FreshPatents.com Logo
stats FreshPatents Stats
n/a views for this patent on FreshPatents.com
Updated: October 26 2014
newTOP 200 Companies filing patents this week


    Free Services  

  • MONITOR KEYWORDS
  • Enter keywords & we'll notify you when a new patent matches your request (weekly update).

  • ORGANIZER
  • Save & organize patents so you can view them later.

  • RSS rss
  • Create custom RSS feeds. Track keywords without receiving email.

  • ARCHIVE
  • View the last few months of your Keyword emails.

  • COMPANY DIRECTORY
  • Patents sorted by company.

Follow us on Twitter
twitter icon@FreshPatents

Methods and compositions for the treatment of psychotic disorders through the identification of the sult4a1-1 haplotype

last patentdownload pdfdownload imgimage previewnext patent


20120277211 patent thumbnailZoom

Methods and compositions for the treatment of psychotic disorders through the identification of the sult4a1-1 haplotype


Methods and compositions that relate to genetic markers of psychotic disorders, e.g., schizophrenia (SZ), are provided. For example, in certain aspects methods for determinations of a SULT4A1-1 haplotype are described. Furthermore, the invention provides methods and compositions involving treatment of psychotic disorders using the haplotype status.
Related Terms: Psychotic Disorders Schizophrenia

Browse recent Suregene LLC patents - Jeffersontown, KY, US
Inventors: Timothy L. Ramsey, Mark D. Brennan
USPTO Applicaton #: #20120277211 - Class: 51421113 (USPTO) - 11/01/12 - Class 514 
Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) >Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai >Hetero Ring Contains Seven Members Including Nitrogen, Carbon And Chalcogen >Polycyclo Ring System Which Contains The Seven-membered Hetero Ring As One Of The Cyclos >Tricyclo Ring System Having The Seven-mmbered Hetero Ring As One Of The Cyclos >Nitrogen Bonded Directly To Ring Carbon Of The Seven-membered Hetero Ring

view organizer monitor keywords


The Patent Description & Claims data below is from USPTO Patent Application 20120277211, Methods and compositions for the treatment of psychotic disorders through the identification of the sult4a1-1 haplotype.

last patentpdficondownload pdfimage previewnext patent

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to U.S. application Ser. No. 12/939,049 filed Nov. 2, 2010, which is a continuation-in-part of co-pending U.S. application Ser. No. 12/859,056, filed Aug. 18, 2010, and co-pending U.S. application Ser. No. 12/858,917, filed Aug. 18, 2010, each of which is a continuation-in-part of U.S. application Ser. No. 12/646,723, filed Dec. 23, 2009, now issued as U.S. Pat. No. 7,790,396, and co-pending U.S. application Ser. No. 12/612,438, filed Nov. 4, 2009. The entire contents of each of the referenced applications are incorporated herein by reference.

This invention was made with government support under SBIR grant MH078347 and grants NOl MH900001 and MH074027 awarded by National Institutes of Mental Health. The government has certain rights in the invention.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates generally to the field of psychotic disorders, such as schizophrenia and bipolar disorders. More particularly, it concerns genetic markers of antipsychotic response, for example, genes and genetic markers that influence or predict a person\'s likely response to antipsychotic medications.

2. Description of Related Art

Numerous drugs exist to treat psychotic disorders, such as schizophrenia (SZ), related SZ-spectrum disorders (including schizotypal personality disorder (SPD) and schizoaffective disorder (SD)), and bipolar disorders (BD). Most of these drugs fall into one of two categories, typical (first generation) and atypical (second generation).

Although head to head studies of large groups of patients, either in the acute phase or outpatient treatment, show that most atypical antipsychotic drugs are equally efficacious for positive symptoms, there are individual differences in response to specific drugs based on differences in drug pharmacology and metabolism, combined with genetic differences between patients. There are currently no proven ways to identify which antipsychotic drug is optimal for a given patient. Thus, patients switch from one drug to another when response is not considered to be adequate or side effects are intolerable. This switching of medication incurs a variety of increased costs, both economic and patient and caregiver hardship. On average, each patient may change medications three times before finding one that works. Additionally, the current drugs have significant side-effects. This combination of side-effects and limited efficacy create a vast unmet need for selecting the optimal antipsychotic for each patient.

Moreover, the limited or partial response that is often seen with antipsychotics leads to polypharmacy, where physicians prescribe two or more antipsychotic drugs plus mood stabilizers and/or antidepressants. Polypharmacy increases medication costs and significantly increases the likelihood of adverse advents and drug interactions (Stahl and Grady, 2006).

