modified microorganisms capable of using CO to produce 1-butanol and/or a precursor thereof, novel methyltransferases and nucleic acids encoding same, methods for producing genetically modified microorganisms using said novel methyltransferases, and methods of producing 1-butanol and/or a precursor thereof by microbial fermentation.... Agent: Lanzatech New Zealand Limited

20140186929 - Compositions and methods comprising a combination silage inoculant: Compositions and methods for the production of biogas from forage are provided. Compositions comprise a combination microbial inoculant, silage produced from forage inoculated with the combination microbial inoculant, and biogas produced from the silage. Various methods are provided for increasing biogas production and decreasing dry matter loss by inoculating forage... Agent:

20140186930 - Methods for the improvement of product yield and production in a microorganism through the addition of alternate electron acceptors: The present invention provides for novel metabolic pathways to reduce or eliminate glycerol production and increase product formation. More specifically, the invention provides for a recombinant microorganism comprising a deletion of one or more native enzymes that function to produce glycerol and/or regulate glycerol synthesis and one or more native... Agent: Mascoma Corporation

20140186931 - Process of operating a plurality of photobioreactors: There is provided a process of operating a plurality of photobioreactors, comprising: while a carbon dioxide-comprising gaseous exhaust material producing process is effecting production of the carbon dioxide-comprising gaseous exhaust material, supplying at least a fraction of the produced carbon dioxide-comprising gaseous exhaust material to a respective reaction zone of... Agent: Pond Biofuels Inc.

20140186932 - Method and apparatus for inoculating and streaking a medium in a plate: e

20140186936 - Dna chip with micro-channel for dna analysis: A DNA chip with micro-channel for DNA analysis of DNA included in an analyte according to a PCR method is a DNA chip with micro-channel for DNA analysis in which is silicon (first layer) and plastic (second layer) are laminated, wherein the second layer is formed on a partial area... Agent: Panasonic Corporation

20140186933 - Method and device for detecting prior drug use, taking inflammation into account to increase test's specificity and reduce false positives: This method and device detects past use of drugs of abuse when the drug substance and its metabolites are no longer present in the body, based on the detection of the antibodies formed in response to said drug, and persist even after this drug and its metabolites are cleared from... Agent:

20140186934 - Rapid diagnostic device, assay and multifunctional buffer: An improved rapid diagnostic device, assay and multifunctional buffer reagent are provided for the detection of a target analyte in a fluid test sample. The 2-step assay utilizes a dual component flow-through device comprising a test unit and a dried indicator reagent delivery unit capable of receiving the fluid sample... Agent: Medmira Inc.

20140186935 - Thin-film layered centrifuge device and analysis method using the same: Disclosed herein is a thin-film layered centrifuge device and an analysis method using the same. One example of an embodiment of the present invention is a thin film layered centrifuge device where a device, such as a lab on a chip, a protein chip and a DNA chip, for diagnosing... Agent: Samsung Electronics Co., Ltd.

20140186937 - Automated tissue engineering system: The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation... Agent: Octane Biotech Inc.

20140186939 - Portable water quality instrument: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes... Agent:

20140186938 - Serial-line-scan-encoded multi-color fluorescence microscopy and imaging flow cytometry: A system for performing high-speed, high-resolution imaging cytometry includes a scanning region that is illuminated by light including at least first and second wavelength bands. The system also includes a cell transport mechanism that transports a cell through the scanning region such that the cell is illuminated. The system further... Agent: Bio-rad Laboratories, Inc.

20140186941 - Cell culture vessel, and culture device equipped with same: Disclosed is a cell culture vessel of the present invention, which is composed of a space enclosed by a housing that supports a medium and a cell attachment part, disposed on the bottom surface of the space, that attaches and supports the cells, the cell attachment part having a cell... Agent:

20140186940 - Nano-pcr: methods and devices for nucleic acid amplification and detection: Methods, devices, and compositions are described that provide for amplification of nucleic acid sequences without reliance upon temperature cycling, thus freeing the methods from conventional benchtop thermal cycling devices. Denaturation of double stranded nucleic acids, primer annealing, and precision control over primer extension by polymerase can be accomplished by applying... Agent: Nanobiosym, Inc.

20140186942 - Methods for genomic modification: Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain embodiments, the methods comprise contacting the host cell genome with one or more integration polynucleotides comprising an exogenous nucleic acid to be integrated into... Agent: Amyris, Inc.

20140186943 - Nucleic acids encoding a human monoclonal antibody that specifically binds to il-1a: Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.... Agent: Xbiotech, Inc.

