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Molecular signature of liver tumor grade and use to evaluate prognosis and therapeutic regimen




Title: Molecular signature of liver tumor grade and use to evaluate prognosis and therapeutic regimen.
Abstract: The present invention concerns a method to determine the gene expression profile on a sample previously obtained from a patient diagnosed for a liver tumor, comprising assaying the expression of a set of genes in this sample and determining the gene expression profile (signature). In a particular embodiment, said method enables to determine the grade of liver tumor, such as hepatoblastoma (HB) or a hepatocellular carcinoma (HCC). The invention is also directed to kits comprising a plurality of pairs of primers or a plurality of probes specific for a set of genes, as well as to solid support or composition comprising a set of probes specific for a set of genes. These methods are useful to determine the grade of a liver tumor in sample obtained from a patient, to determine the risk of developing metastasis and/or to define the therapeutic regimen to apply to a patient. ...


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USPTO Applicaton #: #20120040848
Inventors: Marie-annick Buendia, Carolina Niell, Stefano Cairo, Aurelien De Reynies


The Patent Description & Claims data below is from USPTO Patent Application 20120040848, Molecular signature of liver tumor grade and use to evaluate prognosis and therapeutic regimen.




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stats Patent Info
Application #
US 20120040848 A1
Publish Date
02/16/2012
Document #
File Date
12/31/1969
USPTO Class
Other USPTO Classes
International Class
/
Drawings
0


Hepatoblastoma Hepatocellular Carcinoma Tumor Grade

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20120216|20120040848|molecular signature of liver tumor grade and use to evaluate prognosis and therapeutic regimen|The present invention concerns a method to determine the gene expression profile on a sample previously obtained from a patient diagnosed for a liver tumor, comprising assaying the expression of a set of genes in this sample and determining the gene expression profile (signature). In a particular embodiment, said method |Institut-National-De-La-Sante-Et-De-La-Recherche-Medicale-inserm
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