Pharmacogenomics, using genetic variation to predict altered response and side-effects profiles, will be important for enhanced patient care going forward. There continues to exist, therefore, a need to identify specific genetic variations that are associated with treatment outcomes for psychotic disorders.

SUMMARY

OF THE INVENTION

The invention is in part based on the finding that a particular haplotype, which the inventors refer to as the SULT4A1-1 haplotype, is a biomarker that can be used for selecting a more appropriate antipsychotic treatment plan for a particular subject. For example, the inventors have discovered that patients that have a SULT4A1-1 haplotype respond better when treated with olanzapine than SULT4A1-1 positive patients treated with risperidone, and respond better than SULT4A1-1 negative patients treated with olanzapine. Similarly, the inventors have discovered that patients that have a SULT4A1-1 haplotype respond better when treated with quetiapine than SULT4A1-1 negative patients treated with quetiapine. Further, the inventors have discovered that patients that do not have a SULT4A1-1 haplotype respond better when treated with risperidone than SULT4A1-1 positive patients treated with risperidone. Thus, prior determination of a patient\'s SULT4A1-1 haplotype status can aid in the development of an optimal antipsychotic treatment regimen.

Thus, an aspect of the invention involves determining whether genetic material of the subject comprises a SULT4A1-1 haplotype. Of course, to meet the need to transfer and store genetic information, the results of the determination will preferably be recorded and maintained in a tangible medium, such as a computer-readable disk, a solid state memory device, an optical storage device or the like, more specifically, a storage device such as a hard drive, a Compact Disk (CD) drive, a floppy disk drive, a tape drive, a random access memory (RAM), etc.

One preferred manner of obtaining the genetic haplotype information involves analyzing the genetic material of the subject to determine the presence or absence of the SULT4A1-1 haplotype. This can be accomplished, for example, by testing the subject\'s genetic material through the use of a biological sample. In certain embodiments, the methods set forth will thus involve obtaining a biological sample from the subject and testing the biological sample to identify whether a SULT4A1-1 haplotype is present. The biological sample may be any biological material that contains DNA or RNA of the subject, such as a nucleated cell source. Non-limiting examples of cell sources available in clinical practice include hair, skin, nucleated blood cells, buccal cells, any cells present in tissue obtained by biopsy or any other cell collection method. The biological sample may also be obtained from body fluids, including without limitation blood, saliva, sweat, urine, amniotic fluid (the fluid that surrounds a fetus during pregnancy), cerebrospinal fluid, feces, and tissue exudates. DNA may be extracted from the biologic sample such as the cell source or body fluid using any of the numerous methods that are standard in the art.

In some embodiments, an in vitro method for obtaining genetic information about a test subject is provided. The test subject may be a subject that is undergoing or is to undergo antipsychotic pharmacotherapy. For example, the test subject may be undergoing or is to undergo antipsychotic treatment with olanzapine, risperidone, quetiapine, or perphenazine. The in vitro method may comprise determining whether the genetic material in a biological sample comprises a SULT4A1-1 haplotype, wherein the SULT4A1-1 haplotype is defined as a haplotype comprising rs763120(C), a combination of rs2285162(A)-rs2285167(G), or a combination of rs2285166(T)-rs2285167(G), to thereby obtain the genetic information. Such a method may further comprise extracting DNA from a biological sample, and the genetic material may be analyzed by SNP genotyping or sequencing. In some aspects, the methods provided further comprise recording the genetic information that is determined in a tangible medium, such as, for example, a computer-readable disk, a solid state memory device, or an optical storage device. In other aspects, the methods provided further comprise reporting the determination to the subject, a health care payer, a physician, a pharmacist, a pharmacy benefits manager, or an electronic system. In certain embodiments, the determining step is carried out through the use of an array or a kit comprising a plurality of primers or probes specific for a SULT4A1-1 haplotype, wherein the SULT4A1-1 haplotype is defined as a haplotype comprising rs763120(C), a combination of rs2285162(A)-rs2285167(G) or a combination of rs2285166(T)-rs2285167(G).

