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Process for solubilizing glucagon-like peptide 1 compounds   

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20120101034 patent thumbnailAbstract: Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueous solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemization of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.

Inventors: Walter Francis Prouty, JR., Joseph Vincent Rinella, JR.
USPTO Applicaton #: #20120101034 - Class: 514 72 (USPTO) - 04/26/12 - Class 514 
Related Terms: Amino Acid   Aqueous Solution   Glucagon-Like Peptide 1   Peptide   
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The Patent Description & Claims data below is from USPTO Patent Application 20120101034, Process for solubilizing glucagon-like peptide 1 compounds.

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