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Additives for tobacco cut filler

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Additives for tobacco cut filler


Tobacco smoking mixtures capable of producing tobacco smoke are provided which reduce the cytotoxicity and/or mutagenicity of the tobacco smoke. The tobacco smoking mixtures include tobacco cut filler and glycerin in an amount effective to reduce cytotoxicity and/or mutagenicity of smoke produced by the tobacco smoking mixture. The tobacco smoking mixtures enable a further reduction in cytotoxicity and/or mutagenicity when glycerin is combined with palladium or salts of calcium and/or magnesium.
Related Terms: Glycerin Tobacco Smoke Tobacco Smoking

Browse recent Philip Morris Usa Inc. patents - Richmond, VA, US
Inventors: San LI, Raquel Olegario, Joseph L. Banyasz, Kenneth H. Shafer
USPTO Applicaton #: #20120318285 - Class: 131284 (USPTO) - 12/20/12 - Class 131 
Tobacco > Cigar Or Cigarette Making >With Coating Or Printing

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The Patent Description & Claims data below is from USPTO Patent Application 20120318285, Additives for tobacco cut filler.

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RELATED APPLICATIONS

This application claims priority under 35 U.S.C. §119 to U.S. Provisional Application No. 60/621,546 entitled ADDITIVES FOR TOBACCO CUT FILLER and filed on Oct. 25, 2004, the entire content of which is hereby incorporated by reference.

SUMMARY

A tobacco smoking mixture for a smoking article such as a cigarette and a method of using the tobacco smoking mixture for reducing the cytotoxicity and mutagenicity of tobacco smoke is provided. A tobacco smoking mixture containing additives for tobacco used in smoking articles is provided wherein the additives serve to reduce the cytotoxicity and mutagenicity of the smoke generated upon the smoking article being smoked.

Tobacco smoke contains a highly complex chemical mixture of compounds which may contribute to cytotoxicity or mutagenicity. By way of example, tobacco smoke contains polycyclic aromatic hydrocarbons which may contribute to smoke mutagenicity and chemicals known as “phenolics” which may contribute to smoke cytotoxicity. Phenolics include, for example, hydroquinone, catechol, cresol, phenol and resorcinol. Removal or reduction of one or more of these compounds may result in reduced smoke bioactivities.

In one embodiment, a tobacco smoking mixture capable of producing smoke when burned is provided comprising tobacco and a mixture of palladium and glycerin wherein the glycerin is present in an amount of about 8 to about 13% by weight of the tobacco smoking mixture, and wherein the mixture of glycerin and palladium is present in an amount effective to reduce the cytotoxicity and/or the mutagenicity of the smoke produced when the tobacco smoking mixture is burned.

In another embodiment, a tobacco smoking mixture capable of producing smoke when burned is provided comprising tobacco and a mixture of glycerin and magnesium or calcium salts selected from the group consisting of magnesium nitrate, magnesium chloride, magnesium acetate, magnesium sulfate, calcium nitrate, calcium chloride, calcium acetate, calcium sulfate and a mixture thereof, wherein the glycerin is present in an amount of about 8 to about 13% by weight of the tobacco smoking mixture, and wherein the mixture of glycerin and magnesium or calcium salts is present in an amount effective to reduce the cytotoxicity and/or the mutagenicity of the smoke produced when the tobacco smoking mixture is burned.

In a further embodiment, a tobacco smoking mixture capable of producing smoke when burned is provided comprising tobacco, and a mixture of about 8 to about 13% by weight glycerin and about 0.03 to about 0.10% by weight palladium salt, wherein the mixture of glycerin and palladium salt effectively reduce the cytotoxicity and/or mutagenicity of the smoke produced when the tobacco smoking mixture is burned.

In a further embodiment, a tobacco smoking mixture capable of producing smoke when burned is provided comprising tobacco, and a mixture of about 8 to about 13% by weight glycerin and about 3 to about 8% by weight of magnesium or calcium salts selected from the group consisting of magnesium nitrate, magnesium chloride, magnesium acetate, magnesium sulfate, calcium nitrate, calcium chloride, calcium acetate, calcium sulfate and a mixture thereof, wherein the mixture of glycerin and magnesium or calcium salts effectively reduce the cytotoxicity and/or mutagenicity of the smoke produced when the tobacco smoking mixture is burned.