Determining whether the genetic material exhibits a SULT4A1-1 haplotype polymorphism can be by any method known to those of ordinary skill in the art, such as genotyping (e.g., SNP genotyping) or sequencing. Techniques that may be involved in this determination are well-known to those of ordinary skill in the art. Examples of such techniques include allele specific oligonucleotide hybridization, size analysis, sequencing, hybridization, 5′ nuclease digestion, single-stranded conformation polymorphism analysis, allele specific hybridization, primer specific extension, and oligonucleotide ligation assays. Additional information regarding these techniques is discussed in the specification below.

For haplotype determinations, the sequence of the extracted nucleic acid of the subject may be determined by any means known in the art, including but not limited to direct sequencing, hybridization with allele-specific oligonucleotides, allele-specific PCR, ligase-PCR, HOT cleavage, denaturing gradient gel electrophoresis (DDGE), and single-stranded conformational polymorphism (SSCP) analysis. Direct sequencing may be accomplished by any method, including without limitation chemical sequencing, using the Maxam-Gilbert method, by enzymatic sequencing, using the Sanger method, mass spectrometry sequencing, and sequencing using a chip-based technology. In particular embodiments, DNA from a subject is first subjected to amplification by polymerase chain reaction (PCR) using specific amplification primers. In some embodiments, the method further involves amplification of a nucleic acid from the biological sample. The amplification may or may not involve PCR. In some embodiments, the primers are located on a chip.

In specific embodiments, the subject is a human. For example, in some embodiments the human is a subject who has, is suspected to have, or is at risk of a psychotic disorder, such as schizophrenia, schizotypal personality disorder (SPD), schizoaffective disorder (SD), or bipolar disorder (BD). In one embodiment, the subject is a patient having previously diagnosed a psychotic disorder (e.g., a patient suffering from early, intermediate or aggressive psychotic disorder). In some embodiments, the subject is of Caucasian (CA) descent, i.e., has one or more ancestors who are CA.

Moreover, the inventors contemplate that the genetic structure and sequence, including SNP profiles, of individual subjects will at some point be widely or generally available, or will have been developed by an unrelated third party. In such instances, there will be no need to test or analyze the subject\'s biological material again. Instead, the genetic information will in such cases be obtained simply by analyzing the sequencing or genotyping outcome of the subject, for example, a SNP profile, a whole or partial genome sequence, etc. These outcome can then be obtained from or reported by a sequencing or a genotyping service, a laboratory, a scientist, or any genetic test platforms.

In some further aspects, the method may further comprise reporting the determination to the subject, a health care payer, an attending clinician, a pharmacist, a pharmacy benefits manager, or any person that the determination may be of interest.

In certain embodiments, there is also provided a method of developing a pharmacotherapeutic treatment plan for a subject having or suspected of having a psychotic disorder comprising determining the SULT4A1-1 haplotype status of the patient, wherein a) if the subject comprises a SULT4A1-1 haplotype, the subject is more likely to exhibit a favorable response to olanzapine; and b) if the subject does not comprise a SULT4A1-1 haplotype, the subject is less likely to exhibit a favorable response to olanzapine; and developing the pharmacotherapeutic treatment plan. For example, if the subject comprises a

SULT4A1-1 haplotype, then the method may further comprise treating the subject with olanzapine. If the subject does not comprise the SULT4A1-1 haplotype, then the method may further comprise treating the subject with an antipsychotic treatment other than olanzapine, such as treating with risperidone, or perphenazine.

In certain embodiments, there is also provided a method of determining elevated risk of a patient to discontinue treatment with olanzapine due to a treatment-emergent adverse event, comprising determining the SULT4A1-1 haplotype in a patient sample, wherein a) if the human subject comprises the SULT4A1-1 haplotype, the subject is more likely to exhibit a propensity to continue treatment; and b) if the subject does not comprise the SUTL4A1-1 haplotype, the subject is more likely to exhibit a propensity to discontinue treatment due to a treatment-emergent adverse event. Steps for determining the SULT4A1-1 haplotype and determining the propensity of the subject to continue or discontinue treatment may be carried out in vitro.

