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The present invention relates generally to methods of forming structured sintered articles and particularly to methods of forming structured sintered articles comprising one or more of glass, ceramic, and glass-ceramic particles. The disclosed method has been particularly developed for and may be particularly useful in the manufacture of microfluidic devices and similar structures.
Associates of the present inventors have previously developed techniques for forming glass rib structures, as disclosed for example in U.S. Pat. No. 5,853,446, and related methods for producing microfluidic devices, as disclosed for example in U.S. Pat. No. 6,769,444, both of which are assigned to the Assignee of the present application. These previously developed methods include, among other steps: providing a mixture of a binder and sinterable particles, such as glass, glass-ceramic or ceramic particles or mixtures thereof; molding the mixture to form a desired structure; setting and demolding the structure; and debinding and sintering the structure. Setting is performed by heating the mixture for thermosetting binders, by cooling or allowing the mixture to cool for thermoplastic binders, or by irradiating the mixture for radiation-curable binders. In U.S. Pat. No. 5,853,446 is disclosed that radiation-curable binders may take the form of “hybrid” binders—mixtures of radiation-curable binder materials and thermoplastic binder materials—providing fast radiation-setting and at the same time achieving a more complete debinding or “burnout” of the binder similar to that of thermoplastic binders. In the purely UV or hybrid UV binder embodiments, fast-setting by irradiation is used while the mixture is in the disclosed roll mold and/or simultaneously with removal of the mixture from the roll mold, in order to set the structure and aid removal of the structure from the mold.
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For forming the rather complex structures that may be desirable in a microfluidic device, flat molding processes similar to that disclosed in U.S. Pat. No. 6,769,444 have proven more reliable and adaptable than roll-molding such as disclosed in U.S. Pat. No. 5,853,446. A disadvantage of the flat molding process, however, is that the flat molding process generally requires the use of absorbent material packed around and into the recesses of the formed or structured mixture prior to debinding and sintering, to assist in maintaining the shape of the structured mixture during debinding and sintering. Alumina and more recently calcium carbonate, which both can withstand high temperatures, have been used by the inventors or their colleagues for this purpose. The use of alumina or calcium carbonate is undesirable, however, in that it must later be removed, adding to the number and expense of process steps and providing a potential source of contamination. Furthermore, etching, a typical process available to remove calcium carbonate from glass, is not very environmentally friendly.
Without some absorbent material covering and packing the structure, however, the shape of the structure is not always retained to the degree that may be desired. In particular, without the use of an absorbent material to help maintain the shape of the green structure, as the structure is debinded and sintered, the structure can soften or slump. Although radiation-curable binders and thermo-setting binders can maintain the shape of the structure to a greater degree than thermoplastic binders during debinding and sintering, the use of radiation-curable binders for setting or curing in contact with a mold can cause difficulty in separating shaped structures from a mold, as well as difficulty in achieving desired levels of curing or setting, and in achieving evenly distributed curing or setting.
The present invention provides a method of forming a structured sintered article including providing a mixture comprising a sinterable particulate material and a binder, the binder comprising, as a function of total resin content of the binder, at least 50% by weight of a thermoplastic binder material and at least 5% by weight of a radiation-curable binder material; shaping the mixture with a mold to form a structure; setting the structure by cooling the structure or by allowing the structure to cool; separating the structure from the mold; irradiating the structure so as to at least partially cure the radiation-curable binder material, and debinding and sintering the structure so as to form a structured sintered article. Shaping may include forming a structure having one or more open channels, and sintering may include sintering in together in contact with at least one additional structure so as to cover or enclose the channels.
