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Borinic compositions

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Title: Borinic compositions.
Abstract: A stabilized topical composition comprising a borinic acid derivative, e.g., a borinic ester. ...

Browse recent Colgate-palmolive Company patents - Piscataway, NJ, US
Inventors: Venda Porter, Andre Morgan, Stanislav Jaracz, Jennifer Gronlund, Guofeng Xu, Donghui Wu, Michael Prencipe, Ravi Subramanyam
USPTO Applicaton #: #20120052025 - Class: 424 52 (USPTO) - 03/01/12 - Class 424 
Drug, Bio-affecting And Body Treating Compositions > Dentifrices (includes Mouth Wash) >Fluorine Or Fluorine Compound Containing

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The Patent Description & Claims data below is from USPTO Patent Application 20120052025, Borinic compositions.

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This application claims the benefit of U.S. Provisional Application 61/183,788, filed Jun. 3, 2009 and U.S. Provisional Application 61/183,792, also filed Jun. 3, 2009, the contents of which are incorporated herein by reference.


The present invention relates to antimicrobial compositions containing a borinic acid derivative, e.g. a borinic ester. In particular embodiments, the invention covers topical antimicrobial compositions, for example topical compositions for treating fungal or bacterial infections of the skin or nails, and oral compositions, for example dentifrice, for reducing bacteria in the mouth, e.g. for inhibiting and reducing plaque, gingivitis and dental caries.

Although some borinic esters are effective as antibacterial agents, incorporating borinic esters into oral care compositions presents difficulties, as borinic esters have proven to be unstable when added to aqueous compositions. For example, borinic esters may hydrolyze and decompose, e.g., in oral care compositions. Additionally, borinic esters may be insoluble in aqueous compositions. For example, the solubility of 3-hydroxypyridine-2-carbonyloxy-bis(3-chloro-4-methylphenyl)-borane in water is only 100 ppm, and its solubility in various oils may be less than 0.5%. There remains a need to develop compositions and methods to incorporate borinic acid derivatives stably in oral care compositions.



The present invention is directed to the surprising discovery that certain borinic esters are stable, soluble, and retain antimicrobial activity when incorporated into an topical or oral care composition, e.g., a topical pharmaceutical composition or a dentifrice or mouthwash.

In one embodiment, the borinic acid derivatives of the present invention are borinic esters, e.g. of formula A:

wherein R1 and R2 are the same or different (e.g. the same), and are selected from arylalkyl, aryl, cycloalkyl, or heterocycle (e.g. substituted or unsubstituted aryl or heteroaryl, for example phenyl, chlorophenyl, methylphenyl, or methylchlorophenyl); and R3 is heteroaryl, heteroarylalkyl, heteroarylcarbonyl, or heteroarylalkylcarbonyl (e.g., substituted or unsubstituted heteroaryl, for example quinolinyl or hydroxypyridinylcarbonyl), in free or pharmaceutically acceptable salt form, in combination with a pharmaceutically acceptable carrier. For example, in one embodiment R1 and R2 are the same and are both aryl, e.g., phenyl, chlorophenyl, methylphenyl, or methylchlorophenyl.

Heteroaryl is for example an aryl group containing 1, 2 or 3 nitrogen atoms, for example pyridinyl, quinolinyl, hydroxypyridinyl, or hydroxyquinolinol. Alkyl is for example C1-4 alkyl. Substitutions are for example halogen, e.g., chloro or fluoro, hydroxy, or C1-4 alkyl.

The borinic esters useful in the present invention thus include, for example, (i) boron picolinates, e.g. diaryl boron picolinates, for example 3-hydroxypyridine-2-carbonyloxy-bis(3-chloro-4-methylphenyl)-borane or 3-hydroxypyridine-2-carbonyloxy-bis(2-methyl-4-chlorophenyl)-borane, as well as (ii) diaryl borinic esters, for example diphenylborane-8-hydroxyquinolinate (PBHQ).

In one embodiment, the borinic esters are compounds as described in WO 2006/102604, incorporated herein by reference, e.g., of Formula (I)

wherein R* and R** are independently substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycle; z is 0 or 1, with the proviso, that if z is 1, then A is CR10 or N, and D is N or CR12, and with the further proviso that if z is 0 then D is O, S or NR12a; E is hydrogen, hydroxy, alkoxy, (cycloalkyl)oxy, (cycloheteroalkyl)oxy, carboxy, or alkyloxycarbonyl;

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stats Patent Info
Application #
US 20120052025 A1
Publish Date
Document #
File Date
424 52
Other USPTO Classes
514 64, 424 54
International Class

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