In certain embodiments, there is also provided a method of selecting a pharmacotherapeutic treatment plan for a human subject having the potential to experience a treatment-emergent adverse event when treated with olanzapine, comprising determining the

SULT4A1-1 haplotype in a sample, wherein a) if the human subject does not comprise the SULT4A1-1 haplotype the subject is more likely to experience a treatment-emergent adverse event when treated with olanzapine; and b) if the subject comprises the SUTL4A1-1 haplotype the subject is not more likely to experience a treatment-emergent adverse event when treated with olanzapine; selecting a pharmacotherapeutic treatment plan based on the SULT4A1-1 haplotype; and treating the subject with the selected pharmacotherapeutic treatment. For example, the pharmacotherapeutic selected may be olanzapine or a non-olanzapine antipsychotic treatment, such as risperidone, quetiapine, ziprasidone, or perphenazine. In some embodiments, the subject comprises the SULT4A1-1 haplotype, and the pharmacotherapeutic is olanzapine. In other embodiments, the subject does not comprise the SULT4A1-1 haplotype, and the pharmacotherapeutic is a non-olanzapine antipsychotic treatment. Steps for determining the SUTL4A1-1 haplotype may be carried out in vitro. In certain aspects, the treatment plan selected is a treatment plan for schizophrenia.

Certain aspects of the invention may involve a method for treating a subject having a psychotic disorder and determined to have a SULT4A1-1 haplotype, comprising treating the subject with olanzapine. In some further aspects, the invention may include a method for treating a subject having a psychotic disorder and determined not to have a SULT4A1-1 haplotype, comprising treating the subject with a non-olanzapine antipsychotic treatment, such as treating with risperidone, ziprasidone, or perphenazine. In certain embodiments, the psychotic disorder is schizophrenia.

In other embodiments, there is provided a method for determining response to treatment with risperidone for a human subject having or suspected of having schizophrenia comprising determining the SULT4A1-1 haplotype in a sample, wherein a) if the human subject comprises the SULT4A1-1 haplotype, the subject is less likely to exhibit a favorable response to risperidone; and b) if the subject does not comprise the SUTL4A1-1 haplotype, the subject is more likely to exhibit a favorable response to risperidone.

In other embodiments, there is provided a method for determining elevated risk of a patient to discontinue treatment with risperidone due to a treatment-emergent adverse event or lack of efficacy comprising determining the SULT4A1-1 haplotype in a sample, wherein a) if the human subject comprises the SULT4A1-1 haplotype, the subject is more likely to exhibit a propensity to discontinue treatment due to a treatment-emergent adverse event or lack of efficacy; and b) if the subject does not comprise the SUTL4A1-1 haplotype, the subject is more likely to exhibit a propensity to continue treatment. Steps for determining the SUTL4A1-1 haplotype and determining the propensity of the subject to continue or discontinue treatment may be carried out in vitro.

In certain embodiments, there is also provided a method for selecting a pharmacotherapeutic treatment plan for a human subject having the potential for suffering a treatment-emergent adverse event or lack of efficacy when treated with risperidone, comprising determining the SULT4A1-1 haplotype in a sample, wherein a) if the human subject comprises the SULT4A1-1 haplotype, the subject is more likely to experience a treatment-emergent adverse event or lack of efficacy when treated with risperidone; and b) if the subject does not comprise the SUTL4A1-1 haplotype, the subject is not more likely to experience a treatment-emergent adverse event or lack of efficacy when treated with risperidone; selecting a pharmacotherapeutic treatment plan based on the SULT4A1-1 haplotype; and treating the subject with the selected pharmacotherapeutic treatment. In some embodiments, the pharmacotherapeutic is risperidone, and the subject does not comprise the

SULT4A1-1 haplotype. In other aspects, the pharmacotherapeutic is an antipsychotic other than risperidone, and the subject comprises the SULT4A1-1 haplotype. For example, the antipsychotic other than risperidone may be olanzapine, quetiapine, ziprasidone, or perphenazine. Steps for determining the SUTL4A1-1 haplotype may be carried out in vitro. In certain aspects, the treatment plan selected is a treatment plan for schizophrenia.

Certain aspects of the invention may involve a method for treating a subject having a psychotic disorder and determined to not have the SULT4A1-1 haplotype, comprising treating the subject with risperidone. In some further aspects, the invention may include a method for treating a subject having a psychotic disorder and determined to have a SULT4A1-1 haplotype, comprising treating the subject with a non-risperidone antipsychotic treatment such as treating with olanzapine, quetiapine, ziprasidone, or perphenazine. In certain embodiments, the psychotic disorder is schizophrenia.

In other embodiments, there is provided a method for determining response to treatment with quetiapine for a human subject having or suspected of having schizophrenia comprising determining the SULT4A1-1 haplotype in a sample, wherein if the human subject comprises the SULT4A1-1 haplotype the subject is more likely to exhibit a favorable response to quetiapine and if the subject does not comprise the SULT4A1-1 haplotype the subject is less likely to exhibit a favorable response to quetiapine.

