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Compounds for enzyme inhibition

Title: Compounds for enzyme inhibition.
Abstract: Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include at least three peptide units, an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. ... Browse recent Onyx Pharmaceuticals Inc. patents
USPTO Applicaton #: #20120277146
Inventors: Mark S. Smyth, Guy J. Laidig, Ronald T. Borchardt, Barry A. Bunin, Craig M. Crews, John H. Musser

The Patent Description & Claims data below is from USPTO Patent Application 20120277146, Compounds for enzyme inhibition.

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stats Patent Info
Application #
US 20120277146 A1
Publish Date
Document #
File Date
Other USPTO Classes
530330, 514 201, 514 177, 514 193, 514/23, 514/37
International Class

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