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Methods and compositions for the specific inhibition of gene expression by double-stranded rna

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Title: Methods and compositions for the specific inhibition of gene expression by double-stranded rna.
Abstract: The invention provides compositions and methods for selectively reducing the expression of a gene product from a desired target gene, as well as treating diseases caused by expression of the gene. The method involves introducing into the environment of a cell an amount of a double-stranded RNA (dsRNA) such that a sufficient portion of the dsRNA can enter the cytoplasm of the cell to cause a reduction in the expression of the target gene. The dsRNA has a first oligonucleotide sequence that is between 26 and about 30 nucleotides in length and a second oligonucleotide sequence that anneals to the first sequence under biological conditions. In addition, a region of one of the sequences of the dsRNA having a sequence length of from about 19 to about 23 nucleotides is complementary to a nucleotide sequence of the RNA produced from the target gene. ...


USPTO Applicaton #: #20110065908 - Class: 536 245 (USPTO) - 03/17/11 - Class 536 


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The Patent Description & Claims data below is from USPTO Patent Application 20110065908, Methods and compositions for the specific inhibition of gene expression by double-stranded rna.

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stats Patent Info
Application #
US 20110065908 A1
Publish Date
03/17/2011
Document #
File Date
09/30/2014
USPTO Class
Other USPTO Classes
International Class
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