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06/25/09 - USPTO Class 514 | 1 views | #20090163420 | Prev - Next | About this Page

Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid beta, prion protein, amylin, alpha-synuclein, or polyglutamine repeats for induction of an immune response thereto

Title: Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid beta, prion protein, amylin, alpha-synuclein, or polyglutamine repeats for induction of an immune response thereto

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20090163420, Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid beta, prion protein, amylin, alpha-synuclein, or polyglutamine repeats for induction of an immune response thereto.

What is claimed is:

1. An isolated peptide represented by the formula (A)n-(N-Xaa1GlyAlaXaa2Xaa3-C)n—(B)p wherein: m is 0, 4, 5, 6, 7, 8, 9, or 10; p is 0, 4, 5, 6, 7, 8, 9, or 10; A is Lys or Asp; B is Lys or Asp; n is 1 or 2; N is residues 1-22 of SEQ ID NO:46; C is residues 28-37 of SEQ ID NO:46; Xaa1, Xaa2, and Xaa3 are Phe, Ile, and Leu, respectively, in which zero, one, two or three of residues Xaa1, Xaa2, and Xaa3 is substituted with Pro, Asp, Glu, Lys, Gly, or Ser; and when zero residues is substituted, then either or both m and p is not zero.

2. The peptide of claim 1, wherein all residues are D-amino residues.

3. The peptide of claim 1, wherein p is 0.

4. The peptide of claim 3, wherein the amino acid sequence of said peptide is selected from the group consisting of SEQ ID NO:48 and SEQ ID NO:49.

5. The peptide of claim 1, wherein m is 0.

6. The peptide of claim 5, wherein the amino acid sequence of said peptide is selected from the group consisting of SEQ ID NO:50 and SEQ ID NO:51.

7. The peptide of claim 1, wherein m is not zero and p is not zero.

8. The peptide of claim 7, wherein the amino acid sequence of said peptide is selected from the group consisting of SEQ ID NO:52 and SEQ ID NO:53.

9. A conjugate of the peptide of claim 1 cross-linked to a polymer molecule.

10. The conjugate of claim 9, wherein said polymer molecule is a peptide comprising a promiscuous T helper cell epitope.

11. An immunizing composition, comprising an immunizing effective amount of the peptide of claim 1 or a conjugate thereof, and a pharmaceutically acceptable carrier, excipient, diluent, adjuvant, or auxiliary agent.

Brief Patent Description - Full Patent Description - Patent Claims

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