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Selective and potent peptide inhibitors of kv1.3

Title: Selective and potent peptide inhibitors of kv1.3.
Abstract: Disclosed are compositions of matter having an amino acid sequence of SEQ ID NO:4, or a pharmaceutically acceptable salt thereof, including embodiments comprising a toxin peptide analog related to ShK, HmK, and AETX-K and pharmaceutical compositions or medicaments containing them along with a pharmaceutically acceptable carrier. Some embodiments include a half-life extending moiety. Also disclosed are a method of preventing or mitigating a relapse of a symptom of multiple sclerosis and a method of treating an autoimmune disorder using the compositions. ... Browse recent Amgen Inc. patents
USPTO Applicaton #: #20120121591
Inventors: John K. Sullivan, Leslie P. Miranda, Colin V. Gegg, Shaw-fen Sylvia Hu, Edward J. Belouski, Justin K. Murray, Hung Nguyen, Kenneth W. Walker, Taruna Arora, Frederick W. Jacobsen, Yue-sheng Li, Thomas C. Boone

The Patent Description & Claims data below is from USPTO Patent Application 20120121591, Selective and potent peptide inhibitors of kv1.3.

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stats Patent Info
Application #
US 20120121591 A1
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International Class

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Autoimmune Disorder

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Amgen Inc.

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Drug, Bio-affecting And Body Treating Compositions   Immunoglobulin, Antiserum, Antibody, Or Antibody Fragment, Except Conjugate Or Complex Of The Same With Nonimmunoglobulin Material   Structurally-modified Antibody, Immunoglobulin, Or Fragment Thereof (e.g., Chimeric, Humanized, Cdr-grafted, Mutated, Etc.)   Antibody, Immunoglobulin, Or Fragment Thereof Fused Via Peptide Linkage To Nonimmunoglobulin Protein, Polypeptide, Or Fragment Thereof (i.e., Antibody Or Immunoglobulin Fusion Protein Or Polypeptide)  

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