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02/05/09 - USPTO Class 514 |  62 views | #20090036482 | Prev - Next | About this Page  514 rss/xml feed  monitor keywords

Imidazopyridine-derivatives as inductible no-synthase inhibitors

USPTO Application #: 20090036482
Title: Imidazopyridine-derivatives as inductible no-synthase inhibitors
Abstract: in which R1, R2, R3, R4, R5 and A have the meanings as given in the description are novel effective iNOS inhibitors. The compounds of Formula (I) (end of abstract)



Agent: Nath & Associates PLLC - Alexandria, VA, US
Inventor: Wolf-Ruediger Ulrich
USPTO Applicaton #: 20090036482 - Class: 514303 (USPTO)

Imidazopyridine-derivatives as inductible no-synthase inhibitors description/claims


The Patent Description & Claims data below is from USPTO Patent Application 20090036482, Imidazopyridine-derivatives as inductible no-synthase inhibitors.

Brief Patent Description - Full Patent Description - Patent Application Claims
  monitor keywords FIELD OF APPLICATION OF THE INVENTION

The invention relates to novel imidazopyridine derivatives, which are used in the pharmaceutical industry for the production of pharmaceutical compositions.

KNOWN TECHNICAL BACKGROUND

In the German Patent Application DE 2504252 and in the European Patent Application EP 0125756 3H-imidazo[4,5-b]pyridine derivatives with anti-ulcer activity are described. The international Application WO 0049015 describes pyridine compounds with inhibitory activity on the production of nitric oxide.

The international Application WO 0380607 describes alkoxypyridine derivatives with iNOS Inhibitory activity.

DESCRIPTION OF THE INVENTION

It has now been found that certain novel, purposively selected aminosulfonylphenyl-substituted Imidazopyridine derivatives, which are described in greater details below, differ profoundly from previously individualized compounds and have surprising and particularly advantageous and desired properties.

The invention thus relates to compounds of formula I

in which

R1 is hydrogen or 1-4C-alkyl,

R2 is hydrogen or 1-4C-alkyl,

R3 is hydrogen or halogen,

R4 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy,

R5 is 1-4C-alkyl,

A is 1-4C-alkylene, and the salts, N-oxides and the salts of the N-oxides of these compounds.

1-4-C-Alkyl is a straight-chain or branched alkyl radical having 1 to 4 carbon atoms. Examples are the butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl, and, particularly, the ethyl and methyl radicals.

1-4C-Alkoxy is a radical which, in addition to the oxygen atom, contains a straight-chain or branched alkyl radical having 1 to 4 carbon atoms. Alkoxy radicals having 1 to 4 carbon atoms which may be mentioned in this context are, for example, the butoxy, isobutoxy, sec-butoxy, tert-butoxy, propoxy, isopropoxy, and, particularly, the ethoxy and methoxy radicals.



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Brief Patent Description - Full Patent Description - Patent Application Claims

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