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Multivalent immunoglobulin-based bioactive assemblies




Title: Multivalent immunoglobulin-based bioactive assemblies.
Abstract: The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or more IgG antibody fragments and which may be monospecific or bispecific. The disclosed methods and compositions provide a facile and general way to obtain stably tethered structures of virtually any functionality and/or binding specificity. The stably tethered structures may be administered to subjects for diagnostic and/or therapeutic use, for example for treatment of cancer or autoimmune disease. The stably tethered structures may bind to and/or be conjugated to a variety of known effectors, such as drugs, enzymes, radionuclides, therapeutic agents and/or diagnostic agents. ...


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USPTO Applicaton #: #20120276608
Inventors: Chien-hsing Chang, David M. Goldenberg, Edmund A. Rossi


The Patent Description & Claims data below is from USPTO Patent Application 20120276608, Multivalent immunoglobulin-based bioactive assemblies.




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stats Patent Info
Application #
US 20120276608 A1
Publish Date
11/01/2012
Document #
13483761
File Date
05/30/2012
USPTO Class
435188
Other USPTO Classes
International Class
12N9/96
Drawings
35




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Chemistry: Molecular Biology And Microbiology   Enzyme (e.g., Ligases (6. ), Etc.), Proenzyme; Compositions Thereof; Process For Preparing, Activating, Inhibiting, Separating, Or Purifying Enzymes   Stablizing An Enzyme By Forming A Mixture, An Adduct Or A Composition, Or Formation Of An Adduct Or Enzyme Conjugate  

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20121101|20120276608|multivalent immunoglobulin-based bioactive assemblies|The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Preferred embodiments concern hexameric stably tethered structures comprising one or more IgG antibody fragments and which may be monospecific or bispecific. The disclosed methods and compositions provide a |Ibc-Pharmaceuticals-Inc
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