In the methods according to the present invention, the thermoplastic binder, desirably a low melting binder, remains the primary binder and the binder that performs the function of setting or initially curing the structure, allowing for mold separation and any necessary initial handling. This provides for easily controlled and complete curing by simple means—cooling or allowing the structure to cool. The thermoplastic binder can also provide good flow and lubrication properties during debinding, minimizing cracking and other issues that might occur with a heavily crosslinked polymer as the primary binder. A sufficient amount of radiation-cured resin acts as a rheology modifier belonging to the thermoset family; therefore it does not re-melt continues to be an effective rheology modifier up to and possibly even beyond the thermoplastic binder debinding temperature range, thus maintaining the shape of the structures being debinded and sintered, without the use of particulate material packed around and into the structure.
Additional features and advantages of the invention will be set forth in the detailed description which follows, and in part will be readily apparent to those skilled in the art from that description or recognized by practicing the invention as described herein, including the detailed description which follows, the claims, as well as the appended drawings.
It is to be understood that both the foregoing general description and the following detailed description present embodiments of the invention, and are intended to provide an overview or framework for understanding the nature and character of the invention as it is claimed. The accompanying drawings are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification. The drawings illustrate various embodiments of the invention, and together with the description, serve to explain the principles and operations of the invention.
BRIEF DESCRIPTION OF THE DRAWINGS
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FIGS. 1A-1E are cross sections of one instance of a structured sintered article at various points in a process of being formed according to one or more methods of the present invention;
FIG. 2 is a cross section of an alternative structure useful in the step depicted in FIG. 1D;
FIG. 3 is a cross section of another alternative structure useful in the step depicted in FIG. 1D;
FIGS. 4A-B are cross sections of another instance of a structured sintered article that may be produced by one or more methods of the present invention;
FIG. 5 is a flowchart depicting an embodiment of the method of the present invention;
FIG. 6 is a digital photograph of a structured article produced by a comparative process showing some slumping after debinding and before sintering;
FIG. 7 is a digital photograph of a structured article produced by a process or method according to an embodiment of the present invention showing shape retention after debinding and before sintering in contrast to the article of FIG. 6;
FIG. 8 is a graph of structured feature height for three structures before and after debinding, the first two being comparative and the last being an example according the methods of the present invention;
FIG. 9 is a graph of yield stress as a function of temperature for a structure undergoing a process according to one or more methods of the present invention, along with structures undergoing two comparative processes.
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Reference will now be made in detail to the presently preferred embodiments of the invention, example of which are illustrated in the accompanying drawings. Whenever possible, the same reference numerals will be used throughout the drawings to refer to the same or like parts.
FIGS. 1A-1E are cross sections of one instance of a structured sintered article at various points in a process of being formed according to one or more methods of the present invention. With reference to FIG. 1A, the methods generally include providing a mixture 20 comprising a sinterable particulate material and a binder, the binder comprising, as a function of total resin content of the binder, at least 50% by weight of a thermoplastic binder material, and at least 5% by weight of a radiation-curable binder material. The mixture 20 is shaped with a mold 22 so as to form a structure 26.
In the example of FIG. 1, the mold 22 is used to shape the mixture 20 while the mixture 20 is in contact with a substrate 24, which in the embodiment of FIG. 1 forms part of the resulting shaped structure 26 and the final structured sintered article 50. The step of shaping the mixture 20 with a mold may beneficially be used to form the particular type of structure shown in FIG. 1, a structure 26 having one or more open channels 28. The mixture 20 may be molded at an elevated temperature as needed or desired, and the thermal energy may be supplied in various ways, such as heating the mold, pre-heating the mixture, and the like.
After the mixture 20 is shaped with the mold 22, the resulting structure 26 is then set by cooling the structure 26 or by allowing the structure 26 to cool. The structure 26 is then separated from the mold 22, resulting in a structure 26 comprising the shaped mixture 20 of FIG. 1B.
