Humanized immunoglubulin reactive with alph4beta7 integrin -> Monitor Keywords

Site News |

Monitor Keywords |

Monitor Archive |

Organizer |

Account Info |

01/08/09 - USPTO Class 435 | 1 views | #20090011464 | Prev - Next | About this Page

Humanized immunoglubulin reactive with alph4beta7 integrin

Title: Humanized immunoglubulin reactive with alph4beta7 integrin

Brief Patent Description - Full Patent Description - Patent Claims

The Patent Description & Claims data below is from USPTO Patent Application 20090011464, Humanized immunoglubulin reactive with alph4beta7 integrin.

1. An isolated nucleic acid molecule encoding a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7 integrin, wherein said humanized immunoglobulin or antigen-binding fragment thereof comprises a heavy chain and a light chain, said heavy chain comprising the variable region of SEQ ID NO:19, and said light chain comprising the variable region of SEQ ID NO:21.

2. The isolated nucleic acid molecule of claim 1, wherein said isolated nucleic acid molecule comprises a first nucleotide sequence encoding the variable region of SEQ ID NO:19, and a second nucleotide sequence encoding the variable region of SEQ ID NO:21.

3. The isolated nucleic acid molecule of claim 2, wherein said first nucleotide sequence further encodes an IgG constant region or a modified IgG constant region with reduced Fc receptor binding activity, reduced complement fixing activity, or reduced Fc receptor binding activity and reduced complement fixing activity.

4. An expression vector comprising a nucleotide sequence which encodes a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7 integrin, wherein said humanized immunoglobulin or antigen-binding fragment thereof comprises a heavy chain and a light chain, said heavy chain comprising the variable region of SEQ ID NO:19, and said light chain comprising the variable region of SEQ ID NO:21.

5. The expression vector of claim 4, wherein said expression vector comprises a first nucleotide sequence that encodes the variable region of SEQ ID NO:19, and a second nucleotide sequence that encodes the variable region of SEQ ID NO:21.

6. The expression vector of claim 5, wherein said first nucleotide sequence further encodes an IgG constant region or a modified IgG constant region with reduced Fc receptor binding activity, reduced complement fixing activity, or reduced Fc receptor binding activity and reduced complement fixing activity.

7. A host cell comprising the expression vector of claim 4.

8. A method of preparing a humanized immunoglobulin or antigen-binding fragment thereof, comprising maintaining a host cell of claim 7 under conditions suitable for expression of a humanized immunoglobulin or antigen-binding fragment thereof, whereby a humanized immunoglobulin or antigen-binding fragment thereof is produced.

9. The method of claim 8, further comprising isolating the humanized immunoglobulin or antigen-binding fragment.

10. An isolated nucleic acid molecule encoding a humanized immunoglobulin heavy chain or antigen-binding portion thereof, wherein said heavy chain or antigen-binding portion thereof comprises the variable region of SEQ ID NO:19.

11. The isolated nucleic acid molecule of claim 10, wherein said heavy chain comprises an IgG constant region or a modified IgG constant region with reduced Fc receptor binding activity, reduced complement fixing activity, or reduced Fc receptor binding activity and reduced complement fixing activity.

12. An expression vector comprising a nucleotide sequence that encodes a humanized immunoglobulin heavy chain or antigen-binding portion thereof, wherein said heavy chain or antigen-binding portion thereof comprises the variable region of SEQ ID NO:19.

13. The expression vector of claim 12, wherein said heavy chain comprises an IgG constant region or a modified IgG constant region with reduced Fc receptor binding activity, reduced complement fixing activity, or reduced Fc receptor binding activity and reduced complement fixing activity.

14. A host cell comprising the expression vector of claim 12.

15. A method of preparing a humanized immunoglobulin heavy chain or antigen-binding portion thereof, comprising maintaining a host cell of claim 14 under conditions suitable for expression of a humanized immunoglobulin heavy chain or antigen-binding portion thereof, whereby a humanized immunoglobulin heavy chain or antigen-binding portion thereof is produced.

16. The method of claim 15, further comprising isolating the humanized immunoglobulin heavy chain or antigen-binding portion thereof.

17. An isolated nucleic acid molecule encoding a humanized immunoglobulin light chain or antigen-binding portion thereof, wherein said light chain or antigen-binding portion thereof comprises the variable region of SEQ ID NO:21.

18. The isolated nucleic acid molecule of claim 17, wherein said humanized immunoglobulin light chain further comprises a constant region.

19. An expression vector encoding a humanized immunoglobulin light chain or antigen-binding portion thereof, wherein said light chain or antigen-binding portion thereof comprises the variable region of SEQ ID NO:21.

20. The expression vector of claim 19, wherein said humanized immunoglobulin light chain further comprises a constant region.

21. A host cell comprising the expression vector of claim 19.

22. A method of preparing a humanized immunoglobulin light chain or antigen-binding portion thereof, comprising maintaining a host cell of claim 21 under conditions suitable for expression of a humanized immunoglobulin light chain or antigen-binding portion thereof, whereby a humanized immunoglobulin light chain or antigen-binding portion thereof is produced.

23. The method of claim 22, further comprising isolating the humanized immunoglobulin light chain or antigen-binding portion thereof.

Brief Patent Description - Full Patent Description - Patent Claims

Click on the above for other options relating to this Humanized immunoglubulin reactive with alph4beta7 integrin patent application.
###

How KEYWORD MONITOR works... a FREE service from FreshPatents
1. Sign up (takes 30 seconds). 2. Fill in the keywords to be monitored.
3. Each week you receive an email with patent applications related to your keywords.
Start now! - Receive info on patent apps like Humanized immunoglubulin reactive with alph4beta7 integrin or other areas of interest.
###

Previous Patent Application:
Concatameric immunoadhesion molecule
Next Patent Application:
Method for improving protein production
Industry Class:
Chemistry: molecular biology and microbiology

###

Design/code © 2009 FreshContext LLC/Freshpatents.com. Website Terms and Conditions - Also read: About this Page
Patent data source: patents published by the United States Patent and Trademark Office (USPTO)
Information published here is for research/educational purposes only (and in conjunction with our Keyword Monitor) and is not meant to be used in place of the full USPTO patent document/images or a comprehensive patent archive search. Complete official applications are on file at the USPTO and often contain additional data/images (Freshpatents is currently text-only). FreshPatents.com is not affiliated with or endorsed by the USPTO or firms/individuals or products/designs/ideas related to listed patents.

FreshPatents.com Support
Thank you for viewing the Humanized immunoglubulin reactive with alph4beta7 integrin patent info.
IP-related news and info

Results in 0.04104 seconds

Other interesting Feshpatents.com categories:
Canon USA , Celera Genomics , Cephalon, Inc. , Cingular Wireless , Clorox , Colgate-Palmolive , Corning , Cymer , orig

* Protect your Inventions
* US Patent Office filing

Provisional Patent
Utility Patent

PATENT INFO