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Wound healing device

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Title: Wound healing device.
Abstract: A plasma coating device for treating a wound comprises a plasma chamber having: one or more electrodes, a gas supply inlet, a plasma outlet exposed to ambient pressure, and an ignition system operatively connected to the electrodes for providing a non-thermal equilibrium plasma within the plasma chamber. An aerosol delivery system is operable to introduce a bioresorbable material as an aerosol into the plasma, to produce a coating on the wound surface. ...


Inventors: Joe O'Keeffe, Peter Dobbyn, John O'Donoghus, Liam O'Neil
USPTO Applicaton #: #20120089084 - Class: 604 24 (USPTO) - 04/12/12 - Class 604 
Surgery > Means For Introducing Or Removing Material From Body For Therapeutic Purposes (e.g., Medicating, Irrigating, Aspirating, Etc.) >Gas Application >Gas Mixed With Other Material

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The Patent Description & Claims data below is from USPTO Patent Application 20120089084, Wound healing device.

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BACKGROUND

Electrical plasma devices are well established in medicine. For example, Massarweh et al, J. Am. Coll. Surg., 2006, 202 (3), 520, discloses plasma devices for surgery; Reich et al, European Urology, 2003, 44 (2), 272-276, describe the use of an argon plasma (APC) to coagulate blood and stop bleeding; and Mennel et al, Experimental and Toxicological Pathology, 2002, 54 (3), 255, disclose using a helium plasma to obtain a similar response to the APC technique.

Plasmas can also be used to sterilise skin as disclosed in G. Fridman, A. D. Brooks, M. Balasubramanian, A. Fridman. A. Gustol, V. N. Vasilets, H. Ayan, G. Friedman, Plasma Process. Polym. 4 (2007) 370) and WO2006/116252. The use of plasma devices to promote wound healing has also been disclosed in US2008/0237484 and in WO2009/101143.

Outside of medicine, plasma devices are widely used to produce thin film coatings in industrial applications. Plasma polymers offer a number of advantages over conventional polymer coatings. The combination of reactive plasma and chemically active monomers produces a coating that is uniform, pin hole free and well bonded to the substrate. Furthermore, the curing can occur in a manner that is almost instantaneous, offering numerous processing advantages.

U.S. Pat. No. 4,929,319 describes a method for depositing a polymer coating in which an aerosol is introduced into a corona plasma and the reactive species thereby generated are allowed to deposit in a substrate that is also brought into the corona plasma.

WO 02/28548 describes a process in which an aerosol is introduced into an atmospheric pressure glow discharge (APGD) plasma and a coating is thereby formed on a substrate. The coating chemistry was found to be virtually unchanged from that of the precursor molecules by the exposure to the homogeneous APGD plasma.

WO2005/106477 describes a process for coating a substrate with a biomolecule in which the substrate is placed between two electrodes and a plasma is generated by applying an alternating current in which a positive voltage is applied to the first electrode and a zero voltage to the second electrode, and then a zero voltage to the first electode and a negative voltage to the second electrode. A coating is then applied by introducing a reactive precursor to form a coating and biomolecules are simultaneously immobilised. The biomolecules may be introduced as an aerosol.

WO 05/110626 discloses coating a substrate with a polymer layer containing active agents. The method involves exposing a mixture of polymer forming materials (which react to form chemical bonds in a plasma) and active agents (which do significantly react in the plasma) to plasma. The polymer forming materials listed include various acrylates, alkenes and dienes that can be polymerised by the reactive species present within a plasma.

These prior documents rely on the plasma to induce the polymerisation of a monomer to produce the thin film or coating. The polymerisation can be driven through free radical (A. Bogaerts et al., Spectrochimica Acta Part B, 57 (2002) 609-658) or cationic reaction mechanisms (Daniel C. Guerin, David D. Hinshelwood, Sorin Monolache, Ferencz S. Denes, and Vasgen A. Shamamian, Langmuir, 2002, 18 (10), pp 4118-4123).

Thus, while the methods described in WO 05/106477 and WO 05/110626 do allow for the deposition of polymers containing active agents, they are reliant upon the presence of a precursor which can react in the plasma to form the polymer coating during the deposition process. The requirement to induce reactions within the polymer precursor without damaging the active agent limits the degree of polymerisation that can be achieved.

SUMMARY

OF THE INVENTION

The present invention provides a plasma device as claimed in claim 1.

In a further aspect, there is provided a non-thermal plasma treated bioresorbable material for use in coating a wound as claimed in claim 14.

In a still further aspect there is provided a method of treating a wound according to claim 22.

In embodiments of the present invention, a non-thermal plasma is applied to a wound. The plasma can sterilise the area, coagulate blood and deposit a bioresorbable coating to seal the wound area. The coating can further include active compounds to aid in wound healing.

The bioresorbable material can include blood plasma, chitosan or collagen, but may alternatively or in addition include a protein, a biopolymer (such as chitin, alginates, cellulose or hyaluronan), or a synthetic biodegradable polymer (such as poly (lactic-co-glycolic acid) (PLGA), polylactic acid, polycaprolactone, polyglactin) or a mixture of such materials.

Preferably, the bioresorbable material is introduced into a non-thermal plasma as a pre-cursor in the form of an aerosol. The bioresorbable material pre-cursor can either be dissolved or dispersed in a suitable carrier liquid.

Preferably, the active compound, for example, drug, enzyme, cell, protein or DNA may be either introduced into the plasma dissolved in the bioresorbable material pre-cursor or introduced separately.

In such implementations, the active compound is incorporated alongside a pre-polymerised polymer which allows the polymerisation and film forming steps to be separated out and provides a greater degree of process control.

The mixture of bioresorbable material, active compound and plasma further interact to produce a coating on the wound surface. The wound can either directly contact the plasma or can be placed downstream of the plasma chamber outlet.

In one embodiment, blood constituents are nebulised into the plasma, to deposit a layer of coagulated blood or blood plasma onto a wound surface.

BRIEF DESCRIPTION OF THE DRAWINGS

Embodiments of the invention will now be described, by way of example, with reference to the accompanying drawing, in which:

FIG. 1 is a schematic view of a plasma device in accordance with an embodiment of the present invention.



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stats Patent Info
Application #
US 20120089084 A1
Publish Date
04/12/2012
Document #
13377389
File Date
06/15/2010
USPTO Class
604 24
Other USPTO Classes
530356, 530382, 530395, 536 20, 5361231, 536/3, 536 56, 523105, 424529, 424530, 5147723, 514773, 514777, 514779, 514781, 424 941, 424 931, 514/94, 514 44/R, 514 56, 4241841, 514 54, 424 854, 424548, 424 937, 424577
International Class
/
Drawings
2



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