In certain embodiments, there is also provided a method for treating a human subject having or suspected of having a psychotic disorder comprising a) selecting a subject that has been determined to have a SULT4A1-1 haplotype, defined as a haplotype comprising a C allele at rs763120, a combination of an A allele at rs2285162 and a G allele at rs2285167, or the combination of a T allele atrs2285166 and G allele at rs2285167, and treating the subject with quetiapine or olanzapine; or b) selecting a subject that has been determined not to have the SULT4A1-1 haplotype and treating the subject with an antipsychotic treatment other than quetiapine or olanzapine.

Certain aspects of the invention may involve a method for treating a subject having a psychotic disorder and determined to have a SULT4A1-1 haplotype, comprising treating the subject with quetiapine or olanzapine. In some further aspects, the invention may include a method for treating a subject having a psychotic disorder and determined not to have a SULT4A1-1 haplotype, comprising treating the subject with a an antipsychotic treatment other than quetiapine or olanzapine, such as treating with risperidone, ziprasidone, or perphenazine. In certain embodiments, the psychotic disorder is schizophrenia.

Certain aspects of the invention may involve a method for treating a subject comprising selecting a subject that is determined to have a SULT4A1-1 haplotype and developing an appropriate treatment plan. Other aspects of the invention may involve a method for treating a subject comprising selecting a subject that is determined not to have a SULT4A1-1 haplotype and developing an appropriate treatment plan. Prior determination of a patient\'s SULT4A1-1 haplotype status may be obtained from or reported by a sequencing or a genotyping service, a laboratory, a scientist, or any genetic test platforms.

Some aspects involve an antipsychotic pharmacotherapeutic for use in treating a subject having a psychotic disorder. In some embodiments, the selection of the antipsychotic is based on the presence of absence of a SULT4A1-1 haplotype in the subject to be treated. For example, provided is an antipsychotic pharmacotherapeutic selected from olanzapine and quetiapine for use in treating a subject having a psychotic disorder, wherein the subject has been determined to comprise a SULT4A1-1 haplotype defined as comprising a rs763120(C) allele, a combination of a rs2285162(A) allele and a rs2285167(G) allele, or a combination of a rs2285166(T) allele and a rs2285167(G) allele. In certain aspects, the pharmacotherapeutic is olanzapine or quetiapine. In some embodiments, the psychotic disorder is schizophrenia.

Also provided is an antipsychotic pharmacotherapeutic other than olanzapine or quetiapine for use in treating a subject having a psychotic disorder, wherein the subject has been determined not to comprise a SULT4A1-1 haplotype defined as comprising a rs763120(C) allele, a combination of a rs2285162(A) allele and a rs2285167(G) allele, or a combination of a rs2285166(T) allele and a rs2285167(G) allele. The antipsychotic other than olanzapine or quetiapine may be any non-olanzapine or non-quetiapine antipsychotic pharmacotherapeutic. In certain aspects, the pharmacotherapeutic is risperidone, perphenazine, or ziprasidone. In some embodiments, the psychotic disorder is schizophrenia.

The SULT4A1-1 haplotype characterization may also apply to diagnosis and prognosis of psychotic disorders. For example, there may be provided a method of assessing the severity of such a disorder, comprising obtaining genetic information about the subject by the methods disclosed above, wherein if the subject comprises a SULT4A1-1 haplotype, the subject is at a higher risk for having a more severe disorder, and wherein if the subject does not comprise the SULT4A1-1 haplotype, the subject is at a lower risk for having a more severe disorder. The assessment may be stored in a tangible medium, such as a computer-readable disk, a solid state memory device, and an optical storage device.

Certain aspects of the present invention also contemplate the preparation of kits or arrays for use in accordance with the present invention. Suitable kits include various reagents for use in accordance with the present invention in suitable containers and packaging materials, including tubes, vials, and shrink-wrapped and blow-molded packages. Such an array or a kit may comprise a plurality of primers or probes specific for a SULT4A1-1 haplotype. The array may be a genotyping chip. Also a tangible, computer-readable medium comprising a SNP profile of a subject may also be provided, wherein the SNP profile exhibits the presence or absence of a SULT4A1-1 haplotype.

Embodiments discussed in the context of methods and/or compositions of the invention may be employed with respect to any other method or composition described herein. Thus, an embodiment pertaining to one method or composition may be applied to other methods and compositions of the invention as well.

