stats FreshPatents Stats
n/a views for this patent on
Updated: April 14 2014
newTOP 200 Companies filing patents this week

    Free Services  

  • Enter keywords & we'll notify you when a new patent matches your request (weekly update).

  • Save & organize patents so you can view them later.

  • RSS rss
  • Create custom RSS feeds. Track keywords without receiving email.

  • View the last few months of your Keyword emails.

  • Patents sorted by company.


Follow us on Twitter
twitter icon@FreshPatents

Manufacturing method of foldable artificial vitreous body and mould thereof

last patentdownload pdfdownload imgimage previewnext patent

20120296421 patent thumbnailZoom

Manufacturing method of foldable artificial vitreous body and mould thereof

The present invention relates to a foldable capsular vitreous body (FCVB), and its mould design, method for manufacturing, product appearance, and drug delivery property and so on. A mould for molding a foldable artificial vitreous body comprises an upper mould (1), a lower mould (2) and a core (3). The core (3) is disposed between the upper mould (1) and the lower mould (2) and is connected with a drainage-tube pin connected with an injection channel (4). Heating holes (6) are disposed in the upper mould (1) and/or the lower mould (2). Material is injected to the mould and is heated to vulcanize to mold vitreous body. The FCVB is adapted to be injected with any harmless medium and can be used as a delivery vehicle inside or around the eye ball. The size or shape of the FCVB can be changed depending on the different implant site.
Related Terms: Vitreous

Browse recent Guangzhou Visbor Biotechnology Ltd. patents - Guangzhou, CN
USPTO Applicaton #: #20120296421 - Class: 623 41 (USPTO) - 11/22/12 - Class 623 
Prosthesis (i.e., Artificial Body Members), Parts Thereof, Or Aids And Accessories Therefor > Eye Prosthesis (e.g., Lens Or Corneal Implant, Or Artificial Eye, Etc.)

view organizer monitor keywords

The Patent Description & Claims data below is from USPTO Patent Application 20120296421, Manufacturing method of foldable artificial vitreous body and mould thereof.

last patentpdficondownload pdfimage previewnext patent

This application is a Divisional of application Ser. No. 12/841,667, filed Jul. 22, 2010, which is a Continuation of PCT/CN2009/000336, filed Mar. 30, 2009, which applications are incorporated herein by reference.


The present invention relates to a foldable capsular vitreous body, and its mould design, method for manufacturing, product appearance, drug delivery property, surgical applications, and so on.


Currently, national and international studies on substitutes for vitreous body are numerous, mainly including inert gas, silicone oil, heavy silicone oil, perfluorocarbon liquids, and hydrogels composed of high molecular weight hydrophilic polymers being the national or international research focus in the 1990s. However, their therapy results are not satisfying, some of which could result in serious complications, for example, inert gas for instance C3F8 may cause cataract easily and lose the effect of tamponade at about two weeks after the surgery such that it could not generate sustained top-pressure on the retina; Perfluorocarbon liquids is toxic to the retina such that it could not settle in the cavity of vitreous body for a long time and could be utilized in surgery only. Additionally, perfluorocarbon liquids is easy to remain in the eyes and difficult to remove after reaction with water; Present substitutes for silicon oils widely used in clinic could result in glaucoma and cataract and will self-emulsify within a particular time. The emulsified substitutes had to be removed. However, upon removing, the retina is easy to detach again. Repetitive surgeries not only aggravated the burden of patients but also seriously impaired the vision of the patients; Even though the surgery is successful, the vision of the patients is very poor resulting from that low refractive index of silicon oil could not generate adequate top pressure on the breaks underlying the retina, and that the diopter in eyeball shifted to high hyperopia after filling; Additionally, after surgeries, patients had to lie on stomach for a long time to prevent silicon oil from flowing into the anterior chamber, thus making the patients very agonized. Hydrogels mainly included PVP hydrgels, PVA hydrogels, PAM hydrogels and Poly (1-vinyl-2-pyrrolidone) hydrogels, and so on. However, these hydrogels are still at the experimental stage in ophthalmology, and so far no one of these hydrogels is performed in clinic application resulting in lack of observation on the long-term therapeutic effect on the toxicity to the eyes and the price is very high. The patients could not afford it. Finding out vitreous substitutes which met physiological needs and are more economical is required, which is one of problems disturbing the doctors for vitreous retinal disorders in the century.

How to make an artificial vitreous body of which both structure and function are the same as those of the natural vitreous body is one of the keys to ensure the success of vitrectomy. Up to now, the components of vitreous body are not fully known. Based on the conditions of modern science and technology, the need to make an artificial vitreous body of which both structure and function are perfect is impractical. The current substitutes for vitreous body are sometimes called as artificial vitreous body. Implantation methods are performed by directly injecting the substitutes for vitreous body into the cavity of vitreous body to support the retina to prevent the retina from detaching again.

