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updated 05/17/13

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Molecular signature of liver tumor grade and use to evaluate prognosis and therapeutic regimen

Abstract: The present invention concerns a method to determine the gene expression profile on a sample previously obtained from a patient diagnosed for a liver tumor, comprising assaying the expression of a set of genes in this sample and determining the gene expression profile (signature). In a particular embodiment, said method enables to determine the grade of liver tumor, such as hepatoblastoma (HB) or a hepatocellular carcinoma (HCC). The invention is also directed to kits comprising a plurality of pairs of primers or a plurality of probes specific for a set of genes, as well as to solid support or composition comprising a set of probes specific for a set of genes. These methods are useful to determine the grade of a liver tumor in sample obtained from a patient, to determine the risk of developing metastasis and/or to define the therapeutic regimen to apply to a patient. ...

Agent: Institut National De La Sante Et De La Recherche Medicale (inserm) - Paris Cedex 13, FR
Inventors: Marie-Annick Buendia, Carolina Niell, Stefano Cairo, Aurelien de Reynies
USPTO Applicaton #: #20120040848 - Class: 506009000 (USPTO) -
Related Terms: Gene Gene Expression Genes Hepatoblastoma Hepatocellular Carcinoma Liver Metastasis Patient Profile Prognosis Regimen Signature

The Patent Description & Claims data below is from USPTO Patent Application 20120040848, Molecular signature of liver tumor grade and use to evaluate prognosis and therapeutic regimen.

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