In a further embodiment, a tobacco smoking mixture capable of producing smoke when burned is provided comprising at least about 85% by weight tobacco cut filler and about 8 to about 13% by weight glycerin, wherein the glycerin effectively reduces the cytotoxicity and/or mutagenicity of the smoke produced when the tobacco smoking mixture is burned by at least about 10% of smoke particulate phase cytotoxicity and/or mutagenicity.

In a further embodiment, a tobacco smoking mixture capable of producing smoke when burned is provided comprising at least about 85% by weight tobacco cut filler and about 3 to about 8% by weight of magnesium or calcium salts selected from the group consisting of magnesium nitrate, magnesium chloride, magnesium acetate, magnesium sulfate, calcium nitrate, calcium chloride, calcium acetate, calcium sulfate and a mixture thereof, wherein the magnesium or calcium salts effectively reduce the cytotoxicity and/or mutagenicity of the smoke produced when the tobacco smoking mixture is burned by at least about 10% of smoke particulate phase cytotoxicity and/or mutagenicity.

DETAILED DESCRIPTION

Tobacco smoking mixtures which reduce tobacco smoke cytotoxicity and/or mutagenicity are provided comprising glycerin in particular amounts added to tobacco to form a tobacco smoking mixture capable of producing smoke when burned. The tobacco smoking mixtures result in the reduction of cytotoxicity and/or mutagenicity in the tobacco smoke produced from such tobacco smoking mixtures. In addition, tobacco smoking mixtures comprising tobacco and a mixture of glycerin with other agents further reduces the cytotoxicity and/or the mutagenicity of tobacco smoke produced from the tobacco smoking mixture.

As used herein, cytotoxicity means cellular injury or cellular death as measured by any conventional assay used in the art. Assays for measuring cytotoxicity are known by those of skill in the art. By way of example, the neutral red uptake assay may be used to measure cytotoxicity. Typically, cytotoxicity is measured as the number of cells killed upon exposure to a particular component. Cytotoxicity of tobacco smoke may be measured in the particulate phase or gas phase. It is believed that a reduction of cytoxicity in tobacco smoke reflects a reduction in phenolics in the tobacco smoke.

As used herein, mutagenicity means mutation of bacteria and is typically measured by the number of bacteria affected or mutated upon exposure to a particular component. Assays for measuring mutagenicity are known by those of skill in the art. By way of example, the Ames test may be used to measure mutagenicity of tobacco smoke. The Ames Test is a study whereby bacteria are exposed to a substance to determine if that substance may cause genetic mutations. It is believed that a reduction of mutagenicity reflects a reduction of polycyclic aromatic hydrocarbons in the tobacco smoke.

As used herein, “reduce cytotoxicity and/or mutagenicity” means that the tobacco smoking mixture will exhibit a decrease in either cytotoxicity as measured by known assay techniques suitable for testing tobacco smoke or a decrease in mutagenicity as measured by known assay techniques suitable for testing tobacco smoke or that a decrease in both cytotoxicity and mutagenicity is exhibited when tested as indicated. The applied bio-assay techniques may have variation ranges of 21% (mutagenicity assay), 27% (cytotoxicity of TPM), and 43% (cytotoxicity of gas-vapor phase).

In the tobacco smoking mixtures, glycerin, a polyol, may be used in an amount effective to reduce cytotoxicity and/or mutagenicity of the smoke produced from the tobacco smoking mixture. Glycerin alone has been found to reduce particulate cytotoxicity and mutagenicity of tobacco smoke. Thus, glycerin is preferably used in an amount sufficient to effect a reduction of at least about 10% of smoke particulate phase cytotoxicity and/or mutagenicity. In a preferred embodiment, the amount of glycerin will be about 8 to about 13% by weight of the tobacco smoking mixture.

In one embodiment, glycerin is used in a mixture or combination with another additive or component which increases the reduction in cytotoxicity and/or mutagenicity of the smoke produced from the tobacco smoking mixture over the reduction when glycerin is the only cytotoxicity and/or mutagenicity reducing agent purposefully used. Typically, the mixture of glycerin and other component are used in an amount effective to reduce the cytotoxicity and/or mutagenicity of the smoke produced by the tobacco smoking mixture. Preferably, the mixture of glycerin and additional component is present in an amount effective to reduce the cytotoxicity and/or mutagenicity of the smoke produced by the tobacco smoking mixture by an amount of at least about 20%.

