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Plastic container comprising cyclic polyolefin layer

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Plastic container comprising cyclic polyolefin layer


The present invention provides and a plastic container and multilayered films, which comprises a heat-sealable seal layer, a cyclic polyolefin layer, and an outermost layer, wherein the seal layer comprises polypropylene, the cyclic polyolefin layer comprises a cyclic polyolefin polymer or a cyclic polyolefin copolymer, and the outermost layer comprises a layer containing polypropylene, and which further comprises a resin composition layer comprises a blended product of a propylene polymer and a styrene elastomer. The plastic container of the present invention can suppresses a reduction in the medicament content of a liquid-state medicament and is excellent in terms of shock resistance, handling ability during the filling of the container with the medicament, and the moldability and transparency of the container.

Browse recent Mitsubishi Tanabe Pharma Corporation patents - Tokyo, JP
Inventors: Kazuhiko Ozaki, Munetomo Matsuda, Tetsurou Nishimura, Kenjirou Takayanagi, Hiroshi Kanedo
USPTO Applicaton #: #20120271270 - Class: 604408 (USPTO) - 10/25/12 - Class 604 
Surgery > Container For Blood Or Body Treating Material, Or Means Used Therewith (e.g., Needle For Piercing Container Closure, Etc.) >Bag Type

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The Patent Description & Claims data below is from USPTO Patent Application 20120271270, Plastic container comprising cyclic polyolefin layer.

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TECHNICAL FIELD

The present invention relates to a plastic container suitable for containing a liquid-state medicament and a multilayered film used for this container.

BACKGROUND ART

A reduction in the content of a certain kind of medicament is suppressed using a container composed of cyclic polyolefin. The suppression of a reduction in the content of a certain kind of medicament is disclosed in JP Patent Publication (Kokai) No. 5-293159 A (1993) (Patent Document 1) and JP Patent Publication (Kokai) No. 2003-24415 A (Patent Document 2), for example. However, cyclic polyolefin is rigid and fragile, and further, it is poor in terms of heat-sealing properties. Thus, cyclic polyolefin has been problematic in that a practical bag cannot be directly formed with the cyclic polyolefin itself. In order to solve this problem, JP Patent Publication (Kokai) No. 2002-301796 A (Patent Document 3) and JP Patent Publication (Kohyo) No. 2005-525952 A (Patent Document 4), for example, have proposed a multilayered film comprising a specific ethylene-α-olefin copolymer and cyclic polyolefin and a container constituted with the same.

Moreover, if a constituted multilayered film is rigid and inflexible, it causes problems such as low shock resistance and poor handling ability during the filling of a container with a medicament.

On the other hand, it has been known that a pyrazolone derivative represented by the formula (I) as shown below has, as a medical use, an action to normalize brain function (Patent Document 5; JP Patent Publication (Kokoku) No. 5-31523 B (1993)), an action to suppress generation of lipid peroxide (Patent Document 6; JP Patent Publication (Kokoku) No. 5-35128 B (1993); the compound of Example 1), an antiulcer action (Patent Document 7; JP Patent Publication (Kokai) No. 3-215425 A (1991)), an action to suppress an increase in blood sugar (Patent Document 8; JP Patent Publication (Kokai) No. 3-215426 A (1991)), and the like:

(wherein R1 represents a hydrogen atom, an aryl, an alkyl containing 1 to 5 carbon atoms, or an alkoxycarbonylalkyl containing 3 to 6 carbon atoms in total; R2 represents a hydrogen atom, an aryloxy, an arylmercapto, an alkyl containing 1 to 5 carbon atoms, or a hydroxyalkyl containing 1 to 3 carbon atoms; or R1 and R2 together represent an alkylene containing 3 to 5 carbon atoms; R3 represents a hydrogen atom, an alkyl containing 1 to 5 carbon atoms, a cycloalkyl containing 5 to 7 carbon atoms, a hydroxyalkyl containing 1 to 3 carbon atoms, a benzyl, naphthyl or phenyl, or a phenyl substituted with 1 to 3 identical or different substituents selected from the group consisting of an alkoxy containing 1 to 5 carbon atoms, a hydroxyalkyl containing 1 to 3 carbon atoms, an alkoxycarbonyl containing 2 to 5 carbon atoms in total, an alkylmercapto containing 1 to 3 carbon atoms, an alkylamino containing 1 to 4 carbon atoms, a dialkylamino containing 2 to 8 carbon atoms in total, a halogen atom, a trifluoromethyl, a carboxyl, a cyano, a hydroxyl group, a nitro, an amino, and an acetamide).

Moreover, since June 2001, the compound represented by the formula (I) has been commercially available as a brain-protecting agent (generic name: “Edaravone”; product name: “Radicut”; manufactured and distributed by Mitsubishi Tanabe Pharma Corporation). This “Edaravone” has been reported to have high reactivity with active oxygen (Non-Patent Documents 1 and 2). Thus, Edaravone is a free radical scavenger that acts to scavenge various types of free radicals including active oxygen as a typical example, so as to prevent cell injury.

At present, Radicut is commercially available as a Radicut injection 30 mg in the form of a 20 ml of solution containing 30 mg of 3-methyl-1-phenyl-2-pyrazoline-5-one (Edaravone) filled into a glass ampule. Furthermore, International Publication WO2007/55312 (Patent Document 9) reports a plastic container filled with an aqueous solution containing Edaravone, coloration of which is suppressed. However, a plastic container capable of suppressing a reduction in the content of Edaravone due to adhesion of Edaravone to the plastic container has not yet been disclosed.

[Patent Document 1] JP Patent Publication (Kokai) No. 5-293159 A (1993)

[Patent Document 2] JP Patent Publication (Kokai) No. 2003-24415 A

[Patent Document 3] JP Patent Publication (Kokai) No. 2002-301796 A

[Patent Document 4] JP Patent Publication (Kohyo) No. 2005-525952 A

[Patent Document 5] JP Patent Publication (Kokoku) No. 5-31523 B (1993)

[Patent Document 6] JP Patent Publication (Kokoku) No. 5-35128 B (1993)

[Patent Document 7] JP Patent Publication (Kokai) No. 3-215425 A (1991)

[Patent Document 8] JP Patent Publication (Kokai) No. 3-215426 A (1991)

[Non-Patent Document 1] Kawai, H., et al., J. Pharmacol. Exp. Ther., 281(2), 921, 1997

[Non-Patent Document 2] Wu, TW. et al., 67(19), 2387, 2000

[Patent Document 9] International Publication WO2007/55312

DISCLOSURE OF THE INVENTION

Problems to be Solved by the Invention

It is an object of the present invention to provide a plastic container which suppresses a reduction in the content of a liquid-state medicament and is excellent in terms of shock resistance, handling ability during the filling of the container with the medicament, and the moldability and transparency of the container, and a multilayered film used for the aforementioned container.

Means for Solving the Problems

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stats Patent Info
Application #
US 20120271270 A1
Publish Date
10/25/2012
Document #
13537639
File Date
06/29/2012
USPTO Class
604408
Other USPTO Classes
428349, 206570, 206205, 220 6211
International Class
/
Drawings
0



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