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Resolvins: biotemplates for novel therapeutic interventions

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Title: Resolvins: biotemplates for novel therapeutic interventions.
Abstract: The present invention is generally drawn to novel isolated therapeutic agents, termed resolving, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-II (COX-2) and an analgesic, such as aspirin (ASA). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy EPA or DHA compounds having unique structural and physiological properties. The present invention therefore provides for many new useful therapeutic di- or tri-hydroxy derivatives of EPA or DHA (resolvins) that diminish, prevent, or eliminate inflammation or PMN migration, for example. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification. ...


USPTO Applicaton #: #20100016432 - Class: 514560 (USPTO) - 01/21/10 - Class 514 
Drug, Bio-affecting And Body Treating Compositions > Designated Organic Active Ingredient Containing (doai) >Radical -xh Acid, Or Anhydride, Acid Halide Or Salt Thereof (x Is Chalcogen) Doai >Carboxylic Acid, Percarboxylic Acid, Or Salt Thereof (e.g., Peracetic Acid, Etc.) >Higher Fatty Acid Or Salt Thereof >Carbon To Carbon Unsaturation

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stats Patent Info
Application #
US 20100016432 A1
Publish Date
01/21/2010
Document #
File Date
07/29/2014
USPTO Class
Other USPTO Classes
International Class
/
Drawings
0


Aspirin
Docosahexaenoic Acid
Eicosapentaenoic Acid
Polyunsaturated Fatty Acid


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