Purified arabinogalactan-protein (agp) composition useful in the treatment psoriasis and other disorders

Abstract: A purified Arabinogalactan-Protein (AGP) composition isolated through a selective method from the leaves and/or stems of Argemone mexicana plant is described. Also described is a purified Arabinogalactan-Protein (AGP) composition isolated from the leaves and/or stems of Argemone mexicana plant, which has one or more of the following effects: immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFN-γ inhibition, or IL-10 induction; keratinocyte proliferation inhibition, keratolytic activity and inhibitory activity in Mouse Ear Swelling test (MEST). (end of abstract)

Purified arabinogalactan-protein (agp) composition useful in the treatment psoriasis and other disorders description/claims

Brief Patent Description

Full Patent Description

Patent Application Claims

FIELD OF THE INVENTION

The present invention relates to a purified Arabinogalactan-Protein (AGP) composition isolated through a selective method from the leaves and/or stems of Argemone mexicana plant.

The present invention also relates to a purified Arabinogalactan-Protein (AGP) composition isolated from the leaves and/or stems of Argemone mexicana plant, which has one or more of the following effects: immunosuppression, lymphoproliferation inhibition, cytokine modulation such as IL-2 inhibition, IFN-γ inhibition, or IL-10 induction; keratinocyte proliferation inhibition, keratolytic activity and inhibitory activity in Mouse Ear Swelling test (MEST).

Description of the Abbreviations/Notations Used Herein

Arabinogalactan-Protein: AGP

High Molecular Weight Arabinogalactan-Protein: AGP-HM

Low Molecular Weight Arabinogalactan-Protein: AGP-LM

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1. is a chart summarizing the selective process for isolating purified AGP composition.

FIG. 2: shows the proposed structure of AGP composition.

FIG. 3: shows the effect of AGP composition on IL-10 Induction.

FIG. 4: shows the effect of AGP composition on Percent IL-2 Inhibition.

FIG. 5: shows the effect of AGP composition on Percent IFNγ Inhibition.

FIG. 6: shows the effect of AGP composition on Inhibition of GMCSF.

FIG. 7: shows the effect of AGP composition on Inhibition of human TNFα.

FIG. 8: shows effect of AGP composition on NGF Induced Human Keratinocyte Proliferation.

FIG. 9: shows effect of AGP composition on NGF Induced Human Keratinocyte Proliferation.

FIG. 10: shows effect of AGP composition on Skin Thickness in PPD challenged guinea pigs.

FIG. 11: shows effect of AGP Composition on Inhibition of Epidermal Thickness Induced by TPA (12-O-tetradecanoylphorbol-13-acetate) in Balb/c mice.

FIG. 12: shows the effect of AGP Composition on DNFB Induced Mice Ear Swelling Test in Female C 57/BL 6 Mice.

Continue reading about Purified arabinogalactan-protein (agp) composition useful in the treatment psoriasis and other disorders...
Full patent description for Purified arabinogalactan-protein (agp) composition useful in the treatment psoriasis and other disorders

Brief Patent Description - Full Patent Description - Patent Application Claims

Click on the above for other options relating to this Purified arabinogalactan-protein (agp) composition useful in the treatment psoriasis and other disorders patent application.

Patent Applications in related categories:

20090298749 - Dalbavancin compositions for treatment of bacterial infections - The invention provides methods and compositions for treatment of bacterial infections. The composition may be a combination of factors, which include A0, A1, B1, B2, C0, C1, isoB0, and MAG, in the presence of low level solvent. Methods of the invention include administration of dalbavancin formulations for treatment of a ...

20090298747 - Methods and compositions for treatment of nitric oxide-induced clinical conditions - The present invention provides compositions and methods for modulating cellular nitric oxide (NO) production and for treating a clinical condition associated therewith. ...

20090298748 - Methods of administering dalbavancin for treatment of bacterial infections - The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Dosing regimes include once weekly administration of dalbavancin, which often remains at therapeutic levels ...

###

How KEYWORD MONITOR works... a FREE service from FreshPatents
1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored.
3. Each week you receive an email with patent applications related to your keywords.
Start now! - Receive info on patent apps like Purified arabinogalactan-protein (agp) composition useful in the treatment psoriasis and other disorders or other areas of interest.
###

Previous Patent Application:
Heterocyclic compounds
Next Patent Application:
Compositions and methods for antibiotic potentiation and drug discovery
Industry Class:
Drug, bio-affecting and body treating compositions

###

Design/code © 2009 FreshContext LLC/Freshpatents.com. Website Terms and Conditions - Also read: About this Page
Patent data source: patents published by the United States Patent and Trademark Office (USPTO)
Information published here is for research/educational purposes only (and in conjunction with our Keyword Monitor) and is not meant to be used in place of the full USPTO patent document/images or a comprehensive patent archive search. Complete official applications are on file at the USPTO and often contain additional data/images (Freshpatents is currently text-only). FreshPatents.com is not affiliated with or endorsed by the USPTO or firms/individuals or products/designs/ideas related to listed patents.

FreshPatents.com Support
Thank you for viewing the Purified arabinogalactan-protein (agp) composition useful in the treatment psoriasis and other disorders patent info.
IP-related news and info

Results in 3.14095 seconds

Other interesting Feshpatents.com categories:
Qualcomm , Schering-Plough , Schlumberger , Seagate , Siemens , Texas Instruments , paws