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Medicament administration device

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Medicament administration device


The invention relates to a medicament administration device (1) comprising a rigid medicament container (2) for a liquid medicament with an outlet (3) for the medicament, a storage means (4) for storing solid particles (5), and a feeding means for feeding solid particles (5) from the storage means (4) into the medicament container (2) to displace a dose of medicament by solid particles (5), thereby squeezing the dose of medicament through the outlet (3) of the medicament container (2). In addition the invention relates to a method for administering a liquid medicament stored in a rigid medicament container (2) with an outlet (3) for the medicament, wherein a dose of medicament is squeezed through the outlet (3) of the medicament container (2) by displacing the dose of medicament by solid particles (5) which are fed into the medicament container (2).

Browse recent Sanofi-aventis Deutschland Gmbh patents - Frankfurt Am Main, DE
Inventors: Thomas Nagel, Rene Richter, Robert Witt, Yves Bärtling
USPTO Applicaton #: #20120266877 - Class: 12820312 (USPTO) - 10/25/12 - Class 128 
Surgery > Respiratory Method Or Device >Means For Mixing Treating Agent With Respiratory Gas

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The Patent Description & Claims data below is from USPTO Patent Application 20120266877, Medicament administration device.

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TECHNICAL FIELD

The invention relates to a medicament administration device comprising a rigid medicament container for a liquid medicament with an outlet for the medicament.

BACKGROUND OF THE INVENTION

Many medicaments have to be injected into the body. This applies in particular to medicaments, which are deactivated or have their efficiency remarkably decreased by oral administration, e.g. proteines (such as insulin, growth hormones, interferons), carbohydrates (e.g. heparin), antibodies and the majority of vaccines. Such medicaments are predominantly injected by means of syringes, medicament pens or medicament pumps.

Some medicaments have to be administered by inhaling them from so called inhalers.

U.S. Pat. No. 4,313,439 A discloses a system for the administration of a medicament to a patient in small, controlled doses over an extended period in response to a continuously generated force. The force may be maintained continuously on a reservoir of the medicament in intermittent communication with a site in the body of the patient through a flexible and compressible tube. Alternatively the force may be applied intermittently to the reservoir through the action of an escapement mechanism.

U.S. Pat. No. 4,424,057 A discloses a wet-dry syringe for combining and mixing a liquid and a solid medicament or at least two dissimilar liquid medicaments prior to the application thereof to a patient. The syringe comprises a first vial containing a liquid or solid medicament and a second vial containing a liquid medicament. The second vial has an end seal including a hollow piercing needle to pierce a first end seal of the first vial causing medicament to flow from the second vial into the first vial thereby mixing the medicaments prior to application to a patient by means of a needle piecing assembly which pierces a second end seal of the first vial and a patient. The second vial functions as a piston rod and aids in the discharge of the medicaments.

SUMMARY

OF THE INVENTION

It is an object of the present invention to provide an improved medicament administration device.

The object is achieved by a medicament administration device according to claim 1.

Preferred embodiments of the invention are given in the dependent claims.

A medicament administration device according to the invention comprises a rigid medicament container for a liquid medicament with an outlet for the medicament and a storage means for storing solid particles. In addition it comprises a feeding means for feeding solid particles from the storage means into the medicament container to displace a dose of medicament by solid particles, thereby squeezing the dose of medicament through the outlet of the medicament container.

The storage means and the feeding means allow for dispensing a dose of medicament by displacing the dose by solid particles. In this way the medicament can be dosed very accurately by feeding a definite amount of solid particles into the medicament container.

In a preferred embodiment of the medicament administration device the solid particles are incompressible. This allows for an easy medicament dosing as the incompressibility of the solid particles implies that the total volume of the solid particles fed into the medicament container determines directly the dose of medicament displaced by these solid particles. In particular, using solid particles of equal definite volume, the number of solid particles fed into the medicament container is directly proportional to the dose of medicament displaced by these solid particles.

Preferably the solid particles consist of a material which is inert to chemical reactions with the liquid medicament. This avoids advantageously that the chemical structure of the medicament is affected by the solid particles fed into the medicament container. In particular there is no need to separate the solid particles from the medicament, in contrast to other displacement media such as media used with hydraulic systems. Furthermore chemically inert materials avoid that the volume of the solid particles fed into the medicament container is affected by chemical reactions with the medicament and thus that the dose of medicament displaced by solid particles is affected by such chemical reactions.

In particular the solid particles may consist of glass and/or a rubber material and/or polytetrafluoroethylene. These materials are chemically inert to chemical reactions with many medicaments and are therefore appropriate to a number of medicaments.

Furthermore the solid particles may be ball-shaped or cubical-shaped. This has the advantage that the total volume of solid particles fed into the medicament container can be easily determined from their number and thus allows for an easy medicament dosing. Furthermore ball-shaped or cubical-shaped solid particles do not easily get stuck, in contrast to solid particles with a more complicated shape which may cause catching or jamming of solid particles. Hence ball-shaped or cubical-shaped particles can be more easily stored and fed into the medicament container than solid particles with a more complicated shape.

Preferably the storage means comprises subunits for storing separately portions of solid particles. This allows for preparing medicament doses by correspondingly sizing the subunits. E.g., one may use subunits of equal size that corresponds to a minimum medicament dose to be dispensed, or a fraction thereof. Alternatively one may use subunits of different size such that any needed dose corresponds to a combination of subunits.

The feeding means may comprise a piston to press solid particles out of the storage means. Furthermore the feeding means may comprise connection means connecting the storage means and the medicament container to feed solid particles from the storage means into the medicament container. This allows to feed solid particles into the medicament container through the connection means by using the piston to exert pressure to the storage means.

Preferably the medicament administration device comprises a restraining means to prevent solid particles from leaving the medicament container. The restraining means may comprise a filter for the outlet of the medicament container, the filter being impenetrable for the solid particles. Such a restraining means avoids advantageously that solid particles are dispensed together with a medicament dose. Alternatively, one may use a physical separation method, based, for instance, on a gravitational of centrifugal force, to prevent solid particles from leaving the medicament container.

The medicament container may be part of an injection arrangement or an inhaler arrangement for delivering a liquid medicament to a human or an animal.

The injection arrangement may comprise a valve and a hollow needle for piercing a patient\'s skin, the valve and needle being arranged at the outlet of the medicament container. In that case the outlet of the medicament container may comprise an interface for receiving a hollow injection needle. Alternatively, the needle may be integrated with the medicament container. In case of a jet injector, instead of the needle, a jet nozzle may be arranged.

The medicament container may preferably be used for delivering one of an analgesic, an anticoagulant, insulin, insulin derivate, heparin, Lovenox, a vaccine, a growth hormone, a peptide hormone, a protein, antibodies and complex carbohydrates.

Further scope of applicability of the present invention will become apparent from the detailed description given hereinafter. However, it should be understood that the detailed description and specific examples, while indicating preferred embodiments of the invention, are given by way of illustration only.

BRIEF DESCRIPTION OF THE DRAWINGS



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Previous Patent Application:
Liquid medicine ejection device
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Medicament container
Industry Class:
Surgery
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stats Patent Info
Application #
US 20120266877 A1
Publish Date
10/25/2012
Document #
13392758
File Date
09/15/2010
USPTO Class
12820312
Other USPTO Classes
604131, 604506
International Class
/
Drawings
2



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