Glycerin, used in conjunction with palladium as an additional component in tobacco smoking mixtures capable of producing tobacco smoke further reduces the cytotoxicity and/or mutagenicity of the tobacco smoke generated from such a tobacco smoking mixture when compared to tobacco smoke from a tobacco smoking mixture with glycerin used as the sole constituent purposefully used for the reduction of cytotoxicity and/or mutagenicity.

The palladium may be used in any form, such as in metallic or salt form, but preferably is used in salt form. By way of example, palladium may be incorporated into the tobacco smoking mixture in the form of water-soluble palladium salts which are readily incorporated into and distributed throughout the tobacco smoking mixture. Such palladium salts are known in the art, and include such salts tetrachloropalladate salts such as K2PdCl4, among others.

The tobacco smoking mixtures may comprise tobacco and a mixture of glycerin and palladium an amount effective to reduce the cytotoxicity and/or mutagenicity of the smoke produced by the tobacco smoking mixture. Preferably, the palladium is used in an amount of about 0.03 to about 0.10% by weight and the glycerin is in an amount of about 8 to about 13% by weight. More preferably, the palladium is used in an amount of about 0.05 to about 0.09% by weight palladium.

Glycerin used in conjunction with a magnesium and/or calcium salt as an additional component in tobacco smoking mixtures capable of producing tobacco smoke further reduces the cytotoxicity and/or mutagenicity of the tobacco smoke generated from such a tobacco smoking mixture when compared to tobacco smoke from a tobacco smoking mixture with glycerin used as the sole constituent purposefully used for the reduction of cytotoxicity and/or mutagenicity. In particular, the addition of magnesium and/or calcium salts to a tobacco smoking mixture of tobacco and glycerin has been found to further reduce the cytotoxicity and/or mutagenicity of smoke resulting from such a tobacco smoking mixture. By way of example, the amount of hydroquinone in the smoke was reduced when glycerin alone was added to tobacco cut filler to form a tobacco smoking mixture capable of producing tobacco smoke. The amount of hydroquinone in the tobacco smoke produced from a tobacco smoking mixture of tobacco cut filler and glycerin was further reduced when magnesium and/or calcium salts were combined with glycerin in the tobacco smoking mixture comprising tobacco cut filler and glycerin. Although not wishing to be bound by any theory, it is believed that the reduction of hydroquinone in smoke is indicative of reductions of other phenolic compounds in smoke.

The magnesium and calcium salts typically include the nitrate, chloride, acetate and sulfate salts of magnesium or calcium. Specifically, the salts may be magnesium nitrate, magnesium chloride, magnesium acetate, magnesium sulfate, calcium nitrate, calcium chloride, calcium acetate or calcium sulfate. These salts may be used in combination, if desired. Preferably, the salts are either magnesium acetate, magnesium chloride or calcium chloride. The magnesium and calcium salts may be used in an amount effective to, in combination with the glycerin, reduce the cytotoxicity and/or mutagenicity of the tobacco smoke produced from the tobacco smoking mixture upon burning the tobacco smoking mixture. In a preferred embodiment, the magnesium salts, the calcium salts or the mixtures thereof are used in an amount of about 3 to about 8% by weight of the tobacco smoking mixture.

While a combination of glycerin and magnesium salts or calcium salts has been found to effectively reduce cytotoxicity and/or mutagenicity when used in a tobacco smoking mixture capable of producing smoke, it has also been discovered that magnesium and calcium salts may be used without glycerin in tobacco smoking mixtures to effect a lesser reduction of cytotoxicity and mutagenicity in the smoke resulting from such a tobacco smoking mixture. Magnesium and/or calcium salts may also be used in a mixture with glycerin and palladium to effect a reduction of cytotoxicity and/or mutagenicity.



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Previous Patent Application:
Device for smoking cessation and use of such a device
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Biodegradable cigarette filter and methods for making same
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Tobacco
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stats Patent Info
Application #
US 20120318285 A1
Publish Date
12/20/2012
Document #
13595925
File Date
08/27/2012
USPTO Class
131284
Other USPTO Classes
131334
International Class
/
Drawings
0


Glycerin
Tobacco Smoke
Tobacco Smoking


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