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10/29/09 - USPTO Class 514 |  1 views | #20090270330 | Prev - Next | About this Page  514 rss/xml feed  monitor keywords

Purified arabinogalactan-protein (agp) composition useful in the treatment psoriasis and other disorders

USPTO Application #: 20090270330
Title: Purified arabinogalactan-protein (agp) composition useful in the treatment psoriasis and other disorders
Abstract: A purified Arabinogalactan-Protein (AGP) composition isolated through a selective method from the leaves and/or stems of Argemone mexicana plant is described. Also described is a purified Arabinogalactan-Protein (AGP) composition isolated from the leaves and/or stems of Argemone mexicana plant, which has one or more of the following effects: immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFN-γ inhibition, or IL-10 induction; keratinocyte proliferation inhibition, keratolytic activity and inhibitory activity in Mouse Ear Swelling test (MEST). (end of abstract)



Agent: Ladas & Parry LLP - New York, NY, US
Inventors: Sudershan Kumar ARORA, Sudershan Kumar ARORA, Vandita Srivastava, Vandita Srivastava, Sameer Shankar Walunj, Sameer Shankar Walunj
USPTO Applicaton #: 20090270330 - Class: 514 12 (USPTO)

Purified arabinogalactan-protein (agp) composition useful in the treatment psoriasis and other disorders description/claims


The Patent Description & Claims data below is from USPTO Patent Application 20090270330, Purified arabinogalactan-protein (agp) composition useful in the treatment psoriasis and other disorders.

Brief Patent Description - Full Patent Description - Patent Application Claims
  monitor keywords FIELD OF THE INVENTION

The present invention relates to a purified Arabinogalactan-Protein (AGP) composition isolated through a selective method from the leaves and/or stems of Argemone mexicana plant.

The present invention also relates to a purified Arabinogalactan-Protein (AGP) composition isolated from the leaves and/or stems of Argemone mexicana plant, which has one or more of the following effects: immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFN-γ inhibition, or IL-10 induction; keratinocyte proliferation inhibition, keratolytic activity and inhibitory activity in Mouse Ear Swelling test (MEST).

DESCRIPTION OF THE ABBREVIATIONS/NOTATIONS USED HEREIN

Arabinogalactan-Protein: AGP

High Molecular Weight Arabinogalactan-Protein: AGP-HM

Low Molecular Weight Arabinogalactan-Protein: AGP-LM

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1. is a chart summarizing the selective process for isolating purified AGP composition.

FIG. 2: shows the proposed structure of AGP composition.

FIG. 3: shows the effect of AGP composition on IL-10 Induction.

FIG. 4: shows the effect of AGP composition on Percent IL-2 Inhibition.

FIG. 5: shows the effect of AGP composition on Percent IFNγ Inhibition.

FIG. 6: shows the effect of AGP composition on Inhibition of GMCSF.

FIG. 7: shows the effect of AGP composition on Inhibition of human TNFα.

FIG. 8: shows effect of AGP composition on NGF Induced Human Keratinocyte Proliferation.

FIG. 9: shows effect of AGP composition on NGF Induced Human Keratinocyte Proliferation.

FIG. 10: shows effect of AGP composition on Skin Thickness in PPD challenged guinea pigs.

FIG. 11: shows effect of AGP Composition on Inhibition of Epidermal Thickness Induced by TPA (12-O-tetradecanoylphorbol-13-acetate) in Balb/c mice.

FIG. 12: shows the effect of AGP Composition on DNFB Induced Mice Ear Swelling Test in Female C 57/BL 6 Mice.



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