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05/07/09 - USPTO Class 424 |  58 views | #20090117095 | Prev - Next | About this Page  424 rss/xml feed  monitor keywords

Methods and compositions for diagnosis and treatment of b cell chronic lymphocytic leukemia

USPTO Application #: 20090117095
Title: Methods and compositions for diagnosis and treatment of b cell chronic lymphocytic leukemia
Abstract: Provided are isolated and purified preparations of a combination of a light chain antibody gene and a heavy chain antibody gene, where the light chain and heavy chain antibody genes are the same among more than one patient with B cell chronic lymphocytic leukemia (B-CLL). Vectors comprising those genes and cells comprising those vectors are also provided, as are isolated and purified antibodies encoded by the antibody genes. Anti-idiotype antibodies, peptides, and aptamers that bind to the antigen-binding region of an antibody encoded by the antibody genes are additionally provided, as are multimeric molecules comprising multiple binding sites that bind to the antigen-binding region of an antibody encoded by the antibody genes. Methods of determining whether a patient with B cell chronic lymphocytic leukemia (B-CLL) has a form of B-CLL that is susceptible to treatment directed to eliminating idiotype specific B cell receptor-bearing B-CLL cells are also provided, as are methods of following the progression of treatment of B-CLL in the patient. Additionally, methods of treating a patient having B-CLL are provided, as are methods of identifying a therapeutic agent for B-CLL. (end of abstract)



Agent: Amster, Rothstein & Ebenstein LLP - New York, NY, US
Inventors: Bradley T. Messmer, Nicholas Chiorazzi, Emilia Albesiano
USPTO Applicaton #: 20090117095 - Class: 4241301 (USPTO)

Methods and compositions for diagnosis and treatment of b cell chronic lymphocytic leukemia description/claims


The Patent Description & Claims data below is from USPTO Patent Application 20090117095, Methods and compositions for diagnosis and treatment of b cell chronic lymphocytic leukemia.

Brief Patent Description - Full Patent Description - Patent Application Claims
  monitor keywords CROSS-REFERENCE TO RELATED APPLICATION

This application claims the benefit of U.S. Provisional Application No. 60/509,473, filed Oct. 8, 2003.

STATEMENT REGARDING FEDERALLY FUNDED RESEARCH OR DEVELOPMENT

The U.S. Government has a paid-up license in this invention and the right in limited circumstances to require the patent owner to license others on reasonable terms as provided by the terms of Grants No. CA 81554 and CA 87956 awarded by the National Institutes of Health.

BACKGROUND

The present invention generally relates to methods of diagnosis and treatment of B cell chronic lymphocytic leukemia (B-CLL). More particularly, the invention relates to methods of B-CLL diagnosis and treatment based on the presence of sets of B-CLL patients that have B cell receptor genes in common.

DESCRIPTION OF THE RELATED ART References Cited

  • Bendelac, A., M. Bonneville, and J. F. Kearney. Autoreactivity by design: innate B and T lymphocytes. Nat Rev Immunol. 2001:1:177-186.
  • Borche L et al. Blood 1990; 76:562-569.
  • Brezinschek H P, Foster S J, Brezinschek R I, Dorner T, Domiati-Saad R, Lipsky P E. Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(−)/IgM+B cells. J Clin Invest. 1997; 99:2488-2501.
  • Broker B M et al. J Autoimmun 1988; 1:469-481.
  • Casali P, Schettino E W. Structure and function of natural antibodies. Current Topics in Microbiology & Immunology. 1996; 210:167-179.
  • Chapman C J, Spellerberg M B, Smith G A, Carter S J, Hamblin T J, Stevenson F K. Autoanti-red cell antibodies synthesized by patients with infectious mononucleosis utilize the VH4-21 gene segment. Journal of Immunology 1993; 151:1051-1061.
  • Chiorazzi, N., and M. Ferrarini. Immunoglobulin Variable Region Gene Characteristics and Surface Membrane Phenotype Define B-CLL Subgroups with Distinct Clinical Courses. In Chronic Lyniphoid Leukemias. B. D. Cheson, editor. Marcel Dekker, New York. 2001; 81-109.
  • Chiorazzi, N., and M. Ferrarini. B Cell Chronic Lymphocytic Leukemia: Lessons Learned from Studies of the B Cell Antigen Receptor. In Annual Review of Immunology. W. E. Paul, editor. 2003; 21:841-894.
  • Damle, R. N., T. Wasil, F. Fais, F. Ghiotto, A. Valetto, S. L. Allen, A. Buchbinder, D. Budman, K. Dittmar, J. Kolitz, S. M. Lichtman, P. Schulman, V. P. Vinciguerra, K. R. Rai, M. Ferrarini, and N. Chiorazzi. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999; 94:1840-1847.


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