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Oral fluid rapid assay for hepatitis c virus (hcv) antibodies using non-antibody labeling of lga molecules recognizing hcv peptide epitopes

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Oral fluid rapid assay for hepatitis c virus (hcv) antibodies using non-antibody labeling of lga molecules recognizing hcv peptide epitopes


A method and device to detect Hepatitis C (HCV) antibodies in oral fluid is provided. This method introduces a non-antibody detection molecule that labels all classes of patient antibodies in oral fluid, followed by the specific concentration of labeled anti-HCV antibodies by selective capture in a trapping zone consisting of peptide antigens derived from the HCV genome. Signal generated by the labeled antibodies present in the trapping zone is proportional to the number of anti-HCV antibodies bound to the antigens present in the trapping zone. Presence of signal derived from the capture of antibody/detection molecule complexes in the trapping zone is indicative of past exposure to HCV.

Inventors: Jonathan Zmuda, Lance A. Liotta, Gordon Whiteley
USPTO Applicaton #: #20120276521 - Class: 435 5 (USPTO) - 11/01/12 - Class 435 


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The Patent Description & Claims data below is from USPTO Patent Application 20120276521, Oral fluid rapid assay for hepatitis c virus (hcv) antibodies using non-antibody labeling of lga molecules recognizing hcv peptide epitopes.

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stats Patent Info
Application #
US 20120276521 A1
Publish Date
11/01/2012
Document #
File Date
09/30/2014
USPTO Class
Other USPTO Classes
International Class
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