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Methods for controlling the galactosylation profile of recombinantly-expressed proteins




Title: Methods for controlling the galactosylation profile of recombinantly-expressed proteins.
Abstract: The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose. ...


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USPTO Applicaton #: #20120276631
Inventors: Cornelia T. Bengea, Lisa M. Rives


The Patent Description & Claims data below is from USPTO Patent Application 20120276631, Methods for controlling the galactosylation profile of recombinantly-expressed proteins.




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stats Patent Info
Application #
US 20120276631 A1
Publish Date
11/01/2012
Document #
13457020
File Date
04/26/2012
USPTO Class
435404
Other USPTO Classes
International Class
12N5/10
Drawings
40




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Abbott Laboratories


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Chemistry: Molecular Biology And Microbiology   Animal Cell, Per Se (e.g., Cell Lines, Etc.); Composition Thereof; Process Of Propagating, Maintaining Or Preserving An Animal Cell Or Composition Thereof; Process Of Isolating Or Separating An Animal Cell Or Composition Thereof; Process Of Preparing A Composition Containing An Animal Cell; Culture Media Therefore   Culture Medium, Per Se  

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20121101|20120276631|methods for controlling the galactosylation profile of recombinantly-expressed proteins|The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the galactosylation profile of recombinantly-expressed proteins by supplementing production medium, e.g., a hydrolysate-based or a chemically defined medium, with manganese and/or D-galactose. |Abbott-Laboratories
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