As used herein the specification, “a” or “an” may mean one or more. As used herein in the claim(s), when used in conjunction with the word “comprising”, the words “a” or “an” may mean one or more than one.

The use of the term “or” in the claims is used to mean “and/or” unless explicitly indicated to refer to alternatives only or the alternatives are mutually exclusive, although the disclosure supports a definition that refers to only alternatives and “and/or.” As used herein “another” may mean at least a second or more.

Throughout this application, the term “about” is used to indicate that a value includes the inherent variation of error for the device, the method being employed to determine the value, or the variation that exists among the study subjects.

Other objects, features and advantages of the present invention will become apparent from the following detailed description. It should be understood, however, that the detailed description and the specific examples, while indicating preferred embodiments of the invention, are given by way of illustration only, since various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description.

BRIEF DESCRIPTION OF THE DRAWINGS

The following drawings form part of the present specification and are included to further demonstrate certain aspects of the present invention. The invention may be better understood by reference to one or more of these drawings in combination with the detailed description of specific embodiments presented herein.

FIG. 1: Linkage disequilibrium for the Caucasian sample. The Haploview output shows pairwise correlation coefficients (r2 values in % are given in the diamonds) for the 11 SULT4A1 SNPs from the CATIE study (N=836 persons). Based on the total sample of cases and controls, Haploview identifies a single haplotype block for the 11 SNPs (Barrett et al., 2005). The locations of previously studied SNPs, rs138097 (the SNP is in position 31 of SEQ ID NO:8) and rs138110 (the SNP is in position 31 of SEQ ID NO:13), are indicated by arrows. Only the latter was included in the CATIE study. Previously studied marker rs138060 (the SNP is in position 31 of SEQ ID NO:1) is located approximately 5 kb to the left of rs138067 (the SNP is in position 31 of SEQ ID NO:2), outside the region covered by the SULT4A1 SNPs in CATIE.

FIG. 2: Linkage disequilibrium for the African American sample. The Haploview output shows pairwise correlation coefficients (r2 values in %) for the 11 CATIE SNPs (N=442 persons).

FIG. 3: Response of SULT4A1-1 positive subjects in CATIE at various response thresholds.

FIG. 4: Response of SULT4A1-1 negative subjects in CATIE at various respones thresholds.



Download full PDF for full patent description/claims.

Advertise on FreshPatents.com - Rates & Info


You can also Monitor Keywords and Search for tracking patents relating to this Methods and compositions for the treatment of psychotic disorders through the identification of the sult4a1-1 haplotype patent application.
###
monitor keywords



Keyword Monitor How KEYWORD MONITOR works... a FREE service from FreshPatents
1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored.
3. Each week you receive an email with patent applications related to your keywords.  
Start now! - Receive info on patent apps like Methods and compositions for the treatment of psychotic disorders through the identification of the sult4a1-1 haplotype or other areas of interest.
###


Previous Patent Application:
Solid dispersions containing an apoptosis-inducing agent
Next Patent Application:
Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors
Industry Class:
Drug, bio-affecting and body treating compositions
Thank you for viewing the Methods and compositions for the treatment of psychotic disorders through the identification of the sult4a1-1 haplotype patent info.
- - - Apple patents, Boeing patents, Google patents, IBM patents, Jabil patents, Coca Cola patents, Motorola patents

Results in 1.09761 seconds


Other interesting Freshpatents.com categories:
Computers:  Graphics I/O Processors Dyn. Storage Static Storage Printers

###

Data source: patent applications published in the public domain by the United States Patent and Trademark Office (USPTO). Information published here is for research/educational purposes only. FreshPatents is not affiliated with the USPTO, assignee companies, inventors, law firms or other assignees. Patent applications, documents and images may contain trademarks of the respective companies/authors. FreshPatents is not responsible for the accuracy, validity or otherwise contents of these public document patent application filings. When possible a complete PDF is provided, however, in some cases the presented document/images is an abstract or sampling of the full patent application for display purposes. FreshPatents.com Terms/Support
-g2-0.2575
     SHARE
  
           


stats Patent Info
Application #
US 20120277211 A1
Publish Date
11/01/2012
Document #
13508191
File Date
11/04/2010
USPTO Class
51421113
Other USPTO Classes
514220, 51425941, 5142258, 51425404, 435/611, 506/9
International Class
/
Drawings
7


Psychotic Disorders
Schizophrenia


Follow us on Twitter
twitter icon@FreshPatents