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Elastomeric copolymer coatings for implantable medical devices

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Elastomeric copolymer coatings for implantable medical devices


Implantable medical devices with elastomeric copolymer coatings are disclosed.

Browse recent Abbott Cardiovascular Systems Inc. patents - Santa Clara, CA, US
Inventor: Yunbing Wang
USPTO Applicaton #: #20120330404 - Class: 623 138 (USPTO) - 12/27/12 - Class 623 
Prosthesis (i.e., Artificial Body Members), Parts Thereof, Or Aids And Accessories Therefor > Arterial Prosthesis (i.e., Blood Vessel) >Absorbable In Natural Tissue

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The Patent Description & Claims data below is from USPTO Patent Application 20120330404, Elastomeric copolymer coatings for implantable medical devices.

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CROSS-REFERENCE TO RELATED APPLICATION

This application is a continuation of U.S. application Ser. No. 11/810,652, filed on Jun. 5, 2007, and published as U.S. Patent Application Publication No. 2008-0306592 A1, on Dec. 11, 2008, which is incorporated by reference in its entirety, including any drawings, herein.

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention relates to elastomeric coatings for implantable medical devices.

2. Description of the State of the Art

This invention relates to radially expandable endoprostheses, which are adapted to be implanted in a bodily lumen. An “endoprosthesis” corresponds to an artificial device that is placed inside the body. A “lumen” refers to a cavity of a tubular organ such as a blood vessel.

A stent is an example of such an endoprosthesis. Stents are generally cylindrically shaped devices, which function to hold open and sometimes expand a segment of a blood vessel or other anatomical lumen such as urinary tracts and bile ducts. Stents are often used in the treatment of atherosclerotic stenosis in blood vessels. “Stenosis” refers to a narrowing or constriction of the diameter of a bodily passage or orifice. In such treatments, stents reinforce body vessels and prevent restenosis following angioplasty in the vascular system. “Restenosis” refers to the reoccurrence of stenosis in a blood vessel or heart valve after it has been treated (as by balloon angioplasty, stenting, or valvuloplasty) with apparent success.

The treatment of a diseased site or lesion with a stent involves both delivery and deployment of the stent. “Delivery” refers to introducing and transporting the stent through a bodily lumen to a region, such as a lesion, in a vessel that requires treatment. “Deployment” corresponds to the expanding of the stent within the lumen at the treatment region. Delivery and deployment of a stent are accomplished by positioning the stent about one end of a catheter, inserting the end of the catheter through the skin into a bodily lumen, advancing the catheter in the bodily lumen to a desired treatment location, expanding the stent at the treatment location, and removing the catheter from the lumen.

In the case of a balloon expandable stent, the stent is mounted about a balloon disposed on the catheter. Mounting the stent typically involves compressing or crimping the stent onto the balloon. The stent is then expanded by inflating the balloon. The balloon may then be deflated and the catheter withdrawn. In the case of a self-expanding stent, the stent may be secured to the catheter via a constraining member such as a retractable sheath or a sock. When the stent is in a desired bodily location, the sheath may be withdrawn which allows the stent to self-expand.

The stent must be able to satisfy a number of mechanical requirements. First, the stent must be capable of withstanding the structural loads, namely radial compressive forces, imposed on the stent as it supports the walls of a vessel. Therefore, a stent must possess adequate radial strength. Radial strength, which is the ability of a stent to resist radial compressive forces, is due to strength and rigidity around a circumferential direction of the stent. Radial strength and rigidity, therefore, may also be described as, hoop or circumferential strength and rigidity.

Once expanded, the stent must adequately maintain its size and shape throughout its service life despite the various forces that may come to bear on it, including the cyclic loading induced by the beating heart. For example, a radially directed force may tend to cause a stent to recoil inward. Generally, it is desirable to minimize recoil. In addition, the stent must possess sufficient flexibility to allow for crimping, expansion, and cyclic loading. Longitudinal flexibility is important to allow the stent to be maneuvered through a tortuous vascular path and to enable it to conform to a deployment site that may not be linear or may be subject to flexure. Finally, the stent must be biocompatible so as not to trigger any adverse vascular responses.

The structure of a stent is typically composed of scaffolding that includes a pattern or network of interconnecting structural elements often referred to in the art as struts or bar arms. The scaffolding can be formed from wires, tubes, or sheets of material rolled into a cylindrical shape. The scaffolding is designed so that the stent can be radially compressed (to allow crimping) and radially expanded (to allow deployment). A conventional stent is allowed to expand and contract through movement of individual structural elements of a pattern with respect to each other.

Furthermore, it may be desirable for a stent to be biodegradable. In many treatment applications, the presence of a stent in a body may be necessary for a limited period of time until its intended function of, for example, maintaining vascular patency and/or drug delivery is accomplished. Therefore, stents fabricated from biodegradable, bioabsorbable, and/or bioerodable materials such as bioabsorbable polymers should be configured to completely erode only after the clinical need for them has ended.

Additionally, a medicated stent may be fabricated by coating the surface of either a metallic or polymeric scaffolding with a polymeric carrier that includes an active or bioactive agent or drug. Polymeric scaffolding may also serve as a carrier of an active agent or drug. Potential problems with therapeutic coatings for polymeric implantable medical devices, such as stents, include insufficient toughness, slow degradation rate, and poor adhesion.

SUMMARY

OF THE INVENTION

Certain embodiments of the present invention include an implantable medical device comprising a coating above a polymer surface of the device, the coating comprising: a block copolymer including an elastic block and an anchor block, the elastic block being a homopolymer and elastomeric at physiological conditions, the anchor block being miscible with the surface polymer.

Further embodiments of the present invention include an implantable medical device comprising a coating above a polymer surface of the device, the coating comprising: a elastomeric copolymer including elastic units and anchor units, the elastic units providing elastomeric properties to the copolymer at physiological conditions, wherein the anchor units enhance adhesion of the coating with the surface polymer, wherein the copolymer is a star block copolymer having at least three arms, the arms comprising the elastic units and the anchor units.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 depicts a view of a stent.

FIG. 2A depicts a cross-section of a stent surface with a block copolymer coating layer over a substrate.

FIG. 2B depicts a cross-section of a stent surface with a block copolymer coating layer over a polymeric layer disposed over a substrate of the stent.

FIG. 3 depicts a cross-section of a stent surface with the block-copolymer coating layer over a substrate of the stent showing an interfacial region.



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Previous Patent Application:
Intravascular stent
Next Patent Application:
Implantable medical devices with a topcoat layer of phosphoryl choline for reduced thrombosis, and improved mechanical properties
Industry Class:
Prosthesis (i.e., artificial body members), parts thereof, or aids and accessories therefor
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stats Patent Info
Application #
US 20120330404 A1
Publish Date
12/27/2012
Document #
13598465
File Date
08/29/2012
USPTO Class
623/138
Other USPTO Classes
International Class
61F2/82
Drawings
3



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