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Aminopropanol derivatives

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Aminopropanol derivatives

wherein R1, R2, n and m are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them. Compounds of formula I:

Inventors: Rainer ALBERT, Eric FRANCOTTE, Frédéric ZECRI, Markus ZOLLINGER
USPTO Applicaton #: #20120277194 - Class: 514114 (USPTO) - 11/01/12 - Class 514 
Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) >Phosphorus Containing Other Than Solely As Part Of An Inorganic Ion In An Addition Salt Doai >Nitrogen, Other Than Nitro Or Nitroso, Bonded Indirectly To Phosphorus

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The Patent Description & Claims data below is from USPTO Patent Application 20120277194, Aminopropanol derivatives.

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The present invention relates to organic compounds, a process for their production and pharmaceutical compositions containing them.

More particularly the present invention provides a compound of formula I:

wherein each of m and n, independently, is 1, 2 or 3; X is O or a direct bond;

R1 is

a phenylalkyl wherein alkyl is a straight- or branched (C6-20)carbon chain; or a phenylalkyl wherein alkyl is a straight- or branched (C1-30)carbon chain wherein said phenylalkyl is substituted at the phenyl residue by a straight- or branched (C6-20)carbon chain optionally substituted by halogen, a straight- or branched (C6-20)alkoxy chain optionally substitued by halogen, a straight- or branched (C6-20)alkenyloxy, phenylalkoxy, halophenylalkoxy, phenylalkoxyalkyl, phenoxyalkoxy or phenoxyalkyl, cycloalkylalkyl substituted by C6-20alkyl, heteroarylalkyl substituted by C6-20alkyl, heterocyclic C6-20alkyl or heterocyclic alkyl substituted by C2-20alkyl, and wherein the alkyl moiety may have in the carbon chain, a bond or a heteroatom selected from a double bond, a triple bond, O, S, sulfinyl, sulfonyl, or NR5, wherein R5 is H, alkyl, aralkyl, acyl or alkoxycarbonyl, and as a substituent alkoxy, alkenyloxy, alkynyloxy, aralkyloxy, acyl, alkylamino, alkylthio, acylamino, alkoxycarbonyl, alkoxycarbonylamino, acyloxy, alkylcarbamoyl, nitro, halogen, amino, hydroxy, or carboxy, and

R2 is

wherein each of R3 and R4, independently, is H or C1-4alkyl, wherein alkyl is optionally substituted by 1, 2 or 3 halogen atoms; in free form or in salt form. Halogen is F, Cl, Br or I. Alkyl or alkoxy may be straight or branched chain. Cycloalkyl is preferably C3-10cycloalkyl, more preferably C3-8cycloalkyl and includes, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl. Acyl may be a residue Ry—CO— wherein Ry is C1-6alkyl, C3-6cycloalkyl, phenyl or phenyl-C1-4alkyl.

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Application #
US 20120277194 A1
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Other USPTO Classes
558169, 558 87, 548414, 548119, 436104
International Class

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