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Pharmaceutical combinations for the treatment of metabolic disorders

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Pharmaceutical combinations for the treatment of metabolic disorders


The invention relates to a pharmaceutical composition comprising 1.a and/or 1.b according to claim 1 in combination with at least one second therapeutic agent 2 which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.
Related Terms: Diabetes Mellitus, Type 2 Impaired Glucose Tolerance Type 1 Diabetes Type 2 Diabetes

Browse recent Boehringer Ingelheim International Gmbh patents - Ingelheim Am Rhein, DE
Inventors: Bradford S. Hamilton, Thomas Rauch, Manami Tsutsumi
USPTO Applicaton #: #20120277149 - Class: 514 62 (USPTO) - 11/01/12 - Class 514 


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The Patent Description & Claims data below is from USPTO Patent Application 20120277149, Pharmaceutical combinations for the treatment of metabolic disorders.

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TECHNICAL

FIELD OF THE INVENTION

The invention is directed to pharmaceutical combinations comprising an inhibitor of 11-beta-hydroxysteroid dehydrogenase 1 of formula 1.a or 1.b as one active ingredient in combination with at least one additional active ingredient 2 which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance, impaired fasting blood glucose, hyperglycemia, dyslipidemia/hyperlipidemia.

Furthermore the invention relates to methods for preventing, slowing progression of, delaying, or treating a metabolic disorder; for improving glycemic control and/or for reducing of fasting plasma glucose, of postprandial plasma glucose and/or of glycosylated hemoglobin HbA1c; for preventing, slowing, delaying or reversing progression from impaired glucose tolerance, impaired fasting blood glucose, insulin resistance and/or from metabolic syndrome to type 2 diabetes mellitus; for preventing, slowing progression of, delaying or treating of a condition or disorder selected from the group consisting of complications of diabetes mellitus; for reducing the weight or preventing an increase of the weight or facilitating a reduction of the weight; for preventing or treating the degeneration of pancreatic beta cells and/or for improving and/or restoring the functionality of pancreatic beta cells and/or restoring the functionality of pancreatic insulin secretion; for preventing, slowing, delaying or treating diseases or conditions attributed to an abnormal accumulation of liver fat; maintaining and/or improving the insulin sensitivity and/or for treating or preventing hyperinsulinemia and/or insulin resistance; or preventing, slowing progression of delaying or treating athersclerosis and complications of atherosclerosis; preventing, slowing progression of delaying or treating glaucoma and complications of glaucoma; preventing, slowing progression of delaying or treating dyslipidemia/hyperlipidemia and complications of dyslipidemia/hyperlipidemia; improving glycemic control in patients with type 2 diabetes as an adjunct to diet and exercise; or improving glycemic control in patients with type 2 diabetes

in patients in need thereof characterized in that an inhibitor of 11-beta-hydroxysteroid dehydrogenase 1 of formula 1.a or 1.b as defined hereinafter is administered in combination or alternation with at least one second therapeutic agent 2 as defined hereinafter.

Furthermore the invention relates to methods

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Industry Class:
Drug, bio-affecting and body treating compositions
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stats Patent Info
Application #
US 20120277149 A1
Publish Date
11/01/2012
Document #
File Date
04/17/2014
USPTO Class
Other USPTO Classes
International Class
/
Drawings
0


Diabetes Mellitus, Type 2
Impaired Glucose Tolerance
Type 1 Diabetes
Type 2 Diabetes


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