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Controlled release pharmaceutical compositions comprising a fumaric acid ester

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Controlled release pharmaceutical compositions comprising a fumaric acid ester


The invention features a kit. The kit includes: (i) a first unit dosage form consisting essentially of about 120 mg of dimethylfumarate and one or more pharmaceutically acceptable excipients, wherein the dimethylfumarate is formulated for delayed release; and (ii) a second unit dosage form consisting essentially of about 240 mg of dimethylfumarate and one or more pharmaceutically acceptable excipients, wherein the dimethylfumarate is formulated for delayed release.
Related Terms: Dimethyl Dosage Fumaric Acid Unit Dosage Form

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USPTO Applicaton #: #20130315993 - Class: 424465 (USPTO) - 11/28/13 - Class 424 
Drug, Bio-affecting And Body Treating Compositions > Preparations Characterized By Special Physical Form >Tablets, Lozenges, Or Pills >With Claimed Perfecting Feature In Contents (e.g., Excipient, Lubricant, Etc.)

Inventors: Henrik Nilsson, Florian Schönharting, Bernd W. Müller, Joseph R. Robinson

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The Patent Description & Claims data below is from USPTO Patent Application 20130315993, Controlled release pharmaceutical compositions comprising a fumaric acid ester.

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FIELD OF THE INVENTION

The present invention relates to controlled release pharmaceutical compositions comprising a fumaric acid ester as an active substance. The compositions are suitable for use in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders and are designed to release the fumaric acid ester in a controlled manner so that local high concentrations of the active substance within the gastrointestinal tract upon oral administration can be avoided and, thereby, enabling a reduction in gastro-intestinal related side-effects.

BACKGROUND OF THE INVENTION

Fumaric acid esters, i.e. dimethylfumarate in combination with ethylhydrogenfumarat have been used in the treatment of psoriasis for many years. The combination is marketed under the tradename Fumaderm®. It is in the form of tablets intended for oral use and it is available in two different dosage strengths (Fumaderm® initial and Fumaderm®):

Fumaderm ® Initial Fumaderm ®

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Modified-release dosage forms of 5-ht2c agonists useful for weight management
Industry Class:
Drug, bio-affecting and body treating compositions
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stats Patent Info
Application #
US 20130315993 A1
Publish Date
11/28/2013
Document #
13957147
File Date
08/01/2013
USPTO Class
424465
Other USPTO Classes
514547, 424490, 424489
International Class
/
Drawings
3


Dimethyl
Dosage
Fumaric Acid
Unit Dosage Form


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