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Methods and compositions for the specific inhibition of gene expression by double-stranded rna


Title: Methods and compositions for the specific inhibition of gene expression by double-stranded rna.
Abstract: The invention provides compositions and methods for selectively reducing the expression of a gene product from a desired target gene, as well as treating diseases caused by expression of the gene. The method involves introducing into the environment of a cell an amount of a double-stranded RNA (dsRNA) such that a sufficient portion of the dsRNA can enter the cytoplasm of the cell to cause a reduction in the expression of the target gene. The dsRNA has a first oligonucleotide sequence that is between 26 and about 30 nucleotides in length and a second oligonucleotide sequence that anneals to the first sequence under biological conditions. In addition, a region of one of the sequences of the dsRNA having a sequence length of from about 19 to about 23 nucleotides is complementary to a nucleotide sequence of the RNA produced from the target gene. ... Browse recent City Of Hope patents
USPTO Applicaton #: #20110065908
Inventors: John J. Rossi, Mark A. Behlke, Dongho Kim



The Patent Description & Claims data below is from USPTO Patent Application 20110065908, Methods and compositions for the specific inhibition of gene expression by double-stranded rna.




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stats Patent Info
Application #
US 20110065908 A1
Publish Date
03/17/2011
Document #
12955241
File Date
11/29/2010
USPTO Class
536 245
Other USPTO Classes
International Class
07H21/04
Drawings
14


Your Message Here(14K)


Cytoplasm
Gene Product


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City Of Hope

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Organic Compounds -- Part Of The Class 532-570 Series   Azo Compounds Containing Formaldehyde Reaction Product As The Coupling Component   Carbohydrates Or Derivatives   Nitrogen Containing   Dna Or Rna Fragments Or Modified Forms Thereof (e.g., Genes, Etc.)   Nucleic Acid Expression Inhibitors  

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