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Pyrazolo [3,4-d] pyrimidine derivatives useful to treat respiratory disorders
Pyrazolo [3,4-d] pyrimidine derivatives useful to treat respiratory disorders description/claims
The Patent Description & Claims data below is from USPTO Patent Application 20090131457, Pyrazolo [3,4-d] pyrimidine derivatives useful to treat respiratory disorders.
Brief Patent Description - Full Patent Description - Patent Application Claims
The present invention relates to organic compounds, their preparation and their use as pharmaceuticals.
International Patent Application Publication No. WO03029209 describes pyrazolo[3,4-d]pyrimidines useful as pharmaceuticals.
In a first aspect, the present invention provides use of a compound of formula (I)
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or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein:
R1 is C1-C3-alkyl, optionally substituted by one to seven fluoro groups;
R2 is a 5-6 membered hetaroaryl group, or R2 is phenyl having the substitution pattern,
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where the 5-6 membered heteroaryl group is optionally fused by phenyl, a further 5-6 membered heteroaryl group, a C4-C6 carbocyclic group or a 5-6 membered heterocyclyl group and where the R2 phenyl is optionally fused at R4—R5, R5—R6, R6—R7 or R7—R8 by a further phenyl, a 5-6 membered heteroaryl group, a C4-C6 carbocyclic group or a 5-6 membered heterocyclyl group, where the 5-6 membered heteroaryl or fused 5-6 membered heteroaryl, phenyl or the fused phenyl group is independently optionally substituted by one or more groups selected from List X;
List X represents hydroxyl, cyano, nitro, C1-C8-alkyl, C1-C8-alkenyl, C1-C8-alkynyl, C1-C8-alkoxy, C1-C8-alkenyloxy, C1-C8-alkynyloxy, phenyl, a 5-6 membered heteroaryl group, a C4-C6 carbocyclic group or a 5-6 membered heterocyclyl group, —(C0-C4-alkylene)-(C1-C4-alkylene)-R9, (C0-C4-alkylene)-(C2-C4-alkylene)-R10, (C0-C4-alkylene)-N(R11)—(C1-C4-alkylene)-R12, —(C0-C4-alkylene)-N(R13)—(C2-C4-alkylene)-R14, halogen, formyl, C1-C8-alkylcarbonyl, carboxy, C1-C8-alkoxycarbonyl, C1-C8-alkylaminooxycarbonyl, di-C1-C8-alkylaminooxycarbonyl, amino, C1-C8-alkylamino, di-C1-C8-alkylamino, C1-C8-alkylamidino, —N(H)C(═NH)C1-C8-alkyl, —N(C1-C8-alkyl)C(═NH)C1-C8-alkyl, C1-C8-alkylaminocarbonyl, di-C1-C8-alkylaminocarbonyl, aminocarbonylamino, aminocarbonyl(C1-C8-alkyl)amino, C1-C8-alkylaminocarbonylamino, di-C1-C8-alkylaminocarbonylamino, C1-C8-alkylaminocarbonyl(C1-C8-alkyl)amino, di-C1-C8-alkylaminocarbonyl(C1-C8-alkyl)amino, C1-C8-alkylcarbonylamino, C1-C8-alkylcarbonyl(C1-C8-alkyl)amino, C1-C8-alkylthiocarbonylamino, C1-C8-alkylthiocarbonyl(C1-C8-alkyl)amino, hydroxysulfonyl, C1-C8-alkylsulfonylamino, C1-C8-thioalkyl, C1-C8-alkylsulfinyl, C1-C8-alkylsulfonyl, aminosulfonyl, C1-C8-alkylaminosulfonyl or di-C1-C8-alkylaminosulfonyl, where each of the afore-mentioned hydrocarbon groups may be optionally substituted, where chemically feasible, by one or more halogen, hydroxyl, amino, C1-C8-alkylamino, di-C1-C8-alkylamino or C1-C4-alkoxy groups and where said cyclic groups may be optionally substituted by one or more hydroxyl, cyano, nitro, C1-C8-alkyl, C1-C8-alkenyl, C1-C8-alkynyl, C1-C8-alkoxy, C1-C8-alkenyloxy, C1-C8-alkynyloxy, halogen, C1-C8-alkylcarbonyl, carboxy, C1-C8-alkoxycarbonyl, amino, C1-C8-alkylamino, di-C1-C8-alkylamino, C1-C8-alkylaminocarbonyl, di-C1-C8-alkylaminocarbonyl, C1-C8-alkylcarbonylamino, C1-C8-alkylcarbonyl(C1-C8-alkyl)amino, C1-C8-alkylsulfonylamino, C1-C8-thioalkyl, C1-C8-alkylsulfinyl, C1-C8-alkylsulfonyl, aminosulfonyl, C1-C8-alkylaminosulfonyl or di-C1-C8-alkylaminosulfonyl groups;
R9 and R12 independently represent hydrogen, C1-C4-alkenyl, C1-C4-alkynyl, halogen, cyano, nitro, C1-C8-alkylcarbonyl, carboxy, C1-C8-alkoxycarbonyl, C1-C8-thioalkyl, C1-C8-alkylsulfinyl, C1-C8-alkylsulfonyl, aminosulfonyl, C1-C8-alkylaminosulfonyl, di-C1-C8-alkylaminosulfonyl, phenyl, a C-linked 5-6 membered heteroaryl group, a C4-C6 carbocyclic group or a C-linked 5-6 membered heterocyclyl group, where said phenyl or cyclic groups may be optionally substituted by one or more hydroxyl, cyano, nitro, C1-C8-alkyl, C1-C8-alkenyl, C1-C8-alkynyl, C1-C8-alkoxy, C1-C8-alkenyloxy, C1-C8-alkynyloxy, halogen, C1-C8-alkylcarbonyl, carboxy, C1-C8-alkoxycarbonyl, amino, C1-C8-alkylamino, di-C1-C8-alkylamino, C1-C9-alkylaminocarbonyl, di-C1-C8-alkylaminocarbonyl, C1-C8-alkylcarbonylamino, C1-C8-alkylcarbonyl(C1-C8-alkyl)amino, C1-C8-alkylsulfonylamino, C1-C8-thioalkyl, C1-C8-alkylsulfinyl, C1-C8-alkylsulfonyl, aminosulfonyl, C1-C8-alkylaminosulfonyl or di-C1-C8-alkylaminosulfonyl groups;
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Brief Patent Description - Full Patent Description - Patent Application Claims
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