Therefore, without pursuing to make a fully physiological artificial vitreous body, the research thinking is changed to restore the most important function of vitreous body, i.e. support of retina so as to avoid repetitive retinal detachment, which is also a method to resolve the problem. Here we design a novel therapy method as using foldable capsular vitreous body (FCVB) to substitute the natural vitreous body. The FCVB consist of a thin capsule, drainage tube and valve. And it also equipped with auxiliary tools: the ejector handle. Chinese Patent No. ZL 03126845.5 discloses a technical scheme and manufacture method for FCVB. Chinese Patent Publication No. CN1810301 (A) and US Patent Publication No. US2007173933 (A1) further limit the material and manufacturing process (dip-molding) of FCVB. The present patent application further extends the material and another manufacturing process of FCVB. New mould design method and capsule pressure regulating drainage valve are added.



The object of the present invention is to provide a foldable capsular vitreous body (FCVB) for artificial vitreous body with high biocompatibility and excellent flexibility, advanced and stable technology. The invention also provides a capsule pressure regulating drainage valve, the manufacturing process and the mould thereof.

The object of the present invention is carried out as follows:

A mould for the manufacture of FCVB includes three major parts, an upper mould, a lower mould, and a core between these two moulds. A drainage tube pin is connected to the core and to the plastic injection channel. Heating holes are provided on the upper mould and/or the lower mould. The mold is further connected to a temperature control equipment to control the manufacture to be carried out within a suitable temperature.

The upper mould has a slide block, the core is connected to a positioning plate, and the positioning plate can be positioned in the slide block. The principal axis of the positioning plate is at right angle with respect to the principal axis of the drainage tube pin, the positioning plate and the centre of the core are on the same plane. The drainage tube pin is connected with the drainage valve via the plastic injection channel.

The invention also provides a method using the mould above to manufacture the FCVB. Materials are injected into the mould and vulcanized to form the FCVB. The method including following steps:

(1) mixing evenly natural or modified macromolecule materials, vacuumizing and setting aside;

(2) coating a proper amount of processing materials on the drainage valve and laying a rigid sheet;

(3) putting the core between the upper mould and the lower mould, closing and locking the mould;

(4) injecting the processing materials obtained in the step (1) into the mould cavity from the plastic injection channel;

(5) heating the mould via the heating holes and solidifying the material in the mould cavity;

(6) opening the mould, taking out the core after cooling, and peeling out the capsular bag.

To extend the life of the mould and to prepare for the next manufacturing, the mould must be cleaned each time after the products are stripped out.

The capsular bag for FCVB is mainly made of one selected from the group consisting of polysiloxane, polyurethane, styrene triblock copolymer thermoplastic elastomers, hydroxyethyl methacrylate (HEMA), polyvinyl alcohol (PVA), poly (lactide-co-glycolide) (PLGA) and hyaluronic acid ester.

As an improvement to the present invention, materials of the FCVB, such as polysiloxane or polyurethane are modified by adding hydroxy(—OH)-containing hydrophilic groups, to control water rate in the capsular bag such that the water rate is 5-30%; fluoro group-containing materials are added into the materials of polysiloxane or polyurethane to increase oxygen permeability of the capsular bag.

Preferably, the materials are absorbable materials, so that the implanting FCVB will be absorbed slowly over disease treatment period, to avoid secondary removal of the foldable intraocular vitreous body. Dilution is added into the processing material to alter the physical state of the processing materials. Volatile dilution is preferable, in order to enable the natural volatilization.

In the step (2), by coating a proper amount of processing materials on the drainage valve and fixing on a rigid sheet, the rigid sheet prevents the FCVB from being perforated by the injector pins to ensure the gas-tightness of the body. When artificial plastic injection approach is used, a proper amount of materials may be pre-coated on the upper and lower molds.

After the step (6), the obtained capsule can be further processed: a proper amount of processing materials is coated on the peeling opening of the capsular bag, then put the capsular bag in a sealing device which matches with the peeling opening of the capsular bag to realize the post forming of the peeling opening, and trim the peeling opening by trimmer after agglutination. The operating temperature of the sealing device is in a range of 60° C.-300° C., preferably at 110° C., with working time of more than 2 seconds, preferably 6 seconds.

The capsule products obtained in the step (6) may be processed by the following process:

Download full PDF for full patent description/claims.

Advertise on - Rates & Info

You can also Monitor Keywords and Search for tracking patents relating to this Manufacturing method of foldable artificial vitreous body and mould thereof patent application.
monitor keywords

Keyword Monitor How KEYWORD MONITOR works... a FREE service from FreshPatents
1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored.
3. Each week you receive an email with patent applications related to your keywords.  
Start now! - Receive info on patent apps like Manufacturing method of foldable artificial vitreous body and mould thereof or other areas of interest.

Previous Patent Application:
Annuloplasty ring with piercing wire and segmented wire lumen
Next Patent Application:
Method for designing, evaluating and optimizing ophthalmic lenses and laser vision correction
Industry Class:
Prosthesis (i.e., artificial body members), parts thereof, or aids and accessories therefor
Thank you for viewing the Manufacturing method of foldable artificial vitreous body and mould thereof patent info.
- - - Apple patents, Boeing patents, Google patents, IBM patents, Jabil patents, Coca Cola patents, Motorola patents

Results in 0.49569 seconds

Other interesting categories:
Electronics: Semiconductor Audio Illumination Connectors Crypto ,  -g2--0.7817

FreshNews promo

stats Patent Info
Application #
US 20120296421 A1
Publish Date
Document #
File Date
Other USPTO Classes
International Class


Follow us on Twitter
twitter icon@FreshPatents