20140186944 - Use of cellular extracts for obtaining pluripotent stem cells: The use of a composition including at least one permeabilized nucleus of a first cell, or at least one permeabilized first cell including the nucleus and an extract of female germinal cells, or eggs, of a multicellular organism, the eggs being blocked in the metaphase II of meiosis, the extract... Agent: Centre National De La Recherche Scientifique

20140186945 - Growth of cells: The present invention relates to the use of certain polymers as a substrate for stem cell, such as pluripotent stem cell growth and/or culture. The present invention also relates to articles such as tissue culture materials and cell culture devices comprising at least one polymer hydrogel as described herein.... Agent:

20140186947 - Activation and expansion of t-cells using an engineered multivalent signaling platform as a research tool: Provided are a system and methods for selectively inducing expansion of a population of T cells in the absence of exogenous growth factors, such as lymphokines, and accessory cells for research purposes. The cell based expansion system and methods permit the long-term growth of CTLs, preferably human CTLs. In addition,... Agent: The Trustees Of The University Of Pennsylvania

20140186946 - Cell carrier, associated methods for making cell carrier and culturing cells using the same: A carrier for expansion of pluripotent stem cells is provided, wherein the carrier comprises a substrate comprising one or more outer surfaces, wherein the one or more outer surfaces are modified with gas plasma treatment, and one or more structured indentations on one or more of the outer surfaces. The... Agent: General Electric Company

20140186948 - Small molecules supporting pluripotent cell growth and methods thereof: The present invention relates to compositions and methods for maintaining undifferentiated pluripotent stem cell cultures.... Agent: Viacyte, Inc.

20140186949 - Enhancing a population of insulin releasing cells using gfr alpha-1 agonists: Provided herein are pharmaceutical and transplant compositions and methods related to the treatment and prevention of diabetes. More specifically, the compositions and methods are related to activation of glial derived neurotrophic factor (GDNF) receptors or overexpression of the GFR-α1/c-Ret receptor complex in insulin secreting cells so as to promote cell... Agent: Emory University

20140186951 - Novel opioid antagonists: Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed.... Agent: Adolor Corporation

20140186950 - Synthetic membrane anchors: Cells incorporating a synthetic molecule construct of the structure F—S1—S2-L where: F—S1 is an aminoalkylglycoside where F is a mono-, di-, tri- or oligo-saccharide and S1 is 2-aminoethyl, 3-aminopropyl, 4-aminobutyl, or 5-aminopentyl; S2 is —CO(CH2)2CO—, —CO(CH2)3CO—, —CO(CH2)4CO— or —CO(CH2)5CO—; and L is phosphatidylethanolamine.... Agent: Kode Biotech Limited

20140186953 - Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators: The present invention provides methods to promote differentiation of pluripotent stem cells to pancreatic endoderm cells expressing PDX1, NKX6.1, and HB9. In particular, the methods encompass culturing Stage 4 to Stage 6 cells with a thyroid hormone (e.g. T3), an ALK5 inhibitor, or both.... Agent: Janssen Biotech, Inc.

20140186955 - Generation of neuronal cells from pluripotent stem cells: The invention relates to in vitro methods for differentiating mammalian pluripotent stem cells into cells displaying a neuronal phenotype, more particularly into cortical-type neurons including inter alia pyramidal neurons and cortical inhibitory interneurons. The invention further encompasses so-obtained neuronal cells and cell population, compositions comprising such, and further uses of... Agent: Universite Libre De Bruxelles

20140186954 - Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express hepatocyte phenotypes and hepatocyte progenitor phenotypes. More particularly, the invention relates to methods for culturing cells so that the cells are induced to differentiate into cells that express a... Agent: Katholieke Universiteit Leuven

20140186952 - Scaffold-free tissue constructs: A tissue construct comprising includes a self-assembled, scaffold-free, high-density cell aggregate. The cell aggregate includes a plurality of cells and a plurality of biocompatible and degradable nanoparticles and/or microparticles that are incorporated within the cell aggregate. The nanoparticles and/or microparticles act as a bulking agent and/or provide bioactive agents or... Agent: Case Western Reserve University

20140186956 - Methods of sorting plant embryos: Methods of sorting plant somatic embryos according to germination potential are provided.... Agent: Weyerhaeuser Nr Company

20140186957 - Engineered tal effector proteins with enhanced dna targeting capacity: The present invention provides compositions and methods for DNA targeting using TAL effectors and TAL effector based proteins, including but not limited to targeted gene regulation and targeted cleavage of cellular chromatin in a region of interest and/or homologous recombination at a predetermined site in cells. Compositions include fusion polypeptides... Agent: Iowa State University Research Foundation, Inc.

20140186958 - Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains: The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such... Agent:

20140186959 - Vectors for directional cloning: The invention provides vectors and methods for directional cloning.... Agent: Promega Corporation

  
  
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