After the structure 26 is separated from the mold 22, the structure 26 is irradiated with radiation 30, as depicted diagrammatically in the cross-section of FIG. 1C, so as to at least partially cure the radiation-curable binder material in the mixture 20. Desirably, the structure 26 is irradiated sufficiently such that the resulting yield stress of the mixture 20 is at least 8 Pa (Pascal) at a temperature of 100° C. The irradiation lightly crosslinks the irradiation-curable binder material to provide shaped objects having dimensional stability above the critical shear yield stress of 8 Pa. High yield stress allows molded objects to maintain shapes and avoid distortion and slumping as temperature is raised up to the temperature at which debinding occurs. The crosslinking network acts to lock the particles in place and allows the thermoplastic binder material to melt and vaporize or burn out without the structure slumping. The degree of binder crosslinking is controllable by adjusting the radiation-curable thermoplastic ratio and/or the dose of radiation.
The methods and materials described in the examples below have been shown to be capable of producing yield stresses of the mixture, after irradiation, of 100 Pa or greater at temperatures in the range of 70 to 120° C. The radiation 30 need not be parallel, and need not come only from the direction depicted in the figure, but can be delivered in any suitable fashion, including through the substrate 24 (in the upward direction in the orientation of the figure).
The curing radiation 30 is desirably UV radiation, but other radiation such as visible, electron beam, and others may also be adapted for use in the present invention. The radiation-curable binder material may be a UV-curable material, such as one or more acrylates, methacrylates, a vinyls, epoxies, thiols, styrenics, and combinations thereof. Particularly good performance in the examples below was found using acrylated oligomers, particularly a polyester acrylated oligomer. Although the curable resin composition currently most preferred is cured using free radical initiation, cationically curable compositions are possible.
Desirably, the sinterable particulate material used in the mixture 20 is a particulate material transparent to the radiation 30 employed in the step of irradiating, such as transparent to UV radiation if that is the type employed. Presently preferred materials are glasses, particularly those transparent to UV radiation, such as borosilicate glasses, alumina-containing borosilicate glasses, glass ceramics, ceramics, and mixtures thereof, and presently most preferred is glass. Useful applications may extend, however, to sinterable particles not generally transparent to polymerizing radiation, such as metallic particles, where the desired structure\'s shape and thickness permit.
After the structure 26 is irradiated as depicted in FIG. 1C the structure 26 is then debinded and sintered to form a structured sintered article 50, as shown in the cross section of FIG. 1E. In the case of the article 50 of FIG. 1, an optional step is included, depicted in FIG. 1D, of placing at least one additional structure 32 in contact with the structure 26. In the embodiment shown, the optional additional structure 32 includes a mixture 20A having the same or similar constituents as the mixture 20, and a substrate 24A. The sintering step thus optionally includes sintering the structure 26 in contact with at least one additional structure 32. A weight or other means of applying a force may be applied in the direction across the contact of the structures 26 and 32 during sintering. The result in this particular embodiment is to cover or enclose the channels 28, so as to form a structured sintered 50 article having covered channels 34 formed therein. In the particular embodiment of FIG. 1, the depicted channels 34 form some of the fluidic channels of a microfluidic device. Additional layers of substrates and fluidic channels may also be formed as part of the same device, in the same or subsequent sintering steps, as desired.
FIG. 2 is a cross section of an alternative structure 32 useful in the step depicted in FIG. 1D. The structure 32 includes a formed mixture 20A on a substrate 24A. With the particular form of the mixture 20A shown, the structure 32 also includes open channels 28A. These may or may not line up exactly with the channels 28 of structure 26, and can be used to form more complex enclosed or covered channels within a microfluidic device. Another alternative for structure 32 is shown in FIG. 3. A plain substrate 24A or other suitable structure without a mixture formed thereon may be used.
Aspects of another alternative process according to the methods of the present invention are depicted n FIGS. 4A-B. As shown in FIG. 4A, the mold used in the methods of the present invention may take the form of mold halves 22a and 22b that cooperate to form the mixture 20 into a structure 26 without a substrate. The molding process may be press-molding, casting, injection-molding, vacuum-assisted molding, or other suitable process. The structured sintered device 50 resulting after irradiation and debinding and sintering may be a container or crucible. More complex or intricately shaped parts are possible, particularly by forming with injection molding.