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Solid dispersions containing an apoptosis-inducing agent

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Solid dispersions containing an apoptosis-inducing agent


A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

Browse recent Abbott Laboratories patents - Abbott Park, IL, US
Inventors: Nathaniel Catron, David Lindley, Jonathan M. Miller, Eric A. Schmitt, Ping Tong
USPTO Applicaton #: #20120277210 - Class: 51421021 (USPTO) - 11/01/12 - Class 514 
Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) >Heterocyclic Carbon Compounds Containing A Hetero Ring Having Chalcogen (i.e., O,s,se Or Te) Or Nitrogen As The Only Ring Hetero Atoms Doai >Hetero Ring Is Four-membered And Includes At Least One Ring Nitrogen >Additional Hetero Ring Attached Directly Or Indirectly To The Four-membered Hetero Ring By Nonionic Bonding >The Additional Hetero Ring Contains Ring Nitrogen >Polycyclo Ring System Having The Additional Hetero Ring As One Of The Cyclos

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The Patent Description & Claims data below is from USPTO Patent Application 20120277210, Solid dispersions containing an apoptosis-inducing agent.

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stats Patent Info
Application #
US 20120277210 A1
Publish Date
11/01/2012
Document #
13282773
File Date
10/27/2011
USPTO Class
51421021
Other USPTO Classes
51425304, 5142345, 51425211, 51425409, 5142352, 51425217, 5142282
International Class
/
Drawings
0



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