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Organic compounds


Title: Organic compounds.
Abstract: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition. The present invention provides a compound of formula I: ...
USPTO Applicaton #: #20120277215
Inventors: Gary Michael Ksander, Erik Meredith, Lauren G. Monovich, Julien Papillon, Fariborz Firooznia, Qi-ying Hu



The Patent Description & Claims data below is from USPTO Patent Application 20120277215, Organic compounds.




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stats Patent Info
Application #
US 20120277215 A1
Publish Date
11/01/2012
Document #
13540113
File Date
07/02/2012
USPTO Class
51421402
Other USPTO Classes
5483027, 514393, 544139, 5142332, 546199, 514322, 5483011, 546121, 514300, 540579
International Class
/
Drawings
0


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Aldosterone
Endometrial


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Drug, Bio-affecting And Body Treating Compositions   Designated Organic Active Ingredient Containing (doai)   Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai   Hetero Ring Is Seven-membered Consisting Of One Nitrogen And Six Carbons   Polycyclo Ring System Having The Seven-membered Hetero Ring As One Of The Cyclos   Ring Nitrogen Of The Seven-membered Hetero Ring Is Shared By An Additional Cyclo Of The Polycyclo Ring System   Plural Ring Nitrogens In The Polycyclo Ring System  

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