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Resolvins: biotemplates for novel therapeutic interventions

Title: Resolvins: biotemplates for novel therapeutic interventions.
Abstract: The present invention is generally drawn to novel isolated therapeutic agents, termed resolving, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification. ... Browse recent The Brigham And Women's Hospital, Inc. patents
USPTO Applicaton #: #20100016432
Inventors: Charles N. Serhan

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stats Patent Info
Application #
US 20100016432 A1
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International Class

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Docosahexaenoic Acid
Eicosapentaenoic Acid
Polyunsaturated Fatty Acid

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Drug, Bio-affecting And Body Treating Compositions   Designated Organic Active Ingredient Containing (doai)   Radical -xh Acid, Or Anhydride, Acid Halide Or Salt Thereof (x Is Chalcogen) Doai   Carboxylic Acid, Percarboxylic Acid, Or Salt Thereof (e.g., Peracetic Acid, Etc.)   Higher Fatty Acid Or Salt Thereof   Carbon To Carbon Unsaturation  

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