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Optical reader system and method for monitoring and correcting lateral and angular misalignments of label independent biosensors

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Title: Optical reader system and method for monitoring and correcting lateral and angular misalignments of label independent biosensors.
Abstract: An optical reader system and method are described herein that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In one embodiment, the biosensors are incorporated within the wells of a microplate. ...


Corning Incorporated - Browse recent Corning patents - Corning, NY, US
Inventors: Anthony G. Frutos, Jacques Gollier, Jinlin Peng, Garrett A. Piech, Michael B. Webb
USPTO Applicaton #: #20110043828 - Class: 356614 (USPTO) - 02/24/11 - Class 356 


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The Patent Description & Claims data below is from USPTO Patent Application 20110043828, Optical reader system and method for monitoring and correcting lateral and angular misalignments of label independent biosensors.

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CLAIMING BENEFIT OF CO-PENDING APPLICATIONS

This application is a divisional application of U.S. patent application Ser. No. 11/789,900, filed Apr. 26, 2007, now pending, which is a divisional application of U.S. patent application Ser. No. 11/210,920, filed Aug. 23, 2005, now U.S. Pat. No. 7,629,173, which is a continuation-in-part application of U.S. patent application Ser. No. 11/027,547 filed Dec. 29, 2004, now U.S. Pat. No. 7,604,984. The contents of these documents are hereby incorporated by reference herein.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to an optical reader system and method for detecting a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In one embodiment, the biosensors are incorporated within the wells of a microplate.

2. Description of Related Art

A major challenge today is to design an optical reader system that can properly re-locate a label independent detection (LID) microplate after it is removed and then reinserted back into the optical reader system. In particular, what is needed is an optical reader system that can detect and correct a lateral and/or angular misalignment of a re-positioned LID microplate. This need and other needs are addressed by the optical reader system and method of the present invention.

BRIEF DESCRIPTION OF THE INVENTION

The present invention includes an optical reader system and method that uses one or more fiducial markings (e.g., position sensors) on a LID microplate to monitor and correct if needed any lateral and/or angular misalignment of the microplate. In one embodiment, the method includes the steps of: (a) placing the microplate onto a translation stage; (b) using one or more fiducial marking(s) on the microplate to determine a first position of the microplate; (c) removing the microplate from the translation stage; (d) re-inserting the microplate back onto the translation stage; (e) using the fiducial marking(s) on the microplate to determine a second position of the microplate; (f) comparing the first position and the second position of the microplate; and (g) if there is a difference between the two positions, then addressing the lateral and/or angular misalignment of the microplate by: (1) moving the translation stage so that the microplate is located at or substantially near to the first position; or (2) not moving the microplate but instead adjusting via software a measured reading (e.g., resonance wavelength) based upon the known position error and a known translation sensitivity. Likewise, steps (a)-(g) could be accomplished by using a stationary holder for the microplate and instead the optical beams can be moved that interrogate the stationary microplate. In another embodiment, the optical reader system can be used to monitor and correct a lateral and/or angular misalignment of a biosensor (which has a fiducial marking) that is not incorporated within a microplate.

BRIEF DESCRIPTION OF THE DRAWINGS

A more complete understanding of the present invention may be had by reference to the following detailed description when taken in conjunction with the accompanying drawings wherein:

FIG. 1 is a block diagram of an optical reader system that is used to monitor and correct a lateral and/or angular misalignment of a microplate (or biosensor) in accordance with the present invention;

FIG. 2 is a graph that is used to help describe why the optical reader system should monitor and correct the lateral and/or angular misalignment of the microplate (or biosensor) in accordance with the present invention;

FIGS. 3-5, 6A and 6B are several graphs and diagrams used to help describe one type of fiducial marking that can be formed on the biosensor which enables the optical reader system to monitor and correct the lateral and/or angular misalignment of the microplate (or biosensor) in accordance with the present invention;

FIGS. 6C and 6D are two diagrams used to help describe a second type of fiducial marking that can be formed on the biosensor which enables the optical reader system to monitor and correct the lateral and/or angular misalignment of the microplate (or biosensor) in accordance with the present invention;

FIGS. 7A and 7B are two diagrams used to help describe a third type of fiducial marking that can be formed on the microplate (or biosensor) which enables the optical reader system to monitor and correct the lateral and/or angular misalignment of the microplate (or biosensor) in accordance with the present invention;

FIGS. 8-10 are three graphs which are used to help explain other uses for the third type of fiducial marking in addition to enabling the optical reader system to monitor and correct the lateral and/or angular misalignment of the microplate (biosensor) in accordance with the present invention; and

FIG. 11 is a flowchart illustrating the steps of a method for monitoring and correcting a lateral and/or angular misalignment of a microplate (or biosensor) in accordance with the present invention.

DETAILED DESCRIPTION

OF THE DRAWINGS

Referring to FIGS. 1-11, there are disclosed several diagrams and graphs which are used to help describe the optical reader system 100 and method 1100 of the present invention. As discussed below, the optical reader system 100 is capable of performing two functions: (1) detecting a biological substance 124 (or a biomolecular binding event) on a biosensor 102; and (2) detecting and correcting any lateral and/or angular misalignment of the biosensor 102 which is caused by the removal and subsequent reinsertion of the biosensor 102 into the optical reader system 100. Prior to discussing the second function, a brief description is provided about how the optical reader system 100 can detect a biological substance 124 on the biosensor 102.



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Previous Patent Application:
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Industry Class:
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stats Patent Info
Application #
US 20110043828 A1
Publish Date
02/24/2011
Document #
12938740
File Date
11/03/2010
USPTO Class
356614
Other USPTO Classes
356246
International Class
/
Drawings
8



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