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Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors


Title: Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors.
Abstract: The present invention provides new oxime derivatives of the general formula (I), pharmaceutical compositions containing them and their use for the treatment and/or prophylaxis of conditions associated with altered glutamatergic signalling and/or functions, and/or conditions which can be affected by alteration of glutamate level or signalling in mammals. This invention further provides new oxime derivatives of the general formula (I) consisting of modulators of nervous system receptors sensitive to glutamate, which makes them particularly suitable for the treatment and/or prophylaxis of acute and chronic neurological and/or psychiatric disorders. In particular embodiments, the new oxime derivatives of the invention are modulators of metabotropic glutamate receptors (mGluRs). The invention further provides positive allosteric modulators of mGluRs and more specifically positive alSosteric modulators of mGluR4. ... Browse recent Domain Therapeutics patents
USPTO Applicaton #: #20120277212
Inventors: Stephan Schann, Stanislas Mayer, Christophe Morice, Bruno Giethlen



The Patent Description & Claims data below is from USPTO Patent Application 20120277212, Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors.




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stats Patent Info
Application #
US 20120277212 A1
Publish Date
11/01/2012
Document #
13505235
File Date
10/29/2010
USPTO Class
51421115
Other USPTO Classes
435/71, 436501, 514218, 5142282, 5142305, 5142338, 5142345, 514249, 51425216, 5142591, 514275, 514301, 514303, 514456, 540544, 540575, 544 586, 544105, 544127, 544282, 544331, 544349, 546114, 546118, 549403
International Class
/
Drawings
2


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