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Covalent modification of metal surfaces

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Title: Covalent modification of metal surfaces.
Abstract: The present invention provides modified metal surfaces, methods of preparing the same, and intermediates thereto. These materials are useful in a variety of applications including biomaterials. ...


Browse recent Intezyne Technologies patents - Tampa, FL, US
Inventors: Kurt Breitenkamp, Rebecca Breitenkamp, Kevin N. Sill, Habib Skaff
USPTO Applicaton #: #20120046757 - Class: 623 237 (USPTO) - 02/23/12 - Class 623 
Prosthesis (i.e., Artificial Body Members), Parts Thereof, Or Aids And Accessories Therefor > Implantable Prosthesis >Hollow Or Tubular Part Or Organ (e.g., Bladder, Urethra, Bronchi, Bile Duct, Etc.) >Stent

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The Patent Description & Claims data below is from USPTO Patent Application 20120046757, Covalent modification of metal surfaces.

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CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to U.S. provisional patent application Ser. No. 60/819,200, filed Jul. 7, 2006, the entirety of which is hereby incorporated herein by reference.

BACKGROUND OF THE INVENTION

Modification of inorganic substrates with polymeric materials has been utilized in a range of applications across numerous scientific disciplines including analytical chemistry, biology, and electronics. (Mansky, P., et al. Science 1997, 275, 1458-1460; Huang, Z. Langmuir, 1997, 13, 6480-6484. Granick, S. et. al. J. Polym. Sci. B. 2003, 41, 2755-2793.) Inorganic substrates can be coated with polymers or other molecules using a number of currently available methods. One popular, simple method involves the physical adsorbtion of a polymer to a substrate through coating or other deposition techniques. Other methods utilize covalent or ionic bonding between functionality on a polymer, or small molecule, and functionality present on the substrate surface to achieve modification. (Denes, A. R. et. al. J. Appl. Polym. Sci. 2001, 81, 3425-3438). While simple adsorption of polymers to metal substrates has proven successful in many cases, this procedure does not produce mechanically robust coatings with long-term stability. Post-adsorption crosslinking (Dong, B. et. al.; J. Appl. Polym. Sci., 2005, 97, 485-497.) of the polymer coating may increase the toughness and short-term performance of the resulting film, but such crosslinking can also result in cracking and flaking of the polymer films over time, resulting in mechanical failure and a dramatic reduction in film properties. The chemical attachment of functional polymers to a metal substrate introduces a stable, robust linkage between polymer chains and the metal substrate and represents a more desirable scenario for many applications where the long-term stability of the coating is required for optimal performance. (Hara, H. et. al. Adv. Drug Del. Rev. 2006, 58, 377-388.) However, the methodologies to prepare covalent attachment of polymers to metallic and non-metallic substrates has thus far been limited to only a few examples of suitable substrates and complimentary chemical functionalities. Such examples include the near-covalent interaction between gold substrates and thiol-functionalized molecules, covalent bonds formed between silica and alcohol, silyl chloride, or silyl alcohol-functionalized compounds, and covalent bonds formed between hydrogen-functionalized silicon surfaces and alkene-substituted molecules. (Mansky, P., et. al. Science 1997, 275, 1458-1460, Pesek, J. J.; Matyska, M. T. Interface Science 1997, 5, 103-117.)

Accordingly, it would be advantageous to provide a method of modifying metal surfaces to provide a metal substrate capable of forming covalent bonds with appropriately functionalized polymers or small molecule derivatives.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 depicts a method for covalently modifying a metal surface via dehydration reaction.

FIG. 2 depicts a method for covalently modifying a metal surface via condensation reaction.

FIG. 3 depicts a method for covalently modifying a metal surface via dehydration reaction.

FIG. 4 depicts a method for covalently modifying a metal surface via condensation reaction.

FIG. 5 depicts a method for covalently modifying a metal surface via dehydration reaction.

FIG. 6 depicts a method for covalently modifying a metal surface via condensation reaction.

FIG. 7 depicts a method for covalently modifying a metal surface via dehydration reaction.

FIG. 8 depicts a method for covalently modifying a metal surface via condensation reaction.

FIG. 9 depicts a method for covalently modifying a metal surface and crosslinking via dehydration reaction.

FIG. 10 depicts a method for covalently modifying a metal surface via condensation reaction followed by crosslinking.

FIG. 11 depicts a method for PEGylating a metal surface via dehydration reaction.

FIG. 12 depicts a method for PEGylating a metal surface via condensation reaction.

DETAILED DESCRIPTION

OF CERTAIN EMBODIMENTS OF THE INVENTION 1. General Description of the Invention

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Treatment of nasal cavities with stent having a soft outer layer
Industry Class:
Prosthesis (i.e., artificial body members), parts thereof, or aids and accessories therefor
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stats Patent Info
Application #
US 20120046757 A1
Publish Date
02/23/2012
Document #
13285913
File Date
10/31/2011
USPTO Class
623 237
Other USPTO Classes
528400, 528399, 562 23
International Class
/
Drawings
12



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